Sost (sclerostin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Sost (sclerostin) Heterocephalus glaber
Analyze
Symbol: Sost
Name: sclerostin
RGD ID: 18918977
Description: ENCODES a protein that exhibits carbohydrate binding (ortholog); DNA-binding transcription factor binding (ortholog); molecular function inhibitor activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); canonical Wnt signaling pathway (ortholog); cellular response to parathyroid hormone stimulus (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant craniodiaphyseal dysplasia (ortholog); bone development disease (ortholog); genetic disease (ortholog); FOUND IN extracellular space (ortholog); Golgi apparatus (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,006,813 - 1,008,685 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,006,811 - 1,009,437 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Sost
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,006,813 - 1,008,685 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,006,811 - 1,009,437 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SOST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,753,738 - 43,758,791 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1743,753,738 - 43,758,791 (-)EnsemblGRCh38hg38GRCh38
GRCh371741,831,106 - 41,836,159 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,186,625 - 39,191,682 (-)NCBINCBI36Build 36hg18NCBI36
Build 341739,186,624 - 39,191,682NCBI
Celera1738,539,106 - 38,544,164 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1737,595,207 - 37,600,265 (-)NCBIHuRef
CHM1_11742,066,723 - 42,071,781 (-)NCBICHM1_1
T2T-CHM13v2.01744,606,296 - 44,611,349 (-)NCBIT2T-CHM13v2.0
Sost
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,853,284 - 101,857,841 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,853,284 - 101,857,841 (-)EnsemblGRCm39 Ensembl
GRCm3811101,962,458 - 101,967,015 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,962,458 - 101,967,015 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,823,772 - 101,828,329 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,778,626 - 101,783,105 (-)NCBIMGSCv36mm8
Celera11113,667,734 - 113,672,291 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.48NCBI
Sost
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,412,722 - 87,415,766 (-)NCBIGRCr8
mRatBN7.21086,912,517 - 86,915,561 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,911,517 - 86,915,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,941,934 - 91,944,978 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,417,549 - 91,420,598 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,810,861 - 86,813,910 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,897,087 - 89,900,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,897,087 - 89,900,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,689,512 - 89,692,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,023,712 - 91,026,759 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,038,081 - 91,041,129 (-)NCBI
Celera1085,631,705 - 85,634,749 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Sost
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,054,939 - 17,058,027 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,054,939 - 17,058,027 (-)NCBIChiLan1.0ChiLan1.0
SOST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21921,149,763 - 21,155,219 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11723,114,052 - 23,119,508 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,639,088 - 13,644,152 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,804,374 - 13,809,432 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,804,374 - 13,809,432 (+)Ensemblpanpan1.1panPan2
SOST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,538,713 - 19,544,650 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,539,435 - 19,544,651 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,928,494 - 18,933,390 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,234,523 - 20,239,413 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,234,719 - 20,239,089 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,087,300 - 19,092,190 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,270,262 - 19,275,387 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,415,616 - 19,420,514 (+)NCBIUU_Cfam_GSD_1.0
Sost
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,876,390 - 18,881,316 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541313,287 - 318,176 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541313,308 - 318,109 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,355,234 - 19,360,352 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,354,912 - 19,360,348 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,588,864 - 19,592,789 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,649,053 - 62,656,192 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,651,146 - 62,654,570 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607733,418,277 - 33,423,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004859825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01067273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000017182   ⟹   ENSHGLP00000017011
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247951,006,813 - 1,008,685 (+)Ensembl
RefSeq Acc Id: XM_004859825   ⟹   XP_004859882
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247951,006,811 - 1,009,437 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004859882 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000017011
RefSeq Acc Id: XP_004859882   ⟸   XM_004859825
Ensembl Acc Id: ENSHGLP00000017011   ⟸   ENSHGLT00000017182


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012172 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000017182 ENTREZGENE
NCBI Gene Sost ENTREZGENE