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Gene: Adra2c (adrenergic receptor, alpha 2c) Mus musculus

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Symbol:

Adra2c

Name:

adrenergic receptor, alpha 2c

RGD ID:

10103

MGI Page

MGI

Description:

Enables G protein-coupled receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in axon terminus; cytoplasm; and neuronal cell body. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including adrenal gland; central nervous system; early embryo; oocyte; and sensory organ. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human ADRA2C (adrenoceptor alpha 2C).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

[a]2; [a]2C; Adra; Adra-2c; alp; alpha-2 adrenergic receptor subtype C4; alpha-2C adrenergic receptor; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2CAR; alpha2-C4; alpha2C; subtype alpha2-C4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADRA2C (adrenoceptor alpha 2C)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Adra2c (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADRA2C (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADRA2C (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADRA2C (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADRA2C (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adra2c (adrenoceptor alpha 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Adra2c (adrenoceptor alpha 2C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ADRA2C (adrenoceptor alpha 2C)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	adra2c (adrenoceptor alpha 2C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	Octalpha2R	Alliance	DIOPT (InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	octr-1	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	adra2c	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	35,435,910 - 35,439,107 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	35,435,663 - 35,439,107 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	35,278,566 - 35,281,763 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	35,278,319 - 35,281,763 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	35,621,215 - 35,624,412 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	35,595,575 - 35,598,742 (+)	NCBI		MGSCv36	mm8
Celera	5	32,753,998 - 32,757,254 (+)	NCBI		Celera
Cytogenetic Map	5	B2	NCBI
cM Map	5	18.09	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiomegaly (ISO)

congestive heart failure (ISO)

Ellis-Van Creveld syndrome (ISO)

Fibrosis (ISO)

Hyperalgesia (ISO)

Neuralgia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin (ISO)

(R)-adrenaline (ISO)

(R)-noradrenaline (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-methoxyidazoxan (EXP,ISO)

2-phenylethylamine (ISO)

3,4-methylenedioxymethamphetamine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (ISO)

ammonium chloride (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (EXP)

Bardoxolone methyl (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (ISO)

C60 fullerene (ISO)

calcium atom (ISO)

calcium(0) (ISO)

chlorpyrifos (ISO)

clofibrate (EXP)

clonidine (ISO)

clonidine (amino form) (ISO)

clonidine (imino form) (ISO)

colforsin daropate hydrochloride (ISO)

copper(II) sulfate (ISO)

dexamethasone (ISO)

diallyl trisulfide (ISO)

dichlorine (ISO)

diethylstilbestrol (EXP)

dopamine (EXP)

elemental selenium (ISO)

ethanol (EXP)

fipronil (ISO)

flavonoids (ISO)

genistein (EXP,ISO)

indometacin (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methoxychlor (ISO)

metoprolol (ISO)

N,N-diethyl-m-toluamide (ISO)

naphthalene (ISO)

nickel atom (ISO)

Nonylphenol (ISO)

oxcarbazepine (ISO)

oxymetazoline (ISO)

ozone (ISO)

perfluorooctanoic acid (ISO)

phenylpropanolamine (ISO)

progesterone (ISO)

quercitrin (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sulindac sulfide (ISO)

sunitinib (ISO)

synephrine (ISO)

titanium dioxide (EXP)

trichloroethene (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

vorinostat (ISO)

Xylometazoline (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of protein kinase B activity (ISO)

adrenergic receptor signaling pathway (IEA,ISO)

female pregnancy (IEA,ISO)

G protein-coupled receptor signaling pathway (IDA,ISO)

negative regulation of uterine smooth muscle contraction (IEA,ISO)

platelet activation (IEA)

positive regulation of MAPK cascade (IEA,ISO)

positive regulation of neuron differentiation (IEA,ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of vasoconstriction (IEA,ISO)

