PTGER1 (prostaglandin E receptor 1) - Rat Genome Database

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Gene: PTGER1 (prostaglandin E receptor 1) Homo sapiens
Analyze
Symbol: PTGER1
Name: prostaglandin E receptor 1
RGD ID: 733054
HGNC Page HGNC
Description: Predicted to have prostaglandin E receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; inflammatory response; and positive regulation of cytosolic calcium ion concentration. Predicted to localize to plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EP1; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1 (subtype EP1), 42kD; prostaglandin E receptor 1 (subtype EP1), 42kDa; prostaglandin E receptor 1, subtype EP1; prostaglandin E2 receptor EP1 subtype; prostanoid EP1 receptor
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1914,472,466 - 14,475,354 (-)EnsemblGRCh38hg38GRCh38
GRCh381914,472,466 - 14,475,354 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,583,278 - 14,586,166 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,444,278 - 14,447,174 (-)NCBINCBI36hg18NCBI36
Build 341914,444,278 - 14,447,174NCBI
Celera1914,477,399 - 14,480,295 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1914,153,393 - 14,156,289 (-)NCBIHuRef
CHM1_11914,583,257 - 14,586,164 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1160156   PMID:7759114   PMID:7938166   PMID:8253813   PMID:11235015   PMID:11951086   PMID:12477932   PMID:12642666   PMID:12788892   PMID:12841871   PMID:14562138   PMID:14744769  
PMID:15489334   PMID:15886234   PMID:16393343   PMID:16670773   PMID:16754659   PMID:17496729   PMID:17525067   PMID:17611676   PMID:17877755   PMID:17906615   PMID:18516068   PMID:19064572  
PMID:19336370   PMID:19625175   PMID:19913121   PMID:20178602   PMID:20452482   PMID:20587336   PMID:20628086   PMID:20647315   PMID:20673868   PMID:20858737   PMID:21052031   PMID:21447366  
PMID:21813027   PMID:21873635   PMID:22110249   PMID:22162473   PMID:22276108   PMID:22474323   PMID:22555372   PMID:22924768   PMID:23494562   PMID:23525457   PMID:23842570   PMID:24333447  
PMID:24614038   PMID:25289898   PMID:26211005   PMID:26959713   PMID:27818595   PMID:29134301   PMID:29676528  


Genomics

Comparative Map Data
PTGER1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1914,472,466 - 14,475,354 (-)EnsemblGRCh38hg38GRCh38
GRCh381914,472,466 - 14,475,354 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,583,278 - 14,586,166 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,444,278 - 14,447,174 (-)NCBINCBI36hg18NCBI36
Build 341914,444,278 - 14,447,174NCBI
Celera1914,477,399 - 14,480,295 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1914,153,393 - 14,156,289 (-)NCBIHuRef
CHM1_11914,583,257 - 14,586,164 (-)NCBICHM1_1
Ptger1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,393,171 - 84,399,385 (+)NCBIGRCm39mm39
GRCm39 Ensembl884,393,307 - 84,399,382 (+)Ensembl
GRCm38883,666,644 - 83,672,756 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,666,678 - 83,672,753 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,190,539 - 86,194,002 (+)NCBIGRCm37mm9NCBIm37
MGSCv36886,556,745 - 86,560,208 (+)NCBImm8
Celera887,957,431 - 87,960,894 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.22NCBI
Ptger1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21924,470,258 - 24,473,687 (-)NCBI
Rnor_6.0 Ensembl1924,800,072 - 24,803,373 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01924,799,422 - 24,803,373 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01935,779,098 - 35,782,528 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41926,160,729 - 26,163,156 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11926,165,447 - 26,167,982 (-)NCBI
Celera1924,013,194 - 24,016,495 (-)NCBICelera
Cytogenetic Map19q11NCBI
Ptger1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541533,063,052 - 33,067,580 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541533,063,052 - 33,067,580 (-)NCBIChiLan1.0ChiLan1.0
PTGER1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11914,879,798 - 14,881,969 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01914,035,876 - 14,038,812 (-)NCBIMhudiblu_PPA_v0panPan3
PTGER1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,156,055 - 48,159,838 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,157,973 - 48,159,921 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,030,811 - 48,039,003 (+)NCBI
ROS_Cfam_1.02048,673,636 - 48,681,830 (+)NCBI
UMICH_Zoey_3.12047,888,190 - 47,893,357 (+)NCBI
UNSW_CanFamBas_1.02048,311,534 - 48,319,721 (+)NCBI
UU_Cfam_GSD_1.02048,554,374 - 48,562,556 (+)NCBI
Ptger1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,335,030 - 207,342,686 (+)NCBI
SpeTri2.0NW_0049366593,014,633 - 3,018,617 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGER1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl264,797,220 - 64,800,459 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1264,796,944 - 64,800,199 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,154,866 - 65,156,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGER1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,131,328 - 13,134,457 (-)NCBI
ChlSab1.1 Ensembl613,131,424 - 13,133,190 (-)Ensembl

