Exoc8 (exocyst complex component 8) - Rat Genome Database

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Gene: Exoc8 (exocyst complex component 8) Mus musculus
Analyze
Symbol: Exoc8
Name: exocyst complex component 8
RGD ID: 1551410
MGI Page MGI
Description: Predicted to enable phosphatidylinositol binding activity and small GTPase binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; endosome organization; and extracellular matrix disassembly. Predicted to act upstream of or within exocytosis. Predicted to be located in cell leading edge and late endosome. Predicted to be part of exocyst. Is expressed in several structures, including adrenal gland; genitourinary system; lung; nervous system; and pancreas. Orthologous to human EXOC8 (exocyst complex component 8).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI414418; EXO8; EXO84; Exo84p; exocyst complex 84 kDa subunit; R74783; SEC8; SEC84
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,617,038 - 125,624,444 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,619,847 - 125,624,444 (-)EnsemblGRCm39 Ensembl
GRCm388124,890,299 - 124,897,705 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,893,108 - 124,897,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,414,199 - 127,421,605 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368127,779,198 - 127,783,795 (-)NCBIMGSCv36mm8
Celera8129,198,972 - 129,206,398 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:15345747   PMID:15489334   PMID:16141072   PMID:16141073   PMID:21873635   PMID:22420621  
PMID:24194600   PMID:26582389   PMID:27626380   PMID:28325821   PMID:32325033   PMID:38355793  


Genomics

Comparative Map Data
Exoc8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,617,038 - 125,624,444 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,619,847 - 125,624,444 (-)EnsemblGRCm39 Ensembl
GRCm388124,890,299 - 124,897,705 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,893,108 - 124,897,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,414,199 - 127,421,605 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368127,779,198 - 127,783,795 (-)NCBIMGSCv36mm8
Celera8129,198,972 - 129,206,398 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.82NCBI
EXOC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381231,332,753 - 231,337,852 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1231,332,753 - 231,337,852 (-)EnsemblGRCh38hg38GRCh38
GRCh371231,468,499 - 231,473,598 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361229,535,103 - 229,540,201 (-)NCBINCBI36Build 36hg18NCBI36
Build 341227,775,217 - 227,780,313NCBI
Celera1204,733,352 - 204,738,448 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,951,802 - 201,956,897 (-)NCBIHuRef
CHM1_11232,742,131 - 232,747,227 (-)NCBICHM1_1
T2T-CHM13v2.01230,716,003 - 230,721,102 (-)NCBIT2T-CHM13v2.0
Exoc8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,752,387 - 69,754,876 (-)NCBIGRCr8
mRatBN7.21952,855,010 - 52,857,499 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,852,578 - 52,857,491 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,639,787 - 59,642,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,490,839 - 60,493,328 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,566,254 - 62,568,743 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,647,305 - 57,649,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,647,291 - 57,649,827 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,360,544 - 68,363,033 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,066,272 - 55,068,761 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11955,071,156 - 55,073,642 (-)NCBI
Celera1952,222,177 - 52,224,666 (-)NCBICelera
Cytogenetic Map19q12NCBI
Exoc8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,477,015 - 7,479,165 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,476,866 - 7,481,186 (+)NCBIChiLan1.0ChiLan1.0
EXOC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2117,866,326 - 17,871,305 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,061,958 - 18,070,969 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01206,884,334 - 206,889,753 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11211,908,975 - 211,914,100 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,911,802 - 211,913,979 (-)Ensemblpanpan1.1panPan2
EXOC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,133,526 - 8,138,185 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,133,670 - 8,135,853 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,125,862 - 8,130,738 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.048,158,970 - 8,163,846 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.148,162,330 - 8,167,207 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.048,284,329 - 8,289,206 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.048,512,727 - 8,517,604 (+)NCBIUU_Cfam_GSD_1.0
Exoc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,238,232 - 43,240,797 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648419,403,458 - 19,405,197 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648419,403,458 - 19,407,202 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXOC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,192,434 - 59,197,542 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,192,345 - 59,197,550 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21463,861,048 - 63,866,149 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EXOC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12568,594,174 - 68,599,236 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2568,596,957 - 68,599,134 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605570,502,324 - 70,507,389 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Exoc8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477518,397,673 - 18,399,823 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477518,397,418 - 18,403,669 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Exoc8
317 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1646
Count of miRNA genes:765
Interacting mature miRNAs:958
Transcripts:ENSMUST00000098312
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8111481497130127694Mouse
1357841Phdlc2_mplasma HDL cholesterol 2 (mouse)Not determined8125191161129745061Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8110415083130127694Mouse
26884375Skwq2_mskull length QTL 2, 5 week (mouse)8120726739130027694Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8111481497130127694Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8110415083130127694Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
14746994Manh65_mmandible shape 65 (mouse)8106489629130127694Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
4141546Mrdq3_mmodifier of retinal degeneration QTL 3 (mouse)Not determined114439420126055880Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse

Markers in Region
AI414418  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388124,893,192 - 124,893,346UniSTSGRCm38
MGSCv378127,417,092 - 127,417,246UniSTSGRCm37
Celera8129,201,884 - 129,202,038UniSTS
Cytogenetic Map8E2UniSTS
Whitehead/MRC_RH81448.39UniSTS
RH125106  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388124,893,190 - 124,893,303UniSTSGRCm38
MGSCv378127,417,090 - 127,417,203UniSTSGRCm37
Celera8129,201,882 - 129,201,995UniSTS
Cytogenetic Map8E2UniSTS
UniSTS:236028  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388124,893,464 - 124,893,686UniSTSGRCm38
MGSCv378127,417,364 - 127,417,586UniSTSGRCm37
Celera8129,202,156 - 129,202,378UniSTS
Cytogenetic Map8E2UniSTS
UniSTS:224697  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388124,893,167 - 124,893,317UniSTSGRCm38
MGSCv378127,417,067 - 127,417,217UniSTSGRCm37
Celera8129,201,859 - 129,202,009UniSTS
Cytogenetic Map8E2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000098312   ⟹   ENSMUSP00000095915
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8125,619,847 - 125,624,444 (-)Ensembl
GRCm38.p6 Ensembl8124,893,108 - 124,897,705 (-)Ensembl
RefSeq Acc Id: NM_198103   ⟹   NP_932771
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398125,617,038 - 125,624,444 (-)NCBI
GRCm388124,890,299 - 124,897,705 (-)ENTREZGENE
MGSCv378127,414,199 - 127,421,605 (-)RGD
Celera8129,198,972 - 129,206,398 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_932771 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH57052 (Get FASTA)   NCBI Sequence Viewer  
  EDL11787 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000095915
  ENSMUSP00000095915.3
GenBank Protein Q6PGF7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_932771   ⟸   NM_198103
- UniProtKB: Q6PGF7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000095915   ⟸   ENSMUST00000098312
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PGF7-F1-model_v2 AlphaFold Q6PGF7 1-716 view protein structure

Promoters
RGD ID:8668654
Promoter ID:EPDNEW_M12358
Type:multiple initiation site
Name:Exoc8_1
Description:Mus musculus exocyst complex component 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388124,897,716 - 124,897,776EPDNEW
RGD ID:6843108
Promoter ID:MM_KWN:56188
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000034467,   NM_001111141,   NM_198103
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368127,413,206 - 127,422,742 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2142527 AgrOrtholog
Ensembl Genes ENSMUSG00000053099
  ENSMUSG00000074030 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000098312 ENTREZGENE
  ENSMUST00000098312.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.1210 UniProtKB/Swiss-Prot
  1.20.58.1220 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
InterPro Cullin_repeat-like_dom_sf UniProtKB/Swiss-Prot
  Exo84 UniProtKB/Swiss-Prot
  Exo84_C UniProtKB/Swiss-Prot
  Exo84_C_1 UniProtKB/Swiss-Prot
  Exo84_C_2 UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
KEGG Report mmu:102058 UniProtKB/Swiss-Prot
MGD MGI:2142527 ENTREZGENE
NCBI Gene 102058 ENTREZGENE
PANTHER EXOCYST COMPLEX COMPONENT 8 UniProtKB/Swiss-Prot
  PTHR21426 UniProtKB/Swiss-Prot
Pfam Exo84_C UniProtKB/Swiss-Prot
  Vps51 UniProtKB/Swiss-Prot
PhenoGen Exoc8 PhenoGen
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot
SMART SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF74788 UniProtKB/Swiss-Prot
UniProt EXOC8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE