Limk1 (LIM domain kinase 1) - Rat Genome Database

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Gene: Limk1 (LIM domain kinase 1) Mus musculus
Analyze
Symbol: Limk1
Name: LIM domain kinase 1
RGD ID: 62347
MGI Page MGI
Description: Predicted to enable heat shock protein binding activity and protein serine/threonine kinase activity. Acts upstream of or within positive regulation of axon extension and positive regulation of stress fiber assembly. Located in several cellular components, including focal adhesion; lamellipodium; and male germ cell nucleus. Is expressed in several structures, including alimentary system; early conceptus; embryo ectoderm; genitourinary system; and sensory organ. Used to study Williams-Beuren syndrome. Orthologous to human LIMK1 (LIM domain kinase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: KIZ-1; LIM-domain containing, protein kinase; Limk; LIMK-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Limk1-ps1   Limk1-ps2  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,684,893 - 134,718,713 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,684,893 - 134,717,452 (-)EnsemblGRCm39 Ensembl
GRCm385134,656,039 - 134,689,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,656,039 - 134,688,598 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,131,909 - 135,164,460 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,940,679 - 134,991,269 (-)NCBIMGSCv36mm8
Celera5131,664,058 - 131,696,609 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
Limk1Mouseautism spectrum disorder  ISOLIMK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:21658581 more ...
Limk1Mouseautistic disorder  ISOLIMK1 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Limk1MouseHigh Myopia  ISOLIMK1 (Homo sapiens)8554872ClinVar Annotator: match by term: High myopiaClinVar 
Limk1Mouseintestinal volvulus  ISOLIMK1 (Homo sapiens)8554872ClinVar Annotator: match by term: INTESTINAL MALROTATION and FAMILIALClinVarPMID:25741868
Limk1Mousemyoclonic-atonic epilepsy  ISOLIMK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Undetermined early-onset epileptic encephalopathyClinVar 
Limk1MouseNeurodevelopmental Disorders  ISOLIMK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Limk1Mousepleomorphic xanthoastrocytoma  ISOLIMK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
Limk1Mouseschizophrenia  ISOLIMK1 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
Limk1Mousesupravalvular aortic stenosis  ISOLIMK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Supravalvar aortic stenosisClinVarPMID:10627943 more ...
Limk1MouseVolvulus Of Midgut  ISOLIMK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Volvulus of midgutClinVarPMID:25741868
Limk1MouseWilliams-Beuren syndrome  ISOLIMK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Williams syndromeClinVarPMID:25741868
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Original Reference(s)
Limk1MouseWilliams-Beuren syndrome  IAGP 13592920OMIM:194050MouseDO 

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Original Reference(s)
Limk1Mouse(1->4)-beta-D-glucan multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of LIMK1 mRNACTDPMID:36331819
Limk1Mouse1,2-dimethylhydrazine increases expressionEXP 64804641 and 2-Dimethylhydrazine results in increased expression of LIMK1 mRNACTDPMID:22206623
Limk1Mouse1,2-dimethylhydrazine multiple interactionsEXP 6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of LIMK1 mRNA]CTDPMID:22206623
Limk1Mouse17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of LIMK1 mRNACTDPMID:17555576
Limk1Mouse17alpha-ethynylestradiol multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIMK1 mRNACTDPMID:17942748
Limk1Mouse17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of LIMK1 mRNACTDPMID:17942748
Limk1Mouse17beta-estradiol multiple interactionsISOLIMK1 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of LIMK1 mRNACTDPMID:30165855
Limk1Mouse17beta-estradiol increases expressionISOLIMK1 (Homo sapiens)6480464Estradiol results in increased expression of LIMK1 mRNACTDPMID:31614463
Limk1Mouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOLIMK1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of LIMK1 mRNACTDPMID:12377990
Limk1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOLimk1 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of LIMK1 mRNACTDPMID:34747641
Limk1Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of LIMK1 mRNACTDPMID:21570461
Limk1Mouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIMK1 mRNACTDPMID:17942748
Limk1Mouse2,3,7,8-Tetrachlorodibenzofuran decreases expressionISOLimk1 (Rattus norvegicus)64804642 more ...CTDPMID:32109520
Limk1Mouse3,3',4,4',5-pentachlorobiphenyl increases expressionISOLimk1 (Rattus norvegicus)64804643 more ...CTDPMID:23196670
Limk1Mouse3,3',4,4'-tetrachlorobiphenyl affects expressionISOLIMK1 (Homo sapiens)64804643 more ...CTDPMID:20638727
Limk1Mouse3,4-methylenedioxymethamphetamine increases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of LIMK1 mRNACTDPMID:26251327
Limk1Mouse4,4'-diaminodiphenylmethane decreases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in decreased expression of LIMK1 mRNACTDPMID:18648102
Limk1Mouse4,4'-sulfonyldiphenol decreases methylationEXP 6480464bisphenol S results in decreased methylation of LIMK1 exonCTDPMID:33297965
Limk1Mouse4,4'-sulfonyldiphenol multiple interactionsISOLimk1 (Rattus norvegicus)6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of LIMK1 mRNACTDPMID:36041667
Limk1Mouse5-fluorouracil affects expressionISOLIMK1 (Homo sapiens)6480464Fluorouracil affects the expression of LIMK1 mRNACTDPMID:34151400