Position Markers
RH71361  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371914,583,373 - 14,583,553UniSTSGRCh37
Build 361914,444,373 - 14,444,553RGDNCBI36
Celera1914,477,494 - 14,477,674RGD
Cytogenetic Map19p13.1UniSTS
HuRef1914,153,488 - 14,153,668UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:324
Count of miRNA genes:302
Interacting mature miRNAs:323
Transcripts:ENST00000292513
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 40 3 1 1 105 1 5 10 10 63 56 74 4 3
Low 1777 679 1106 181 374 103 1562 810 1969 164 801 1167 82 835 884
Below cutoff 595 1789 554 389 663 312 2509 1103 1716 119 551 341 87 1 357 1679 5

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000292513   ⟹   ENSP00000292513
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,472,466 - 14,475,354 (-)Ensembl
RefSeq Acc Id: NM_000955   ⟹   NP_000946
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381914,472,466 - 14,475,354 (-)NCBI
GRCh371914,583,278 - 14,586,174 (-)ENTREZGENE
Build 361914,444,278 - 14,447,174 (-)NCBI Archive
HuRef1914,153,393 - 14,156,289 (-)ENTREZGENE
CHM1_11914,583,257 - 14,586,164 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000946   ⟸   NM_000955
- UniProtKB: P34995 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000292513   ⟸   ENST00000292513

