FTH1 (ferritin heavy chain 1) - Rat Genome Database

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Gene: FTH1 (ferritin heavy chain 1) Chlorocebus sabaeus
Analyze
Symbol: FTH1
Name: ferritin heavy chain 1
RGD ID: 18795887
Description: ENCODES a protein that exhibits iron ion binding (ortholog); INVOLVED IN iron ion transport (ortholog); negative regulation of cellular process (ortholog); PARTICIPATES IN iron storage pathway; ASSOCIATED WITH autosomal dominant vitreoretinochoroidopathy (ortholog); bestrophinopathy (ortholog); Chronic Cerebral Hypoperfusion (ortholog); FOUND IN cytosol (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ferritin heavy chain
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,837,533 - 11,840,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038109,211,114 - 109,214,623 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FTH1Green MonkeyChronic Cerebral Hypoperfusion  ISOFth1 (Rattus norvegicus)9068941protein:increased expression:hippocampusRGDPMID:22639386 and REF_RGD_ID:11541085
FTH1Green Monkeycongestive heart failure  ISOFth1 (Rattus norvegicus)9068941protein:decreased expression:heartRGDPMID:18992754 and REF_RGD_ID:2315110
FTH1Green MonkeyCOVID-19 severityISOFTH1 (Homo sapiens)9068941associated with hyperglycemia and protein:increased expression:serum (human)RGDPMID:32406594 and REF_RGD_ID:32698682
FTH1Green MonkeyCOVID-19 severityISOFTH1 (Homo sapiens)9068941protein:increased expression:serum (human)RGDPMID:32365221 and REF_RGD_ID:30310229
FTH1Green Monkeyhepatocellular carcinoma  ISOFth1 (Rattus norvegicus)9068941mRNA:increased expression:liver (rat)RGDPMID:9054589 and REF_RGD_ID:632698
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FTH1Green Monkeyautosomal dominant vitreoretinochoroidopathy  ISOFTH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10788642 more ...
FTH1Green Monkeybestrophinopathy  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive bestrophinopathyClinVarPMID:10788642 more ...
FTH1Green Monkeyfundus dystrophy  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:10394929 more ...
FTH1Green Monkeygenetic disease  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
FTH1Green Monkeyhemochromatosis type 5  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hemochromatosis type 5ClinVarPMID:11389486 more ...
FTH1Green Monkeyintellectual disability  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
FTH1Green MonkeyIron Overload  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Iron OverloadClinVarPMID:14615048 more ...
FTH1Green Monkeyleukocyte adhesion deficiency 3  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Leukocyte adhesion deficiency 3ClinVarPMID:28492532
FTH1Green MonkeyNeurodegeneration with Brain Iron Accumulation 9  ISOFTH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:14615048 more ...
FTH1Green Monkeyretinitis pigmentosa  ISOFTH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:14615048 more ...
FTH1Green Monkeyretinitis pigmentosa  ISOFTH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:14615048 more ...
FTH1Green Monkeyretinitis pigmentosa 50  ISOFTH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10788642 more ...
FTH1Green MonkeyVitelliform Macular Dystrophy 2  ISOFTH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Vitelliform macular dystrophy 2ClinVarPMID:10394929 more ...
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FTH1Green Monkeycontact dermatitis  ISOFTH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25724174
FTH1Green Monkeydepressive disorder  ISOFTH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17063146
FTH1Green Monkeyhigh grade glioma  ISOFTH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21385903
FTH1Green MonkeyKeloid  ISOFTH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20128793
FTH1Green Monkeymalignant mesothelioma  ISOFTH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:26818092
FTH1Green MonkeyNeoplasm Invasiveness  ISOFTH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20390345
FTH1Green Monkeyneurodegenerative disease  ISOFTH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15964507
FTH1Green Monkeypre-malignant neoplasm  ISOFTH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21785164
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FTH1Green Monkeyhemochromatosis type 5  ISOFTH1 (Homo sapiens)7240710 OMIM 
FTH1Green MonkeyNeurodegeneration with Brain Iron Accumulation 9  ISOFTH1 (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FTH1Green Monkeyintracellular iron ion homeostasis involved_inIEAInterPro:IPR001519150520179 InterProGO_REF:0000002
FTH1Green Monkeyintracellular iron ion homeostasis involved_inIEAUniProtKB-KW:KW-0409150520179 UniProtGO_REF:0000043
FTH1Green Monkeyiron ion transport involved_inIEAPANTHER:PTN000153138150520179 TreeGrafterGO_REF:0000118
FTH1Green Monkeyiron ion transport acts_upstream_of_or_withinISOFth1 (Mus musculus)9068941 PMID:21886823MGIPMID:21886823
FTH1Green Monkeyiron ion transport involved_inIEAInterPro:IPR001519150520179 InterProGO_REF:0000002
FTH1Green Monkeynegative regulation of cellular process  ISOFth1 (Rattus norvegicus)9068941cardiomyocyte necrotic deathRGDPMID:18992754 and REF_RGD_ID:2315110
FTH1Green Monkeynegative regulation of ferroptosis involved_inIEAUniProtKB:P02794 and ensembl:ENSP00000273550150520179 EnsemblGO_REF:0000107
FTH1Green Monkeynegative regulation of fibroblast proliferation involved_inIEAUniProtKB:P02794 and ensembl:ENSP00000273550150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FTH1Green Monkeyautolysosome located_inIEAUniProtKB:P02794 and ensembl:ENSP00000273550150520179 EnsemblGO_REF:0000107
FTH1Green Monkeyautophagosome located_inIEAUniProtKB-SubCell:SL-0023150520179 UniProtGO_REF:0000044
FTH1Green Monkeycytoplasm located_inIEAPANTHER:PTN000153138150520179 TreeGrafterGO_REF:0000118
FTH1Green Monkeycytosol is_active_inISOFth1 (Mus musculus)9068941 PMID:29074498MGIPMID:29074498
FTH1Green Monkeymembrane is_active_inISOFth1 (Mus musculus)9068941 PMID:29074498MGIPMID:29074498