Cellular Component

axon (ISO)

axon terminus (IEA,ISO)

cytoplasm (IEA,ISO)

glutamatergic synapse (IEA,ISO)

neuronal cell body (IEA,ISO)

plasma membrane (IBA,ISO)

postsynaptic density membrane (IEA,ISO)

postsynaptic membrane (ISO)

Molecular Function

alpha-2A adrenergic receptor binding (IEA,ISO)

alpha2-adrenergic receptor activity (IBA,ISO,TAS)

epinephrine binding (IBA,IEA,ISO)

G protein-coupled receptor activity (IDA)

protein binding (ISO)

protein heterodimerization activity (IEA,ISO)

protein homodimerization activity (IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal placenta development (IAGP)

abnormal spatial working memory (IAGP)

abnormal synaptic norepinephrine release (IAGP)

abnormal visceral yolk sac morphology (IAGP)

cardiac hypertrophy (IAGP)

decreased heart rate (IAGP)

embryonic lethality during organogenesis, complete penetrance (IAGP)

increased coping response (IAGP)

increased startle reflex (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Decreased spinal alpha2a- and alpha2c-adrenergic receptor subtype mRNA in a rat model of neuropathic pain.	Leiphart JW, etal., Neurosci Lett. 2003 Sep 25;349(1):5-8.
2.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
3.	MGDs mouse GO annotations	MGD data from the GO Consortium
4.	MGD IEA	MGD IEA
5.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Activation of spinal alpha-2 adrenoceptors, but not mu-opioid receptors, reduces the intrathecal N-methyl-D-aspartate-induced increase in spinal NR1 subunit phosphorylation and nociceptive behaviors in the rat.	Roh DH, etal., Anesth Analg. 2010 Feb 1;110(2):622-9. Epub 2009 Dec 10.
11.	Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.	Small KM, etal., N Engl J Med 2002 Oct 10;347(15):1135-42.

Additional References at PubMed

PMID:1353249	PMID:1676978	PMID:7623774	PMID:7959747	PMID:8177505	PMID:8281014	PMID:8387367	PMID:8670422	PMID:8762185	PMID:8843087	PMID:8889548	PMID:9016344
PMID:9139936	PMID:9235896	PMID:9370299	PMID:9415717	PMID:9421280	PMID:9526020	PMID:9605877	PMID:9692731	PMID:9730916	PMID:9806851	PMID:9892019	PMID:9988767
PMID:10051760	PMID:10385696	PMID:10523817	PMID:10647009	PMID:10767319	PMID:11110696	PMID:11125002	PMID:11181434	PMID:11642653	PMID:11927164	PMID:12068299	PMID:12384461
PMID:12527480	PMID:12764077	PMID:14514350	PMID:14712229	PMID:15026130	PMID:15591786	PMID:16141072	PMID:16417582	PMID:16428542	PMID:16602821	PMID:16839770	PMID:17075569
PMID:17244791	PMID:17261653	PMID:17597596	PMID:17618305	PMID:17636168	PMID:17673674	PMID:17975126	PMID:17977919	PMID:18326714	PMID:18632114	PMID:19125280	PMID:19225179
PMID:19251826	PMID:19505981	PMID:19744502	PMID:20083574	PMID:20595538	PMID:20599923	PMID:20814988	PMID:21209093	PMID:21267068	PMID:21873635	PMID:22088943	PMID:22266179
PMID:22805283	PMID:22859407	PMID:22933299	PMID:23400995	PMID:23658728	PMID:24952961	PMID:25037566	PMID:25186490	PMID:26815679	PMID:27751959	PMID:31533035	PMID:32409748
PMID:37758766	PMID:37841583

Genomics

Comparative Map Data

Adra2c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	35,435,910 - 35,439,107 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	35,435,663 - 35,439,107 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	35,278,566 - 35,281,763 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	35,278,319 - 35,281,763 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	35,621,215 - 35,624,412 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	35,595,575 - 35,598,742 (+)	NCBI		MGSCv36	mm8
Celera	5	32,753,998 - 32,757,254 (+)	NCBI		Celera
Cytogenetic Map	5	B2	NCBI
cM Map	5	18.09	NCBI

