Grik4 (glutamate ionotropic receptor kainate type subunit 4) - Rat Genome Database

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Gene: Grik4 (glutamate ionotropic receptor kainate type subunit 4) Rattus norvegicus
Analyze
Symbol: Grik4
Name: glutamate ionotropic receptor kainate type subunit 4
RGD ID: 2734
Description: Contributes to glutamate-gated receptor activity. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Located in dendrite; perikaryon; and terminal bouton. Is active in glutamatergic synapse and presynaptic membrane. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GluK4; glutamate receptor ionotropic, kainate 4; glutamate receptor KA-1; glutamate receptor, ionotropic kainate 4; glutamate receptor, ionotropic, kainate 4; KA1; kainate receceptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SS.LEW-(D8Chm14-D8Rat16)/Ayd  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8851,802,045 - 52,228,751 (-)NCBIGRCr8
mRatBN7.2842,903,043 - 43,331,990 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl842,905,056 - 43,193,751 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx848,399,407 - 48,703,806 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0846,678,080 - 46,982,490 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0844,545,682 - 44,850,105 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0846,804,134 - 47,237,546 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl846,806,147 - 47,094,352 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0845,279,673 - 45,708,193 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4845,510,258 - 45,681,279 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1845,519,023 - 45,690,019 (-)NCBI
Celera842,498,513 - 42,796,671 (-)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Contributions of different kainate receptor subunits to the properties of recombinant homomeric and heteromeric receptors. Fisher MT and Fisher JL, Neuroscience. 2014 Oct 10;278:70-80. doi: 10.1016/j.neuroscience.2014.08.009. Epub 2014 Aug 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Regulation of kainate receptor subunit mRNA by stress and corticosteroids in the rat hippocampus. Hunter RG, etal., PLoS One. 2009;4(1):e4328. Epub 2009 Jan 30.
5. Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78.
6. Presynaptic low- and high-affinity kainate receptors in nociceptive spinal afferents. Lucifora S, etal., Pain. 2006 Jan;120(1-2):97-105. Epub 2005 Dec 15.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate. Schiffer HH, etal., Neuron 1997 Nov;19(5):1141-6.
14. The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Szpirer C, etal., Proc Natl Acad Sci U S A 1994 Dec 6;91(25):11849-53.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1648176   PMID:12954862   PMID:20303934   PMID:21734292   PMID:27524200  


Genomics

Comparative Map Data
Grik4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8851,802,045 - 52,228,751 (-)NCBIGRCr8
mRatBN7.2842,903,043 - 43,331,990 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl842,905,056 - 43,193,751 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx848,399,407 - 48,703,806 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0846,678,080 - 46,982,490 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0844,545,682 - 44,850,105 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0846,804,134 - 47,237,546 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl846,806,147 - 47,094,352 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0845,279,673 - 45,708,193 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4845,510,258 - 45,681,279 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1845,519,023 - 45,690,019 (-)NCBI
Celera842,498,513 - 42,796,671 (-)NCBICelera
Cytogenetic Map8q22NCBI
GRIK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811120,511,748 - 120,988,906 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11120,511,746 - 120,988,906 (+)EnsemblGRCh38hg38GRCh38
GRCh3711120,382,457 - 120,859,615 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611120,036,238 - 120,362,179 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411120,036,237 - 120,362,179NCBI
Celera11117,690,453 - 118,016,395 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11116,471,471 - 116,686,109 (+)NCBIHuRef
HuRef11116,709,134 - 116,796,826 (+)NCBIHuRef
CHM1_111120,418,299 - 120,744,397 (+)NCBICHM1_1
T2T-CHM13v2.011120,535,497 - 121,012,594 (+)NCBIT2T-CHM13v2.0
Grik4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39942,431,708 - 42,856,296 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl942,429,431 - 42,855,789 (-)EnsemblGRCm39 Ensembl
GRCm38942,518,182 - 42,945,000 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl942,518,135 - 42,944,493 (-)EnsemblGRCm38mm10GRCm38
MGSCv37942,328,519 - 42,752,454 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36942,271,429 - 42,695,366 (-)NCBIMGSCv36mm8
Celera939,769,322 - 40,069,762 (-)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map923.8NCBI
Grik4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541221,563,595 - 21,934,427 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541221,563,879 - 21,932,292 (+)NCBIChiLan1.0ChiLan1.0
GRIK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29121,216,115 - 121,693,585 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111122,319,363 - 122,796,369 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011115,348,836 - 115,827,873 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111119,415,857 - 119,726,563 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11119,564,412 - 119,750,000 (+)Ensemblpanpan1.1panPan2
GRIK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1513,075,323 - 13,453,458 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl513,073,968 - 13,370,034 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha513,130,110 - 13,552,989 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0513,020,970 - 13,444,218 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl513,019,606 - 13,314,772 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1513,141,155 - 13,563,981 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0513,063,169 - 13,485,982 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0513,101,941 - 13,524,911 (-)NCBIUU_Cfam_GSD_1.0
Grik4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947102,480,625 - 102,844,802 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365425,599,785 - 5,763,616 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365425,600,517 - 5,764,042 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl947,639,988 - 48,097,870 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1947,639,987 - 48,095,803 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2953,199,184 - 53,306,028 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11112,067,251 - 112,425,025 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1112,230,644 - 112,425,014 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604313,657,400 - 14,146,869 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grik4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248804,250,763 - 4,580,177 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248804,250,322 - 4,583,742 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grik4
2663 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:284
Count of miRNA genes:194
Interacting mature miRNAs:214
Transcripts:ENSRNOT00000048347
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat

Markers in Region
D8Rat232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2842,913,941 - 42,914,164 (+)MAPPERmRatBN7.2
Rnor_6.0846,815,033 - 46,815,255NCBIRnor6.0
Rnor_5.0845,288,572 - 45,288,794UniSTSRnor5.0
RGSC_v3.4845,519,143 - 45,519,365RGDRGSC3.4
RGSC_v3.4845,519,144 - 45,519,366UniSTSRGSC3.4
RGSC_v3.1845,527,909 - 45,528,131RGD
Celera842,507,377 - 42,507,599UniSTS
FHH x ACI Map832.56RGD
FHH x ACI Map832.56UniSTS
Cytogenetic Map8q22UniSTS
RH143968  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2842,905,281 - 42,905,394 (+)MAPPERmRatBN7.2
Rnor_6.0846,806,373 - 46,806,485NCBIRnor6.0
Rnor_5.0845,279,912 - 45,280,024UniSTSRnor5.0
RGSC_v3.4845,510,484 - 45,510,596UniSTSRGSC3.4
Celera842,498,739 - 42,498,851UniSTS
RH 3.4 Map4626.13UniSTS
Cytogenetic Map8q22UniSTS


Related Rat Strains
The following Strains have been annotated to Grik4
SS.LEW-(D8Chm14-D8Rat16)/Ayd    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 48
Low 12 10 2 2 1 3 26 25 34 6 1
Below cutoff 3 31 33 28 8 28 7 8 10 7 5 7

Sequence


Ensembl Acc Id: ENSRNOT00000048347   ⟹   ENSRNOP00000047794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl842,905,056 - 43,193,751 (-)Ensembl
Rnor_6.0 Ensembl846,806,147 - 47,094,352 (-)Ensembl
RefSeq Acc Id: NM_012572   ⟹   NP_036704
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8851,802,058 - 52,102,063 (-)NCBI
mRatBN7.2842,905,056 - 43,205,077 (-)NCBI
Rnor_6.0846,806,147 - 47,107,917 (-)NCBI
Rnor_5.0845,279,673 - 45,708,193 (-)NCBI
RGSC_v3.4845,510,258 - 45,681,279 (-)RGD
Celera842,498,513 - 42,796,671 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595454   ⟹   XP_017450943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8851,802,045 - 52,228,751 (-)NCBI
mRatBN7.2842,903,043 - 43,331,987 (-)NCBI
Rnor_6.0846,804,134 - 47,237,546 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595455   ⟹   XP_017450944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8851,802,045 - 52,228,751 (-)NCBI
mRatBN7.2842,903,043 - 43,331,988 (-)NCBI
Rnor_6.0846,804,134 - 47,237,546 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080792   ⟹   XP_038936720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8851,802,045 - 52,086,907 (-)NCBI
mRatBN7.2842,903,043 - 43,189,931 (-)NCBI
RefSeq Acc Id: XM_039080793   ⟹   XP_038936721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8851,802,045 - 52,228,751 (-)NCBI
mRatBN7.2842,903,043 - 43,331,990 (-)NCBI
RefSeq Acc Id: XM_039080795   ⟹   XP_038936723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8851,802,045 - 51,879,198 (-)NCBI
mRatBN7.2842,903,043 - 42,982,205 (-)NCBI
RefSeq Acc Id: XM_063264892   ⟹   XP_063120962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8851,802,045 - 52,228,751 (-)NCBI
RefSeq Acc Id: XM_063264893   ⟹   XP_063120963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8851,802,045 - 52,228,751 (-)NCBI
RefSeq Acc Id: NP_036704   ⟸   NM_012572
- Peptide Label: precursor
- UniProtKB: Q62642 (UniProtKB/Swiss-Prot),   Q01812 (UniProtKB/Swiss-Prot),   A0A140TAG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450944   ⟸   XM_017595455
- Peptide Label: isoform X1
- UniProtKB: Q62642 (UniProtKB/Swiss-Prot),   Q01812 (UniProtKB/Swiss-Prot),   A0A140TAG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450943   ⟸   XM_017595454
- Peptide Label: isoform X1
- UniProtKB: Q62642 (UniProtKB/Swiss-Prot),   Q01812 (UniProtKB/Swiss-Prot),   A0A140TAG0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047794   ⟸   ENSRNOT00000048347
RefSeq Acc Id: XP_038936721   ⟸   XM_039080793
- Peptide Label: isoform X4
- UniProtKB: Q62642 (UniProtKB/Swiss-Prot),   Q01812 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038936720   ⟸   XM_039080792
- Peptide Label: isoform X2
- UniProtKB: Q62642 (UniProtKB/Swiss-Prot),   Q01812 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038936723   ⟸   XM_039080795
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063120963   ⟸   XM_063264893
- Peptide Label: isoform X5
- UniProtKB: Q62642 (UniProtKB/Swiss-Prot),   Q01812 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063120962   ⟸   XM_063264892
- Peptide Label: isoform X3
- UniProtKB: Q62642 (UniProtKB/Swiss-Prot),   Q01812 (UniProtKB/Swiss-Prot)
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and   Receptor ligand binding region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01812-F1-model_v2 AlphaFold Q01812 1-956 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2734 AgrOrtholog
BioCyc Gene G2FUF-30765 BioCyc
Ensembl Genes ENSRNOG00000030910 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048347.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24406 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24406 ENTREZGENE
PANTHER GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GRIK4 RGD
PhenoGen Grik4 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030910 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC223479
UniProt A0A140TAG0 ENTREZGENE, UniProtKB/TrEMBL
  A6J3T4_RAT UniProtKB/TrEMBL
  GRIK4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62642 ENTREZGENE
UniProt Secondary Q62642 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grik4  glutamate ionotropic receptor kainate type subunit 4  Grik4  glutamate receptor, ionotropic, kainate 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grik4  Glutamate receptor, ionotropic, kainate 4      Symbol and Name status set to approved 70586 APPROVED