RELN (reelin) - Rat Genome Database
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Pathways
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Gene: RELN (reelin) Canis lupus familiaris
Analyze
Symbol: RELN
Name: reelin
RGD ID: 12432761
Description: ENCODES a protein that exhibits lipoprotein particle receptor binding (ortholog); very-low-density lipoprotein particle receptor binding (ortholog); INVOLVED IN associative learning (ortholog); axon guidance (ortholog); brain development (ortholog); PARTICIPATES IN altered Reelin signaling pathway; Reelin signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Ataxia (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: reelin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1816,275,837 - 16,773,875 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11816,275,822 - 16,773,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
associative learning  (IEA,ISO)
axon guidance  (IEA,ISO)
brain development  (ISO)
cell adhesion  (IEA)
cell migration  (ISO)
cell morphogenesis involved in differentiation  (ISO)
cellular response to dexamethasone stimulus  (ISO)
central nervous system development  (IBA,ISO)
cerebral cortex development  (ISO)
cerebral cortex tangential migration  (IEA,ISO)
dendrite development  (IEA,ISO)
dentate gyrus development  (ISO)
forebrain development  (ISO)
glial cell differentiation  (IEA,ISO)
hippocampus development  (IEA,ISO)
hypothalamus development  (ISO)
lateral motor column neuron migration  (IEA,ISO)
layer formation in cerebral cortex  (IEA,ISO)
learning  (ISO)
locomotory behavior  (IEA,ISO)
long-term memory  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
memory  (ISO)
midgut development  (ISO)
modulation of chemical synaptic transmission  (ISO)
neuron migration  (IBA,ISO)
NMDA glutamate receptor clustering  (IEA,ISO)
orbitofrontal cortex development  (ISO)
peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of AMPA receptor activity  (IEA,ISO)
positive regulation of CREB transcription factor activity  (IEA,ISO)
positive regulation of dendritic spine morphogenesis  (IEA,ISO)
positive regulation of excitatory postsynaptic potential  (IEA,ISO)
positive regulation of lateral motor column neuron migration  (IEA,ISO)
positive regulation of long-term synaptic potentiation  (IEA,ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA,ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein tyrosine kinase activity  (IEA,ISO)
positive regulation of small GTPase mediated signal transduction  (IEA,ISO)
positive regulation of synapse maturation  (IEA,ISO)
positive regulation of synaptic transmission, glutamatergic  (IEA,ISO)
positive regulation of TOR signaling  (IEA,ISO)
postsynaptic density protein 95 clustering  (IEA,ISO)
protein localization to synapse  (ISO)
receptor localization to synapse  (IEA,ISO)
reelin-mediated signaling pathway  (IEA,ISO)
regulation of behavior  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of NMDA receptor activity  (IEA,ISO)
response to amino acid  (ISO)
response to axon injury  (ISO)
response to corticosterone  (ISO)
response to drug  (ISO)
response to electrical stimulus  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to hormone  (ISO)
response to insecticide  (ISO)
response to lithium ion  (ISO)
response to mechanical stimulus  (ISO)
response to organic cyclic compound  (ISO)
response to pain  (IEA,ISO)
response to progesterone  (ISO)
response to toxic substance  (ISO)
social behavior  (ISO)
spinal cord patterning  (IEA,ISO)
thyroid hormone metabolic process  (ISO)
ventral spinal cord development  (IEA,ISO)

Cellular Component
axon  (ISO)
cytoplasm  (IEA,ISO)
dendrite  (IEA,ISO)
extracellular matrix  (IEA,ISO)
extracellular space  (IBA,IEA,ISO)
neuron projection  (IBA,ISO)
neuronal cell body  (ISO)
perikaryon  (ISO)
plasma membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
RELN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1816,275,837 - 16,773,875 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11816,275,822 - 16,773,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
RELN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7103,471,784 - 103,989,658 (-)EnsemblGRCh38hg38GRCh38
GRCh387103,471,789 - 103,989,658 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377103,112,231 - 103,629,963 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh377103,112,236 - 103,630,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367102,899,473 - 103,417,198 (-)NCBINCBI36hg18NCBI36
Build 347102,706,187 - 103,223,913NCBI
Celera797,918,553 - 98,435,889 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef797,472,665 - 97,989,692 (-)NCBIHuRef
CHM1_17103,045,544 - 103,563,285 (-)NCBICHM1_1
CRA_TCAGchr7v27102,473,053 - 102,990,385 (-)NCBI
Reln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39522,089,452 - 22,549,703 (-)NCBIGRCm39mm39
GRCm38521,884,454 - 22,344,705 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl521,884,454 - 22,344,702 (-)EnsemblGRCm38mm10GRCm38
MGSCv37521,390,272 - 21,850,523 (-)NCBIGRCm37mm9NCBIm37
MGSCv36521,396,293 - 21,856,514 (-)NCBImm8
Celera518,857,999 - 19,307,447 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.98NCBI
Reln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2412,736,177 - 13,162,956 (+)NCBI
Rnor_6.0 Ensembl49,347,528 - 9,773,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.049,347,533 - 9,774,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.049,349,408 - 9,775,894 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.448,150,873 - 8,609,141 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.148,150,872 - 8,609,141 (+)NCBI
Celera48,330,632 - 8,754,202 (+)NCBICelera
Cytogenetic Map4q11NCBI
Reln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554108,424,394 - 8,863,969 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554108,424,439 - 8,863,966 (-)NCBIChiLan1.0ChiLan1.0
RELN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17108,208,344 - 108,728,037 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7108,208,344 - 108,728,037 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0795,464,285 - 95,984,813 (-)NCBIMhudiblu_PPA_v0panPan3
Reln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647919,628,488 - 20,088,278 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RELN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9103,460,857 - 103,963,965 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19103,460,855 - 103,963,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29114,069,880 - 114,180,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RELN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12172,440,988 - 72,951,173 (-)NCBI
ChlSab1.1 Ensembl2172,440,160 - 72,950,747 (-)Ensembl
Reln
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473925,472,626 - 25,918,064 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 11 6 6 4 6 5
Low 2 2 10 6 2 1 5 8 5 6
Below cutoff 3 1 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000039321   ⟹   ENSCAFP00000035157
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1816,275,837 - 16,772,861 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000047394   ⟹   ENSCAFP00000038736
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1816,275,837 - 16,773,875 (+)Ensembl
RefSeq Acc Id: XM_540392   ⟹   XP_540392
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11816,275,822 - 16,773,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_844371   ⟹   XP_849464
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11816,275,822 - 16,773,875 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_849464   ⟸   XM_844371
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_540392   ⟸   XM_540392
- Peptide Label: isoform X2
- UniProtKB: J9NZL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000035157   ⟸   ENSCAFT00000039321
RefSeq Acc Id: ENSCAFP00000038736   ⟸   ENSCAFT00000047394
Protein Domains
EGF-like   Reelin

Promoters
RGD ID:13686445
Promoter ID:EPDNEW_C4513
Type:single initiation site
Name:RELN_1
Description:reelin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11816,275,651 - 16,275,711EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000025345 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000035157 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000038736 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000039321 UniProtKB/TrEMBL
  ENSCAFT00000047394 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.260 UniProtKB/TrEMBL
  2.60.40.4060 UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  EGF_extracell UniProtKB/TrEMBL
  EGF_Tenascin UniProtKB/TrEMBL
  Galactose-bd-like UniProtKB/TrEMBL
  Reeler_dom UniProtKB/TrEMBL
  Reeler_sf UniProtKB/TrEMBL
  Reelin UniProtKB/TrEMBL
  Sialidase_sf UniProtKB/TrEMBL
NCBI Gene RELN ENTREZGENE
PANTHER PTHR11841 UniProtKB/TrEMBL
Pfam EGF_2 UniProtKB/TrEMBL
  EGF_Tenascin UniProtKB/TrEMBL
  Reeler UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  REELIN UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
Superfamily-SCOP SSF50939 UniProtKB/TrEMBL
UniProt F1PYH1_CANLF UniProtKB/TrEMBL
  J9NZL6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45470 ENTREZGENE