Smarca2 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2) - Rat Genome Database

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Gene: Smarca2 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2) Heterocephalus glaber
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Symbol: Smarca2
Name: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 (Ensembl:SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2)
RGD ID: 18932000
Description: ENCODES a protein that exhibits chromatin binding (ortholog); transcription cis-regulatory region binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN aortic smooth muscle cell differentiation (ortholog); cell population proliferation (ortholog); fibroblast proliferation (ortholog); PARTICIPATES IN histone modification pathway; SWI/SNF family mediated chromatin remodeling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Arnold-Chiari Malformation (ortholog); autism spectrum disorder (ortholog); FOUND IN chromatin (ortholog); intermediate filament cytoskeleton (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: probable global transcription activator SNF2L2; Putative global transcription activator SNF2L2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247366,695,658 - 6,865,809 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247366,681,491 - 6,863,403 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Smarca2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247366,695,658 - 6,865,809 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247366,681,491 - 6,863,403 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SMARCA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3892,015,347 - 2,193,620 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl91,980,290 - 2,193,624 (+)EnsemblGRCh38hg38GRCh38
GRCh3792,015,347 - 2,193,620 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3692,005,342 - 2,183,624 (+)NCBINCBI36Build 36hg18NCBI36
Build 3492,005,341 - 2,183,624NCBI
Celera91,933,296 - 2,111,552 (+)NCBICelera
Cytogenetic Map9p24.3NCBI
HuRef91,969,240 - 2,147,484 (+)NCBIHuRef
CHM1_192,015,467 - 2,193,714 (+)NCBICHM1_1
T2T-CHM13v2.092,017,871 - 2,196,083 (+)NCBIT2T-CHM13v2.0
Smarca2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391926,582,578 - 26,755,721 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1926,582,450 - 26,755,722 (+)EnsemblGRCm39 Ensembl
GRCm381926,605,073 - 26,778,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1926,605,050 - 26,778,322 (+)EnsemblGRCm38mm10GRCm38
MGSCv371926,679,650 - 26,852,811 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361926,672,257 - 26,845,418 (+)NCBIMGSCv36mm8
Celera1927,388,592 - 27,561,569 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1921.17NCBI
Smarca2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81233,617,277 - 233,784,908 (+)NCBIGRCr8
mRatBN7.21224,191,125 - 224,358,640 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1224,191,125 - 224,358,684 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1232,628,052 - 232,795,552 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01239,558,151 - 239,725,654 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,378,904 - 232,546,407 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01244,615,811 - 244,783,736 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,615,821 - 244,782,706 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01251,867,320 - 252,035,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41230,015,057 - 230,183,451 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11230,179,079 - 230,347,474 (+)NCBI
Celera1221,383,226 - 221,550,796 (+)NCBICelera
Cytogenetic Map1q52NCBI
Smarca2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554346,420,854 - 6,594,425 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554346,420,850 - 6,592,797 (+)NCBIChiLan1.0ChiLan1.0
SMARCA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211122,394,494 - 122,574,119 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19122,400,390 - 122,580,062 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v091,818,004 - 1,997,652 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.192,043,336 - 2,189,409 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl92,013,237 - 2,189,409 (+)Ensemblpanpan1.1panPan2
SMARCA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1190,709,221 - 90,884,295 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl190,712,520 - 90,883,622 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha191,177,680 - 91,352,646 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0191,256,337 - 91,431,025 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl191,270,959 - 91,431,021 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1190,903,604 - 91,078,531 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0190,622,040 - 90,796,824 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0191,390,477 - 91,565,374 (+)NCBIUU_Cfam_GSD_1.0
Smarca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947138,171,713 - 138,337,488 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365032,835,496 - 3,001,381 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365032,835,512 - 3,001,365 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMARCA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,573,535 - 219,815,421 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,624,773 - 219,815,438 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21245,489,523 - 245,677,930 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMARCA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11277,364,468 - 77,546,356 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1277,375,500 - 77,546,314 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603865,710,587 - 65,892,953 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000007229   ⟹   ENSHGLP00000007144
