Reln (reelin) - Rat Genome Database

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Gene: Reln (reelin) Heterocephalus glaber
Analyze
Symbol: Reln
Name: reelin
RGD ID: 18901365
Description: ENCODES a protein that exhibits receptor ligand activity (ortholog); very-low-density lipoprotein particle receptor binding (ortholog); INVOLVED IN associative learning (ortholog); axon guidance (ortholog); brain development (ortholog); PARTICIPATES IN altered Reelin signaling pathway; Reelin signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Ataxia (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473925,472,561 - 25,918,167 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473925,472,626 - 25,918,064 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
associative learning  (ISO)
axon guidance  (ISO)
brain development  (ISO)
cell adhesion  (IEA)
cell migration  (ISO)
cell morphogenesis  (ISO)
cellular response to dexamethasone stimulus  (ISO)
central nervous system development  (IEA,ISO)
cerebral cortex development  (ISO)
cerebral cortex tangential migration  (ISO)
dendrite development  (ISO)
dentate gyrus development  (ISO)
forebrain development  (ISO)
glial cell differentiation  (ISO)
hippocampus development  (ISO)
hypothalamus development  (ISO)
interneuron migration  (ISO)
lateral motor column neuron migration  (ISO)
layer formation in cerebral cortex  (ISO)
learning  (ISO)
locomotory behavior  (ISO)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
memory  (ISO)
midgut development  (ISO)
modulation of chemical synaptic transmission  (ISO)
motor neuron migration  (ISO)
neuron migration  (IEA,ISO)
NMDA glutamate receptor clustering  (ISO)
orbitofrontal cortex development  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of AMPA receptor activity  (ISO)
positive regulation of CREB transcription factor activity  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of lateral motor column neuron migration  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of small GTPase mediated signal transduction  (ISO)
positive regulation of synapse maturation  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of TOR signaling  (ISO)
postsynaptic density assembly  (ISO)
postsynaptic density protein 95 clustering  (ISO)
protein localization to synapse  (ISO)
proteolysis  (IEA)
receptor localization to synapse  (ISO)
reelin-mediated signaling pathway  (ISO)
regulation of behavior  (ISO)
regulation of gene expression  (ISO)
regulation of NMDA receptor activity  (ISO)
regulation of synapse maturation  (ISO)
response to amino acid  (ISO)
response to axon injury  (ISO)
response to corticosterone  (ISO)
response to electrical stimulus  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to hormone  (ISO)
response to insecticide  (ISO)
response to mechanical stimulus  (ISO)
response to organic cyclic compound  (ISO)
response to pain  (ISO)
response to progesterone  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
social behavior  (ISO)
spinal cord patterning  (ISO)
synaptic vesicle exocytosis  (ISO)
thyroid hormone metabolic process  (ISO)
ventral spinal cord development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Reln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473925,472,561 - 25,918,167 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473925,472,626 - 25,918,064 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RELN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387103,471,789 - 103,989,658 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7103,471,381 - 103,989,658 (-)EnsemblGRCh38hg38GRCh38
GRCh377103,112,236 - 103,630,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367102,899,473 - 103,417,198 (-)NCBINCBI36Build 36hg18NCBI36
Build 347102,706,187 - 103,223,913NCBI
Celera797,918,553 - 98,435,889 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef797,472,665 - 97,989,692 (-)NCBIHuRef
CHM1_17103,045,544 - 103,563,285 (-)NCBICHM1_1
T2T-CHM13v2.07104,786,230 - 105,303,683 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27102,473,053 - 102,990,385 (-)NCBI
Reln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39522,089,452 - 22,549,703 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl522,089,452 - 22,549,700 (-)EnsemblGRCm39 Ensembl
GRCm38521,884,454 - 22,344,705 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl521,884,454 - 22,344,702 (-)EnsemblGRCm38mm10GRCm38
MGSCv37521,390,272 - 21,850,523 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36521,396,293 - 21,856,514 (-)NCBIMGSCv36mm8
Celera518,857,999 - 19,307,447 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.98NCBI
Reln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8413,628,440 - 14,055,201 (+)NCBIGRCr8
