BMP6 (bone morphogenetic protein 6) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: BMP6 (bone morphogenetic protein 6) Sus scrofa
Analyze
Symbol: BMP6
Name: bone morphogenetic protein 6
RGD ID: 14029151
Description: ENCODES a protein that exhibits growth factor activity (inferred); protein heterodimerization activity (inferred); INVOLVED IN cell differentiation (ortholog); cellular response to BMP stimulus (ortholog); cellular response to mechanical stimulus (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH adult T-cell leukemia (ortholog); allergic contact dermatitis (ortholog); anemia (ortholog); FOUND IN cytoplasm (ortholog); vesicle (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl75,058,817 - 5,211,316 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.175,058,817 - 5,208,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.275,163,209 - 5,313,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (IBA)
cell differentiation  (ISO)
cellular iron ion homeostasis  (IEA)
cellular response to BMP stimulus  (ISO)
cellular response to iron ion  (IEA)
cellular response to mechanical stimulus  (ISO)
endochondral ossification  (IEA)
eye development  (IEA)
immune response  (IEA)
inflammatory response  (IEA)
kidney development  (IEA)
male genitalia development  (IEA)
multicellular organismal iron ion homeostasis  (IEA)
negative regulation of adherens junction organization  (IEA)
negative regulation of cell-cell adhesion mediated by cadherin  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
ossification  (ISO)
osteoblast differentiation  (IEA)
positive regulation of aldosterone biosynthetic process  (IEA)
positive regulation of aldosterone secretion  (ISO)
positive regulation of bone mineralization  (IEA)
positive regulation of chondrocyte differentiation  (ISO)
positive regulation of endothelial cell differentiation  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of lipopolysaccharide-mediated signaling pathway  (IEA)
positive regulation of neuron differentiation  (IEA)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IBA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of SMAD protein signal transduction  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of vascular permeability  (IEA)
response to activity  (ISO)
response to glucocorticoid  (ISO)
response to iron ion  (ISO)
response to magnesium ion  (ISO)
response to retinoic acid  (ISO)
signal transduction  (IEA)
SMAD protein signal transduction  (IBA)
type B pancreatic cell development  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:19359354  


Genomics

Comparative Map Data
BMP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl75,058,817 - 5,211,316 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.175,058,817 - 5,208,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.275,163,209 - 5,313,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl67,726,099 - 7,881,728 (+)EnsemblGRCh38hg38GRCh38
GRCh3867,726,099 - 7,881,728 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3767,727,011 - 7,881,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3667,672,010 - 7,826,960 (+)NCBINCBI36hg18NCBI36
Build 3467,672,008 - 7,826,726NCBI
Celera68,956,438 - 9,111,399 (+)NCBI
Cytogenetic Map6p24.3NCBI
HuRef67,604,128 - 7,759,039 (+)NCBIHuRef
CHM1_167,728,829 - 7,884,079 (+)NCBICHM1_1
Bmp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391338,529,692 - 38,684,290 (+)NCBIGRCm39mm39
GRCm381338,345,716 - 38,500,314 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1338,345,107 - 38,500,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv371338,437,585 - 38,591,597 (+)NCBIGRCm37mm9NCBIm37
MGSCv361338,353,182 - 38,507,194 (+)NCBImm8
Celera1339,464,167 - 39,615,905 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1318.15NCBI
Bmp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01726,955,142 - 27,112,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1726,955,142 - 27,112,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01728,870,345 - 29,029,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41732,380,199 - 32,689,295 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11732,383,039 - 32,692,136 (-)NCBI
Celera1725,955,026 - 26,103,008 (-)NCBICelera
Cytogenetic Map17p12NCBI
RH 3.4 Map17342.3RGD
Bmp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554656,054,931 - 6,200,377 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554656,053,600 - 6,201,254 (-)NCBIChiLan1.0ChiLan1.0
BMP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.167,848,255 - 8,002,030 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl67,848,249 - 8,000,649 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v067,564,164 - 7,720,341 (+)NCBIMhudiblu_PPA_v0panPan3
BMP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl357,804,231 - 7,831,845 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1357,780,763 - 7,833,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Bmp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365344,707,658 - 4,871,865 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11764,279,243 - 64,436,356 (-)NCBI
ChlSab1.1 Ensembl1764,280,609 - 64,435,382 (-)Ensembl
Bmp6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475617,742,822 - 17,894,931 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 7 3 3 3 1 7 1 2 1
Below cutoff 3 1 2 1 14 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000001120   ⟹   ENSSSCP00000001098
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl75,058,817 - 5,210,270 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000037826   ⟹   ENSSSCP00000055803
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl75,058,817 - 5,211,316 (+)Ensembl
RefSeq Acc Id: NM_001168001   ⟹   NP_001161473
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.175,058,817 - 5,208,868 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001161473 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACD70393 (Get FASTA)   NCBI Sequence Viewer  
  ACY54512 (Get FASTA)   NCBI Sequence Viewer  
  CAX36909 (Get FASTA)   NCBI Sequence Viewer  
  CBA34954 (Get FASTA)   NCBI Sequence Viewer  
  CBA34955 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001161473   ⟸   NM_001168001
- Peptide Label: precursor
- UniProtKB: D0VFJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000001098   ⟸   ENSSSCT00000001120
RefSeq Acc Id: ENSSSCP00000055803   ⟸   ENSSSCT00000037826
Protein Domains
TGF_BETA_2   TGFb_propeptide


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001027 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070001100 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000001098 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000055803 UniProtKB/TrEMBL
  ENSSSCP00070001750 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001120 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000037826 UniProtKB/TrEMBL
  ENSSSCT00070002091 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
KEGG Report ssc:100155536 UniProtKB/TrEMBL
NCBI Gene BMP6 ENTREZGENE
PANTHER PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniGene Ssc.66765 ENTREZGENE
UniProt A0A287BGT4_PIG UniProtKB/TrEMBL
  A0A4X1SHG9_PIG UniProtKB/TrEMBL
  B3GEL7_PIG UniProtKB/TrEMBL
  C7C1K4_PIG UniProtKB/TrEMBL
  C7U1J8_PIG UniProtKB/TrEMBL
  D0VFJ0 ENTREZGENE, UniProtKB/TrEMBL
  F1RW73_PIG UniProtKB/TrEMBL
VGNC ID VGNC:85845 ENTREZGENE