Limk1 (LIM domain kinase 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Limk1 (LIM domain kinase 1) Mus musculus
Analyze
Symbol: Limk1
Name: LIM domain kinase 1
RGD ID: 62347
MGI Page MGI
Description: Predicted to enable heat shock protein binding activity and protein serine/threonine kinase activity. Acts upstream of or within positive regulation of axon extension and positive regulation of stress fiber assembly. Located in several cellular components, including focal adhesion; lamellipodium; and male germ cell nucleus. Is expressed in several structures, including alimentary system; early conceptus; embryo ectoderm; genitourinary system; and sensory organ. Used to study Williams-Beuren syndrome. Orthologous to human LIMK1 (LIM domain kinase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: KIZ-1; LIM-domain containing, protein kinase; Limk; LIMK-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Limk1-ps1   Limk1-ps2  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,684,893 - 134,718,713 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,684,893 - 134,717,452 (-)EnsemblGRCm39 Ensembl
GRCm385134,656,039 - 134,689,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,656,039 - 134,688,598 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,131,909 - 135,164,460 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,940,679 - 134,991,269 (-)NCBIMGSCv36mm8
Celera5131,664,058 - 131,696,609 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
ethanol  (EXP)
excitatory amino acid agonist  (ISO)
fenvalerate  (ISO)
fipronil  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
inulin  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methylmercury(1+)  (EXP)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
ouabain  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probucol  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Sanggenon C  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (EXP)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
2. Comparative mapping of the region of human chromosome 7 deleted in williams syndrome. DeSilva U, etal., Genome Res 1999 May;9(5):428-36.
3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
4. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Martindale DW, etal., Mamm Genome 2000 Oct;11(10):890-8.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s). Valero MC, etal., Genomics 2000 Oct 1;69(1):1-13.
Additional References at PubMed
PMID:7478547   PMID:7848918   PMID:8541208   PMID:8812497   PMID:8941371   PMID:9126492   PMID:9337408   PMID:9434941   PMID:9500551   PMID:9521869   PMID:10349636   PMID:10431247  
PMID:10575226   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11352562   PMID:11779826   PMID:12073613   PMID:12123613   PMID:12226475   PMID:12323073   PMID:12477932   PMID:12777619  
PMID:12952863   PMID:15023529   PMID:15056216   PMID:15199148   PMID:15458846   PMID:15538389   PMID:15615879   PMID:15660133   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16204183  
PMID:16399995   PMID:16602821   PMID:17229766   PMID:17875933   PMID:18028908   PMID:18079118   PMID:18287559   PMID:18329113   PMID:18332102   PMID:18601981   PMID:18978953   PMID:19129405  
PMID:19424295   PMID:19679840   PMID:19696021   PMID:19808661   PMID:20049703   PMID:20067919   PMID:20412781   PMID:20534669   PMID:20737509   PMID:21084599   PMID:21167960   PMID:21177343  
PMID:21248105   PMID:21267068   PMID:21677750   PMID:21868383   PMID:21873635   PMID:22173944   PMID:22798677   PMID:22810622   PMID:22988430   PMID:23017662   PMID:23071748   PMID:23620575  
PMID:23700283   PMID:23934191   PMID:24154525   PMID:24792215   PMID:24858712   PMID:24952961   PMID:25107909   PMID:25186760   PMID:25315299   PMID:25593987   PMID:25609610   PMID:25645926  
PMID:25714010   PMID:25721396   PMID:26169470   PMID:26545494   PMID:26585954   PMID:26671787   PMID:26681218   PMID:26880202   PMID:26921097   PMID:26943578   PMID:26969129   PMID:27273096  
PMID:27549340   PMID:27588418   PMID:27844143   PMID:28465421   PMID:28669900   PMID:29319181   PMID:29439133   PMID:29943641   PMID:30228103   PMID:30333726   PMID:30689541   PMID:30833597  
PMID:30837367   PMID:31319858   PMID:31577955   PMID:31578231   PMID:31933141   PMID:32259557   PMID:32325033   PMID:33616869   PMID:33854034   PMID:34315506   PMID:34407403   PMID:35914814  
PMID:36301793   PMID:37718806  


Genomics

Comparative Map Data
Limk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,684,893 - 134,718,713 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,684,893 - 134,717,452 (-)EnsemblGRCm39 Ensembl
GRCm385134,656,039 - 134,689,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,656,039 - 134,688,598 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,131,909 - 135,164,460 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,940,679 - 134,991,269 (-)NCBIMGSCv36mm8
Celera5131,664,058 - 131,696,609 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.73NCBI
LIMK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,083,804 - 74,122,525 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl774,082,933 - 74,122,525 (+)EnsemblGRCh38hg38GRCh38
GRCh37773,498,134 - 73,536,855 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,136,092 - 73,174,790 (+)NCBINCBI36Build 36hg18NCBI36
Build 34772,942,806 - 72,981,505NCBI
Celera768,977,591 - 69,016,280 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,382,814 - 69,418,976 (+)NCBIHuRef
CHM1_1773,643,562 - 73,682,183 (+)NCBICHM1_1
T2T-CHM13v2.0775,286,937 - 75,325,667 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,831,179 - 72,869,927 (+)NCBI
Limk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,663,177 - 27,697,085 (+)NCBIGRCr8
