Slc11a1 (solute carrier family 11 member 1) - Rat Genome Database

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Gene: Slc11a1 (solute carrier family 11 member 1) Heterocephalus glaber
Analyze
Symbol: Slc11a1
Name: solute carrier family 11 member 1
RGD ID: 18929904
Description: ENCODES a protein that exhibits cadmium ion transmembrane transporter activity (inferred); iron ion transmembrane transporter activity (inferred); manganese ion transmembrane transporter activity (inferred); INVOLVED IN activation of protein kinase activity (ortholog); antigen processing and presentation of peptide antigen (ortholog); defense response to bacterium (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); alacrima, achalasia, and impaired intellectual development syndrome (ortholog); asthma (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); late endosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: natural resistance-associated macrophage protein 1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,612,452 - 6,625,300 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,612,452 - 6,625,047 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
antigen processing and presentation of peptide antigen  (IEA,ISO)
cadmium ion transmembrane transport  (IEA)
cellular detoxification of cadmium ion  (IEA)
defense response to bacterium  (IEA,ISO)
defense response to Gram-negative bacterium  (IEA,ISO)
defense response to protozoan  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
inflammatory response  (IEA,ISO)
intracellular iron ion homeostasis  (IEA,ISO)
iron ion transmembrane transport  (IEA)
iron ion transport  (IEA)
L-arginine transmembrane transport  (IEA,ISO)
macrophage activation  (IEA,ISO)
manganese ion transmembrane transport  (IEA)
manganese ion transport  (IEA,ISO)
MAPK cascade  (ISO)
metal ion transport  (IEA)
MHC class II biosynthetic process  (IEA,ISO)
mRNA stabilization  (IEA,ISO)
multicellular organismal-level iron ion homeostasis  (IEA,ISO)
negative regulation of cytokine production  (IEA,ISO)
nitrite transport  (IEA,ISO)
phagocytosis  (IEA,ISO)
positive regulation of cytokine production  (IEA,ISO)
positive regulation of dendritic cell antigen processing and presentation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of phagocytosis  (IEA,ISO)
positive regulation of T-helper 1 type immune response  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of type II interferon production  (IEA,ISO)
proton transmembrane transport  (IEA)
respiratory burst  (IEA,ISO)
response to bacterium  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to type II interferon  (IEA,ISO)
T cell proliferation involved in immune response  (IEA,ISO)
vacuolar acidification  (IEA,ISO)
wound healing  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Slc11a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,612,452 - 6,625,300 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,612,452 - 6,625,047 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SLC11A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,382,273 - 218,396,894 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,382,029 - 218,396,894 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,246,996 - 219,261,617 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,954,996 - 218,969,861 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,072,421 - 219,086,002NCBI
Celera2213,013,369 - 213,028,238 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,100,043 - 211,114,917 (+)NCBIHuRef
CHM1_12219,253,406 - 219,268,272 (+)NCBICHM1_1
T2T-CHM13v2.02218,868,403 - 218,883,023 (+)NCBIT2T-CHM13v2.0
Slc11a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,414,318 - 74,429,974 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,414,354 - 74,425,221 (+)EnsemblGRCm39 Ensembl
GRCm38174,375,014 - 74,386,057 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,375,195 - 74,386,062 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,421,777 - 74,432,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,308,436 - 74,319,269 (+)NCBIMGSCv36mm8
Celera174,932,506 - 74,943,551 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.54NCBI
Slc11a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,406,327 - 83,417,252 (+)NCBIGRCr8
mRatBN7.2975,957,193 - 75,968,115 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl975,957,316 - 75,968,101 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,402,352 - 84,413,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,531,293 - 89,542,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0987,917,487 - 87,928,297 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,655,590 - 81,666,697 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,655,629 - 81,666,706 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,420,556 - 81,431,345 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,714,692 - 73,725,523 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera973,531,012 - 73,541,597 (+)NCBICelera
Cytogenetic Map9q33NCBI
