Gene: Grk1 (G protein-coupled receptor kinase 1) Rattus norvegicus
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Symbol: Grk1
Name: G protein-coupled receptor kinase 1
Description: ENCODES a protein that exhibits rhodopsin kinase activity; INVOLVED IN protein autophosphorylation; response to drug; response to light stimulus; PARTICIPATES IN visual phototransduction pathway; chemokine mediated signaling pathway; endocytosis pathway; ASSOCIATED WITH congestive heart failure; Diabetes Mellitus, Experimental ; retinal disease; FOUND IN photoreceptor outer segment (ortholog); INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; ammonium chloride
AGR Description: Exhibits rhodopsin kinase activity; involved in protein autophosphorylation, response to drug, and response to light stimulus; predicted to localize to the photoreceptor outer segment; used to study congestive heart failure; biomarker of retinal disease; orthologous to human GRK1 (G protein-coupled receptor kinase 1).
Merged Description: Exhibits rhodopsin kinase activity; involved in protein autophosphorylation, response to drug, and response to light stimulus; predicted to localize to the photoreceptor outer segment; used to study congestive heart failure; biomarker of retinal disease; orthologous to human GRK1 (G protein-coupled receptor kinase 1); PARTICIPATES IN visual phototransduction pathway; chemokine mediated signaling pathway; endocytosis pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: G protein-coupled receptpr kinase 1; rhodopsin kinase; Rhok; RK
Orthologs:
Homo sapiens (human) : GRK1 (G protein-coupled receptor kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Grk1 (G protein-coupled receptor kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk1 (G protein-coupled receptor kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK1 (G protein-coupled receptor kinase 1)
Canis lupus familiaris (dog) : GRK1 (G protein-coupled receptor kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk1 (G protein-coupled receptor kinase 1)
Sus scrofa (pig) : GRK1 (G protein-coupled receptor kinase 1)
more info ...
Allele / Splice: Grk1Tn(sb-T2/Bart3)2.234Mcwi  
Genetic Models: F344-Grk1Tn(sb-T2/Bart3)2.234Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01681,153,489 - 81,165,442 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01680,641,991 - 80,657,693 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,979,323 - 80,991,796 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11680,979,589 - 80,992,061 (-)NCBI
Celera1673,931,302 - 73,943,259 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Grk1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619712
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.