mRatBN7.2412,736,177 - 13,162,956 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl412,736,130 - 13,162,211 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx417,880,111 - 18,309,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0413,705,793 - 14,126,350 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,061,189 - 12,495,212 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,347,533 - 9,774,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,347,528 - 9,773,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.049,349,408 - 9,775,894 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.448,150,873 - 8,609,141 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.148,150,872 - 8,609,141 (+)NCBI
Celera48,330,632 - 8,754,202 (+)NCBICelera
Cytogenetic Map4q11NCBI
Reln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554108,424,394 - 8,863,969 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554108,424,439 - 8,863,966 (-)NCBIChiLan1.0ChiLan1.0
RELN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26140,332,563 - 140,853,083 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17188,602,533 - 189,123,051 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0795,464,285 - 95,984,813 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17108,208,344 - 108,728,037 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7108,208,344 - 108,728,037 (-)Ensemblpanpan1.1panPan2
RELN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11816,275,822 - 16,773,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1816,275,837 - 16,773,875 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1815,920,416 - 16,416,804 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01816,579,791 - 17,064,382 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1816,579,785 - 17,064,382 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11816,349,469 - 16,829,572 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01816,282,254 - 16,767,463 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01816,555,196 - 17,036,210 (+)NCBIUU_Cfam_GSD_1.0
Reln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511858,504,719 - 58,964,509 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647919,628,940 - 20,087,250 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647919,628,488 - 20,088,278 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RELN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9103,460,863 - 103,963,883 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19103,460,855 - 103,963,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29114,069,880 - 114,180,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RELN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12172,440,988 - 72,951,173 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2172,440,160 - 72,950,747 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604231,044,210 - 31,561,114 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000008118   ⟹   ENSHGLP00000008030
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473925,472,561 - 25,918,167 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000008119   ⟹   ENSHGLP00000008031
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473925,472,830 - 25,917,037 (+)Ensembl
RefSeq Acc Id: XM_004839709   ⟹   XP_004839766
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473925,472,830 - 25,918,064 (+)NCBI
RefSeq Acc Id: XM_004839710   ⟹   XP_004839767
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473925,472,830 - 25,918,064 (+)NCBI
RefSeq Acc Id: XM_021253949   ⟹   XP_021109608
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473925,472,626 - 25,912,253 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004839766 (Get FASTA)   NCBI Sequence Viewer  
  XP_004839767 (Get FASTA)   NCBI Sequence Viewer  
  XP_021109608 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000008030
  ENSHGLP00000008031
RefSeq Acc Id: XP_021109608   ⟸   XM_021253949
- Peptide Label: isoform X1
- UniProtKB: G5BI47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004839767   ⟸   XM_004839710
- Peptide Label: isoform X2
- UniProtKB: G5BI47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004839766   ⟸   XM_004839709
- Peptide Label: isoform X3
- UniProtKB: G5BI47 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000008030   ⟸   ENSHGLT00000008118
Ensembl Acc Id: ENSHGLP00000008031   ⟸   ENSHGLT00000008119


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005815 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000008118 ENTREZGENE
  ENSHGLT00000008119 ENTREZGENE
Gene3D-CATH Galactose-binding domain-like UniProtKB/TrEMBL
  Reeler domain UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  EGF_extracell UniProtKB/TrEMBL
  EGF_Tenascin UniProtKB/TrEMBL
  Reeler_dom UniProtKB/TrEMBL
  Reeler_sf UniProtKB/TrEMBL
  Reelin UniProtKB/TrEMBL
  Reelin_subrepeat-B UniProtKB/TrEMBL
  Sialidase_sf UniProtKB/TrEMBL
NCBI Gene Reln ENTREZGENE
PANTHER REELIN UniProtKB/TrEMBL
  REELIN UniProtKB/TrEMBL
Pfam EGF_2 UniProtKB/TrEMBL
  EGF_Tenascin UniProtKB/TrEMBL
  Reeler UniProtKB/TrEMBL
  Reelin_subrepeat-B UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  REELIN UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
Superfamily-SCOP Sialidases UniProtKB/TrEMBL
UniProt G5BI47 ENTREZGENE, UniProtKB/TrEMBL