ADRA2C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	3,766,385 - 3,768,526 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	3,766,348 - 3,768,526 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	3,768,112 - 3,770,253 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	3,738,094 - 3,740,051 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	3,804,398 - 3,807,217	NCBI
Celera	4	3,671,112 - 3,673,097 (+)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	3,705,412 - 3,707,390 (+)	NCBI		HuRef
CHM1_1	4	3,766,238 - 3,768,183 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	3,765,283 - 3,767,445 (+)	NCBI		T2T-CHM13v2.0

Adra2c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	79,695,514 - 79,697,476 (-)	NCBI		GRCr8
mRatBN7.2	14	75,470,884 - 75,472,846 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	75,471,143 - 75,472,846 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	79,924,216 - 79,926,175 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	81,165,071 - 81,167,030 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	77,610,079 - 77,612,038 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	80,730,307 - 80,732,010 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	80,730,307 - 80,732,010 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	81,422,130 - 81,423,833 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	81,107,907 - 81,109,610 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	81,110,297 - 81,112,001 (-)	NCBI
Celera	14	74,399,360 - 74,401,063 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

ADRA2C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	4,099,781 - 4,102,012 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	4,033,469 - 4,035,654 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	3,904,346 - 3,906,577 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	3,894,575 - 3,897,018 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

ADRA2C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	60,608,632 - 60,648,112 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	60,646,132 - 60,647,722 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	63,296,546 - 63,298,547 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	61,121,798 - 61,123,799 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	61,122,360 - 61,123,799 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	60,615,963 - 60,617,962 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	60,821,563 - 60,823,566 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	61,177,369 - 61,179,380 (-)	NCBI		UU_Cfam_GSD_1.0

ADRA2C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	2,320,226 - 2,321,608 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	2,320,125 - 2,322,162 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	2,048,614 - 2,050,639 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADRA2C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	44,950,928 - 44,953,245 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	44,951,457 - 44,952,827 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	1,297,830 - 1,299,978 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adra2c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	24,300,347 - 24,301,693 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	24,299,985 - 24,301,824 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Adra2c
92 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	235
Count of miRNA genes:	176
Interacting mature miRNAs:	205
Transcripts:	ENSMUST00000049545
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301555	Alcp10_m	alcohol preference locus 10 (mouse)			Not determined		5	31024275	65024480	Mouse
4140990	Lgq6_m	late growth QTL 6 (mouse)			Not determined			32133234	100777931	Mouse
10043995	Hbnr9_m	Heligmosomoides bakeri nematode resistance 9 (mouse)			Not determined		5	33488667	67488876	Mouse
1301776	Skts3_m	skin tumor susceptibility 3 (mouse)			Not determined		5	21667295	55667403	Mouse
1301685	Estq2_m	estradiol regulated response QTL 2 (mouse)			Not determined		5	15634084	49634190	Mouse
11537367	Hmtb11_m	hemostasis and thrombosis 11 (mouse)					5	22100823	64806579	Mouse
4141207	Imrfq1_m	immune response to Factor IX QTL 1 (mouse)			Not determined		5	8124117	42124239	Mouse
11537368	Hmtb10_m	hemostasis and thrombosis 10 (mouse)					5	22100823	54500318	Mouse
1301403	Alcp9_m	alcohol preference locus 9 (mouse)			Not determined		5	31024275	65024480	Mouse
15039371	Nmrs21_m	NAFLD-associated magnetic resonance shift 21 (mouse)					5	3504823	37504823	Mouse
1301693	Sle6_m	systemic lupus erythematosus susceptibility 6 (mouse)			Not determined		5	8890693	87841837	Mouse
1300701	Cd8ts1_m	CD8 T cell subset 1 (mouse)			Not determined		5	27215348	61215451	Mouse
11353827	Hplq1_m	hot plate latency 1 (mouse)					5	31570458	65570458	Mouse
1357478	Kdnw1_m	kidney weight 1 (mouse)			Not determined		5	8915949	40529869	Mouse
11341716	Rvfs3_m	Rift Valley fever susceptibility 3 (mouse)					5	26441234	138455402	Mouse
14696730	Kidlq1_m	kidney weight, left QTL 1 (mouse)					5	13563152	47563152	Mouse
1300719	Iba5_m	induction of brown adipocytes 5 (mouse)			Not determined		5	20686993	54687134	Mouse
4141219	W10q16_m	weight 10 weeks QTL 16 (mouse)			Not determined			32133234	100777931	Mouse
1301806	Actd2_m	activity-distance traveled 2 (mouse)			Not determined		5	5384520	39384652	Mouse

