Mnat1 (MNAT1 component of CDK activating kinase) - Rat Genome Database

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Gene: Mnat1 (MNAT1 component of CDK activating kinase) Rattus norvegicus
Analyze
Symbol: Mnat1
Name: MNAT1 component of CDK activating kinase
RGD ID: 628874
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and zinc ion binding activity. Involved in G1/S transition of mitotic cell cycle; negative regulation of apoptotic process; and positive regulation of smooth muscle cell proliferation. Predicted to be located in chromosome; cytoplasm; and nucleus. Predicted to be part of CAK-ERCC2 complex; RNA polymerase II transcription regulator complex; and cyclin-dependent protein kinase holoenzyme complex. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase); PARTICIPATES IN RNA polymerase II transcription initiation pathway; nucleotide excision repair pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CDK-activating kinase assembly factor MAT1; menage a trois 1; menage a trois homolog 1, cyclin H assembly factor; menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis); MNAT CDK-activating kinase assembly factor 1; MNAT1, CDK activating kinase assembly factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8697,550,566 - 97,706,598 (+)NCBIGRCr8
mRatBN7.2691,814,703 - 91,971,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl691,814,749 - 91,970,744 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx692,215,265 - 92,360,395 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,514,762 - 92,659,893 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0691,942,664 - 92,087,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0695,995,341 - 96,153,331 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl696,007,805 - 96,153,330 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06105,442,513 - 105,587,335 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4695,548,845 - 95,698,573 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1695,552,300 - 95,702,028 (+)NCBI
Celera690,288,391 - 90,433,268 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mnat1RatBranchiootic Syndrome 3  ISOMNAT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Branchiootic syndrome 3ClinVarPMID:25414181 and PMID:28492532

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Object Symbol
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Reference
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Original Reference(s)
Mnat1Rat(S)-amphetamine decreases expressionISOMnat1 (Mus musculus)6480464Dextroamphetamine results in decreased expression of MNAT1 mRNACTDPMID:12558987
Mnat1Rat1,2-dimethylhydrazine decreases expressionISOMnat1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of MNAT1 mRNACTDPMID:22206623
Mnat1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMnat1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MNAT1 mRNACTDPMID:21570461
Mnat1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of MNAT1 mRNACTDPMID:21346803
Mnat1Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of MNAT1 mRNACTDPMID:21346803
Mnat1Rat2-hydroxypropanoic acid decreases expressionISOMNAT1 (Homo sapiens)6480464Lactic Acid results in decreased expression of MNAT1 mRNACTDPMID:30851411
Mnat1Rat4,4'-diaminodiphenylmethane affects expressionISOMnat1 (Mus musculus)64804644 and 4'-diaminodiphenylmethane affects the expression of MNAT1 mRNACTDPMID:18648102
Mnat1Rataflatoxin B1 multiple interactionsEXP 6480464[sulforaphane co-treated with Aflatoxin B1] affects the expression of MNAT1 mRNACTDPMID:25450479
Mnat1RatAflatoxin B2 alpha decreases methylationISOMNAT1 (Homo sapiens)6480464aflatoxin B2 results in decreased methylation of MNAT1 intronCTDPMID:30157460
Mnat1Ratall-trans-retinoic acid multiple interactionsISOMNAT1 (Homo sapiens)6480464Tretinoin results in increased ubiquitination of and results in increased degradation of MNAT1 proteinCTDPMID:16935935
Mnat1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of MNAT1 mRNACTDPMID:16483693
