Mthfd1l (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like) - Rat Genome Database

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Gene: Mthfd1l (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like) Heterocephalus glaber
Analyze
Symbol: Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
RGD ID: 18928310
Description: ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN 10-formyltetrahydrofolate biosynthetic process (ortholog); embryonic neurocranium morphogenesis (ortholog); embryonic viscerocranium morphogenesis (ortholog); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; hereditary folate malabsorption pathway; ASSOCIATED WITH chromosome 6q24-q25 deletion syndrome (ortholog); Craniofacial Abnormalities (ortholog); genetic disease (ortholog); FOUND IN cytosol (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: monofunctional C1-tetrahydrofolate synthase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247857,129,859 - 7,328,153 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247857,129,969 - 7,328,331 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
mitochondrion  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mthfd1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247857,129,859 - 7,328,153 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247857,129,969 - 7,328,331 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MTHFD1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386150,865,702 - 151,101,887 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6150,865,679 - 151,101,887 (+)EnsemblGRCh38hg38GRCh38
GRCh376151,186,838 - 151,423,023 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366151,228,384 - 151,464,716 (+)NCBINCBI36Build 36hg18NCBI36
Build 346151,278,804 - 151,515,135NCBI
Celera6151,920,551 - 152,156,863 (+)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6148,750,394 - 148,986,848 (+)NCBIHuRef
CHM1_16151,450,554 - 151,687,113 (+)NCBICHM1_1
T2T-CHM13v2.06152,066,259 - 152,302,476 (+)NCBIT2T-CHM13v2.0
Mthfd1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39103,918,282 - 4,117,081 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl103,923,118 - 4,117,081 (+)EnsemblGRCm39 Ensembl
GRCm38103,972,892 - 4,167,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl103,973,118 - 4,167,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv37106,179,460 - 6,373,466 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36106,190,430 - 6,373,423 (-)NCBIMGSCv36mm8
Celera103,900,899 - 4,096,959 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.06NCBI
Mthfd1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,849,424 - 43,038,313 (+)NCBIGRCr8
mRatBN7.2140,443,926 - 40,632,911 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl140,444,008 - 40,632,905 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx140,971,049 - 41,159,905 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,958,247 - 47,147,101 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,046,668 - 41,235,517 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0140,529,092 - 40,719,232 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,529,045 - 40,719,391 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0141,876,363 - 42,065,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4134,759,445 - 34,800,865 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1134,690,706 - 34,876,868 (+)NCBI
Celera136,135,294 - 36,323,637 (+)NCBICelera
Cytogenetic Map1p11-q11NCBI
Mthfd1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543910,438,883 - 10,621,768 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543910,432,732 - 10,621,991 (-)NCBIChiLan1.0ChiLan1.0
MTHFD1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25170,883,747 - 171,125,490 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16168,777,226 - 169,016,733 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06148,679,587 - 148,919,002 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16153,384,532 - 153,619,884 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6153,390,498 - 153,619,884 (+)Ensemblpanpan1.1panPan2
MTHFD1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1141,316,247 - 41,495,226 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl141,309,419 - 41,495,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,149,900 - 42,336,703 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0141,493,594 - 41,680,491 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl141,492,925 - 41,680,486 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1141,368,435 - 41,555,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0141,212,380 - 41,399,156 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0141,717,070 - 41,904,119 (+)NCBIUU_Cfam_GSD_1.0