Markers in Region

BB310481

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	35,281,562 - 35,281,675	UniSTS	GRCm38
MGSCv37	5	35,624,211 - 35,624,324	UniSTS	GRCm37
Celera	5	32,757,053 - 32,757,166	UniSTS
Cytogenetic Map	5	B2	UniSTS
cM Map	5	20.0	UniSTS
Whitehead/MRC_RH	5	465.72	UniSTS
Whitehead/MRC_RH	5	464.43	UniSTS

RH131895

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	35,281,515 - 35,281,721	UniSTS	GRCm38
MGSCv37	5	35,624,164 - 35,624,370	UniSTS	GRCm37
Celera	5	32,757,006 - 32,757,212	UniSTS
Cytogenetic Map	5	B2	UniSTS
cM Map	5	20.0	UniSTS

M97516

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	35,281,437 - 35,281,587	UniSTS	GRCm38
MGSCv37	5	35,624,086 - 35,624,236	UniSTS	GRCm37
Celera	5	32,756,928 - 32,757,078	UniSTS
Cytogenetic Map	5	B2	UniSTS
cM Map	5	20.0	UniSTS
Whitehead_YAC	5		UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_007418	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC164118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY965033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BE648133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BE957015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BE994823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ062611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK622790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M97516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M99376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000049545 ⟹ ENSMUSP00000059705

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	35,435,663 - 35,439,107 (+)	Ensembl
GRCm38.p6 Ensembl	5	35,278,319 - 35,281,763 (+)	Ensembl

RefSeq Acc Id:

NM_007418 ⟹ NP_031444

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	35,435,910 - 35,439,107 (+)	NCBI
GRCm38	5	35,278,566 - 35,281,763 (+)	ENTREZGENE
MGSCv37	5	35,621,215 - 35,624,412 (+)	RGD
Celera	5	32,753,998 - 32,757,254 (+)	RGD
cM Map	5		ENTREZGENE

Sequence:

