MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like) - Rat Genome Database

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Gene: MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like) Canis lupus familiaris
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Symbol: MTHFD1L
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
RGD ID: 12429406
Description: ENCODES a protein that exhibits ATP binding (inferred); formate-tetrahydrofolate ligase activity (inferred); methylenetetrahydrofolate dehydrogenase (NADP+) activity (inferred); INVOLVED IN folic acid-containing compound metabolic process (ortholog); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; hereditary folate malabsorption pathway; ASSOCIATED WITH Craniofacial Abnormalities (ortholog); neural tube defect (ortholog); FOUND IN mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; monofunctional C1-tetrahydrofolate synthase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1141,316,247 - 41,495,226 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl141,309,419 - 41,495,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,149,900 - 42,336,703 (+)NCBI
ROS_Cfam_1.0141,493,594 - 41,680,491 (+)NCBI
UMICH_Zoey_3.1141,368,435 - 41,555,234 (+)NCBI
UNSW_CanFamBas_1.0141,212,380 - 41,399,156 (+)NCBI
UU_Cfam_GSD_1.0141,717,070 - 41,904,119 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)
mitochondrion  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
MTHFD1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1141,316,247 - 41,495,226 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl141,309,419 - 41,495,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,149,900 - 42,336,703 (+)NCBI
ROS_Cfam_1.0141,493,594 - 41,680,491 (+)NCBI
UMICH_Zoey_3.1141,368,435 - 41,555,234 (+)NCBI
UNSW_CanFamBas_1.0141,212,380 - 41,399,156 (+)NCBI
UU_Cfam_GSD_1.0141,717,070 - 41,904,119 (+)NCBI
MTHFD1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6150,865,679 - 151,101,887 (+)EnsemblGRCh38hg38GRCh38
GRCh386150,865,684 - 151,101,887 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376151,186,838 - 151,423,023 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366151,228,384 - 151,464,716 (+)NCBINCBI36hg18NCBI36
Build 346151,278,804 - 151,515,135NCBI
Celera6151,920,551 - 152,156,863 (+)NCBI
Cytogenetic Map6q25.1NCBI
HuRef6148,750,394 - 148,986,848 (+)NCBIHuRef
CHM1_16151,450,554 - 151,687,113 (+)NCBICHM1_1
Mthfd1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39103,918,282 - 4,117,081 (+)NCBIGRCm39mm39
GRCm39 Ensembl103,923,118 - 4,117,081 (+)Ensembl
GRCm38103,972,892 - 4,167,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl103,973,118 - 4,167,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv37106,179,460 - 6,373,466 (-)NCBIGRCm37mm9NCBIm37
MGSCv36106,190,430 - 6,373,423 (-)NCBImm8
Celera103,900,899 - 4,096,959 (+)NCBICelera
Cytogenetic Map10A1NCBI
Mthfd1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2140,443,926 - 40,632,911 (+)NCBI
Rnor_6.0 Ensembl140,529,045 - 40,719,391 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0140,529,092 - 40,719,232 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0141,876,363 - 42,065,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4134,759,445 - 34,800,865 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1134,690,706 - 34,876,868 (+)NCBI
Celera136,135,294 - 36,323,637 (+)NCBICelera
Cytogenetic Map1p11-q11NCBI
Mthfd1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543910,438,883 - 10,621,768 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543910,432,732 - 10,621,991 (-)NCBIChiLan1.0ChiLan1.0
MTHFD1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16153,384,532 - 153,619,884 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6153,390,498 - 153,619,884 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06148,679,587 - 148,919,002 (+)NCBIMhudiblu_PPA_v0panPan3
Mthfd1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946136,625,481 - 136,807,195 (+)NCBI
SpeTri2.0NW_0049364893,877,423 - 4,060,129 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTHFD1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,140,898 - 15,329,966 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,140,929 - 15,330,265 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,550,520 - 17,655,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTHFD1L
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11378,306,770 - 78,539,884 (+)NCBI
ChlSab1.1 Ensembl1378,306,821 - 78,477,200 (+)Ensembl
Vero_WHO_p1.0NW_02366604050,602,217 - 50,869,140 (+)NCBI
Mthfd1l
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247857,129,969 - 7,328,331 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 12 2 2 12 4
Low 5 5 10 6 4 6 4 1 8 6 6
Below cutoff 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000000656   ⟹   ENSCAFP00000000601
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl141,309,419 - 41,495,216 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000066094   ⟹   ENSCAFP00000044668
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl141,309,419 - 41,452,812 (+)Ensembl
RefSeq Acc Id: XM_014115652   ⟹   XP_013971127
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1141,316,247 - 41,495,226 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038465676   ⟹   XP_038321604
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1141,368,435 - 41,555,234 (+)NCBI
RefSeq Acc Id: XM_038515317   ⟹   XP_038371245
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha142,149,900 - 42,336,703 (+)NCBI
RefSeq Acc Id: XM_038526323   ⟹   XP_038382251
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0141,717,070 - 41,904,119 (+)NCBI
RefSeq Acc Id: XM_038590627   ⟹   XP_038446555
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0141,212,380 - 41,399,156 (+)NCBI
RefSeq Acc Id: XM_038654441   ⟹   XP_038510369
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0141,493,594 - 41,680,491 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_013971127   ⟸   XM_014115652
- Sequence:
RefSeq Acc Id: ENSCAFP00000000601   ⟸   ENSCAFT00000000656
RefSeq Acc Id: ENSCAFP00000044668   ⟸   ENSCAFT00000066094
RefSeq Acc Id: XP_038321604   ⟸   XM_038465676
RefSeq Acc Id: XP_038446555   ⟸   XM_038590627
RefSeq Acc Id: XP_038510369   ⟸   XM_038654441
RefSeq Acc Id: XP_038371245   ⟸   XM_038515317
RefSeq Acc Id: XP_038382251   ⟸   XM_038526323
Protein Domains
THF_DHG_CYH   THF_DHG_CYH_C


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000413 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000000601 UniProtKB/TrEMBL
  ENSCAFP00000044668 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000656 UniProtKB/TrEMBL
  ENSCAFT00000066094 UniProtKB/TrEMBL
InterPro Formate_THF_ligase UniProtKB/TrEMBL
  Formate_THF_ligase_CS UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  THF_DH/CycHdrlase UniProtKB/TrEMBL
  THF_DH/CycHdrlase_cat_dom UniProtKB/TrEMBL
  THF_DH/CycHdrlase_NAD-bd_dom UniProtKB/TrEMBL
NCBI Gene MTHFD1L ENTREZGENE
Pfam FTHFS UniProtKB/TrEMBL
  THF_DHG_CYH UniProtKB/TrEMBL
  THF_DHG_CYH_C UniProtKB/TrEMBL
PRINTS THFDHDRGNASE UniProtKB/TrEMBL
PROSITE FTHFS_1 UniProtKB/TrEMBL
  FTHFS_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A5F4BS50_CANLF UniProtKB/TrEMBL
  F1PH90_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:98515 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 MTHFD1L  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like  Symbol and/or name change 5135510 APPROVED