Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Grk1 (G protein-coupled receptor kinase 1) Mus musculus
Symbol: Grk1
Name: G protein-coupled receptor kinase 1
Description: Predicted to have rhodopsin kinase activity. Involved in several processes, including photoreceptor cell morphogenesis; positive regulation of phosphorylation; and post-embryonic retina morphogenesis in camera-type eye. Localizes to photoreceptor outer segment. Is expressed in retina outer nuclear layer. Used to study Oguchi disease-2. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1); PARTICIPATES IN visual phototransduction pathway; endocytosis pathway; INTERACTS WITH bis(2-ethylhexyl) phthalate; dinitrogen; dioxygen.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G-protein receptor kinase 1; Gprk1; rhodopsin kinase; rhodopsin kinase GRK1; Rhok; Rk
Homo sapiens (human) : GRK1 (G protein-coupled receptor kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Grk1 (G protein-coupled receptor kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk1 (G protein-coupled receptor kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK1 (G protein-coupled receptor kinase 1)
Canis lupus familiaris (dog) : GRK1 (G protein-coupled receptor kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk1 (G protein-coupled receptor kinase 1)
Sus scrofa (pig) : GRK1 (G protein-coupled receptor kinase 1)
Chlorocebus sabaeus (African green monkey) : GRK1 (G protein-coupled receptor kinase 1)
Heterocephalus glaber (naked mole-rat) : Grk1 (G protein-coupled receptor kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl813,405,081 - 13,421,951 (+)EnsemblGRCm38mm10GRCm38
GRCm38813,405,081 - 13,421,951 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37813,405,081 - 13,421,951 (+)NCBIGRCm37mm9NCBIm37
MGSCv36813,405,058 - 13,417,557 (+)NCBImm8
Celera813,573,519 - 13,590,102 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Grk1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731414
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.