Molecular Function
1 to 20 of 22 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FTH1Green Monkeyferric iron binding enablesIEAPANTHER:PTN000153138150520179 TreeGrafterGO_REF:0000118
FTH1Green Monkeyferric iron binding enablesIEAInterPro:IPR001519 and InterPro:IPR008331150520179 InterProGO_REF:0000002
FTH1Green Monkeyferrous iron binding enablesIEAPANTHER:PTN000153138150520179 TreeGrafterGO_REF:0000118
FTH1Green Monkeyferrous iron binding enablesIEAUniProtKB:P02794 and ensembl:ENSP00000273550150520179 EnsemblGO_REF:0000107
FTH1Green Monkeyferroxidase activity enablesIEAUniProtKB:P02794 and ensembl:ENSP00000273550150520179 EnsemblGO_REF:0000107
FTH1Green Monkeyidentical protein binding enablesIEAUniProtKB:P02794 and ensembl:ENSP00000273550150520179 EnsemblGO_REF:0000107
FTH1Green Monkeyiron ion binding enablesISOFth1 (Mus musculus)9068941 PMID:21886823MGIPMID:21886823
FTH1Green Monkeyiron ion sequestering activity enablesIEAUniProtKB:P02794 and ensembl:ENSP00000273550150520179 EnsemblGO_REF:0000107
FTH1Green Monkeymetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
FTH1Green Monkeyprotein binding enablesISOUniProtKB:P027869068941 PMID:20133674IntActPMID:20133674
FTH1Green Monkeyprotein binding enablesISOUniProtKB:P27958-PRO_00000375769068941 PMID:15607035AgBasePMID:15607035
FTH1Green Monkeyprotein binding enablesISOUniProtKB:P51116 and UniProtKB:Q925749068941 PMID:21653829IntActPMID:21653829
FTH1Green Monkeyprotein binding enablesISOUniProtKB:Q925749068941 PMID:17355907IntActPMID:17355907
FTH1Green Monkeyprotein binding enablesISOUniProtKB:P02792 and UniProtKB:P511169068941 PMID:16189514 and PMID:31515488IntActPMID:16189514 and PMID:31515488
FTH1Green Monkeyprotein binding enablesISOUniProtKB:O00560 more ...9068941 PMID:25416956IntActPMID:25416956
FTH1Green Monkeyprotein binding  ISOCxcr4 (Rattus norvegicus)9068941 RGDPMID:19244528 and REF_RGD_ID:2315109
FTH1Green Monkeyprotein binding enablesISOUniProtKB:Q9UER79068941 PMID:21573799 and PMID:21988832IntActPMID:21573799 and PMID:21988832
FTH1Green Monkeyprotein binding enablesISOUniProtKB:P047929068941 PMID:25277244IntActPMID:25277244
FTH1Green Monkeyprotein binding enablesISOUniProtKB:Q2Q0679068941 PMID:22458338IntActPMID:22458338
FTH1Green Monkeyprotein binding enablesISOUniProtKB:P612449068941 PMID:20195357IntActPMID:20195357
1 to 20 of 22 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FTH1Green Monkeyiron storage pathway  ISOFTH1 (Homo sapiens)9068941 RGDPMID:25119494 more ...
PMID:22301074   PMID:30032202  



