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Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network.

Authors: Devlin, Bernie  Bennett, Pamela  Dawson, Geraldine  Figlewicz, Denise A  Grigorenko, Elena L  McMahon, William  Minshew, Nancy  Pauls, David  Smith, Moyra  Spence, M Anne  Rodier, Patricia M  Stodgell, Chris  Schellenberg, Gerard D  CPEA Genetics Network,  
Citation: Devlin B, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):46-50.
Pubmed: (View Article at PubMed) PMID:15048647
DOI: Full-text: DOI:10.1002/ajmg.b.20125

A recent study by Persico et al. [2001: Mol Psychiatry 6:150-159] suggests alleles of a CGG polymorphism, just 5' of the reelin gene (RELN) initiator codon, confer liability for autism, especially alleles bearing 11 or more CGG repeats (long alleles). The association is consistent across both a case-control and family-based sample. We attempted to replicate their finding using a larger, independent family-based sample from the NIH Collaborative Programs of Excellence in Autism (CPEA) Network. In our data, allele transmissions to individuals with autism versus unaffected individuals are unbiased, both when alleles are classified by repeat length and when they are classified into long/short categories. Because of the apparent linkage of autism to chromosome 7q, particularly related to the development of language, we also evaluate the relationship between Reelin alleles and the age at which autism subjects use their first word or first phrase. Neither is significantly associated with Reelin alleles. Our results are not consistent with a major role for Reelin alleles in liability to autism.


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RGD Object Information
RGD ID: 13207520
Created: 2017-08-03
Species: All species
Last Modified: 2017-08-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.