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Biological Process
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Cellular Component
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Original Reference(s)
Limk1Mouseaxonal growth cone  ISOLimk1 (Rattus norvegicus)9068941 RGDPMID:15090620 and REF_RGD_ID:5131992
Limk1Mouseaxonal growth cone located_inISOLimk1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Limk1Mousecytoplasm located_inISOUniProtKB:P536672290270 GO_CentralGO_REF:0000119
Limk1Mousecytoplasm is_active_inIBAPANTHER:PTN001510238 more ...2290270 GO_CentralGO_REF:0000033
Limk1Mousecytoplasm located_inIDA 2290270 PMID:16204183 and PMID:16399995UniProtPMID:16204183 and PMID:16399995
Limk1Mousecytoskeleton located_inIEAUniProtKB-SubCell:SL-00902290270 UniProtGO_REF:0000044
Limk1Mousecytosol located_inIEAUniProtKB:P53667 and ensembl:ENSP000003367402290270 EnsemblGO_REF:0000107
Limk1Mousecytosol located_inISOUniProtKB:P536672290270 GO_CentralGO_REF:0000119
Limk1Mousefocal adhesion located_inIDA 2290270 PMID:15023529 and PMID:16399995MGIPMID:15023529 and PMID:16399995
Limk1Mouseglutamatergic synapse located_inIEAUniProtKB:P53667 and ensembl:ENSP000003367402290270 EnsemblGO_REF:0000107
Limk1Mouseglutamatergic synapse is_active_inISOUniProtKB:P536672290270 GO_CentralGO_REF:0000119
Limk1Mouselamellipodium located_inIDA 2290270 PMID:25107909UniProtPMID:25107909
Limk1Mousemale germ cell nucleus located_inIDA 2290270 PMID:16399995MGIPMID:16399995
Limk1Mousemembrane located_inIDA 2290270 PMID:24792215MGIPMID:24792215
Limk1Mouseneuron projection is_active_inIBAPANTHER:PTN002925496 more ...2290270 GO_CentralGO_REF:0000033
Limk1Mouseneuron projection located_inIDA 2290270 PMID:16204183UniProtPMID:16204183
Limk1Mousenuclear speck located_inIEAUniProtKB:P53667 and ensembl:ENSP000003367402290270 EnsemblGO_REF:0000107
Limk1Mousenuclear speck located_inISOUniProtKB:P536672290270 GO_CentralGO_REF:0000119
Limk1Mousenucleus is_active_inIBAPANTHER:PTN001510238 more ...2290270 GO_CentralGO_REF:0000033
Limk1Mousenucleus located_inIDA 2290270 PMID:15023529 and PMID:16399995MGIPMID:15023529 and PMID:16399995
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Molecular Function
1 to 20 of 36 rows