Mthfd1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946136,625,481 - 136,807,195 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364893,876,680 - 4,051,933 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364893,877,423 - 4,060,129 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTHFD1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,140,899 - 15,329,986 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,140,929 - 15,330,265 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,550,520 - 17,655,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTHFD1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11378,306,770 - 78,539,884 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1378,306,821 - 78,477,200 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604050,602,217 - 50,869,140 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000014944   ⟹   ENSHGLP00000014799
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247857,129,859 - 7,328,153 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000014945   ⟹   ENSHGLP00000014800
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247857,178,413 - 7,328,153 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000014946   ⟹   ENSHGLP00000014801
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247857,187,008 - 7,328,153 (-)Ensembl
RefSeq Acc Id: XM_004856880   ⟹   XP_004856937
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247857,129,969 - 7,328,153 (-)NCBI
RefSeq Acc Id: XM_013076727   ⟹   XP_012932181
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247857,129,969 - 7,328,254 (-)NCBI
RefSeq Acc Id: XM_021237945   ⟹   XP_021093604
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247857,173,065 - 7,328,254 (-)NCBI
RefSeq Acc Id: XM_021237946   ⟹   XP_021093605
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247857,187,064 - 7,328,254 (-)NCBI
RefSeq Acc Id: XM_021237947   ⟹   XP_021093606
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247857,173,061 - 7,328,254 (-)NCBI
RefSeq Acc Id: XM_021237948   ⟹   XP_021093607
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247857,187,215 - 7,328,254 (-)NCBI
RefSeq Acc Id: XM_021237949   ⟹   XP_021093608
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247857,298,591 - 7,328,331 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_012932181   ⟸   XM_013076727
- Peptide Label: isoform X2
- UniProtKB: G5C0E7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004856937   ⟸   XM_004856880
- Peptide Label: isoform X4
- UniProtKB: G5C0E7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093606   ⟸   XM_021237947
- Peptide Label: isoform X5
- UniProtKB: G5C0E7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093604   ⟸   XM_021237945
- Peptide Label: isoform X1
- UniProtKB: G5C0E7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093605   ⟸   XM_021237946
- Peptide Label: isoform X3
- UniProtKB: G5C0E7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093607   ⟸   XM_021237948
- Peptide Label: isoform X6
- UniProtKB: G5C0E7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093608   ⟸   XM_021237949
- Peptide Label: isoform X7
RefSeq Acc Id: ENSHGLP00000014799   ⟸   ENSHGLT00000014944
RefSeq Acc Id: ENSHGLP00000014801   ⟸   ENSHGLT00000014946
RefSeq Acc Id: ENSHGLP00000014800   ⟸   ENSHGLT00000014945


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010567 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000014944 ENTREZGENE
  ENSHGLT00000014945 ENTREZGENE
  ENSHGLT00000014946 ENTREZGENE
Gene3D-CATH 1.10.8.770 UniProtKB/TrEMBL
  Formyltetrahydrofolate synthetase, domain 3 UniProtKB/TrEMBL
  Leucine Dehydrogenase, chain A, domain 1 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
  P-loop containing nucleotide triphosphate hydrolases UniProtKB/TrEMBL
InterPro Aminoacid_DH-like_N_sf UniProtKB/TrEMBL
  Formate_THF_ligase UniProtKB/TrEMBL
  Formate_THF_ligase_CS UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  THF_DH/CycHdrlase UniProtKB/TrEMBL
  THF_DH/CycHdrlase_cat_dom UniProtKB/TrEMBL
  THF_DH/CycHdrlase_NAD-bd_dom UniProtKB/TrEMBL
NCBI Gene Mthfd1l ENTREZGENE
PANTHER C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED UniProtKB/TrEMBL
  MONOFUNCTIONAL C1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam FTHFS UniProtKB/TrEMBL
  THF_DHG_CYH UniProtKB/TrEMBL
  THF_DHG_CYH_C UniProtKB/TrEMBL
PRINTS THFDHDRGNASE UniProtKB/TrEMBL
PROSITE FTHFS_1 UniProtKB/TrEMBL
  FTHFS_2 UniProtKB/TrEMBL
Superfamily-SCOP Aminoacid dehydrogenase-like, N-terminal domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-fold domains UniProtKB/TrEMBL
  P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL
UniProt G5C0E7 ENTREZGENE, UniProtKB/TrEMBL