SPHK2 (sphingosine kinase 2) - Rat Genome Database

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Gene: SPHK2 (sphingosine kinase 2) Chlorocebus sabaeus
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Symbol: SPHK2
Name: sphingosine kinase 2
RGD ID: 18777038
Description: ENCODES a protein that exhibits ATP binding (inferred); D-erythro-sphingosine kinase activity (inferred); histone binding (inferred); INVOLVED IN blood vessel development (ortholog); brain development (ortholog); cell population proliferation (ortholog); PARTICIPATES IN ceramide signaling pathway; Fabry disease pathway; Gaucher's disease pathway; ASSOCIATED WITH Memory Disorders (ortholog); middle cerebral artery infarction (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); endoplasmic reticulum (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,865,921 - 41,881,889 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl641,867,139 - 41,881,268 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607321,738,797 - 21,749,747 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SPHK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,865,921 - 41,881,889 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl641,867,139 - 41,881,268 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607321,738,797 - 21,749,747 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SPHK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,619,506 - 48,630,405 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,619,291 - 48,630,717 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,122,763 - 49,133,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,814,360 - 53,825,474 (+)NCBINCBI36Build 36hg18NCBI36
Build 341953,814,359 - 53,825,473NCBI
Celera1945,987,413 - 45,998,527 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,501,739 - 45,513,199 (+)NCBIHuRef
CHM1_11949,124,423 - 49,135,537 (+)NCBICHM1_1
T2T-CHM13v2.01951,613,990 - 51,624,887 (+)NCBIT2T-CHM13v2.0
Sphk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,358,887 - 45,367,426 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,358,891 - 45,367,426 (-)EnsemblGRCm39 Ensembl
GRCm38745,709,463 - 45,718,002 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,709,467 - 45,718,002 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,964,833 - 52,973,372 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,578,303 - 45,585,957 (-)NCBIMGSCv36mm8
Celera741,172,020 - 41,180,543 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.45NCBI
Sphk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,317,332 - 105,324,985 (-)NCBIGRCr8
mRatBN7.2196,180,872 - 96,188,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,180,887 - 96,188,391 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,566,308 - 101,570,613 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,039,006 - 110,043,311 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,329,383 - 103,333,688 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,692,972 - 101,700,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,692,973 - 101,697,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,771,785 - 102,779,436 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,178,615 - 96,182,920 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,256,726 - 96,261,031 (-)NCBI
Celera190,434,071 - 90,438,377 (-)NCBICelera
Cytogenetic Map1q22NCBI
Sphk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,917,301 - 1,928,493 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,921,479 - 1,929,450 (-)NCBIChiLan1.0ChiLan1.0
SPHK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,725,763 - 54,735,466 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,652,115 - 56,661,802 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,620,980 - 45,631,786 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,213,166 - 54,224,033 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,213,166 - 54,224,767 (+)Ensemblpanpan1.1panPan2
SPHK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,681,425 - 107,689,790 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,680,599 - 107,689,707 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,202,917 - 107,211,393 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,205,468 - 108,213,966 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,205,468 - 108,212,765 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,872,017 - 107,880,502 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,519,318 - 107,527,797 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,355,012 - 108,363,506 (-)NCBIUU_Cfam_GSD_1.0
Sphk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,050,633 - 21,058,418 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,669,920 - 2,676,587 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,668,708 - 2,676,608 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPHK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,979,012 - 53,986,768 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,982,911 - 53,986,779 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,726,086 - 49,734,104 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sphk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,246,895 - 5,253,207 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,246,328 - 5,254,247 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000000851   ⟹   ENSCSAP00000015212
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl641,867,139 - 41,881,268 (+)Ensembl
RefSeq Acc Id: XM_007997435   ⟹   XP_007995626
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1641,865,921 - 41,881,889 (+)NCBI
Vero_WHO_p1.0NW_02366607321,738,797 - 21,749,747 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007997436   ⟹   XP_007995627
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1641,866,314 - 41,881,889 (+)NCBI
Vero_WHO_p1.0NW_02366607321,739,016 - 21,749,747 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007997437   ⟹   XP_007995628
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1641,876,361 - 41,881,889 (+)NCBI
Vero_WHO_p1.0NW_02366607321,743,928 - 21,749,747 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007997438   ⟹   XP_007995629
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1641,874,828 - 41,881,889 (+)NCBI
Vero_WHO_p1.0NW_02366607321,742,387 - 21,749,747 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007997439   ⟹   XP_007995630
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1641,874,828 - 41,881,889 (+)NCBI
Vero_WHO_p1.0NW_02366607321,742,387 - 21,749,747 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007997441   ⟹   XP_007995632
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1641,875,954 - 41,881,889 (+)NCBI
Vero_WHO_p1.0NW_02366607321,743,489 - 21,749,747 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037991347   ⟹   XP_037847275
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607321,739,212 - 21,749,747 (+)NCBI
RefSeq Acc Id: XM_037991349   ⟹   XP_037847277
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607321,738,938 - 21,749,747 (+)NCBI
RefSeq Acc Id: XP_007995626   ⟸   XM_007997435
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S2X3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007995627   ⟸   XM_007997436
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S2X3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007995630   ⟸   XM_007997439
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007995629   ⟸   XM_007997438
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007995632   ⟸   XM_007997441
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007995628   ⟸   XM_007997437
- Peptide Label: isoform X2
Ensembl Acc Id: ENSCSAP00000015212   ⟸   ENSCSAT00000000851
RefSeq Acc Id: XP_037847277   ⟸   XM_037991349
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037847275   ⟸   XM_037991347
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S2X3 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002832 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000851.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.40 UniProtKB/TrEMBL
InterPro ATP-NAD_kinase_N UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/TrEMBL
  Lipid_Phosphate_FormReg UniProtKB/TrEMBL
  NAD/diacylglycerol_kinase_sf UniProtKB/TrEMBL
  YegS/DAGK_C UniProtKB/TrEMBL
KEGG Report csab:103234983 UniProtKB/TrEMBL
NCBI Gene SPHK2 ENTREZGENE
PANTHER SPHINGOSINE KINASE UniProtKB/TrEMBL
  SPHINGOSINE KINASE 2 UniProtKB/TrEMBL
Pfam DAGK_cat UniProtKB/TrEMBL
  YegS_C UniProtKB/TrEMBL
PROSITE DAGK UniProtKB/TrEMBL
SMART DAGKc UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/TrEMBL
UniProt A0A0D9S2X3 ENTREZGENE, UniProtKB/TrEMBL