  
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Original Reference(s)
Limk1Mouse3-phosphoinositide-dependent protein kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1MouseAMP-activated protein kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1MouseATP binding enablesIEAUniProtKB-KW:KW-00672290270 UniProtGO_REF:0000043
Limk1MouseDNA-dependent protein kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mouseeukaryotic translation initiation factor 2alpha kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mouseheat shock protein binding enablesISOUniProtKB:P536672290270 GO_CentralGO_REF:0000119
Limk1Mouseheat shock protein binding enablesIEAUniProtKB:P53667 and ensembl:ENSP000003367402290270 EnsemblGO_REF:0000107
Limk1Mousehistone H2AS1 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mousehistone H2AS121 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mousehistone H2AT120 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mousehistone H2AXS139 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mousehistone H2BS14 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mousehistone H2BS36 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mousehistone H3S10 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mousehistone H3S28 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mousehistone H3S57 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mousehistone H3T11 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mousehistone H3T3 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mousehistone H3T45 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
Limk1Mousehistone H3T6 kinase activity enablesIEAEC:2.7.11.12290270 UniProtGO_REF:0000003
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RGD Manual Annotations


  

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#
Reference Title
Reference Citation
1. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
2. Comparative mapping of the region of human chromosome 7 deleted in williams syndrome. DeSilva U, etal., Genome Res 1999 May;9(5):428-36.
3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
4. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Martindale DW, etal., Mamm Genome 2000 Oct;11(10):890-8.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s). Valero MC, etal., Genomics 2000 Oct 1;69(1):1-13.
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PMID:7478547   PMID:7848918   PMID:8541208   PMID:8812497   PMID:8941371   PMID:9126492   PMID:9337408   PMID:9434941   PMID:9500551   PMID:9521869   PMID:10349636   PMID:10431247  
PMID:10575226   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11352562   PMID:11779826   PMID:12073613   PMID:12123613   PMID:12226475   PMID:12323073   PMID:12477932   PMID:12777619  
PMID:12952863   PMID:15023529   PMID:15056216   PMID:15199148   PMID:15458846   PMID:15538389   PMID:15615879   PMID:15660133   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16204183  
PMID:16399995   PMID:16602821   PMID:17229766   PMID:17875933   PMID:18028908   PMID:18079118   PMID:18287559   PMID:18329113   PMID:18332102   PMID:18601981   PMID:18978953   PMID:19129405  
PMID:19424295   PMID:19679840   PMID:19696021   PMID:19808661   PMID:20049703   PMID:20067919   PMID:20412781   PMID:20534669   PMID:20737509   PMID:21084599   PMID:21167960   PMID:21177343  
PMID:21248105   PMID:21267068   PMID:21677750   PMID:21868383   PMID:21873635   PMID:22173944   PMID:22798677   PMID:22810622   PMID:22988430   PMID:23017662   PMID:23071748   PMID:23620575  
PMID:23700283   PMID:23934191   PMID:24154525   PMID:24792215   PMID:24858712   PMID:24952961   PMID:25107909   PMID:25186760   PMID:25315299   PMID:25593987   PMID:25609610   PMID:25645926  
PMID:25714010   PMID:25721396   PMID:26169470   PMID:26545494   PMID:26585954   PMID:26671787   PMID:26681218   PMID:26880202   PMID:26921097   PMID:26943578   PMID:26969129   PMID:27273096  
PMID:27549340   PMID:27588418   PMID:27844143   PMID:28465421   PMID:28669900   PMID:29319181   PMID:29439133   PMID:29943641   PMID:30228103   PMID:30333726   PMID:30689541   PMID:30833597  
PMID:30837367   PMID:31319858   PMID:31577955   PMID:31578231   PMID:31933141   PMID:32259557   PMID:32325033   PMID:33616869   PMID:33854034   PMID:34315506   PMID:34407403   PMID:35914814  
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Limk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,684,893 - 134,718,713 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,684,893 - 134,717,452 (-)EnsemblGRCm39 Ensembl
GRCm385134,656,039 - 134,689,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,656,039 - 134,688,598 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,131,909 - 135,164,460 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,940,679 - 134,991,269 (-)NCBIMGSCv36mm8
Celera5131,664,058 - 131,696,609 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.73NCBI
LIMK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,083,804 - 74,122,525 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl774,082,933 - 74,122,525 (+)EnsemblGRCh38hg38GRCh38
GRCh37773,498,134 - 73,536,855 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,136,092 - 73,174,790 (+)NCBINCBI36Build 36hg18NCBI36
Build 34772,942,806 - 72,981,505NCBI
Celera768,977,591 - 69,016,280 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,382,814 - 69,418,976 (+)NCBIHuRef
CHM1_1773,643,562 - 73,682,183 (+)NCBICHM1_1
T2T-CHM13v2.0775,286,937 - 75,325,667 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,831,179 - 72,869,927 (+)NCBI
Limk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,663,177 - 27,697,085 (+)NCBIGRCr8
mRatBN7.21222,026,697 - 22,060,605 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,026,672 - 22,060,606 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,167,689 - 23,203,752 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,780,037 - 23,814,843 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,847,911 - 22,881,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,036,630 - 25,070,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,036,605 - 25,070,539 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,037,250 - 27,070,939 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,091,809 - 23,125,717 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,951,901 - 22,985,835 (+)NCBI
Celera1223,790,979 - 23,824,570 (+)NCBICelera
Cytogenetic Map12q12NCBI
Limk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545613,750,889 - 13,774,021 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545613,751,135 - 13,773,722 (-)NCBIChiLan1.0ChiLan1.0
LIMK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2690,777,071 - 90,815,787 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17139,041,703 - 139,080,418 (-)NCBINHGRI_mPanPan1
PanPan1.1781,233,453 - 81,271,282 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl781,231,876 - 81,271,282 (+)Ensemblpanpan1.1panPan2
LIMK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,263,374 - 6,285,734 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,264,548 - 6,286,026 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,959,877 - 7,983,548 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,076,858 - 6,100,527 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,078,155 - 6,100,709 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,067,274 - 6,090,947 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,015,097 - 6,038,762 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,178,780 - 6,202,457 (-)NCBIUU_Cfam_GSD_1.0
LOC101971716
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344130,788,070 - 130,851,137 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365433,224,392 - 3,248,526 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049365433,185,201 - 3,208,388 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365433,190,741 - 3,208,232 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIMK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,252,648 - 11,279,284 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,252,820 - 11,279,286 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,936,786 - 10,961,582 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIMK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,953,095 - 8,988,848 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,952,957 - 8,988,672 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660707,555,472 - 7,591,095 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Limk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474013,823,437 - 13,847,808 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474013,824,930 - 13,847,605 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Limk1
1870 total Variants

Predicted Target Of
Summary Value
Count of predictions:2717
Count of miRNA genes:672
Interacting mature miRNAs:863
Transcripts:ENSMUST00000015137, ENSMUST00000111233, ENSMUST00000132027, ENSMUST00000134093, ENSMUST00000137897, ENSMUST00000138590
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 31 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse

1 to 10 of 31 rows
X86569  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,656,124 - 134,656,248UniSTSGRCm38
MGSCv375135,131,994 - 135,132,118UniSTSGRCm37
Celera5131,664,143 - 131,664,267UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Whitehead/MRC_RH51639.0UniSTS
G48114  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,656,129 - 134,656,284UniSTSGRCm38
MGSCv375135,131,999 - 135,132,154UniSTSGRCm37
Celera5131,664,148 - 131,664,303UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
G48154  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,657,162 - 134,657,310UniSTSGRCm38
MGSCv375135,133,032 - 135,133,180UniSTSGRCm37
Celera5131,665,181 - 131,665,329UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Limk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv375135,133,136 - 135,133,485UniSTSGRCm37
Celera5131,665,285 - 131,665,634UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
cM Map575.0UniSTS
Limk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,657,266 - 134,657,615UniSTSGRCm38
MGSCv375135,133,136 - 135,133,485UniSTSGRCm37
Celera5131,665,285 - 131,665,634UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Limk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS






1 to 28 of 28 rows
RefSeq Transcripts NM_001305875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_131247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC166938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF139987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF289665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ828670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX527775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY230595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ066818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV563459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  G48114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  G48154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U15159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U55191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 28 of 28 rows

