Xbp1 (X-box binding protein 1) - Rat Genome Database

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Gene: Xbp1 (X-box binding protein 1) Heterocephalus glaber
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Symbol: Xbp1
Name: X-box binding protein 1
RGD ID: 18927174
Description: ENCODES a protein that exhibits chromatin DNA binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN adipose tissue development (ortholog); angiogenesis (ortholog); cellular response to amino acid stimulus (ortholog); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; forkhead class A signaling pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); borna disease (ortholog); Breast Cancer, Familial (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: X-box-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247475,123,085 - 5,128,465 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
angiogenesis  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to antibiotic  (ISO)
cellular response to fluid shear stress  (ISO)
cellular response to fructose stimulus  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-4  (ISO)
cellular response to laminar fluid shear stress  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nutrient  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
cholesterol homeostasis  (ISO)
endoplasmic reticulum unfolded protein response  (ISO)
endothelial cell proliferation  (ISO)
epithelial cell maturation involved in salivary gland development  (ISO)
exocrine pancreas development  (ISO)
fatty acid homeostasis  (ISO)
glandular epithelial cell maturation  (ISO)
intracellular triglyceride homeostasis  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
liver development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of endoplasmic reticulum unfolded protein response  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of myotube differentiation  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
neuron development  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of B cell differentiation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of lactation  (ISO)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of plasma cell differentiation  (ISO)
positive regulation of protein acetylation  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of TOR signaling  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vascular wound healing  (ISO)
protein destabilization  (ISO)
regulation of autophagy  (ISO)
regulation of cell growth  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of protein stability  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to electrical stimulus  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to insulin-like growth factor stimulus  (ISO)
response to nutrient  (ISO)
response to xenobiotic stimulus  (ISO)
serotonin secretion, neurotransmission  (ISO)
sterol homeostasis  (ISO)
transcription by RNA polymerase II  (ISO)
ubiquitin-dependent protein catabolic process  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:26763976   PMID:30032202  


Genomics

Comparative Map Data
Xbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247475,123,085 - 5,128,465 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
XBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382228,794,560 - 28,800,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2228,794,555 - 28,800,597 (-)EnsemblGRCh38hg38GRCh38
GRCh372229,190,548 - 29,196,557 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,520,548 - 27,526,560 (-)NCBINCBI36Build 36hg18NCBI36
Build 342227,515,102 - 27,521,114NCBI
Celera2212,990,518 - 12,996,530 (-)NCBICelera
Cytogenetic Map22q12.1NCBI
HuRef2212,155,463 - 12,161,487 (-)NCBIHuRef
CHM1_12229,149,582 - 29,155,594 (-)NCBICHM1_1
T2T-CHM13v2.02229,255,848 - 29,261,869 (-)NCBIT2T-CHM13v2.0
Xbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,470,641 - 5,475,993 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,470,659 - 5,475,893 (+)EnsemblGRCm39 Ensembl
GRCm38115,520,641 - 5,525,993 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,520,659 - 5,525,893 (+)EnsemblGRCm38mm10GRCm38
MGSCv37115,420,970 - 5,425,875 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,420,970 - 5,425,875 (+)NCBIMGSCv36mm8
Celera116,013,954 - 6,018,865 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.61NCBI
Xbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,604,623 - 84,609,707 (+)NCBIGRCr8
mRatBN7.21480,390,629 - 80,395,713 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,390,643 - 80,395,693 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1484,792,890 - 84,797,957 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,033,004 - 86,038,075 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,482,326 - 82,487,393 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01485,753,736 - 85,758,820 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,753,760 - 85,758,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01486,423,839 - 86,428,923 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,151,910 - 86,156,975 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11486,171,054 - 86,176,119 (+)NCBI
Celera1479,276,264 - 79,281,348 (+)NCBICelera
Cytogenetic Map14q21NCBI
Xbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554553,037,885 - 3,041,827 (-)NCBIChiLan1.0ChiLan1.0
XBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22338,792,985 - 38,799,011 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12241,491,735 - 41,497,760 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0229,863,479 - 9,869,491 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12227,566,423 - 27,572,627 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2227,567,041 - 27,571,943 (-)Ensemblpanpan1.1panPan2
XBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,162,675 - 22,168,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,163,222 - 22,168,105 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2622,034,265 - 22,039,738 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02622,536,044 - 22,541,803 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2622,536,033 - 22,541,796 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,246,365 - 22,251,835 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02622,509,837 - 22,515,563 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02622,572,658 - 22,578,379 (-)NCBIUU_Cfam_GSD_1.0
Xbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,975,309 - 112,979,534 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366572,891,907 - 2,896,174 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366572,891,171 - 2,895,409 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,008,377 - 46,016,526 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,011,239 - 46,016,526 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,015,849 - 49,016,650 (-)NCBISscrofa10.2Sscrofa10.2susScr3
XBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11911,670,605 - 11,677,168 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045114,476,586 - 114,483,163 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_013071981   ⟹   XP_012927435
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247475,123,085 - 5,128,465 (-)NCBI
Protein Sequences
Protein RefSeqs XP_012927435 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AIZ09081 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_012927435   ⟸   XM_013071981
- UniProtKB: A0AAX6QTE3 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
InterPro bZIP UniProtKB/TrEMBL
  bZIP_sf UniProtKB/TrEMBL
  ER_Stress-Reg_TF UniProtKB/TrEMBL
NCBI Gene Xbp1 ENTREZGENE
PANTHER X-BOX BINDING PROTEIN 1 UniProtKB/TrEMBL
  X-BOX BINDING PROTEIN 1 UniProtKB/TrEMBL
Pfam bZIP_2 UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP Leucine zipper domain UniProtKB/TrEMBL
UniProt A0AAX6QTE3 ENTREZGENE, UniProtKB/TrEMBL