Mnat1Ratantimycin A decreases expressionISOMNAT1 (Homo sapiens)6480464Antimycin A results in decreased expression of MNAT1 mRNACTDPMID:33512557
Mnat1Ratantirheumatic drug increases expressionISOMNAT1 (Homo sapiens)6480464Antirheumatic Agents results in increased expression of MNAT1 mRNACTDPMID:24449571
Mnat1Ratbenzo[a]pyrene decreases expressionISOMNAT1 (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of MNAT1 mRNACTDPMID:20064835
Mnat1Ratbenzo[a]pyrene affects methylationISOMNAT1 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of MNAT1 promoterCTDPMID:27901495
Mnat1Ratbenzo[a]pyrene increases expressionISOMnat1 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of MNAT1 mRNACTDPMID:22228805
Mnat1Ratbenzo[a]pyrene diol epoxide I decreases expressionISOMNAT1 (Homo sapiens)64804647 more ...CTDPMID:20382639
Mnat1Ratbeta-lapachone increases expressionISOMNAT1 (Homo sapiens)6480464beta-lapachone results in increased expression of MNAT1 mRNACTDPMID:38218311
Mnat1Ratbis(2-ethylhexyl) phthalate increases expressionISOMnat1 (Mus musculus)6480464Diethylhexyl Phthalate results in increased expression of MNAT1 mRNACTDPMID:34319233
Mnat1Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of MNAT1 mRNACTDPMID:25181051

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Biological Process
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Object Symbol
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Reference
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Original Reference(s)
Mnat1Ratadult heart development acts_upstream_of_or_withinISOMnat1 (Mus musculus)1624291MGI:3707001 PMID:17276355RGDPMID:17276355
Mnat1Ratadult heart development acts_upstream_of_or_withinIEAUniProtKB:P51949 and ensembl:ENSMUSP000000215231600115GO_REF:0000107EnsemblGO_REF:0000107
Mnat1RatDNA repair involved_inIBAPANTHER:PTN000293747 and SGD:S0000028681600115GO_REF:0000033GO_CentralGO_REF:0000033
Mnat1RatG1/S transition of mitotic cell cycle  IMP 2308868 RGD 
Mnat1Ratnegative regulation of apoptotic process  IMP 2308868 RGD 
Mnat1Ratnucleotide-excision repair involved_inIEAInterPro:IPR0045751600115GO_REF:0000002InterProGO_REF:0000002
Mnat1Ratpositive regulation of smooth muscle cell proliferation  IMP 2308868 RGD 
Mnat1Ratregulation of DNA-templated transcription acts_upstream_of_or_withinISOMnat1 (Mus musculus)1624291MGI:3707001 PMID:17276355RGDPMID:17276355
Mnat1Ratregulation of DNA-templated transcription acts_upstream_of_or_withinIEAUniProtKB:P51949 and ensembl:ENSMUSP000000215231600115GO_REF:0000107EnsemblGO_REF:0000107
Mnat1Ratregulation of G1/S transition of mitotic cell cycle involved_inISOMNAT1 (Homo sapiens)1624291 PMID:23622515RGDPMID:23622515
Mnat1Ratregulation of G1/S transition of mitotic cell cycle involved_inIEAUniProtKB:P51948 and ensembl:ENSP000002612451600115GO_REF:0000107EnsemblGO_REF:0000107
Mnat1Ratregulation of transcription by RNA polymerase II involved_inISOMNAT1 (Homo sapiens)1624291 PMID:10801852 more ...RGDPMID:10801852 more ...
Mnat1Ratregulation of transcription by RNA polymerase II involved_inIEAUniProtKB:P51948 and ensembl:ENSP000002612451600115GO_REF:0000107EnsemblGO_REF:0000107
Mnat1Ratregulation of transcription by RNA polymerase II involved_inIBAPANTHER:PTN000293747 and UniProtKB:P519481600115GO_REF:0000033GO_CentralGO_REF:0000033
Mnat1Ratresponse to calcium ion acts_upstream_of_or_withinISOMnat1 (Mus musculus)1624291MGI:3707001 PMID:17276355RGDPMID:17276355
Mnat1Ratresponse to calcium ion acts_upstream_of_or_withinIEAUniProtKB:P51949 and ensembl:ENSMUSP000000215231600115GO_REF:0000107EnsemblGO_REF:0000107
Mnat1Rattranscription initiation at RNA polymerase II promoter involved_inIEAUniProtKB:P51948 and ensembl:ENSP000002612451600115GO_REF:0000107EnsemblGO_REF:0000107
Mnat1Rattranscription initiation at RNA polymerase II promoter involved_inISOMNAT1 (Homo sapiens)1624291 PMID:8692841RGDPMID:8692841
Mnat1Ratventricular system development acts_upstream_of_or_withinISOMnat1 (Mus musculus)1624291MGI:3707001 PMID:17276355RGDPMID:17276355
Mnat1Ratventricular system development acts_upstream_of_or_withinIEAUniProtKB:P51949 and ensembl:ENSMUSP000000215231600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Object Symbol
