Adcy7 (adenylate cyclase 7) - Rat Genome Database

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Gene: Adcy7 (adenylate cyclase 7) Heterocephalus glaber
Analyze
Symbol: Adcy7
Name: adenylate cyclase 7
RGD ID: 18929079
Description: ENCODES a protein that exhibits adenylate cyclase activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); cellular response to ethanol (ortholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); Chromosome 16q12 Duplication Syndrome (ortholog); juvenile rheumatoid arthritis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Adenylate cyclase type 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247576,338,006 - 6,389,032 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247576,336,395 - 6,391,149 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Adcy7Naked Mole-RatChromosome 16q12 Duplication Syndrome  ISOADCY7 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 16q12 duplication syndromeClinVarPMID:25741868
Adcy7Naked Mole-Ratnephronophthisis 14  ISOADCY7 (Homo sapiens)8554872ClinVar Annotator: match by term: Nephronophthisis 14ClinVarPMID:12915476 more ...
Adcy7Naked Mole-RatTownes-Brocks syndrome  ISOADCY7 (Homo sapiens)8554872ClinVar Annotator: match by term: Townes syndromeClinVarPMID:12915476 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Adcy7Naked Mole-Ratacute myeloid leukemia  ISOADCY7 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18206229
Adcy7Naked Mole-Ratjuvenile rheumatoid arthritis  ISOADCY7 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19565504
Adcy7Naked Mole-Ratschizophrenia  ISOADCY7 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21822266
Adcy7Naked Mole-Ratulcerative colitis  ISOADCY7 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:28067910


Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Adcy7Naked Mole-Ratadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inIEAPANTHER:PTN000229526150520179 TreeGrafterGO_REF:0000118
Adcy7Naked Mole-Ratadenylate cyclase-activating G protein-coupled receptor signaling pathway  ISOAdcy7 (Rattus norvegicus)9068941 RGDPMID:19549762 and REF_RGD_ID:2316039
Adcy7Naked Mole-Ratadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway involved_inIEAPANTHER:PTN000229526150520179 TreeGrafterGO_REF:0000118
Adcy7Naked Mole-RatcAMP biosynthetic process involved_inIEAPANTHER:PTN000229526150520179 TreeGrafterGO_REF:0000118
Adcy7Naked Mole-RatcAMP biosynthetic process involved_inIEAInterPro:IPR009398 and InterPro:IPR030672150520179 InterProGO_REF:0000002
Adcy7Naked Mole-RatcAMP biosynthetic process involved_inIEAUniProtKB-KW:KW-0115150520179 UniProtGO_REF:0000043
Adcy7Naked Mole-RatcAMP biosynthetic process  ISOAdcy7 (Rattus norvegicus)9068941 RGDPMID:12711600 and REF_RGD_ID:2312674
Adcy7Naked Mole-Ratcellular response to ethanol involved_inISOADCY7 (Homo sapiens)9068941 PMID:12454008 and PMID:17760784UniProtPMID:12454008 and PMID:17760784
Adcy7Naked Mole-Ratcellular response to lithium ion involved_inISOAdcy7 (Mus musculus)9068941 PMID:18205980UniProtPMID:18205980
Adcy7Naked Mole-Ratcyclic nucleotide biosynthetic process involved_inIEAInterPro:IPR001054 and InterPro:IPR018297150520179 InterProGO_REF:0000002
Adcy7Naked Mole-Ratintracellular signal transduction involved_inIEAInterPro:IPR001054 and InterPro:IPR018297150520179 InterProGO_REF:0000002
Adcy7Naked Mole-Ratmaternal process involved in female pregnancy  ISOAdcy7 (Rattus norvegicus)9068941 RGDPMID:9314580 and REF_RGD_ID:2316040
Adcy7Naked Mole-Ratnegative regulation of cytokine production involved in inflammatory response involved_inISOAdcy7 (Mus musculus)9068941 PMID:20505140UniProtPMID:20505140
Adcy7Naked Mole-Ratregulation of adaptive immune response involved_inISOAdcy7 (Mus musculus)9068941 PMID:20505140UniProtPMID:20505140
1 to 14 of 14 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Adcy7Naked Mole-Ratmembrane located_inIEAUniProtKB-SubCell:SL-0162150520179 UniProtGO_REF:0000044
Adcy7Naked Mole-Ratmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
Adcy7Naked Mole-Ratplasma membrane located_inIEAInterPro:IPR009398 and InterPro:IPR030672150520179 InterProGO_REF:0000002
Adcy7Naked Mole-Ratplasma membrane located_inIEAPANTHER:PTN000229526150520179 TreeGrafterGO_REF:0000118

Molecular Function
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Adcy7Naked Mole-Ratadenylate cyclase activity  ISOAdcy7 (Rattus norvegicus)9068941 RGDPMID:12711600 and REF_RGD_ID:2312674
Adcy7Naked Mole-Ratadenylate cyclase activity enablesIEAInterPro:IPR009398 and InterPro:IPR030672150520179 InterProGO_REF:0000002
Adcy7Naked Mole-Ratadenylate cyclase activity enablesIEAEC:4.6.1.1150520179 UniProtGO_REF:0000003
Adcy7Naked Mole-Ratadenylate cyclase activity enablesIEAPANTHER:PTN000229526150520179 TreeGrafterGO_REF:0000118
Adcy7Naked Mole-RatATP binding enablesIEAUniRule:UR000734751150520179 UniProtGO_REF:0000104
Adcy7Naked Mole-RatATP binding enablesIEAUniProtKB-KW:KW-0067150520179 UniProtGO_REF:0000043
Adcy7Naked Mole-Ratlyase activity enablesIEAUniProtKB-KW:KW-0456150520179 UniProtGO_REF:0000043
Adcy7Naked Mole-Ratmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
Adcy7Naked Mole-Ratnucleotide binding enablesIEAUniProtKB-KW:KW-0547150520179 UniProtGO_REF:0000043
Adcy7Naked Mole-Ratphosphorus-oxygen lyase activity enablesIEAInterPro:IPR018297150520179 InterProGO_REF:0000002
1 to 10 of 10 rows

RGD Manual Annotations


  

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Adcy7Naked Mole-Ratendothelin signaling pathway  ISOADCY7 (Homo sapiens)9068941 PIDPID:200005
PMID:21993625   PMID:22301074   PMID:30032202  



Adcy7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247576,338,006 - 6,389,032 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247576,336,395 - 6,391,149 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ADCY7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381650,244,699 - 50,318,135 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1650,246,137 - 50,318,135 (+)EnsemblGRCh38hg38GRCh38
GRCh371650,300,462 - 50,352,046 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361648,879,324 - 48,909,544 (+)NCBINCBI36Build 36hg18NCBI36
Build 341648,879,322 - 48,909,544NCBI
Celera1634,836,237 - 34,866,457 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
HuRef1636,209,729 - 36,239,954 (+)NCBIHuRef
CHM1_11651,728,925 - 51,759,142 (+)NCBICHM1_1
T2T-CHM13v2.01656,042,542 - 56,115,969 (+)NCBIT2T-CHM13v2.0
Adcy7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39888,998,818 - 89,056,593 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl888,999,031 - 89,056,590 (+)EnsemblGRCm39 Ensembl
GRCm38888,272,190 - 88,329,965 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,272,403 - 88,329,962 (+)EnsemblGRCm38mm10GRCm38
MGSCv37890,796,302 - 90,853,861 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36891,162,508 - 91,220,066 (+)NCBIMGSCv36mm8
Celera892,546,581 - 92,603,919 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map843.06NCBI
Adcy7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81934,913,154 - 34,972,366 (-)NCBIGRCr8
mRatBN7.21918,740,875 - 18,798,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1918,740,875 - 18,776,311 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1920,420,432 - 20,442,652 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01925,615,052 - 25,637,279 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01928,572,695 - 28,594,923 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01919,702,307 - 19,762,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,704,859 - 19,727,081 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,730,189 - 30,752,411 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41920,051,639 - 20,073,861 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1918,626,035 - 18,648,205 (-)NCBICelera
Cytogenetic Map19p11NCBI
Adcy7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,362,756 - 8,426,997 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,362,957 - 8,428,773 (+)NCBIChiLan1.0ChiLan1.0
ADCY7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21859,702,690 - 59,775,133 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11665,607,365 - 65,680,787 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01630,507,836 - 30,581,068 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11649,410,136 - 49,462,178 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,410,143 - 49,462,278 (+)Ensemblpanpan1.1panPan2
ADCY7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1265,003,891 - 65,034,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl265,006,038 - 65,034,777 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,576,124 - 61,613,996 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,548,675 - 65,586,554 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,548,666 - 65,581,747 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1262,372,148 - 62,410,016 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0263,391,818 - 63,429,762 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0264,280,085 - 64,318,009 (-)NCBIUU_Cfam_GSD_1.0
Adcy7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934956,195,769 - 56,248,303 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364753,340,800 - 3,394,698 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364753,368,069 - 3,393,306 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,519,180 - 34,585,779 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,521,503 - 34,586,384 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ADCY7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1536,086,680 - 36,122,021 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl536,065,319 - 36,113,921 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604740,386,043 - 40,459,914 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000008618   ⟹   ENSHGLP00000008528
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247576,338,006 - 6,389,032 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000008619   ⟹   ENSHGLP00000008529
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247576,339,042 - 6,360,221 (-)Ensembl
RefSeq Acc Id: XM_021260932   ⟹   XP_021116591
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247576,336,395 - 6,390,951 (-)NCBI
RefSeq Acc Id: XM_021260933   ⟹   XP_021116592
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247576,336,395 - 6,391,149 (-)NCBI
RefSeq Acc Id: XM_021260934   ⟹   XP_021116593
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247576,336,395 - 6,390,396 (-)NCBI
RefSeq Acc Id: XM_021260935   ⟹   XP_021116594
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247576,336,395 - 6,390,951 (-)NCBI
RefSeq Acc Id: XM_021260936   ⟹   XP_021116595
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247576,336,395 - 6,374,558 (-)NCBI
RefSeq Acc Id: XM_021260937   ⟹   XP_021116596
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247576,336,395 - 6,390,948 (-)NCBI
RefSeq Acc Id: XM_021260938   ⟹   XP_021116597
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247576,336,395 - 6,390,948 (-)NCBI
RefSeq Acc Id: XM_021260939   ⟹   XP_021116598
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247576,336,395 - 6,390,948 (-)NCBI
RefSeq Acc Id: XM_021260940   ⟹   XP_021116599
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247576,336,395 - 6,390,947 (-)NCBI
RefSeq Acc Id: XR_002396144
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247576,340,299 - 6,390,960 (-)NCBI
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: XP_021116592   ⟸   XM_021260933
- Peptide Label: isoform X1
- UniProtKB: A0AAX6T7P6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116594   ⟸   XM_021260935
- Peptide Label: isoform X1
- UniProtKB: A0AAX6T7P6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116591   ⟸   XM_021260932
- Peptide Label: isoform X1
- UniProtKB: A0AAX6T7P6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116598   ⟸   XM_021260939
- Peptide Label: isoform X3
- UniProtKB: A0AAX6T6N3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116597   ⟸   XM_021260938
- Peptide Label: isoform X2
- UniProtKB: G5C247 (UniProtKB/TrEMBL)



1 to 26 of 26 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000006152 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000008618 ENTREZGENE
  ENSHGLT00000008619 ENTREZGENE
Gene3D-CATH 3.30.70.1230 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/TrEMBL
  AC_N UniProtKB/TrEMBL
  Adcy UniProtKB/TrEMBL
  Adcy_conserved_dom UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
KEGG Report hgl:101712483 UniProtKB/TrEMBL
NCBI Gene Adcy7 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/TrEMBL
  ADENYLATE CYCLASE TYPE 7 UniProtKB/TrEMBL
Pfam AC_N UniProtKB/TrEMBL
  DUF1053 UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/TrEMBL
PIRSF Ade_cyc UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
SMART CYCc UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/TrEMBL
UniProt A0AAX6T6N3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6T739 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6T7P6 ENTREZGENE, UniProtKB/TrEMBL
  G5C247 ENTREZGENE, UniProtKB/TrEMBL
1 to 26 of 26 rows