Exoc8 (exocyst complex component 8) - Rat Genome Database

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Gene: Exoc8 (exocyst complex component 8) Rattus norvegicus
Analyze
Symbol: Exoc8
Name: exocyst complex component 8
RGD ID: 620245
Description: Predicted to enable phosphatidylinositol binding activity and small GTPase binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; endosome organization; and extracellular matrix disassembly. Predicted to act upstream of or within exocytosis. Located in cell leading edge. Part of exocyst. Orthologous to human EXOC8 (exocyst complex component 8); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Exo84; exocyst complex 84 kDa subunit; exocyst complex 84-kDa subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,752,387 - 69,754,876 (-)NCBIGRCr8
mRatBN7.21952,855,010 - 52,857,499 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,852,578 - 52,857,491 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,639,787 - 59,642,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,490,839 - 60,493,328 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,566,254 - 62,568,743 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,647,305 - 57,649,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,647,291 - 57,649,827 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,360,544 - 68,363,033 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,066,272 - 55,068,761 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11955,071,156 - 55,073,642 (-)NCBI
Celera1952,222,177 - 52,224,666 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Subunit structure of the mammalian exocyst complex. Kee Y, etal., Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14438-43.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Parrini MC, etal., Mol Cell. 2011 Jun 10;42(5):650-61. doi: 10.1016/j.molcel.2011.03.032.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. Rosse C, etal., PLoS Biol. 2009 Nov;7(11):e1000235. Epub 2009 Nov 3.
Additional References at PubMed
PMID:12954101   PMID:14525976   PMID:15920473   PMID:19946888   PMID:24056301   PMID:24344185   PMID:26582389   PMID:30053369  


