Bmp6 (bone morphogenetic protein 6) - Rat Genome Database

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Gene: Bmp6 (bone morphogenetic protein 6) Heterocephalus glaber
Analyze
Symbol: Bmp6
Name: bone morphogenetic protein 6
RGD ID: 18917059
Description: ENCODES a protein that exhibits BMP receptor binding (ortholog); growth factor activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); bone development (ortholog); cellular response to BMP stimulus (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH Acute Otitis Media (ortholog); adult T-cell leukemia/lymphoma (ortholog); allergic contact dermatitis (ortholog); FOUND IN enzyme activator complex (ortholog); extracellular space (ortholog); vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475617,743,834 - 17,894,753 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475617,742,822 - 17,894,931 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bmp6Naked Mole-RatAcute Otitis Media  ISOBmp6 (Mus musculus)9068941mRNA:decreased expression:middle ear (mouse)RGDPMID:21889218 and REF_RGD_ID:127284853
Bmp6Naked Mole-Ratanemia  ISOBmp6 (Rattus norvegicus)9068941mRNA and protein:decreased expression:liverRGDPMID:21859731 and REF_RGD_ID:7242407
Bmp6Naked Mole-RatBrain Injuries  ISOBmp6 (Rattus norvegicus)9068941protein:increased expression:brain more ...RGDPMID:16388909 and REF_RGD_ID:2289020
Bmp6Naked Mole-Ratbrain ischemia  ISOBmp6 (Rattus norvegicus)9068941 RGDPMID:11245809 and REF_RGD_ID:2289024
Bmp6Naked Mole-Ratbreast cancer  ISOBMP6 (Homo sapiens)9068941mRNA:decreased expression:breastRGDPMID:17004110 and REF_RGD_ID:1643590
Bmp6Naked Mole-Ratcolitis  ISOBmp6 (Rattus norvegicus)9068941 RGDPMID:22361727 and REF_RGD_ID:7242194
Bmp6Naked Mole-Ratesophagus squamous cell carcinoma  ISOBMP6 (Homo sapiens)9068941protein:increased expression:esophagusRGDPMID:22364398 and REF_RGD_ID:7242413
Bmp6Naked Mole-RatNeoplasm Metastasis severityISOBMP6 (Homo sapiens)9068941associated with Prostatic Neoplasms and protein:increased expression:boneRGDPMID:16166304 and REF_RGD_ID:2289018
Bmp6Naked Mole-Ratprostate cancer  ISOBMP6 (Homo sapiens)9068941protein:increased expression:prostateRGDPMID:18072288 and REF_RGD_ID:2289017
Bmp6Naked Mole-Ratrenal cell carcinoma  ISOBMP6 (Homo sapiens)9068941mRNA and protein:increased expression:kidneyRGDPMID:20016212 and REF_RGD_ID:7242419
Bmp6Naked Mole-Ratrenal fibrosis severityISOBmp6 (Mus musculus)9068941associated with Ureteral ObstructionRGDPMID:21356359 and REF_RGD_ID:7242415
Bmp6Naked Mole-RatReperfusion Injury  ISOBmp6 (Rattus norvegicus)9068941 RGDPMID:11245809 and REF_RGD_ID:2289024
Bmp6Naked Mole-RatTibial Fractures  ISOBmp6 (Rattus norvegicus)9068941 RGDPMID:23097200 and REF_RGD_ID:7242189
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bmp6Naked Mole-Ratarrhythmogenic right ventricular dysplasia 8  ISOBMP6 (Homo sapiens)8554872ClinVar Annotator: match by term: Arrhythmogenic right ventricular cardiomyopathy and type 8ClinVarPMID:28492532
Bmp6Naked Mole-RatCarvajal syndrome  ISOBMP6 (Homo sapiens)8554872ClinVar Annotator: match by term: Carvajal syndromeClinVarPMID:28492532
Bmp6Naked Mole-RatIron Overload  ISOBMP6 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:26582087 more ...
Bmp6Naked Mole-RatNeonatal Hemochromatosis  ISOBMP6 (Homo sapiens)8554872ClinVar Annotator: match by term: Neonatal hemochromatosisClinVarPMID:25741868
Bmp6Naked Mole-Ratprimary ovarian insufficiency  ISOBMP6 (Homo sapiens)8554872ClinVar Annotator: match by term: Premature ovarian failureClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bmp6Naked Mole-Ratadult T-cell leukemia/lymphoma  ISOBMP6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18688853
Bmp6Naked Mole-Ratallergic contact dermatitis  ISOBMP6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17374397
Bmp6Naked Mole-Rathemochromatosis  ISOBMP6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19252486 and PMID:19252488
Bmp6Naked Mole-Ratosteoarthritis  ISOBMP6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20008919
Bmp6Naked Mole-Ratrheumatoid arthritis  ISOBMP6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20008919
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bmp6Naked Mole-RatIron Overload susceptibilityISOBMP6 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 20 of 48 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bmp6Naked Mole-RatBMP signaling pathway acts_upstream_of_or_withinISOBmp6 (Mus musculus)9068941 PMID:14623234 and PMID:19852960MGIPMID:14623234 and PMID:19852960
Bmp6Naked Mole-RatBMP signaling pathway involved_inIEAPANTHER:PTN000712817150520179 TreeGrafterGO_REF:0000118
Bmp6Naked Mole-Ratbone development involved_inISOBMP6 (Homo sapiens)9068941 PMID:16798745BHF-UCLPMID:16798745
Bmp6Naked Mole-Ratcellular response to BMP stimulus involved_inISOBMP6 (Homo sapiens)9068941 PMID:18326817BHF-UCLPMID:18326817
Bmp6Naked Mole-Ratcellular response to iron ion involved_inISOBmp6 (Mus musculus)9068941 PMID:19252488BHF-UCLPMID:19252488
Bmp6Naked Mole-Ratcellular response to mechanical stimulus  ISOBmp6 (Rattus norvegicus)9068941 RGDPMID:23198877 and REF_RGD_ID:7242187
Bmp6Naked Mole-Ratendochondral ossification acts_upstream_of_or_withinISOMGI:21369859068941 PMID:9664685MGIPMID:9664685
Bmp6Naked Mole-Rateye development involved_inISOUniProtKB:P233599068941 PMID:16154126UniProtPMID:16154126
Bmp6Naked Mole-Ratimmune response involved_inISOBMP6 (Homo sapiens)9068941 PMID:16886151BHF-UCLPMID:16886151
Bmp6Naked Mole-Ratinflammatory response involved_inISOBmp6 (Mus musculus)9068941 PMID:12151307UniProtPMID:12151307
Bmp6Naked Mole-Ratintracellular iron ion homeostasis acts_upstream_of_or_withinISOMGI:21369859068941 PMID:21703414MGIPMID:21703414
Bmp6Naked Mole-Ratintracellular iron ion homeostasis involved_inISOBmp6 (Mus musculus)9068941 PMID:19252488BHF-UCLPMID:19252488
Bmp6Naked Mole-Ratkidney development involved_inISOUniProtKB:P233599068941 PMID:16154126UniProtPMID:16154126
Bmp6Naked Mole-Ratmale genitalia development acts_upstream_of_or_withinISOMGI:881819068941 PMID:9664685MGIPMID:9664685
Bmp6Naked Mole-Ratmulticellular organismal-level iron ion homeostasis involved_inISOBmp6 (Mus musculus)9068941 PMID:19252488BHF-UCLPMID:19252488
Bmp6Naked Mole-Ratmulticellular organismal-level iron ion homeostasis involved_inISOBMP6 (Homo sapiens)9068941 PMID:26582087 more ...UniProtPMID:26582087 more ...
Bmp6Naked Mole-Ratnegative regulation of adherens junction organization involved_inISOBMP6 (Homo sapiens)9068941 PMID:26598555ARUK-UCLPMID:26598555
Bmp6Naked Mole-Ratnegative regulation of cell-cell adhesion mediated by cadherin involved_inISOBMP6 (Homo sapiens)9068941 PMID:26598555ARUK-UCLPMID:26598555
Bmp6Naked Mole-Ratnegative regulation of transcription by RNA polymerase II involved_inISOBmp6 (Mus musculus)9068941 PMID:19252488BHF-UCLPMID:19252488
Bmp6Naked Mole-Ratneuron differentiation acts_upstream_of_or_withinISOMGI:21590139068941 PMID:14623245MGIPMID:14623245
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Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bmp6Naked Mole-Ratenzyme activator complex part_ofISOBMP6 (Homo sapiens)9068941 PMID:31800957UniProtPMID:31800957
Bmp6Naked Mole-Ratextracellular region located_inIEAInterPro:IPR015615150520179 InterProGO_REF:0000002
Bmp6Naked Mole-Ratextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
Bmp6Naked Mole-Ratextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
Bmp6Naked Mole-Ratextracellular space  ISOBmp6 (Rattus norvegicus)9068941 RGDPMID:11245809 and REF_RGD_ID:2289024
Bmp6Naked Mole-Ratextracellular space located_inIEAPANTHER:PTN000712817150520179 TreeGrafterGO_REF:0000118
Bmp6Naked Mole-Ratextracellular space  ISOBmp6 (Rattus norvegicus)9068941matrix vesicles - cell derived and extracellular vesicles that are initiation sites of mineralizationRGDPMID:18758911 and REF_RGD_ID:2301841
Bmp6Naked Mole-Ratvesicle  ISOBmp6 (Rattus norvegicus)9068941matrix vesicles - cell derived and extracellular vesicles that are initiation sites of mineralizationRGDPMID:18758911 and REF_RGD_ID:2301841

