Msr1 (macrophage scavenger receptor 1) - Rat Genome Database

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Gene: Msr1 (macrophage scavenger receptor 1) Heterocephalus glaber
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Symbol: Msr1
Name: macrophage scavenger receptor 1
RGD ID: 18916667
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); cargo receptor activity (ortholog); low-density lipoprotein particle binding (ortholog); INVOLVED IN amyloid-beta clearance (ortholog); cellular response to organic cyclic compound (ortholog); cholesterol transport (ortholog); ASSOCIATED WITH arteriosclerosis (ortholog); Barrett's esophagus (ortholog); COVID-19 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Macrophage scavenger receptor types I and II; macrophage scavenger receptor types I and II isoform type 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624839694,032 - 770,254 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624839694,149 - 769,322 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074  


Genomics

Comparative Map Data
Msr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624839694,032 - 770,254 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624839694,149 - 769,322 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MSR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38816,107,881 - 16,192,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl816,107,878 - 16,567,490 (-)EnsemblGRCh38hg38GRCh38
GRCh37815,965,390 - 16,050,160 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36816,009,758 - 16,094,671 (-)NCBINCBI36Build 36hg18NCBI36
Build 34816,009,760 - 16,094,595NCBI
Celera814,929,936 - 15,014,828 (-)NCBICelera
Cytogenetic Map8p22NCBI
HuRef814,509,923 - 14,594,638 (-)NCBIHuRef
CHM1_1816,167,312 - 16,251,899 (-)NCBICHM1_1
T2T-CHM13v2.0816,374,329 - 16,459,913 (-)NCBIT2T-CHM13v2.0
Msr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39839,996,284 - 40,095,790 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl840,034,726 - 40,095,714 (-)EnsemblGRCm39 Ensembl
GRCm38839,543,232 - 39,642,750 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl839,581,685 - 39,642,673 (-)EnsemblGRCm38mm10GRCm38
MGSCv37840,667,054 - 40,728,032 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36841,102,269 - 41,141,495 (-)NCBIMGSCv36mm8
Celera842,254,529 - 42,315,500 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
Msr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81659,421,250 - 59,507,070 (+)NCBIGRCr8
mRatBN7.21652,717,775 - 52,803,602 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1652,717,732 - 52,799,676 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1658,047,955 - 58,113,146 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01661,453,017 - 61,518,269 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01656,681,953 - 56,747,156 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01656,817,714 - 56,900,025 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1656,813,791 - 56,900,052 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01656,516,982 - 56,597,180 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41656,278,223 - 56,345,472 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1650,621,592 - 50,686,791 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
Msr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554631,197,022 - 1,264,765 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554631,197,086 - 1,263,943 (+)NCBIChiLan1.0ChiLan1.0
MSR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2734,577,677 - 34,663,873 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1810,315,632 - 10,401,269 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0815,335,795 - 15,421,472 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1812,091,543 - 12,175,927 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl812,088,873 - 12,175,927 (-)Ensemblpanpan1.1panPan2
MSR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11639,434,948 - 39,513,727 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1639,436,753 - 39,527,438 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1639,918,454 - 39,996,751 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01641,487,019 - 41,565,417 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1641,487,570 - 41,565,264 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11639,583,887 - 39,662,157 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01640,129,035 - 40,207,399 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01640,253,347 - 40,331,889 (-)NCBIUU_Cfam_GSD_1.0
Msr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494339,750,600 - 39,814,340 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365735,328,526 - 5,388,901 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365735,345,282 - 5,391,946 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl173,859,692 - 3,939,726 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1173,859,903 - 3,939,612 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2174,110,409 - 4,191,629 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1814,221,389 - 14,305,059 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl814,220,529 - 14,304,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605228,000,740 - 28,084,945 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000004424   ⟹   ENSHGLP00000004364
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624839694,032 - 770,254 (+)Ensembl
RefSeq Acc Id: XM_004867636   ⟹   XP_004867693
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624839694,149 - 769,322 (+)NCBI
RefSeq Acc Id: XM_004867637   ⟹   XP_004867694
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624839694,149 - 745,953 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004867693 (Get FASTA)   NCBI Sequence Viewer  
  XP_004867694 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB08261 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000004364
  ENSHGLP00100010544
GenBank Protein JAN95980 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004867693   ⟸   XM_004867636
- Peptide Label: isoform X1
- UniProtKB: G5BG50 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004867694   ⟸   XM_004867637
- Peptide Label: isoform X2
Ensembl Acc Id: ENSHGLP00000004364   ⟸   ENSHGLT00000004424


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003185 Ensembl, ENTREZGENE
  ENSHGLG00100007837 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000004424 ENTREZGENE
  ENSHGLT00100010668 UniProtKB/TrEMBL
Gene3D-CATH 3.10.250.10 UniProtKB/TrEMBL
InterPro Collagen UniProtKB/TrEMBL
  SR-AI/II UniProtKB/TrEMBL
  SRCR UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/TrEMBL
  SRCR-S1_Scavenger_Rcptor UniProtKB/TrEMBL
NCBI Gene Msr1 ENTREZGENE
PANTHER NEUROTRYPSIN UniProtKB/TrEMBL
  SRCR DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Collagen UniProtKB/TrEMBL
  Macscav_rec UniProtKB/TrEMBL
  SRCR UniProtKB/TrEMBL
PRINTS MACSCAVRCPTR UniProtKB/TrEMBL
  SPERACTRCPTR UniProtKB/TrEMBL
PROSITE SRCR_1 UniProtKB/TrEMBL
  SRCR_2 UniProtKB/TrEMBL
SMART SM00202 UniProtKB/TrEMBL
Superfamily-SCOP SSF56487 UniProtKB/TrEMBL
UniProt A0AAX6Q5P5_HETGA UniProtKB/TrEMBL
  A0AAX6Q652_HETGA UniProtKB/TrEMBL
  G5BG50 ENTREZGENE, UniProtKB/TrEMBL