Promoters
RGD ID:6795955
Promoter ID:HG_KWN:29113
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562
Transcripts:NM_000955
Position:
Human AssemblyChrPosition (strand)Source
Build 361914,447,106 - 14,447,817 (-)MPROMDB
RGD ID:7238839
Promoter ID:EPDNEW_H25165
Type:initiation region
Name:PTGER1_1
Description:prostaglandin E receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381914,475,337 - 14,475,397EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-13.12(chr19:12132052-14751798)x3 copy number gain See cases [RCV000052910] Chr19:12132052..14751798 [GRCh38]
Chr19:12242867..14862610 [GRCh37]
Chr19:12103867..14723610 [NCBI36]
Chr19:19p13.2-13.12		 pathogenic
GRCh38/hg38 19p13.12-q11(chr19:13974677-27839676)x3 copy number gain See cases [RCV000052912] Chr19:13974677..27839676 [GRCh38]
Chr19:14085489..28330584 [GRCh37]
Chr19:13946489..33022424 [NCBI36]
Chr19:19p13.12-q11		 pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11227942-14532135)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|See cases [RCV000053944] Chr19:11227942..14532135 [GRCh38]
Chr19:11338618..14642947 [GRCh37]
Chr19:11199618..14503947 [NCBI36]
Chr19:19p13.2-13.12		 pathogenic
NM_002741.3(PKN1):c.2096C>T (p.Ala699Val) single nucleotide variant Malignant melanoma [RCV000071955] Chr19:14469460 [GRCh38]
Chr19:14580272 [GRCh37]
Chr19:14441272 [NCBI36]
Chr19:19p13.12		 not provided
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh38/hg38 19p13.12-13.11(chr19:14154962-16914313)x1 copy number loss See cases [RCV000134176] Chr19:14154962..16914313 [GRCh38]
Chr19:14265774..17025123 [GRCh37]
Chr19:14126774..16886123 [NCBI36]
Chr19:19p13.12-13.11		 pathogenic
GRCh38/hg38 19p13.13-13.12(chr19:13533925-15371089)x1 copy number loss See cases [RCV000136502] Chr19:13533925..15371089 [GRCh38]
Chr19:13644739..15481900 [GRCh37]
Chr19:13505739..15342900 [NCBI36]
Chr19:19p13.13-13.12		 pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12580427-14742673)x1 copy number loss See cases [RCV000135937] Chr19:12580427..14742673 [GRCh38]
Chr19:12691241..14853485 [GRCh37]
Chr19:12552241..14714485 [NCBI36]
Chr19:19p13.2-13.12		 pathogenic|likely pathogenic
GRCh38/hg38 19p13.12(chr19:14406909-15410770)x1 copy number loss See cases [RCV000136896] Chr19:14406909..15410770 [GRCh38]
Chr19:14517721..15521581 [GRCh37]
Chr19:14378721..15382581 [NCBI36]
Chr19:19p13.12		 uncertain significance
GRCh37/hg19 19p13.2-13.12(chr19:9678768-14853426) copy number gain See cases [RCV000446985] Chr19:9678768..14853426 [GRCh37]
Chr19:19p13.2-13.12		 pathogenic
GRCh37/hg19 19p13.12-13.11(chr19:14124666-16431349)x1 copy number loss See cases [RCV000448818] Chr19:14124666..16431349 [GRCh37]
Chr19:19p13.12-13.11		 pathogenic
GRCh37/hg19 19p13.12(chr19:14580590-14588566)x3 copy number gain See cases [RCV000447728] Chr19:14580590..14588566 [GRCh37]
Chr19:19p13.12		 likely benign
GRCh37/hg19 19p13.2-13.12(chr19:13592592-14717528)x1 copy number loss See cases [RCV000511445] Chr19:13592592..14717528 [GRCh37]
Chr19:19p13.2-13.12		 likely pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:12574343-14726197)x1 copy number loss See cases [RCV000511130] Chr19:12574343..14726197 [GRCh37]
Chr19:19p13.2-13.12		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.12(chr19:14368330-15712368)x1 copy number loss not provided [RCV001007034] Chr19:14368330..15712368 [GRCh37]
Chr19:19p13.12		 pathogenic
GRCh37/hg19 19p13.12-12(chr19:14286624-20956753)x3 copy number gain not provided [RCV001259370] Chr19:14286624..20956753 [GRCh37]
Chr19:19p13.12-12		 pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9593 AgrOrtholog
COSMIC PTGER1 COSMIC
Ensembl Genes ENSG00000160951 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000292513 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000292513 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000160951 GTEx
HGNC ID HGNC:9593 ENTREZGENE
Human Proteome Map PTGER1 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Prostanoid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostglndn_DP_rcpt UniProtKB/Swiss-Prot
  Prostglndn_EP1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5731 UniProtKB/Swiss-Prot
NCBI Gene 5731 ENTREZGENE
OMIM 176802 OMIM
PANTHER PTHR11866 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11866:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB PA286 PharmGKB
PRINTS PROSTAGLNDNR UniProtKB/Swiss-Prot
  PROSTANOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRSTNOIDEP1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt P34995 ENTREZGENE, UniProtKB/Swiss-Prot
  Q05C32_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q5U5U4 UniProtKB/Swiss-Prot
  Q86UH3 UniProtKB/Swiss-Prot
  Q86VB5 UniProtKB/Swiss-Prot
  Q8NHB2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 PTGER1  prostaglandin E receptor 1    prostaglandin E receptor 1 (subtype EP1), 42kDa  Symbol and/or name change 5135510 APPROVED
2011-08-17 PTGER1  prostaglandin E receptor 1 (subtype EP1), 42kDa  PTGER1  prostaglandin E receptor 1 (subtype EP1), 42kDa  Symbol and/or name change 5135510 APPROVED