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Reference
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Source
Original Reference(s)
Mnat1RatCAK-ERCC2 complex part_ofISOMNAT1 (Homo sapiens)1624291 PMID:8692841RGDPMID:8692841
Mnat1RatCAK-ERCC2 complex part_ofIEAUniProtKB:P51948 and ensembl:ENSP000002612451600115GO_REF:0000107EnsemblGO_REF:0000107
Mnat1Ratchromosome located_inISOMNAT1 (Sus scrofa)1624291 PMID:21778139RGDPMID:21778139
Mnat1Ratcyclin-dependent protein kinase holoenzyme complex part_ofISOMNAT1 (Homo sapiens)1624291 PMID:23622515RGDPMID:23622515
Mnat1Ratcyclin-dependent protein kinase holoenzyme complex part_ofIEAUniProtKB:P51948 and ensembl:ENSP000002612451600115GO_REF:0000107EnsemblGO_REF:0000107
Mnat1Ratcytoplasm located_inISOMNAT1 (Sus scrofa)1624291 PMID:21778139RGDPMID:21778139
Mnat1Ratgerminal vesicle located_inISOMNAT1 (Sus scrofa)1624291 PMID:21778139RGDPMID:21778139
Mnat1Ratnucleoplasm located_inISOMNAT1 (Homo sapiens) and UniProtKB:P51948-11624291 RGDGO_REF:0000052
Mnat1Ratnucleoplasm located_inIEAUniProtKB:A0A024R688 and ensembl:ENSP000002612451600115GO_REF:0000107EnsemblGO_REF:0000107
Mnat1Ratnucleoplasm located_inIEAUniProtKB:P51948 and ensembl:ENSP000002612451600115GO_REF:0000107EnsemblGO_REF:0000107
Mnat1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Mnat1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Mnat1Rattranscription factor TFIIH core complex part_ofISOMNAT1 (Homo sapiens)1624291 PMID:8692841RGDPMID:8692841
Mnat1Rattranscription factor TFIIH core complex part_ofIEAUniProtKB:P51948 and ensembl:ENSP000002612451600115GO_REF:0000107EnsemblGO_REF:0000107
Mnat1Rattranscription factor TFIIH holo complex part_ofISOMNAT1 (Homo sapiens)1624291 PMID:9852112RGDPMID:9852112
Mnat1Rattranscription factor TFIIH holo complex part_ofIEAUniProtKB:P51948 and ensembl:ENSP000002612451600115GO_REF:0000107EnsemblGO_REF:0000107
Mnat1Rattranscription factor TFIIH holo complex part_ofIBAFB:FBgn0024956 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mnat1Rattranscription factor TFIIH holo complex part_ofIEAInterPro:IPR0045751600115GO_REF:0000002InterProGO_REF:0000002
Mnat1Rattranscription factor TFIIH holo complex part_ofIEAUniRule:UR0011167921600115GO_REF:0000104UniProtGO_REF:0000104
Mnat1Rattranscription factor TFIIK complex part_ofISOMNAT1 (Homo sapiens)1624291 PMID:8692841RGDPMID:8692841
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Molecular Function

  
Object Symbol
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Reference
Notes
Source
Original Reference(s)
Mnat1Ratcyclin-dependent protein serine/threonine kinase activator activity enablesIEAUniRule:UR0011167921600115GO_REF:0000104UniProtGO_REF:0000104
Mnat1Ratcyclin-dependent protein serine/threonine kinase activator activity enablesIEAInterPro:IPR0045751600115GO_REF:0000002InterProGO_REF:0000002
Mnat1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Mnat1Ratprotein binding enablesISOMNAT1 (Homo sapiens)1624291UniProtKB:O60260-5 more ...RGDPMID:10801852 more ...
Mnat1Ratprotein binding enablesISOMnat1 (Mus musculus)1624291PR:O70343 more ...RGDPMID:17276355
Mnat1Ratzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mnat1RatRNA polymerase II transcription initiation pathway  ISOMNAT1 (Homo sapiens)9681726 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mnat1Ratnucleotide excision repair pathway   IEA 6907045 KEGGrno:03420

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#
Reference Title
Reference Citation
1. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM and Coin F, DNA Repair (Amst). 2011 Jul 15;10(7):714-21. doi: 10.1016/j.dnarep.2011.04.021. Epub 2011 May 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Information Derived from GenBank Report RGD, Sept. 2003
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. RNA antisense abrogation of MAT1 induces G1 phase arrest and triggers apoptosis in aortic smooth muscle cells. Wu L, etal., J Biol Chem. 1999 Feb 26;274(9):5564-72.
