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Gene: Grk1 (G protein-coupled receptor kinase 1) Mus musculus
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Symbol: Grk1
Name: G protein-coupled receptor kinase 1
Description: Predicted to have rhodopsin kinase activity. Involved in several processes, including photoreceptor cell morphogenesis; positive regulation of phosphorylation; and post-embryonic retina morphogenesis in camera-type eye. Localizes to photoreceptor outer segment. Is expressed in retina outer nuclear layer. Used to study Oguchi disease-2. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1); PARTICIPATES IN visual phototransduction pathway; endocytosis pathway; INTERACTS WITH bis(2-ethylhexyl) phthalate; dinitrogen; dioxygen.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G-protein receptor kinase 1; Gprk1; rhodopsin kinase; rhodopsin kinase GRK1; Rhok; Rk
Orthologs:
Homo sapiens (human) : GRK1 (G protein-coupled receptor kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Grk1 (G protein-coupled receptor kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk1 (G protein-coupled receptor kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK1 (G protein-coupled receptor kinase 1)
Canis lupus familiaris (dog) : GRK1 (G protein-coupled receptor kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk1 (G protein-coupled receptor kinase 1)
Sus scrofa (pig) : GRK1 (G protein-coupled receptor kinase 1)
Chlorocebus sabaeus (African green monkey) : GRK1 (G protein-coupled receptor kinase 1)
Heterocephalus glaber (naked mole-rat) : Grk1 (G protein-coupled receptor kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl813,405,081 - 13,421,951 (+)EnsemblGRCm38mm10GRCm38
GRCm38813,405,081 - 13,421,951 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37813,405,081 - 13,421,951 (+)NCBIGRCm37mm9NCBIm37
MGSCv36813,405,058 - 13,417,557 (+)NCBImm8
Celera813,573,519 - 13,590,102 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
 
More on Grk1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731414
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.