Molecular Function
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1 to 11 of 11 rows

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bmp6Naked Mole-RatBone morphogenetic proteins signaling pathway  ISOBMP6 (Homo sapiens)9068941 PIDPID:200144
PMID:22301074   PMID:30032202  



Bmp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475617,743,834 - 17,894,753 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475617,742,822 - 17,894,931 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
BMP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3867,726,099 - 7,881,728 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl67,726,099 - 7,881,728 (+)EnsemblGRCh38hg38GRCh38
GRCh3767,726,332 - 7,881,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3667,672,010 - 7,826,960 (+)NCBINCBI36Build 36hg18NCBI36
Build 3467,672,008 - 7,826,726NCBI
Celera68,956,438 - 9,111,399 (+)NCBICelera
Cytogenetic Map6p24.3NCBI
HuRef67,604,128 - 7,759,039 (+)NCBIHuRef
CHM1_167,728,829 - 7,884,079 (+)NCBICHM1_1
T2T-CHM13v2.067,594,835 - 7,750,477 (+)NCBIT2T-CHM13v2.0
Bmp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391338,529,098 - 38,684,283 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1338,529,083 - 38,684,278 (+)EnsemblGRCm39 Ensembl
GRCm381338,345,716 - 38,500,314 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1338,345,107 - 38,500,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv371338,437,585 - 38,591,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361338,353,182 - 38,507,194 (+)NCBIMGSCv36mm8
Celera1339,464,167 - 39,615,905 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1318.15NCBI
Bmp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81726,523,704 - 26,785,558 (-)NCBIGRCr8
mRatBN7.21726,318,121 - 26,469,691 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1726,318,569 - 26,470,365 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1726,176,967 - 26,326,912 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01727,780,553 - 27,930,507 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01726,125,854 - 26,275,216 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01726,955,142 - 27,112,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1726,955,142 - 27,112,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01728,870,345 - 29,029,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41732,380,199 - 32,689,295 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11732,383,039 - 32,692,136 (-)NCBI
Celera1725,955,026 - 26,103,008 (-)NCBICelera
RH 3.4 Map17342.3RGD
Cytogenetic Map17p12NCBI
Bmp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554656,054,931 - 6,200,377 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554656,053,600 - 6,201,254 (-)NCBIChiLan1.0ChiLan1.0
BMP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2522,365,813 - 22,522,551 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1618,363,471 - 18,519,549 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v067,564,164 - 7,720,341 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.167,848,255 - 8,002,030 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl67,848,249 - 8,000,649 (+)Ensemblpanpan1.1panPan2
BMP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,780,763 - 7,833,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,804,231 - 7,831,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha357,690,267 - 7,840,113 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0357,770,103 - 7,915,608 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl357,770,103 - 7,915,377 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1357,622,630 - 7,772,359 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0357,648,291 - 7,798,326 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,982,152 - 9,131,717 (+)NCBIUU_Cfam_GSD_1.0
Bmp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494616,438,976 - 16,602,907 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365344,709,064 - 4,871,023 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365344,707,658 - 4,871,865 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl75,058,817 - 5,210,270 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.175,058,817 - 5,208,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.275,163,209 - 5,313,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11764,279,243 - 64,436,356 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1764,280,609 - 64,435,382 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660447,712,261 - 7,873,910 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000021518   ⟹   ENSHGLP00000021310
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475617,743,834 - 17,894,753 (-)Ensembl
RefSeq Acc Id: XM_004847720   ⟹   XP_004847777
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475617,742,822 - 17,894,931 (-)NCBI
Protein RefSeqs XP_004847777 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000021310
RefSeq Acc Id: XP_004847777   ⟸   XM_004847720
- UniProtKB: A0AAX6PBK5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000021310   ⟸   ENSHGLT00000021518



1 to 20 of 20 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000015229 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000021518 ENTREZGENE
Gene3D-CATH 2.60.120.970 UniProtKB/TrEMBL
  Cystine-knot cytokines UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
NCBI Gene Bmp6 ENTREZGENE
PANTHER BONE MORPHOGENETIC PROTEIN 6 UniProtKB/TrEMBL
  TGF-BETA FAMILY UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP Cystine-knot cytokines UniProtKB/TrEMBL
UniProt A0AAX6PBK5 ENTREZGENE, UniProtKB/TrEMBL
1 to 20 of 20 rows