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247366,695,658 - 6,861,108 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000007230   ⟹   ENSHGLP00000007145
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247366,695,658 - 6,860,975 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000007231   ⟹   ENSHGLP00000007146
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247366,833,336 - 6,865,809 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000007232   ⟹   ENSHGLP00000007147
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247366,833,984 - 6,862,539 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000007233   ⟹   ENSHGLP00000007148
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247366,833,984 - 6,836,850 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000007234   ⟹   ENSHGLP00000007149
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247366,835,572 - 6,862,539 (+)Ensembl
RefSeq Acc Id: XM_013069686   ⟹   XP_012925140
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247366,833,462 - 6,863,403 (+)NCBI
RefSeq Acc Id: XM_021252751   ⟹   XP_021108410
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247366,683,852 - 6,863,403 (+)NCBI
RefSeq Acc Id: XM_021252752   ⟹   XP_021108411
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247366,681,491 - 6,863,403 (+)NCBI
RefSeq Acc Id: XM_021252753   ⟹   XP_021108412
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247366,683,347 - 6,863,403 (+)NCBI
RefSeq Acc Id: XM_021252754   ⟹   XP_021108413
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247366,682,438 - 6,863,403 (+)NCBI
RefSeq Acc Id: XM_021252755   ⟹   XP_021108414
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247366,682,317 - 6,863,403 (+)NCBI
RefSeq Acc Id: XM_021252756   ⟹   XP_021108415
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247366,683,762 - 6,863,403 (+)NCBI
RefSeq Acc Id: XM_021252757   ⟹   XP_021108416
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247366,695,658 - 6,863,403 (+)NCBI
RefSeq Acc Id: XP_021108411   ⟸   XM_021252752
- Peptide Label: isoform X1
- UniProtKB: G5C7C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108414   ⟸   XM_021252755
- Peptide Label: isoform X1
- UniProtKB: G5C7C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108413   ⟸   XM_021252754
- Peptide Label: isoform X1
- UniProtKB: G5C7C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108412   ⟸   XM_021252753
- Peptide Label: isoform X1
- UniProtKB: G5C7C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108415   ⟸   XM_021252756
- Peptide Label: isoform X1
- UniProtKB: G5C7C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108410   ⟸   XM_021252751
- Peptide Label: isoform X1
- UniProtKB: G5C7C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108416   ⟸   XM_021252757
- Peptide Label: isoform X2
- UniProtKB: G5C7C3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012925140   ⟸   XM_013069686
- Peptide Label: isoform X3
Ensembl Acc Id: ENSHGLP00000007149   ⟸   ENSHGLT00000007234
Ensembl Acc Id: ENSHGLP00000007146   ⟸   ENSHGLT00000007231
Ensembl Acc Id: ENSHGLP00000007145   ⟸   ENSHGLT00000007230
Ensembl Acc Id: ENSHGLP00000007144   ⟸   ENSHGLT00000007229
Ensembl Acc Id: ENSHGLP00000007148   ⟸   ENSHGLT00000007233
Ensembl Acc Id: ENSHGLP00000007147   ⟸   ENSHGLT00000007232


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005215 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000007229 ENTREZGENE
  ENSHGLT00000007230 ENTREZGENE
  ENSHGLT00000007231 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  3.40.5.120 UniProtKB/TrEMBL
  Bromodomain-like UniProtKB/TrEMBL
  P-loop containing nucleotide triphosphate hydrolases UniProtKB/TrEMBL
  Tandem AAA-ATPase domain UniProtKB/TrEMBL
InterPro BRK_domain UniProtKB/TrEMBL
  BRK_sf UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/TrEMBL
  Bromodomain_CS UniProtKB/TrEMBL
  Gln-Leu-Gln_QLQ UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  HSA_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  SnAC UniProtKB/TrEMBL
  SNF2-like_sf UniProtKB/TrEMBL
  SNF2/RAD54-like_C UniProtKB/TrEMBL
  SNF2_N UniProtKB/TrEMBL
NCBI Gene Smarca2 ENTREZGENE
PANTHER GLOBAL TRANSCRIPTION ACTIVATOR SNF2L2-RELATED UniProtKB/TrEMBL
  SNF2/RAD54 HELICASE FAMILY UniProtKB/TrEMBL
Pfam BRK UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  HSA UniProtKB/TrEMBL
  QLQ UniProtKB/TrEMBL
  SnAC UniProtKB/TrEMBL
  SNF2-rel_dom UniProtKB/TrEMBL
PRINTS BROMODOMAIN UniProtKB/TrEMBL
PROSITE BROMODOMAIN_1 UniProtKB/TrEMBL
  BROMODOMAIN_2 UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  HSA UniProtKB/TrEMBL
  QLQ UniProtKB/TrEMBL
SMART BRK UniProtKB/TrEMBL
  BROMO UniProtKB/TrEMBL
  DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
  HSA UniProtKB/TrEMBL
  QLQ UniProtKB/TrEMBL
  SnAC UniProtKB/TrEMBL
Superfamily-SCOP BRK domain-like UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
  P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL
UniProt G5C7C3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-09-25 Smarca2  SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2  Smarca2  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2  Symbol and/or name change 5135510 APPROVED