Genomics

Comparative Map Data
Exoc8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,752,387 - 69,754,876 (-)NCBIGRCr8
mRatBN7.21952,855,010 - 52,857,499 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,852,578 - 52,857,491 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,639,787 - 59,642,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,490,839 - 60,493,328 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,566,254 - 62,568,743 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,647,305 - 57,649,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,647,291 - 57,649,827 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,360,544 - 68,363,033 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,066,272 - 55,068,761 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11955,071,156 - 55,073,642 (-)NCBI
Celera1952,222,177 - 52,224,666 (-)NCBICelera
Cytogenetic Map19q12NCBI
EXOC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381231,332,753 - 231,337,852 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1231,332,753 - 231,337,852 (-)EnsemblGRCh38hg38GRCh38
GRCh371231,468,499 - 231,473,598 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361229,535,103 - 229,540,201 (-)NCBINCBI36Build 36hg18NCBI36
Build 341227,775,217 - 227,780,313NCBI
Celera1204,733,352 - 204,738,448 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,951,802 - 201,956,897 (-)NCBIHuRef
CHM1_11232,742,131 - 232,747,227 (-)NCBICHM1_1
T2T-CHM13v2.01230,716,003 - 230,721,102 (-)NCBIT2T-CHM13v2.0
Exoc8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,617,038 - 125,624,444 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,619,847 - 125,624,444 (-)EnsemblGRCm39 Ensembl
GRCm388124,890,299 - 124,897,705 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,893,108 - 124,897,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,414,199 - 127,421,605 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368127,779,198 - 127,783,795 (-)NCBIMGSCv36mm8
Celera8129,198,972 - 129,206,398 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.82NCBI
Exoc8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,477,015 - 7,479,165 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,476,866 - 7,481,186 (+)NCBIChiLan1.0ChiLan1.0
EXOC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2117,866,326 - 17,871,305 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,061,958 - 18,070,969 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01206,884,334 - 206,889,753 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11211,908,975 - 211,914,100 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,911,802 - 211,913,979 (-)Ensemblpanpan1.1panPan2
EXOC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,133,526 - 8,138,185 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,133,670 - 8,135,853 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,125,862 - 8,130,738 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.048,158,970 - 8,163,846 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.148,162,330 - 8,167,207 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.048,284,329 - 8,289,206 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.048,512,727 - 8,517,604 (+)NCBIUU_Cfam_GSD_1.0
Exoc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,238,232 - 43,240,797 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648419,403,458 - 19,405,197 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648419,403,458 - 19,407,202 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXOC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,192,434 - 59,197,542 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,192,345 - 59,197,550 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21463,861,048 - 63,866,149 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EXOC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12568,594,174 - 68,599,236 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2568,596,957 - 68,599,134 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605570,502,324 - 70,507,389 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Exoc8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477518,397,673 - 18,399,823 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477518,397,418 - 18,403,669 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Exoc8
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:16
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000026757
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 6 16 19 70 26 21 11
Low 1 37 41 41 41 8 11 4 9 20 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000026757   ⟹   ENSRNOP00000026757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1952,852,578 - 52,857,491 (-)Ensembl
Rnor_6.0 Ensembl1957,647,291 - 57,649,827 (-)Ensembl
RefSeq Acc Id: NM_139043   ⟹   NP_620612
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,752,387 - 69,754,876 (-)NCBI
mRatBN7.21952,855,010 - 52,857,499 (-)NCBI
Rnor_6.01957,647,305 - 57,649,794 (-)NCBI
Rnor_5.01968,360,544 - 68,363,033 (-)NCBI
RGSC_v3.41955,066,272 - 55,068,761 (-)RGD
Celera1952,222,177 - 52,224,666 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620612 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC01581 (Get FASTA)   NCBI Sequence Viewer  
  EDL96746 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026757
  ENSRNOP00000026757.1
  ENSRNOP00055030989
  ENSRNOP00060034752
  ENSRNOP00065026184
GenBank Protein O54924 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620612   ⟸   NM_139043
- UniProtKB: O54924 (UniProtKB/Swiss-Prot),   A6KJ24 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026757   ⟸   ENSRNOT00000026757
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54924-F1-model_v2 AlphaFold O54924 1-716 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701244
Promoter ID:EPDNEW_R11766
Type:multiple initiation site
Name:Exoc8_1
Description:exocyst complex component 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01957,649,729 - 57,649,789EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620245 AgrOrtholog
BioCyc Gene G2FUF-5227 BioCyc
Ensembl Genes ENSRNOG00000019766 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055022082 UniProtKB/Swiss-Prot
  ENSRNOG00060024218 UniProtKB/Swiss-Prot
  ENSRNOG00065019454 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026757 ENTREZGENE
  ENSRNOT00000026757.4 UniProtKB/Swiss-Prot
  ENSRNOT00055037948 UniProtKB/Swiss-Prot
  ENSRNOT00060041906 UniProtKB/Swiss-Prot
  ENSRNOT00065032759 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.1210 UniProtKB/Swiss-Prot
  1.20.58.1220 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  Exo84p, C-terminal helical domain UniProtKB/TrEMBL
  Exo84p, N-terminal helical domain UniProtKB/TrEMBL
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
InterPro Cullin_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Exo84 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Exo84_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Exo84_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Exo84_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:245709 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 245709 ENTREZGENE
PANTHER EXOCYST COMPLEX COMPONENT 8 UniProtKB/Swiss-Prot
  EXOCYST COMPLEX COMPONENT 8 UniProtKB/TrEMBL
  EXOCYST COMPLEX COMPONENT 8 UniProtKB/TrEMBL
  PTHR21426 UniProtKB/Swiss-Prot
Pfam Exo84_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vps51 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Exoc8 PhenoGen
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019766 RatGTEx
  ENSRNOG00055022082 RatGTEx
  ENSRNOG00060024218 RatGTEx
  ENSRNOG00065019454 RatGTEx
SMART SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Cullin repeat-like UniProtKB/TrEMBL
  PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF74788 UniProtKB/Swiss-Prot
UniProt A6KJ24 ENTREZGENE, UniProtKB/TrEMBL
  EXOC8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-06 Exoc8  exocyst complex component 8  Exo84  exocyst complex 84-kDa subunit  Symbol and Name updated 1299863 APPROVED
2002-08-07 Exo84  exocyst complex 84-kDa subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression broadly expressed 69988
gene_protein 84 kDa 69988