RGD Reference Report - A murine intraperitoneal infection model reveals that host resistance to Campylobacter jejuni is Nramp1 dependent. - Rat Genome Database

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A murine intraperitoneal infection model reveals that host resistance to Campylobacter jejuni is Nramp1 dependent.

Authors: Champion, OL  Valdez, Y  Thorson, L  Guttman, JA  Menendez, A  Gaynor, EC  Finlay, BB 
Citation: Champion OL, etal., Microbes Infect. 2008 Jul;10(8):922-7. Epub 2008 May 14.
RGD ID: 5684976
Pubmed: PMID:18656410   (View Abstract at PubMed)
DOI: DOI:10.1016/j.micinf.2008.05.001   (Journal Full-text)

We tested the hypothesis that host resistance to Campylobacter jejuni is Nramp1 dependent. Following intraperitoneal (IP) inoculation of Nramp1+/+ and isogenic Nramp1-deficient (Nramp1-/-) mice C. jejuni primarily associated with mac1-positive cells in liver tissue. A significant reduction of C. jejuni was observed in Nramp1+/+ mice 4 days post-infection (PI) (liver) and 8 days PI cecum-colon. In contrast, Nramp1-/- mice showed no significant reduction of C. jejuni and instead had a chronic inflammatory response and significant histopathological lesions 30 days PI. Differential cytokine profiles were observed in C. jejuni infected Nramp1+/+ and Nramp1-/- primary dendritic cells. Taken together these data indicate that Nramp1 is critical for host resistance to C. jejuni.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SLC11A1Humancampylobacteriosis  ISOSlc11a1 (Mus musculus) RGD 
Slc11a1Mousecampylobacteriosis  IMP  RGD 
Slc11a1Ratcampylobacteriosis  ISOSlc11a1 (Mus musculus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc11a1  (solute carrier family 11 member 1)

Genes (Mus musculus)
Slc11a1  (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1)

Genes (Homo sapiens)
SLC11A1  (solute carrier family 11 member 1)


Additional Information