show sequence

TGTGAAAAGCGGGATCACACAGCATTAAGATTCAACTTCAACAATTGCCAACATGGGTATAGAG
CTTGGGAGCTTGATCTGGGCCTCGACTGACACCGTGGTTATGATTCACGATCCCGCAGCGCTGA
GAGGTACTCAGAGGAGGGAACTGAGGCTGACTGAGGAGGTGGCTCTGCAGGGGAGCAGGGACCC
TAAGCTCCAAAGGAATGATGCGCACCAGCAGTGTCTCTGCCATGCTGCTACAAGCGCACTCTCC
AATCAGGCCGCGGACCCCGAGCCAGCCCCTTACGAGCCGGTGTGCGCGCCCGCGCGCGCTCCGT
CGCCTGTAACCGAGTGAGGTGGAGACTACGATCTTAGAAAGAGCAGGCTTCTAGAACTCACCGC
TCAGGCCAGCCCGCGCTCAGCCGGGCCCCGCAGGCTGCAGTTGGCCCTGGAGGGGGCGCCCTCG
CCGAGTGCGCGCCCTGCGCCGCCGCCTAGGGCTCCTCCCCGGCGCCGCCGGCAGGTTCGCCCAG
GCGGCCGCGGGCTCCGGCTCCCGGCCCGCTCCCCCCGGGCCCGCGGCTCGGGCCTGCGGGGCGC
CCCGCCCCGCCCCGCTGCGCCCTCCCCGCTGCGCTACTGGACTCAAGTTGGAAGCCGAGCCCGG
GCGACAGCACTTGCGCCAAGCGCTCCGCGGCGGCGGAGACGCTGCACCGGCGAGCGGGGAGGGC
GAGGCGGCGCCCGCACGGCCGAACGCGGACCTTGGGGGGCGCCCGCACTCGGGAGCAGCAGGAG
GACCGCGGGTGTCGGCGCCCAGCCCCGCAAAGTAAAGTTGCAGGGACCCGGAAGAACGGCAACC
TGCGCCCCGGCTCGCTTAGCCCCAGCCAGCCCGTTGGGAAGCAGAGTGTCCGGGCCGCCGCCTG
CAGCCTGCAGCCCAGTCGGGCACCCGGACCGTGGAGCCGCTTGCGTGCACCAGCTTGGACACCG
CATCTCCGTGGGCTGGCGGCCGGGACGCTCCCACTGAACCCAGGCCGAGGGCGGGGCCGCTCGA
GGACCCGGGACCTACCCCCATTCCCCCCCACCGCCGCGTCGCCGCGCTCTCTGGGCACCTCCAG
CTCTGCACTTACGCGCGCGGCAGCTGCGGGGAGCCCGGCAGCCACGCTCTCCGGCGCGCCGCCC
GCCCGCCGGGCCACCACGGCCGAGAGCCGGCTGCGGGGCTTCGTGGCCCCCAGCCGGCGCGCCG
GAGGAGCAGGCGGCGATGCGGACGCCGACCCTGGCTGTGGGGCGCCCGAGCTGCCGAGGCTGCG
CCCGGGCTCCTGGCAGGACCGCGTAGCTCTCGGGAGGACCATGGCGTCCCCAGCGCTGGCCGCG
GCGCTGGCGGCGGCGGCGGCTGAGGGCCCCAACGGGAGCGACGCGGGCGAATGGGGTAGCGGCG
GGGGTGCCAACGCCTCGGGGACCGACTGGGTGCCACCGCCGGGCCAGTACTCCGCAGGTGCTGT
GGCGGGGTTGGCAGCTGTGGTGGGTTTCCTCATCGTTTTCACCGTGGTAGGCAATGTGCTCGTG
GTGATCGCTGTGTTGACCAGCCGAGCACTGCGCGCCCCGCAGAACCTCTTCCTGGTGTCTCTGG
CCTCAGCTGACATCCTGGTGGCCACACTGGTCATGCCCTTTTCTCTGGCCAATGAGCTCATGGC
CTACTGGTACTTCGGGCAAGTGTGGTGTGGTGTATACCTGGCACTGGACGTGCTCTTCTGCACC
TCGTCCATCGTGCACCTGTGTGCCATTAGTCTGGACCGCTACTGGTCGGTGACGCAAGCGGTAG
AGTACAACCTGAAGCGCACGCCGCGCCGTGTCAAGGCCACCATCGTGGCCGTGTGGCTCATCTC
CGCTGTCATCTCCTTCCCGCCTCTCGTCTCGTTCTACCGCCGGCCCGACGGCGCCGCCTATCCG
CAGTGCGGCCTCAACGATGAGACCTGGTACATCTTGTCCTCCTGCATAGGCTCCTTCTTCGCGC
CCTGCCTCATCATGGGCCTGGTCTATGCGCGCATCTACCGCGTGGCCAAGCTGCGCACGCGTAC
GCTCAGCGAGAAACGCGGCCCCGCCGGCCCCGACGGCGCGTCCCCGACCACAGAGAATGGGCTG
GGCAAGGCAGCGGGGGAGAACGGGCATTGCGCGCCCCCGCGCACTGAAGTGGAGCCGGATGAGA
GCAGTGCGGCCGAGAGGCGGAGGCGCCGGGGCGCGCTGCGCAGAGGAGGACGGCGGCGAGAGGG
TGCTGAGGGGGACACGGGCAGTGCGGACGGACCGGGACCGGGACTGGCAGCCGAGCAGGGTGCT
CGGACGGCGTCTCGGTCCCCAGGCCCCGGAGGGCGCCTGTCGCGGGCCAGCTCGCGCTCCGTCG
AGTTCTTCCTGTCGCGTCGGCGCCGGGCGCGCAGCAGTGTGTGCCGCCGCAAGGTGGCCCAGGC
ACGCGAGAAGCGCTTCACCTTCGTGTTGGCGGTGGTCATGGGCGTGTTCGTACTGTGCTGGTTC
CCCTTCTTCTTCAGCTACAGCCTGTATGGCATCTGCCGTGAGGCCTGCCAGTTGCCAGAACCGC
TCTTTAAGTTTTTCTTCTGGATCGGCTACTGCAACAGTTCGCTCAACCCGGTCATCTACACTGT
CTTCAATCAGGACTTCAGGCGCTCTTTCAAGCATATCCTCTTTCGAAGGAGGAGAAGGGGCTTC
AGGCAATGACCCTCTGGCCTCCTGGACCTGGACCCACTGACGTCCTGGACAGCTCTGAACTCGG
GTAGACAGAGAGACCAACAGTGTGGTCTCTCCAGAGTCCCAGGGTGGACTTCAGGGCACAGTGT
GGGATGTGGCAGACAGGAGCTGGGCGAGAGACAACTGGGCCTTGGGGAGTGGGGAGGAGAAAGG
GAGACCTTTGCCTTCCCATCTCAGCGAGGGGCTGTAGCTAGGTTGTGGATCCAGTTCCTGAGAA
GGCTTCTGTGGAGTGTGGCTGTGAACTTAGGGCTTTAGAGCTCAGACAACTAAACCACACCAAG
AAAGGAGCACACCACCCCCTTCTCGGTCTTCCCTGTGAGCAAGGGCTGACTTCCTATGACCTGA
AAAAGGCATCTGTCTGGGGGAGGAGAGATAGCACAGGCAATCTCTGGTTACTGAGATTGTTTGC
CAAATACAATGACAGCCAAAACAACCAAACCATTTTTTTTTAAATAAACCTTTGTAATCTAAAA
AAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_031444	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA37183	(Get FASTA)	NCBI Sequence Viewer
	AAA37212	(Get FASTA)	NCBI Sequence Viewer
	EDL37478	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000059705
	ENSMUSP00000059705.6
GenBank Protein	Q01337	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_031444 ⟸ NM_007418

