Advanced Search (OLGA)

Gene: Adra2c (adrenoceptor alpha 2C) Rattus rattus

Analyze

Symbol:

Adra2c

Name:

adrenoceptor alpha 2C

RGD ID:

626035601

Description:

ENCODES a protein that exhibits alpha-2A adrenergic receptor binding (ortholog); alpha2-adrenergic receptor activity (ortholog); epinephrine binding (ortholog); INVOLVED IN adrenergic receptor signaling pathway (ortholog); epidermal growth factor receptor signaling pathway (ortholog); female pregnancy (ortholog); ASSOCIATED WITH Cardiomegaly (ortholog); congestive heart failure (ortholog); Fibrosis (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

alpha-2C adrenergic receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADRA2C (adrenoceptor alpha 2C)	NCBI	Ortholog
Mus musculus (house mouse):	Adra2c (adrenergic receptor, alpha 2c)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Adra2c (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADRA2C (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADRA2C (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adra2c (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADRA2C (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADRA2C (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adra2c (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Rrattus_CSIRO_v1 - Rrattus_CSIRO_v1 Assembly

Position:

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	69,792,228 - 69,794,766 (-)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiomegaly (ISO)

congestive heart failure (ISO)

Fibrosis (ISO)

Hyperalgesia (ISO)

Neuralgia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adrenergic receptor signaling pathway (ISO)

epidermal growth factor receptor signaling pathway (ISO)

female pregnancy (ISO)

G protein-coupled receptor signaling pathway (ISO)

negative regulation of norepinephrine secretion (ISO)

negative regulation of uterine smooth muscle contraction (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of neuron differentiation (ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of vasoconstriction (ISO)

Cellular Component

axon (ISO)

axon terminus (ISO)

cytoplasm (ISO)

glutamatergic synapse (ISO)

neuronal cell body (ISO)

plasma membrane (ISO)

postsynaptic density membrane (ISO)

postsynaptic membrane (ISO)

Molecular Function

alpha-2A adrenergic receptor binding (ISO)

alpha2-adrenergic receptor activity (ISO)

epinephrine binding (ISO)

G protein-coupled receptor activity (ISO)

protein heterodimerization activity (ISO)

protein homodimerization activity (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Adra2c
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	69,792,228 - 69,794,766 (-)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

ADRA2C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	3,766,385 - 3,768,526 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	3,766,348 - 3,768,526 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	4	3,768,112 - 3,770,253 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	3,738,094 - 3,740,051 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	3,804,398 - 3,807,217	NCBI
Celera	4	3,671,112 - 3,673,097 (+)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	3,705,412 - 3,707,390 (+)	NCBI		HuRef
CHM1_1	4	3,766,238 - 3,768,183 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	3,765,283 - 3,767,445 (+)	NCBI		T2T-CHM13v2.0

Adra2c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	35,435,910 - 35,439,107 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	35,435,663 - 35,439,107 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	35,278,566 - 35,281,763 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	35,278,319 - 35,281,763 (+)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	5	35,621,215 - 35,624,412 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	35,595,575 - 35,598,742 (+)	NCBI		MGSCv36	mm8
Celera	5	32,753,998 - 32,757,254 (+)	NCBI		Celera
Cytogenetic Map	5	B2	NCBI
cM Map	5	18.09	NCBI

Adra2c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	79,695,514 - 79,697,476 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	79,694,995 - 79,706,656 (-)	Ensembl				GRCr8
mRatBN7.2	14	75,470,884 - 75,472,846 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	75,471,143 - 75,472,846 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	79,924,216 - 79,926,175 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	81,165,071 - 81,167,030 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	77,610,079 - 77,612,038 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	14	80,230,393 - 80,232,352 (-)	NCBI
Lyon_Normotensive	14	78,855,329 - 78,857,288 (-)	NCBI
Lyon_Hypertensive	14	80,377,917 - 80,379,876 (-)	NCBI
F344_StmMcwi	14	79,288,994 - 79,290,956 (-)	NCBI
Rnor_6.0	14	80,730,307 - 80,732,010 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	80,730,307 - 80,732,010 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	14	81,422,130 - 81,423,833 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	81,107,907 - 81,109,610 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	74,399,360 - 74,401,063 (-)	NCBI		Celera
RGSC_v3.1	14	81,110,297 - 81,112,001 (-)	NCBI
Cytogenetic Map	14	q21	NCBI

ADRA2C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	4,099,781 - 4,102,012 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	4,033,469 - 4,035,654 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	3,904,346 - 3,906,577 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	3,894,575 - 3,897,018 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

ADRA2C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	60,608,632 - 60,648,112 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	60,646,132 - 60,647,722 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	63,296,546 - 63,298,547 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	61,121,798 - 61,123,799 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	61,122,360 - 61,123,799 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	60,615,963 - 60,617,962 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	60,821,563 - 60,823,566 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	61,177,369 - 61,179,380 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Adra2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	9	2,683,162 - 2,685,814 (+)	NCBI		mIctTri1.hap1

ADRA2C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	2,320,226 - 2,321,608 (+)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	8	2,320,125 - 2,322,162 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	2,048,614 - 2,050,639 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADRA2C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	27	45,933,856 - 45,936,042 (-)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666051	1,297,830 - 1,299,978 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	27	44,950,928 - 44,953,245 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	44,951,457 - 44,952,827 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Adra2c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624755	24,299,985 - 24,301,824 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624755	24,300,347 - 24,301,693 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_032916841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAAIVD010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_032916841 ⟹ XP_032772732

Type:

CODING

Position:

Black Rat Assembly	Chr	Position (strand)	Source
Rrattus_CSIRO_v1	11	69,792,228 - 69,794,766 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_032772732	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_032772732 ⟸ XM_032916841

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Adra2c	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - CTD