mRatBN7.21222,026,697 - 22,060,605 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,026,672 - 22,060,606 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,167,689 - 23,203,752 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,780,037 - 23,814,843 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,847,911 - 22,881,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,036,630 - 25,070,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,036,605 - 25,070,539 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,037,250 - 27,070,939 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,091,809 - 23,125,717 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,951,901 - 22,985,835 (+)NCBI
Celera1223,790,979 - 23,824,570 (+)NCBICelera
Cytogenetic Map12q12NCBI
Limk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545613,750,889 - 13,774,021 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545613,751,135 - 13,773,722 (-)NCBIChiLan1.0ChiLan1.0
LIMK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2690,777,071 - 90,815,787 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17139,041,703 - 139,080,418 (-)NCBINHGRI_mPanPan1
PanPan1.1781,233,453 - 81,271,282 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl781,231,876 - 81,271,282 (+)Ensemblpanpan1.1panPan2
LIMK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,263,374 - 6,285,734 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,264,548 - 6,286,026 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,959,877 - 7,983,548 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,076,858 - 6,100,527 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,078,155 - 6,100,709 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,067,274 - 6,090,947 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,015,097 - 6,038,762 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,178,780 - 6,202,457 (-)NCBIUU_Cfam_GSD_1.0
LOC101971716
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344130,788,070 - 130,851,137 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365433,224,392 - 3,248,526 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049365433,185,201 - 3,208,388 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365433,190,741 - 3,208,232 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIMK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,252,648 - 11,279,284 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,252,820 - 11,279,286 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,936,786 - 10,961,582 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIMK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,953,095 - 8,988,848 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,952,957 - 8,988,672 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660707,555,472 - 7,591,095 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Limk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474013,823,437 - 13,847,808 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474013,824,930 - 13,847,605 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2717
Count of miRNA genes:672
Interacting mature miRNAs:863
Transcripts:ENSMUST00000015137, ENSMUST00000111233, ENSMUST00000132027, ENSMUST00000134093, ENSMUST00000137897, ENSMUST00000138590
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse

Markers in Region
X86569  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,656,124 - 134,656,248UniSTSGRCm38
MGSCv375135,131,994 - 135,132,118UniSTSGRCm37
Celera5131,664,143 - 131,664,267UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Whitehead/MRC_RH51639.0UniSTS
G48114  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,656,129 - 134,656,284UniSTSGRCm38
MGSCv375135,131,999 - 135,132,154UniSTSGRCm37
Celera5131,664,148 - 131,664,303UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
G48154  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,657,162 - 134,657,310UniSTSGRCm38
MGSCv375135,133,032 - 135,133,180UniSTSGRCm37
Celera5131,665,181 - 131,665,329UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Limk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv375135,133,136 - 135,133,485UniSTSGRCm37
Celera5131,665,285 - 131,665,634UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
cM Map575.0UniSTS
Limk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385134,657,266 - 134,657,615UniSTSGRCm38
MGSCv375135,133,136 - 135,133,485UniSTSGRCm37
Celera5131,665,285 - 131,665,634UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Limk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001305875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_131247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC166938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF139987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF289665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ828670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX527775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY230595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ066818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV563459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  G48114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  G48154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U15159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U55191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000015137   ⟹   ENSMUSP00000015137
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,684,893 - 134,717,452 (-)Ensembl
GRCm38.p6 Ensembl5134,656,039 - 134,688,598 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111233   ⟹   ENSMUSP00000106864