Ensembl Acc Id: ENSMUST00000015137   ⟹   ENSMUSP00000015137
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,684,893 - 134,717,452 (-)Ensembl
GRCm38.p6 Ensembl5134,656,039 - 134,688,598 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111233   ⟹   ENSMUSP00000106864
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,684,894 - 134,707,102 (-)Ensembl
GRCm38.p6 Ensembl5134,656,040 - 134,678,248 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132027
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,697,027 - 134,717,428 (-)Ensembl
GRCm38.p6 Ensembl5134,668,173 - 134,688,574 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134093   ⟹   ENSMUSP00000121718
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,685,053 - 134,707,074 (-)Ensembl
GRCm38.p6 Ensembl5134,656,199 - 134,678,220 (-)Ensembl
Ensembl Acc Id: ENSMUST00000137897
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,692,798 - 134,697,273 (-)Ensembl
GRCm38.p6 Ensembl5134,663,944 - 134,668,419 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138590   ⟹   ENSMUSP00000118268
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,688,848 - 134,693,059 (-)Ensembl
GRCm38.p6 Ensembl5134,659,994 - 134,664,205 (-)Ensembl
RefSeq Acc Id: NM_001305875   ⟹   NP_001292804
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395134,684,893 - 134,707,102 (-)NCBI
GRCm385134,656,039 - 134,678,248 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010717   ⟹   NP_034847
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395134,684,893 - 134,717,444 (-)NCBI
GRCm385134,656,039 - 134,688,590 (-)NCBI
MGSCv375135,131,909 - 135,164,460 (-)RGD
Celera5131,664,058 - 131,696,609 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_131247
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395134,684,893 - 134,707,102 (-)NCBI
GRCm385134,656,039 - 134,678,248 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164831   ⟹   XP_036020724
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395134,684,893 - 134,718,713 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164832   ⟹   XP_036020725
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395134,684,893 - 134,707,192 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034847   ⟸   NM_010717
- Peptide Label: isoform 1
- UniProtKB: P53668 (UniProtKB/Swiss-Prot),   Q3UR47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001292804   ⟸   NM_001305875
- Peptide Label: isoform 2
- UniProtKB: E9PVB6 (UniProtKB/TrEMBL),   Q3TA53 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000106864   ⟸   ENSMUST00000111233
Ensembl Acc Id: ENSMUSP00000118268   ⟸   ENSMUST00000138590
Ensembl Acc Id: ENSMUSP00000015137   ⟸   ENSMUST00000015137
LIM zinc-binding   PDZ   Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-P53668-F1-model_v2 AlphaFold P53668 1-647 view protein structure

RGD ID:6888268
Promoter ID:EPDNEW_M7585
Type:initiation region
Name:Limk1_2
Description:Mus musculus LIM-domain containing, protein kinase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7586  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385134,678,236 - 134,678,296EPDNEW
RGD ID:6888270
Promoter ID:EPDNEW_M7586
Type:initiation region
Name:Limk1_1
Description:Mus musculus LIM-domain containing, protein kinase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7585  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385134,688,612 - 134,688,672EPDNEW
RGD ID:6837802
Promoter ID:MM_KWN:44311
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000064771
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365135,139,861 - 135,140,361 (-)MPROMDB
RGD ID:6837801
Promoter ID:MM_KWN:44314
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:ENSMUST00000100642,   UC008ZWR.1,   UC008ZWS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365135,154,026 - 135,154,727 (-)MPROMDB
RGD ID:6849177
Promoter ID:MM_XEF:5709
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1
Transcripts:NM_001079432,   NM_001087708
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365135,163,176 - 135,163,676 (-)MPROMDB
RGD ID:6837799
Promoter ID:MM_KWN:44315
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   Brain,   Kidney,   Lung,   MEF_B4,   Spleen
Transcripts:NM_010717,   UC008ZWU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365135,164,056 - 135,164,932 (-)MPROMDB


1 to 40 of 45 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000029674 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000015137 ENTREZGENE
  ENSMUST00000015137.10 UniProtKB/Swiss-Prot
  ENSMUST00000111233 ENTREZGENE
  ENSMUST00000134093 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  Cysteine Rich Protein UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Actin_reg-Ser/Thr_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Znf_LIM UniProtKB/Swiss-Prot
KEGG Report mmu:16885 UniProtKB/Swiss-Prot
MGD MGI:104572 ENTREZGENE
NCBI Gene 16885 ENTREZGENE
PANTHER LIM DOMAIN KINASE 1 UniProtKB/Swiss-Prot
  LIM DOMAIN KINASE 1 UniProtKB/Swiss-Prot
Pfam LIM UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
PhenoGen Limk1 PhenoGen
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
SMART LIM UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt E9PVB6 ENTREZGENE, UniProtKB/TrEMBL
  F6PZ73_MOUSE UniProtKB/TrEMBL
  F6XM68_MOUSE UniProtKB/TrEMBL
1 to 40 of 45 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-11 Limk1  LIM domain kinase 1  Limk1  LIM-domain containing, protein kinase  Symbol and/or name change 5135510 APPROVED