MNAT1 (MNAT1 component of CDK activating kinase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: MNAT1 (MNAT1 component of CDK activating kinase) Sus scrofa
Analyze
Symbol: MNAT1
Name: MNAT1 component of CDK activating kinase
RGD ID: 14141852
Description: ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase activator activity (inferred); kinase activity (inferred); metal ion binding (inferred); INVOLVED IN adult heart development (ortholog); G1/S transition of mitotic cell cycle (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN RNA polymerase II transcription initiation pathway; ASSOCIATED WITH Branchiootic Syndrome 3 (ortholog); genetic disease (ortholog); FOUND IN chromosome; cytoplasm; germinal vesicle; INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CDK-activating kinase assembly factor MAT1; MAT1; menage a trois homolog 1, cyclin H assembly factor; MNAT1, CDK activating kinase assembly factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1189,690,354 - 189,910,589 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11189,690,343 - 189,908,144 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21210,944,891 - 210,956,358 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MNAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1189,690,354 - 189,910,589 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11189,690,343 - 189,908,144 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21210,944,891 - 210,956,358 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MNAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381460,734,761 - 60,969,965 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1460,734,742 - 60,969,965 (+)EnsemblGRCh38hg38GRCh38
GRCh371461,201,479 - 61,436,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361460,271,223 - 60,505,151 (+)NCBINCBI36Build 36hg18NCBI36
Build 341460,271,222 - 60,505,151NCBI
Celera1441,251,714 - 41,485,662 (+)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1441,364,391 - 41,598,757 (+)NCBIHuRef
CHM1_11461,140,780 - 61,374,681 (+)NCBICHM1_1
T2T-CHM13v2.01454,941,243 - 55,176,505 (+)NCBIT2T-CHM13v2.0
Mnat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391273,158,957 - 73,320,762 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1273,170,491 - 73,320,762 (+)EnsemblGRCm39 Ensembl
GRCm381273,112,185 - 73,273,988 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1273,123,717 - 73,273,988 (+)EnsemblGRCm38mm10GRCm38
MGSCv371274,224,704 - 74,374,975 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361274,042,567 - 74,191,687 (+)NCBIMGSCv36mm8
Celera1274,235,147 - 74,385,303 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1230.37NCBI
Mnat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8697,550,566 - 97,706,598 (+)NCBIGRCr8
mRatBN7.2691,814,703 - 91,971,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl691,814,749 - 91,970,744 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx692,215,265 - 92,360,395 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,514,762 - 92,659,893 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0691,942,664 - 92,087,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0695,995,341 - 96,153,331 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl696,007,805 - 96,153,330 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06105,442,513 - 105,587,335 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4695,548,845 - 95,698,573 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1695,552,300 - 95,702,028 (+)NCBI
Celera690,288,391 - 90,433,268 (+)NCBICelera
Cytogenetic Map6q24NCBI
Mnat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554668,690,960 - 8,895,021 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554668,690,960 - 8,895,021 (-)NCBIChiLan1.0ChiLan1.0
MNAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21561,872,516 - 62,105,486 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11461,089,035 - 61,321,999 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01441,342,530 - 41,576,690 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11459,603,209 - 59,835,408 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1459,603,209 - 59,835,408 (+)Ensemblpanpan1.1panPan2
MNAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1835,747,883 - 35,946,353 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl835,756,933 - 35,946,353 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha835,510,966 - 35,699,760 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0835,990,042 - 36,179,803 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl835,990,189 - 36,179,799 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1835,602,177 - 35,790,354 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0835,679,632 - 35,867,792 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0836,041,067 - 36,229,645 (+)NCBIUU_Cfam_GSD_1.0
Mnat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864069,063,584 - 69,282,287 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364954,909,380 - 5,128,113 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364954,909,427 - 5,128,113 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MNAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12437,922,347 - 38,161,467 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2437,922,353 - 38,162,226 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605326,174,914 - 26,419,489 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mnat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473440,154,577 - 40,389,402 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473440,148,761 - 40,389,233 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MNAT1
2580 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 3 1 6
Low 9 4 5 1 17 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000005610   ⟹   ENSSSCP00000005469
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1189,690,354 - 189,910,589 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000066607   ⟹   ENSSSCP00000064596
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1189,690,354 - 189,910,589 (+)Ensembl
RefSeq Acc Id: NM_001166316   ⟹   NP_001159788
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11189,690,482 - 189,907,808 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021064622   ⟹   XP_020920281
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11189,690,343 - 189,845,924 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021064673   ⟹   XP_020920332
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11189,690,344 - 189,908,144 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002336325
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11189,690,345 - 189,908,144 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002336329
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11189,690,344 - 189,845,924 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020920281   ⟸   XM_021064622
- Peptide Label: isoform X1
- UniProtKB: A0A4X1WD01 (UniProtKB/TrEMBL),   A0A8D1ZXN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020920332   ⟸   XM_021064673
- Peptide Label: isoform X2
- UniProtKB: A0A8D0J3F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001159788   ⟸   NM_001166316
- UniProtKB: C9K507 (UniProtKB/TrEMBL),   A0A4X1WCT0 (UniProtKB/TrEMBL),   F6Q8T7 (UniProtKB/TrEMBL),   A0A8D1ZXN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000005469   ⟸   ENSSSCT00000005610
RefSeq Acc Id: ENSSSCP00000064596   ⟸   ENSSSCT00000066607
Protein Domains
Cdk-activating kinase assembly factor MAT1 centre   RING-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005090 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005023095 UniProtKB/TrEMBL
  ENSSSCG00025054731 UniProtKB/TrEMBL
  ENSSSCG00035010641 UniProtKB/TrEMBL
  ENSSSCG00055008717 UniProtKB/TrEMBL
  ENSSSCG00060004786 UniProtKB/TrEMBL
  ENSSSCG00065069968 UniProtKB/TrEMBL
  ENSSSCG00070030515 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005610 ENTREZGENE
  ENSSSCT00000005610.4 UniProtKB/TrEMBL
  ENSSSCT00000066607.1 UniProtKB/TrEMBL
  ENSSSCT00005036824.1 UniProtKB/TrEMBL
  ENSSSCT00025074948.1 UniProtKB/TrEMBL
  ENSSSCT00025075076.1 UniProtKB/TrEMBL
  ENSSSCT00025075207.1 UniProtKB/TrEMBL
  ENSSSCT00035013312.1 UniProtKB/TrEMBL
  ENSSSCT00035013315.1 UniProtKB/TrEMBL
  ENSSSCT00035013319.1 UniProtKB/TrEMBL
  ENSSSCT00055017030.1 UniProtKB/TrEMBL
  ENSSSCT00055017082.1 UniProtKB/TrEMBL
  ENSSSCT00055017128.1 UniProtKB/TrEMBL
  ENSSSCT00060005956.1 UniProtKB/TrEMBL
  ENSSSCT00060005964.1 UniProtKB/TrEMBL
  ENSSSCT00060005970.1 UniProtKB/TrEMBL
  ENSSSCT00065096061.1 UniProtKB/TrEMBL
  ENSSSCT00065096074.1 UniProtKB/TrEMBL
  ENSSSCT00065096077.1 UniProtKB/TrEMBL
  ENSSSCT00065096082.1 UniProtKB/TrEMBL
  ENSSSCT00070061430.1 UniProtKB/TrEMBL
  ENSSSCT00070061431.1 UniProtKB/TrEMBL
  ENSSSCT00070061432.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro Cdk-activating_kinase_MAT1_cen UniProtKB/TrEMBL
  MAT1/Tfb3 UniProtKB/TrEMBL
  UIM_dom UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report ssc:100310799 UniProtKB/TrEMBL
NCBI Gene MNAT1 ENTREZGENE
PANTHER CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1 UniProtKB/TrEMBL
  PTHR12683:SF13 UniProtKB/TrEMBL
Pfam MAT1 UniProtKB/TrEMBL
  zf-C3HC4_5 UniProtKB/TrEMBL
PIRSF MAT1_metazoa UniProtKB/TrEMBL
PROSITE UIM UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A4X1W7E3_PIG UniProtKB/TrEMBL
  A0A4X1WCT0 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WD01 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QRC7_PIG UniProtKB/TrEMBL
  A0A8D0J3F2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1ZXN0 ENTREZGENE, UniProtKB/TrEMBL
  C9K507 ENTREZGENE, UniProtKB/TrEMBL
  F6Q8T7 ENTREZGENE
UniProt Secondary F6Q8T7 UniProtKB/TrEMBL
VGNC ID VGNC:90286 ENTREZGENE