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PMID:8692841   PMID:8692842   PMID:9852112   PMID:10801852   PMID:11445587   PMID:17276355   PMID:21778139  



Mnat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8697,550,566 - 97,706,598 (+)NCBIGRCr8
mRatBN7.2691,814,703 - 91,971,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl691,814,749 - 91,970,744 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx692,215,265 - 92,360,395 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,514,762 - 92,659,893 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0691,942,664 - 92,087,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0695,995,341 - 96,153,331 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl696,007,805 - 96,153,330 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06105,442,513 - 105,587,335 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4695,548,845 - 95,698,573 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1695,552,300 - 95,702,028 (+)NCBI
Celera690,288,391 - 90,433,268 (+)NCBICelera
Cytogenetic Map6q24NCBI
MNAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381460,734,761 - 60,969,965 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1460,734,742 - 60,969,965 (+)EnsemblGRCh38hg38GRCh38
GRCh371461,201,479 - 61,436,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361460,271,223 - 60,505,151 (+)NCBINCBI36Build 36hg18NCBI36
Build 341460,271,222 - 60,505,151NCBI
Celera1441,251,714 - 41,485,662 (+)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1441,364,391 - 41,598,757 (+)NCBIHuRef
CHM1_11461,140,780 - 61,374,681 (+)NCBICHM1_1
T2T-CHM13v2.01454,941,243 - 55,176,505 (+)NCBIT2T-CHM13v2.0
Mnat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391273,158,957 - 73,320,762 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1273,170,491 - 73,320,762 (+)EnsemblGRCm39 Ensembl
GRCm381273,112,185 - 73,273,988 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1273,123,717 - 73,273,988 (+)EnsemblGRCm38mm10GRCm38
MGSCv371274,224,704 - 74,374,975 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361274,042,567 - 74,191,687 (+)NCBIMGSCv36mm8
Celera1274,235,147 - 74,385,303 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1230.37NCBI
Mnat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554668,690,960 - 8,895,021 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554668,690,960 - 8,895,021 (-)NCBIChiLan1.0ChiLan1.0
MNAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21561,872,516 - 62,105,486 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11461,089,035 - 61,321,999 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01441,342,530 - 41,576,690 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11459,603,209 - 59,835,408 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1459,603,209 - 59,835,408 (+)Ensemblpanpan1.1panPan2
MNAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1835,747,883 - 35,946,353 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl835,756,933 - 35,946,353 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha835,510,966 - 35,699,760 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0835,990,042 - 36,179,803 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl835,990,189 - 36,179,799 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1835,602,177 - 35,790,354 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0835,679,632 - 35,867,792 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0836,041,067 - 36,229,645 (+)NCBIUU_Cfam_GSD_1.0
Mnat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864069,063,584 - 69,282,287 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364954,909,380 - 5,128,113 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364954,909,427 - 5,128,113 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MNAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1189,690,354 - 189,910,589 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11189,690,343 - 189,908,144 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21210,944,891 - 210,956,358 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MNAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12437,922,347 - 38,161,467 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2437,922,353 - 38,162,226 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605326,174,914 - 26,419,489 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mnat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473440,154,577 - 40,389,402 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473440,148,761 - 40,389,233 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Mnat1
453 total Variants

Predicted Target Of
Summary Value
Count of predictions:268
Count of miRNA genes:187
Interacting mature miRNAs:206
Transcripts:ENSRNOT00000010163
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat

1 to 10 of 29 rows
D6Got118  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8697,676,514 - 97,676,639 (+)Marker Load Pipeline
mRatBN7.2691,940,658 - 91,940,783 (+)MAPPERmRatBN7.2
Rnor_6.0696,123,145 - 96,123,269NCBIRnor6.0
Rnor_5.06105,557,501 - 105,557,625UniSTSRnor5.0
RGSC_v3.4695,666,280 - 95,666,405RGDRGSC3.4
RGSC_v3.4695,666,281 - 95,666,405UniSTSRGSC3.4
RGSC_v3.1695,669,737 - 95,669,861RGD
Celera690,403,082 - 90,403,206UniSTS
RH 3.4 Map6661.4UniSTS
RH 3.4 Map6661.4RGD
Cytogenetic Map6q24UniSTS
BE120601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2691,966,552 - 91,966,728 (+)MAPPERmRatBN7.2
Rnor_6.0696,149,140 - 96,149,315NCBIRnor6.0
Rnor_5.06105,583,144 - 105,583,319UniSTSRnor5.0
RGSC_v3.4695,694,382 - 95,694,557UniSTSRGSC3.4
Celera690,429,077 - 90,429,252UniSTS
RH 3.4 Map6657.7UniSTS
Cytogenetic Map6q24UniSTS
AI008314  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2691,840,783 - 91,840,964 (+)MAPPERmRatBN7.2
Rnor_6.0696,023,311 - 96,023,491NCBIRnor6.0
Rnor_5.06105,458,019 - 105,458,199UniSTSRnor5.0
RGSC_v3.4695,564,920 - 95,565,100UniSTSRGSC3.4
Celera690,303,861 - 90,304,041UniSTS
RH 3.4 Map6661.5UniSTS
Cytogenetic Map6q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000010163   ⟹   ENSRNOP00000010163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl691,814,749 - 91,970,742 (+)Ensembl
Rnor_6.0 Ensembl696,007,805 - 96,153,330 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102762   ⟹   ENSRNOP00000097795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl691,814,749 - 91,938,812 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107749   ⟹   ENSRNOP00000083064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl691,814,749 - 91,898,221 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114452   ⟹   ENSRNOP00000084909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl691,853,034 - 91,970,744 (+)Ensembl
RefSeq Acc Id: NM_153472   ⟹   NP_703202
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8697,561,156 - 97,706,598 (+)NCBI
mRatBN7.2691,825,283 - 91,970,744 (+)NCBI
Rnor_6.0696,007,805 - 96,153,331 (+)NCBI
Rnor_5.06105,442,513 - 105,587,335 (+)NCBI
RGSC_v3.4695,548,845 - 95,698,573 (+)RGD
Celera690,288,391 - 90,433,268 (+)RGD
Sequence:
RefSeq Acc Id: XM_063261569   ⟹   XP_063117639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8697,550,566 - 97,637,890 (+)NCBI
RefSeq Acc Id: XM_063261570   ⟹   XP_063117640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8697,561,068 - 97,706,598 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_703202 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117639 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117640 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78712 (Get FASTA)   NCBI Sequence Viewer  
  AAN10147 (Get FASTA)   NCBI Sequence Viewer  
  EDM03609 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010163
  ENSRNOP00000010163.4
  ENSRNOP00000083064.1
  ENSRNOP00000084909.1
  ENSRNOP00000097795.1
1 to 11 of 11 rows
RefSeq Acc Id: NP_703202   ⟸   NM_153472
- UniProtKB: Q8CIR5 (UniProtKB/TrEMBL),   A6HC54 (UniProtKB/TrEMBL),   Q6AZ68 (UniProtKB/TrEMBL),   A0A8I5ZYY1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010163   ⟸   ENSRNOT00000010163
Ensembl Acc Id: ENSRNOP00000083064   ⟸   ENSRNOT00000107749
Ensembl Acc Id: ENSRNOP00000097795   ⟸   ENSRNOT00000102762
Ensembl Acc Id: ENSRNOP00000084909   ⟸   ENSRNOT00000114452
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CIR5-F1-model_v2 AlphaFold Q8CIR5 1-309 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694663
Promoter ID:EPDNEW_R5187
Type:initiation region
Name:Mnat1_1
Description:MNAT1, CDK activating kinase assembly factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0696,007,744 - 96,007,804EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-37117 BioCyc
Ensembl Genes ENSRNOG00000007267 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010163 ENTREZGENE
  ENSRNOT00000010163.6 UniProtKB/TrEMBL
  ENSRNOT00000102762.1 UniProtKB/TrEMBL
  ENSRNOT00000107749.1 UniProtKB/TrEMBL
  ENSRNOT00000114452.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128354 IMAGE-MGC_LOAD
InterPro Cdk-activating_kinase_MAT1 UniProtKB/TrEMBL
  MAT1 UniProtKB/TrEMBL
  Ubiquitin-int_motif UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:266713 UniProtKB/TrEMBL
MGC_CLONE MGC:93132 IMAGE-MGC_LOAD
NCBI Gene 266713 ENTREZGENE
PANTHER CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1 UniProtKB/TrEMBL
  PTHR12683:SF13 UniProtKB/TrEMBL
Pfam MAT1 UniProtKB/TrEMBL
  zf-C3HC4_5 UniProtKB/TrEMBL
PhenoGen Mnat1 PhenoGen
PIRSF MAT1_metazoa UniProtKB/TrEMBL
PROSITE UIM UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007267 RatGTEx
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A8I5ZV40 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYY1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATM4 ENTREZGENE, UniProtKB/TrEMBL
  A6HC54 ENTREZGENE, UniProtKB/TrEMBL
  F7EX11 ENTREZGENE, UniProtKB/TrEMBL
  Q6AZ68 ENTREZGENE, UniProtKB/TrEMBL
  Q8CIR5 ENTREZGENE
UniProt Secondary Q8CIR5 UniProtKB/TrEMBL
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Mnat1  MNAT1 component of CDK activating kinase  Mnat1  MNAT1, CDK activating kinase assembly factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-03-29 Mnat1  MNAT1, CDK activating kinase assembly factor  Mnat1  MNAT CDK-activating kinase assembly factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-14 Mnat1  MNAT CDK-activating kinase assembly factor 1  Mnat1  menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Mnat1  menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)  Mnat1  menage a trois 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Mnat1  menage a trois 1      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Mnat1  menage a trois 1      Symbol and Name status set to provisional 70820 PROVISIONAL