- UniProtKB:

Q01337 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWVPPPGQYSAGAVAGLAAVVGFLIVF
TVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYL
ALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYR
RPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGA
SPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGP
GLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVM
GVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHIL
FRRRRRGFRQ

hide sequence

Ensembl Acc Id:

ENSMUSP00000059705 ⟸ ENSMUST00000049545

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q01337-F1-model_v2	AlphaFold	Q01337	1-458	view protein structure

Promoters

RGD ID:

6837000

Promoter ID:

MM_KWN:42004

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Brain

Transcripts:

NM_007418

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	5	35,622,936 - 35,623,436 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:87936	AgrOrtholog
Ensembl Genes	ENSMUSG00000045318	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000049545	ENTREZGENE
	ENSMUST00000049545.7	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
InterPro	ADR_fam	UniProtKB/Swiss-Prot
	ADRA2C_rcpt	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
KEGG Report	mmu:11553	UniProtKB/Swiss-Prot
MGD	MGI:87936	ENTREZGENE
NCBI Gene	11553	ENTREZGENE
PANTHER	ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot
	PTHR24248:SF25	UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot
PharmGKB	ADRA2C	RGD
PhenoGen	Adra2c	PhenoGen
PRINTS	ADRENERGICR	UniProtKB/Swiss-Prot
	ADRENRGCA2CR	UniProtKB/Swiss-Prot
	GPCRRHODOPSN	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
UniProt	ADA2C_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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