FTH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,837,533 - 11,840,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038109,211,114 - 109,214,623 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
FTH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,964,285 - 61,967,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,959,718 - 61,967,634 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,731,757 - 61,735,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,488,333 - 61,491,708 (-)NCBINCBI36Build 36hg18NCBI36
Build 341161,488,334 - 61,491,708NCBI
Celera1159,067,058 - 59,070,433 (-)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1158,059,745 - 58,063,103 (-)NCBIHuRef
CHM1_11161,614,953 - 61,618,328 (-)NCBICHM1_1
T2T-CHM13v2.01161,953,110 - 61,956,459 (-)NCBIT2T-CHM13v2.0
Fth1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39199,957,964 - 9,962,475 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl199,957,962 - 9,962,462 (+)EnsemblGRCm39 Ensembl
GRCm38199,980,600 - 9,985,111 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl199,980,598 - 9,985,098 (+)EnsemblGRCm38mm10GRCm38
MGSCv371910,057,193 - 10,059,582 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361910,049,748 - 10,052,137 (+)NCBIMGSCv36mm8
Celera1910,680,030 - 10,682,419 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map196.23NCBI
Fth1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,052,037 - 216,054,325 (+)NCBIGRCr8
mRatBN7.21206,627,142 - 206,629,430 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1206,627,103 - 206,725,424 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,005,534 - 215,007,822 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,060,660 - 222,062,948 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,755,668 - 214,757,956 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,030,940 - 226,033,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,030,938 - 226,033,228 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,979,122 - 232,981,410 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41212,430,453 - 212,432,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11212,588,882 - 212,591,171 (+)NCBI
Celera1204,122,676 - 204,124,964 (+)NCBICelera
RH 3.4 Map14258.8RGD
Cytogenetic Map1q43NCBI
Fth1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555115,771,777 - 5,773,112 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555115,772,374 - 5,773,224 (+)NCBIChiLan1.0ChiLan1.0
FTH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2963,197,979 - 63,203,292 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11164,241,728 - 64,244,902 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01157,329,163 - 57,332,248 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11160,687,517 - 60,690,080 (-)NCBIpanpan1.1PanPan1.1panPan2
FTH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,466,167 - 54,468,733 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,466,023 - 54,468,732 (+)EnsemblCanFam3.1canFam3CanFam3.1
UMICH_Zoey_3.12832,593,900 - 32,594,536 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02832,618,740 - 32,619,377 (-)NCBIUNSW_CanFamBas_1.0
Fth1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,005,083 - 11,006,769 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365811,118,905 - 1,120,592 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FTH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.129,535,051 - 9,537,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,983,179 - 8,986,091 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Fth1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624926469,870 - 471,142 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in FTH1
47 total Variants






RefSeq Acc Id: XM_037999208   ⟹   XP_037855136
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038109,211,114 - 109,214,623 (+)NCBI
RefSeq Acc Id: XM_037999209   ⟹   XP_037855137
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038109,211,706 - 109,214,623 (+)NCBI
Protein RefSeqs XP_037855136 (Get FASTA)   NCBI Sequence Viewer  
  XP_037855137 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000002772.1
  ENSCSAP00000019100.1
RefSeq Acc Id: XP_037855136   ⟸   XM_037999208
- UniProtKB: A0A0D9R2D3 (UniProtKB/TrEMBL),   A0A0D9SE11 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037855137   ⟸   XM_037999209
- UniProtKB: A0A0D9R2D3 (UniProtKB/TrEMBL),   A0A0D9SE11 (UniProtKB/TrEMBL)



1 to 22 of 22 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000006491 UniProtKB/TrEMBL
  ENSCSAG00000019601 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004521.1 UniProtKB/TrEMBL
  ENSCSAT00000019691.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.10 UniProtKB/TrEMBL
InterPro Ferritin UniProtKB/TrEMBL
  Ferritin-like UniProtKB/TrEMBL
  Ferritin-like_diiron UniProtKB/TrEMBL
  Ferritin-like_SF UniProtKB/TrEMBL
  Ferritin_CS UniProtKB/TrEMBL
  Ferritin_DPS_dom UniProtKB/TrEMBL
KEGG Report csab:103226189 UniProtKB/TrEMBL
NCBI Gene FTH1 ENTREZGENE
PANTHER FERRITIN UniProtKB/TrEMBL
  FERRITIN HEAVY CHAIN UniProtKB/TrEMBL
Pfam Ferritin UniProtKB/TrEMBL
PROSITE FERRITIN_1 UniProtKB/TrEMBL
  FERRITIN_2 UniProtKB/TrEMBL
  FERRITIN_LIKE UniProtKB/TrEMBL
Superfamily-SCOP Ferritin-like UniProtKB/TrEMBL
UniProt A0A0D9R2D3 ENTREZGENE, UniProtKB/TrEMBL
  A0A0D9SE11 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows