RGD Reference Report - Decreased spinal alpha2a- and alpha2c-adrenergic receptor subtype mRNA in a rat model of neuropathic pain. - Rat Genome Database

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Decreased spinal alpha2a- and alpha2c-adrenergic receptor subtype mRNA in a rat model of neuropathic pain.

Authors: Leiphart, JW  Dills, CV  Levy, RM 
Citation: Leiphart JW, etal., Neurosci Lett. 2003 Sep 25;349(1):5-8.
RGD ID: 6893571
Pubmed: PMID:12946573   (View Abstract at PubMed)

Northern blot analyses performed on the lumbar spinal cords (L4-L6) of rats with the Bennett and Xie chronic constriction injury (CCI) nerve ligation model of neuropathic pain were compared to non-ligation surgery and unoperated control rats to determine if there is a change in alpha2-adrenergic receptor mRNA expression with neuropathic pain. Compared to unoperated rats, CCI rats had bilaterally lower RG-20 mRNA, corresponding to the alpha2A-adrenergic receptor subtype (affected 62.4 +/- 22.1% and contralateral 69.5 +/- 16.6% of unoperated, P<0.05), and RG-10 mRNA, corresponding to the alpha2C-adrenergic receptor subtype (affected 49.2 +/- 19.1% and contralateral 50.0 +/- 14.4% of unoperated, P<0.05). These results would suggest a corresponding decrease in alpha2A- and alpha2C-adrenergic receptor concentrations in the CCI and non-ligation surgery rats' spinal cords.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADRA2AHumanNeuralgia  ISOAdra2a (Rattus norvegicus) RGD 
ADRA2CHumanNeuralgia  ISOAdra2c (Rattus norvegicus) RGD 
Adra2aRatNeuralgia  IEP  RGD 
Adra2aMouseNeuralgia  ISOAdra2a (Rattus norvegicus) RGD 
Adra2cRatNeuralgia  IEP  RGD 
Adra2cMouseNeuralgia  ISOAdra2c (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adra2a  (adrenoceptor alpha 2A)
Adra2c  (adrenoceptor alpha 2C)

Genes (Mus musculus)
Adra2a  (adrenergic receptor, alpha 2a)
Adra2c  (adrenergic receptor, alpha 2c)

Genes (Homo sapiens)
ADRA2A  (adrenoceptor alpha 2A)
ADRA2C  (adrenoceptor alpha 2C)


Additional Information