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,684,894 - 134,707,102 (-)Ensembl
GRCm38.p6 Ensembl5134,656,040 - 134,678,248 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132027
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,697,027 - 134,717,428 (-)Ensembl
GRCm38.p6 Ensembl5134,668,173 - 134,688,574 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134093   ⟹   ENSMUSP00000121718
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,685,053 - 134,707,074 (-)Ensembl
GRCm38.p6 Ensembl5134,656,199 - 134,678,220 (-)Ensembl
Ensembl Acc Id: ENSMUST00000137897
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,692,798 - 134,697,273 (-)Ensembl
GRCm38.p6 Ensembl5134,663,944 - 134,668,419 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138590   ⟹   ENSMUSP00000118268
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5134,688,848 - 134,693,059 (-)Ensembl
GRCm38.p6 Ensembl5134,659,994 - 134,664,205 (-)Ensembl
RefSeq Acc Id: NM_001305875   ⟹   NP_001292804
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395134,684,893 - 134,707,102 (-)NCBI
GRCm385134,656,039 - 134,678,248 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010717   ⟹   NP_034847
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395134,684,893 - 134,717,444 (-)NCBI
GRCm385134,656,039 - 134,688,590 (-)NCBI
MGSCv375135,131,909 - 135,164,460 (-)RGD
Celera5131,664,058 - 131,696,609 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_131247
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395134,684,893 - 134,707,102 (-)NCBI
GRCm385134,656,039 - 134,678,248 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164831   ⟹   XP_036020724
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395134,684,893 - 134,718,713 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164832   ⟹   XP_036020725
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395134,684,893 - 134,707,192 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034847   ⟸   NM_010717
- Peptide Label: isoform 1
- UniProtKB: P53668 (UniProtKB/Swiss-Prot),   Q3UR47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001292804   ⟸   NM_001305875
- Peptide Label: isoform 2
- UniProtKB: E9PVB6 (UniProtKB/TrEMBL),   Q3TA53 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000106864   ⟸   ENSMUST00000111233
Ensembl Acc Id: ENSMUSP00000118268   ⟸   ENSMUST00000138590
Ensembl Acc Id: ENSMUSP00000015137   ⟸   ENSMUST00000015137
Ensembl Acc Id: ENSMUSP00000121718   ⟸   ENSMUST00000134093
RefSeq Acc Id: XP_036020724   ⟸   XM_036164831
- Peptide Label: isoform X1
- UniProtKB: Q3UR47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036020725   ⟸   XM_036164832
- Peptide Label: isoform X2
- UniProtKB: Q3TA53 (UniProtKB/TrEMBL)
Protein Domains
LIM zinc-binding   PDZ   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53668-F1-model_v2 AlphaFold P53668 1-647 view protein structure

Promoters
RGD ID:6888268
Promoter ID:EPDNEW_M7585
Type:initiation region
Name:Limk1_2
Description:Mus musculus LIM-domain containing, protein kinase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7586  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385134,678,236 - 134,678,296EPDNEW
RGD ID:6888270
Promoter ID:EPDNEW_M7586
Type:initiation region
Name:Limk1_1
Description:Mus musculus LIM-domain containing, protein kinase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7585  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385134,688,612 - 134,688,672EPDNEW
RGD ID:6837802
Promoter ID:MM_KWN:44311
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000064771
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365135,139,861 - 135,140,361 (-)MPROMDB
RGD ID:6837801
Promoter ID:MM_KWN:44314
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:ENSMUST00000100642,   UC008ZWR.1,   UC008ZWS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365135,154,026 - 135,154,727 (-)MPROMDB
RGD ID:6849177
Promoter ID:MM_XEF:5709
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1
Transcripts:NM_001079432,   NM_001087708
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365135,163,176 - 135,163,676 (-)MPROMDB
RGD ID:6837799
Promoter ID:MM_KWN:44315
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   Brain,   Kidney,   Lung,   MEF_B4,   Spleen
Transcripts:NM_010717,   UC008ZWU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365135,164,056 - 135,164,932 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104572 AgrOrtholog
Ensembl Genes ENSMUSG00000029674 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000015137 ENTREZGENE
  ENSMUST00000015137.10 UniProtKB/Swiss-Prot
  ENSMUST00000111233 ENTREZGENE
  ENSMUST00000111233.8 UniProtKB/TrEMBL
  ENSMUST00000134093 ENTREZGENE
  ENSMUST00000134093.2 UniProtKB/TrEMBL
  ENSMUST00000138590.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Actin_reg-Ser/Thr_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16885 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104572 ENTREZGENE
NCBI Gene 16885 ENTREZGENE
PANTHER LIM DOMAIN KINASE 1 UniProtKB/Swiss-Prot
  LIM DOMAIN KINASE 1 UniProtKB/Swiss-Prot
  LIM DOMAIN KINASE 1 UniProtKB/TrEMBL
  LIM DOMAIN KINASE 1 UniProtKB/TrEMBL
Pfam LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Limk1 PhenoGen
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PVB6 ENTREZGENE, UniProtKB/TrEMBL
  F6PZ73_MOUSE UniProtKB/TrEMBL
  F6XM68_MOUSE UniProtKB/TrEMBL
  LIMK1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TA53 ENTREZGENE, UniProtKB/TrEMBL
  Q3TDI9_MOUSE UniProtKB/TrEMBL
  Q3UR47 ENTREZGENE, UniProtKB/TrEMBL
  Q3UTQ4_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-11 Limk1  LIM domain kinase 1  Limk1  LIM-domain containing, protein kinase  Symbol and/or name change 5135510 APPROVED