Pou4f2 (POU class 4 homeobox 2) - Rat Genome Database

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Gene: Pou4f2 (POU class 4 homeobox 2) Heterocephalus glaber
Analyze
Symbol: Pou4f2
Name: POU class 4 homeobox 2
RGD ID: 18910602
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN axon extension (ortholog); axon guidance (ortholog); axonogenesis (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH methylmalonic acidemia cblA type (ortholog); FOUND IN cytoplasm (ortholog); euchromatin (ortholog); nuclear speck (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: POU domain, class 4, transcription factor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248535,446,694 - 5,448,637 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248535,446,575 - 5,448,704 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon extension  (ISO)
axon guidance  (ISO)
axonogenesis  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to oxygen levels  (ISO)
dorsal root ganglion development  (ISO)
estrogen receptor signaling pathway  (ISO)
heart development  (ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
MAPK cascade  (ISO)
negative regulation of adipose tissue development  (ISO)
negative regulation of amacrine cell differentiation  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuromuscular process controlling balance  (ISO)
neuron differentiation  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of D-glucose import  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of programmed cell death  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of DNA-binding transcription factor activity  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (ISO)
regulation of retinal ganglion cell axon guidance  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
retina development in camera-type eye  (ISO)
retinal ganglion cell axon guidance  (ISO)
sensory perception of sound  (ISO)
spermatogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pou4f2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248535,446,694 - 5,448,637 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248535,446,575 - 5,448,704 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
POU4F2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384146,638,893 - 146,642,474 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4146,638,893 - 146,642,474 (+)EnsemblGRCh38hg38GRCh38
GRCh374147,560,045 - 147,563,626 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364147,779,495 - 147,783,073 (+)NCBINCBI36Build 36hg18NCBI36
Build 344147,917,692 - 147,921,228NCBI
Celera4144,880,585 - 144,884,163 (+)NCBICelera
Cytogenetic Map4q31.22NCBI
HuRef4143,287,267 - 143,290,856 (+)NCBIHuRef
CHM1_14147,537,342 - 147,540,923 (+)NCBICHM1_1
T2T-CHM13v2.04149,962,609 - 149,966,195 (+)NCBIT2T-CHM13v2.0
Pou4f2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39879,159,638 - 79,163,276 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl879,159,639 - 79,163,274 (-)EnsemblGRCm39 Ensembl
GRCm38878,433,009 - 78,436,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl878,433,010 - 78,436,645 (-)EnsemblGRCm38mm10GRCm38
MGSCv37880,956,908 - 80,960,551 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36881,329,081 - 81,332,724 (-)NCBIMGSCv36mm8
Celera882,709,269 - 82,712,912 (-)NCBICelera
Cytogenetic Map8C1NCBI
cM Map836.99NCBI
Pou4f2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81946,390,958 - 46,394,599 (+)NCBIGRCr8
mRatBN7.21929,486,686 - 29,490,327 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1929,486,686 - 29,490,327 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1936,334,714 - 36,338,345 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01936,988,601 - 36,992,232 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01939,237,705 - 39,241,336 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01933,160,180 - 33,163,821 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1933,160,180 - 33,163,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01944,051,763 - 44,055,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41931,388,907 - 31,392,548 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11931,395,364 - 31,395,583 (+)NCBI
Celera1928,985,198 - 28,988,839 (+)NCBICelera
Cytogenetic Map19q11NCBI
Pou4f2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554282,324,834 - 2,329,205 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554282,325,775 - 2,329,122 (+)NCBIChiLan1.0ChiLan1.0
POU4F2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23144,502,661 - 144,505,603 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14144,868,893 - 144,871,835 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04138,969,157 - 138,972,730 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14150,626,392 - 150,629,961 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4150,626,392 - 150,629,961 (+)Ensemblpanpan1.1panPan2
POU4F2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11545,030,818 - 45,034,446 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1545,031,094 - 45,032,784 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1545,426,310 - 45,427,991 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01545,704,140 - 45,705,824 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1545,704,140 - 45,705,824 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11544,976,012 - 44,977,696 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01545,068,621 - 45,070,311 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01545,333,613 - 45,335,300 (+)NCBIUU_Cfam_GSD_1.0
Pou4f2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530145,265,697 - 45,274,468 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365352,705,162 - 2,711,813 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365352,705,184 - 2,711,785 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POU4F2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl882,043,643 - 82,047,675 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1882,044,443 - 82,046,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2887,200,440 - 87,201,609 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POU4F2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1793,150,105 - 93,160,977 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl793,150,186 - 93,151,857 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603772,832,429 - 72,836,291 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004868927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01091258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000000911   ⟹   ENSHGLP00000000870
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248535,446,694 - 5,448,637 (+)Ensembl
RefSeq Acc Id: XM_004868927   ⟹   XP_004868984
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248535,446,575 - 5,448,704 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004868984 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000000870
RefSeq Acc Id: XP_004868984   ⟸   XM_004868927
- UniProtKB: A0AAX6Q9X3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000000870   ⟸   ENSHGLT00000000911


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000719 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000000911 ENTREZGENE
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
  lambda repressor-like DNA-binding domains UniProtKB/TrEMBL
InterPro Homeobox_CS UniProtKB/TrEMBL
  Homeodomain-like_sf UniProtKB/TrEMBL
  IPR001356 UniProtKB/TrEMBL
  Lambda_DNA-bd_dom_sf UniProtKB/TrEMBL
  POU UniProtKB/TrEMBL
  POU_dom UniProtKB/TrEMBL
  POU_domain_TF UniProtKB/TrEMBL
NCBI Gene Pou4f2 ENTREZGENE
PANTHER POU DOMAIN UniProtKB/TrEMBL
  POU DOMAIN, CLASS 4, TRANSCRIPTION FACTOR 2 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
  Pou UniProtKB/TrEMBL
PRINTS POUDOMAIN UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  POU_1 UniProtKB/TrEMBL
  POU_2 UniProtKB/TrEMBL
  POU_3 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
  POU UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain-like UniProtKB/TrEMBL
  lambda repressor-like DNA-binding domains UniProtKB/TrEMBL
UniProt A0AAX6Q9X3 ENTREZGENE, UniProtKB/TrEMBL