Slc11a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,980,562 - 14,995,608 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,980,562 - 14,995,118 (-)NCBIChiLan1.0ChiLan1.0
SLC11A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,013,434 - 121,028,331 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,028,394 - 121,041,725 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B105,640,613 - 105,655,524 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,238,284 - 224,252,941 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,238,284 - 224,252,941 (+)Ensemblpanpan1.1panPan2
SLC11A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,039,203 - 25,047,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,038,360 - 25,047,282 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3725,859,294 - 25,867,379 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,054,994 - 25,063,083 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,053,097 - 25,063,084 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13724,960,561 - 24,968,638 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03724,894,238 - 24,902,300 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03724,914,545 - 24,922,623 (+)NCBIUU_Cfam_GSD_1.0
Slc11a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,544,696 - 174,553,261 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936569887,742 - 895,977 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936569888,309 - 895,991 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC11A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,433,952 - 120,446,396 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,434,100 - 120,446,396 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,452,820 - 133,454,896 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC11A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,276,553 - 104,288,466 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604095,112,392 - 95,128,910 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000022763   ⟹   ENSHGLP00000022549
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248236,612,452 - 6,625,300 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000022764   ⟹   ENSHGLP00000022550
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248236,612,452 - 6,625,300 (-)Ensembl
RefSeq Acc Id: XM_004864592   ⟹   XP_004864649
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248236,612,452 - 6,624,914 (-)NCBI
RefSeq Acc Id: XM_004864593   ⟹   XP_004864650
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248236,612,452 - 6,624,918 (-)NCBI
RefSeq Acc Id: XM_004864594   ⟹   XP_004864651
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248236,612,452 - 6,624,910 (-)NCBI
RefSeq Acc Id: XM_004864596   ⟹   XP_004864653
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248236,612,452 - 6,624,911 (-)NCBI
RefSeq Acc Id: XM_021244243   ⟹   XP_021099902
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248236,612,452 - 6,625,036 (-)NCBI
RefSeq Acc Id: XM_021244244   ⟹   XP_021099903
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248236,612,452 - 6,624,929 (-)NCBI
RefSeq Acc Id: XM_021244245   ⟹   XP_021099904
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248236,612,452 - 6,625,037 (-)NCBI
RefSeq Acc Id: XM_021244246   ⟹   XP_021099905
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248236,612,452 - 6,625,047 (-)NCBI
RefSeq Acc Id: XR_002389304
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248236,612,452 - 6,624,925 (-)NCBI
RefSeq Acc Id: XP_021099905   ⟸   XM_021244246
- Peptide Label: isoform X8
RefSeq Acc Id: XP_021099904   ⟸   XM_021244245
- Peptide Label: isoform X6
- UniProtKB: G5AZJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021099902   ⟸   XM_021244243
- Peptide Label: isoform X4
- UniProtKB: G5AZJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021099903   ⟸   XM_021244244
- Peptide Label: isoform X5
RefSeq Acc Id: XP_004864650   ⟸   XM_004864593
- Peptide Label: isoform X2
- UniProtKB: G5AZJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004864649   ⟸   XM_004864592
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J8T1 (UniProtKB/TrEMBL),   G5AZJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004864653   ⟸   XM_004864596
- Peptide Label: isoform X7
- UniProtKB: G5AZJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004864651   ⟸   XM_004864594
- Peptide Label: isoform X3
- UniProtKB: G5AZJ0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000022549   ⟸   ENSHGLT00000022763
Ensembl Acc Id: ENSHGLP00000022550   ⟸   ENSHGLT00000022764


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016083 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000022763 ENTREZGENE
  ENSHGLT00000022764 ENTREZGENE
  ENSHGLT00000062403 UniProtKB/TrEMBL
InterPro NRAMP_fam UniProtKB/TrEMBL
KEGG Report hgl:101707446 UniProtKB/TrEMBL
NCBI Gene Slc11a1 ENTREZGENE
PANTHER NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1 UniProtKB/TrEMBL
  PTHR11706 UniProtKB/TrEMBL
Pfam Nramp UniProtKB/TrEMBL
PRINTS NATRESASSCMP UniProtKB/TrEMBL
UniProt A0A0P6J8T1 ENTREZGENE, UniProtKB/TrEMBL
  G5AZJ0 ENTREZGENE, UniProtKB/TrEMBL