SLC11A1 (solute carrier family 11 member 1) - Rat Genome Database

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Gene: SLC11A1 (solute carrier family 11 member 1) Sus scrofa
Analyze
Symbol: SLC11A1
Name: solute carrier family 11 member 1
RGD ID: 14252983
Description: ENCODES a protein that exhibits iron ion transmembrane transporter activity (ortholog); manganese ion transmembrane transporter activity (ortholog); metal cation:proton antiporter activity (ortholog); INVOLVED IN MAPK cascade; response to lipopolysaccharide; activation of protein kinase activity (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); alacrima, achalasia, and impaired intellectual development syndrome (ortholog); asthma (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); late endosome (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: natural resistance-associated macrophage protein 1; NRAMP 1; NRAMP1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,433,952 - 120,446,396 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,434,100 - 120,446,396 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,452,820 - 133,454,896 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
antigen processing and presentation of peptide antigen  (IEA)
cadmium ion transmembrane transport  (IEA)
cellular detoxification of cadmium ion  (IEA)
defense response to bacterium  (IEA)
defense response to Gram-negative bacterium  (IEA)
defense response to protozoan  (IEA)
establishment of localization in cell  (IEA)
inflammatory response  (IEA)
intracellular iron ion homeostasis  (IEA)
iron ion transmembrane transport  (IBA,IEA)
iron ion transport  (IEA,ISS)
L-arginine transmembrane transport  (IEA)
macrophage activation  (IEA)
manganese ion transmembrane transport  (IEA)
manganese ion transport  (IBA,IEA,ISO,ISS)
MAPK cascade  (IDA)
metal ion transport  (IEA)
MHC class II biosynthetic process  (IEA)
monoatomic ion transport  (IEA)
mRNA stabilization  (IEA)
multicellular organismal-level iron ion homeostasis  (IEA)
negative regulation of cytokine production  (IEA)
nitrite transport  (IEA)
phagocytosis  (IEA)
positive regulation of cytokine production  (IEA)
positive regulation of dendritic cell antigen processing and presentation  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of T-helper 1 type immune response  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of type II interferon production  (IEA)
proton transmembrane transport  (IEA)
respiratory burst  (IEA)
response to bacterium  (IEA)
response to lipopolysaccharide  (IDA,IEA)
response to type II interferon  (IEA)
T cell proliferation involved in immune response  (IEA)
vacuolar acidification  (IEA)
wound healing  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:9027577   PMID:10678911   PMID:14681463   PMID:17145712   PMID:17654007   PMID:18407056   PMID:22301074   PMID:24757812   PMID:28362979   PMID:30032202  


Genomics

Comparative Map Data
SLC11A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,433,952 - 120,446,396 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,434,100 - 120,446,396 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,452,820 - 133,454,896 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC11A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,382,273 - 218,396,894 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,382,029 - 218,396,894 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,246,996 - 219,261,617 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,954,996 - 218,969,861 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,072,421 - 219,086,002NCBI
Celera2213,013,369 - 213,028,238 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,100,043 - 211,114,917 (+)NCBIHuRef
CHM1_12219,253,406 - 219,268,272 (+)NCBICHM1_1
T2T-CHM13v2.02218,868,403 - 218,883,023 (+)NCBIT2T-CHM13v2.0
Slc11a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,414,318 - 74,429,974 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,414,354 - 74,425,221 (+)EnsemblGRCm39 Ensembl
GRCm38174,375,014 - 74,386,057 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,375,195 - 74,386,062 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,421,777 - 74,432,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,308,436 - 74,319,269 (+)NCBIMGSCv36mm8
Celera174,932,506 - 74,943,551 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.54NCBI
Slc11a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,406,327 - 83,417,252 (+)NCBIGRCr8
mRatBN7.2975,957,193 - 75,968,115 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl975,957,316 - 75,968,101 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,402,352 - 84,413,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,531,293 - 89,542,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0987,917,487 - 87,928,297 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,655,590 - 81,666,697 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,655,629 - 81,666,706 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,420,556 - 81,431,345 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,714,692 - 73,725,523 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera973,531,012 - 73,541,597 (+)NCBICelera
Cytogenetic Map9q33NCBI
Slc11a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,980,562 - 14,995,608 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,980,562 - 14,995,118 (-)NCBIChiLan1.0ChiLan1.0
SLC11A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,013,434 - 121,028,331 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,028,394 - 121,041,725 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B105,640,613 - 105,655,524 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,238,284 - 224,252,941 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,238,284 - 224,252,941 (+)Ensemblpanpan1.1panPan2
SLC11A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,039,203 - 25,047,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,038,360 - 25,047,282 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3725,859,294 - 25,867,379 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,054,994 - 25,063,083 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,053,097 - 25,063,084 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13724,960,561 - 24,968,638 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03724,894,238 - 24,902,300 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03724,914,545 - 24,922,623 (+)NCBIUU_Cfam_GSD_1.0
Slc11a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,544,696 - 174,553,261 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936569887,742 - 895,977 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936569888,309 - 895,991 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC11A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,276,553 - 104,288,466 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604095,112,392 - 95,128,910 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc11a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,612,452 - 6,625,300 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,612,452 - 6,625,047 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC11A1
345 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 4 6 1 2 4 12 12 6 1 3 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_213821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF132037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK232181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK236615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK237267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK350418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK397833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY368480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF200584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF200585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01044814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM754433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF314185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ400032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U55068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSSCT00000031352   ⟹   ENSSSCP00000026144
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15120,433,952 - 120,446,396 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000050912   ⟹   ENSSSCP00000042337
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15120,433,952 - 120,446,396 (+)Ensembl
RefSeq Acc Id: NM_213821   ⟹   NP_998986
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115120,434,100 - 120,446,396 (+)NCBI
Sequence:
RefSeq Acc Id: NP_998986   ⟸   NM_213821
- UniProtKB: A0A287AET4 (UniProtKB/TrEMBL),   A0A4X1UIF3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000042337   ⟸   ENSSSCT00000050912
Ensembl Acc Id: ENSSSCP00000026144   ⟸   ENSSSCT00000031352


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000039798 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000050912 ENTREZGENE
InterPro NRAMP_fam UniProtKB/Swiss-Prot
KEGG Report ssc:396764 UniProtKB/Swiss-Prot
NCBI Gene SLC11A1 ENTREZGENE
PANTHER NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR11706 UniProtKB/Swiss-Prot
Pfam Nramp UniProtKB/Swiss-Prot
PRINTS NATRESASSCMP UniProtKB/Swiss-Prot
UniProt A0A0E3KN72_PIG UniProtKB/TrEMBL
  A0A287AET4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UG37_PIG UniProtKB/TrEMBL
  A0A4X1UG79_PIG UniProtKB/TrEMBL
  A0A4X1UIF3 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UK45_PIG UniProtKB/TrEMBL
  A0A4X1UK70_PIG UniProtKB/TrEMBL
  A0A8D0R6Z8_PIG UniProtKB/TrEMBL
  A0A8D1A6G1_PIG UniProtKB/TrEMBL
  B2KKJ6_PIG UniProtKB/TrEMBL
  B2KKJ7_PIG UniProtKB/TrEMBL
  NRAM1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9N1Y2 UniProtKB/Swiss-Prot
VGNC ID VGNC:104057 ENTREZGENE