Sphk2 (sphingosine kinase 2) - Rat Genome Database
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Gene: Sphk2 (sphingosine kinase 2) Mus musculus
Analyze
Symbol: Sphk2
Name: sphingosine kinase 2
RGD ID: 1317132
MGI Page MGI
Description: Exhibits D-erythro-sphingosine kinase activity. Involved in several processes, including cytokine production; regulation of intracellular signal transduction; and sphingolipid metabolic process. Localizes to several cellular components, including cytosol; endoplasmic reticulum; and mitochondrial inner membrane. Is expressed in several structures, including alimentary system; integumental system; respiratory system; telencephalon; and urinary system. Orthologous to human SPHK2 (sphingosine kinase 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C76851; MGC102297; SK 2; Sk2; SPK 2; Spk2; Spk2, Sk2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,358,887 - 45,367,426 (-)NCBIGRCm39mm39
GRCm39 Ensembl745,358,891 - 45,367,426 (-)Ensembl
GRCm38745,709,463 - 45,718,002 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,709,467 - 45,718,002 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,964,833 - 52,973,372 (-)NCBIGRCm37mm9NCBIm37
MGSCv36745,578,303 - 45,585,957 (-)NCBImm8
Celera741,172,020 - 41,180,543 (-)NCBICelera
Cytogenetic Map7B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel development  (IGI)
brain development  (IGI)
cellular response to phorbol 13-acetate 12-myristate  (ISO)
female pregnancy  (ISO)
histone H2A-K5 acetylation  (ISO)
histone H2B-K12 acetylation  (ISO)
negative regulation of cell growth  (IDA)
negative regulation of histone deacetylase activity  (ISO)
negative regulation of histone deacetylation  (ISO)
phosphorylation  (IBA)
positive regulation of apoptotic process  (IBA,IDA,ISO)
positive regulation of calcium ion import  (IMP)
positive regulation of cell population proliferation  (IGI)
positive regulation of ceramide biosynthetic process  (IDA,ISO)
positive regulation of cytokine production involved in immune response  (IMP)
positive regulation of gene expression, epigenetic  (ISO)
positive regulation of histone H3-K9 acetylation  (ISO)
positive regulation of interleukin-13 production  (IMP)
positive regulation of interleukin-6 production  (IMP)
positive regulation of mast cell activation involved in immune response  (IMP)
positive regulation of mast cell degranulation  (IMP)
positive regulation of protein kinase C signaling  (IMP)
positive regulation of tumor necrosis factor production  (IMP)
regulation of ATP biosynthetic process  (IMP)
regulation of cytochrome-c oxidase activity  (IMP,ISO)
regulation of I-kappaB kinase/NF-kappaB signaling  (IMP)
regulation of reactive oxygen species biosynthetic process  (IMP)
sphinganine-1-phosphate biosynthetic process  (IBA,IDA,ISO)
sphingolipid metabolic process  (IBA)
sphingosine biosynthetic process  (IBA,ISO)
sphingosine metabolic process  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell physiology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal immune serum protein physiology  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal lymphocyte cell number  (IAGP)
abnormal NK cell differentiation  (IAGP)
abnormal Peyer's patch T cell area morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal thymus cell ratio  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
decreased B cell number  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased embryonic neuroepithelium thickness  (IAGP)
decreased NK cell number  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased splenocyte number  (IAGP)
decreased T cell number  (IAGP)
dilated brain ventricles  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
exencephaly  (IAGP)
hemopericardium  (IAGP)
hemorrhage  (IAGP)
incomplete rostral neuropore closure  (IAGP)
increased B cell number  (IAGP)
increased embryonic neuroepithelium apoptosis  (IAGP)
increased hindbrain apoptosis  (IAGP)
increased midbrain apoptosis  (IAGP)
increased NK cell number  (IAGP)
increased vascular permeability  (IAGP)
intracranial hemorrhage  (IAGP)
intraventricular hemorrhage  (IAGP)
no abnormal phenotype detected  (IAGP)
spinal hemorrhage  (IAGP)
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10751414   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12835323   PMID:12874225   PMID:12954646   PMID:14610273  
PMID:14681479   PMID:15489334   PMID:15782199   PMID:16093248   PMID:16103110   PMID:16118219   PMID:16141072   PMID:16141073   PMID:16223773   PMID:16314531   PMID:16316995   PMID:16434032  
PMID:16622018   PMID:17292973   PMID:17346996   PMID:17363629   PMID:17579353   PMID:17885683   PMID:17947634   PMID:18287559   PMID:18783337   PMID:18799693   PMID:18805787   PMID:18824518  
PMID:18971925   PMID:19073640   PMID:19168577   PMID:19234089   PMID:19596980   PMID:19603543   PMID:19644058   PMID:19808259   PMID:20026661   PMID:20194596   PMID:20197547   PMID:20220090  
PMID:20407207   PMID:20671234   PMID:20959514   PMID:21084291   PMID:21256823   PMID:21267068   PMID:21319224   PMID:21331079   PMID:21642988   PMID:21677750   PMID:21716257   PMID:21849969  
PMID:21872577   PMID:21873635   PMID:21904650   PMID:21960637   PMID:21980199   PMID:22002221   PMID:22020265   PMID:22096531   PMID:22314269   PMID:22322303   PMID:22668972   PMID:22747486  
PMID:22759398   PMID:22859402   PMID:22922818   PMID:23043544   PMID:23096701   PMID:23273921   PMID:23301082   PMID:23315259   PMID:23359503   PMID:23638983   PMID:23775711   PMID:23933064  
PMID:23995678   PMID:24081141   PMID:24667638   PMID:24686171   PMID:24859201   PMID:24928515   PMID:25131845   PMID:25180446   PMID:25505239   PMID:25637806   PMID:25808625   PMID:25908104  
PMID:26082434   PMID:26129975   PMID:26283908   PMID:26808312   PMID:26822263   PMID:27487469   PMID:27582371   PMID:27799486   PMID:28082351   PMID:28082452   PMID:28248965   PMID:28625547  
PMID:28682313   PMID:28739604   PMID:28807595   PMID:28842426   PMID:28916166   PMID:29044125   PMID:29392309   PMID:29518138   PMID:29662056   PMID:29673590   PMID:29728804   PMID:29748384  
PMID:29787576   PMID:29991026   PMID:30077738   PMID:30251698   PMID:30452878   PMID:30593892   PMID:30655318   PMID:30997640   PMID:31003959   PMID:31123291   PMID:31128248   PMID:31160320  
PMID:31641049   PMID:31797978   PMID:31842752   PMID:32091396   PMID:32209471   PMID:32521763   PMID:32546724   PMID:32897877   PMID:32917816  


Genomics

Comparative Map Data
Sphk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,358,887 - 45,367,426 (-)NCBIGRCm39mm39
GRCm39 Ensembl745,358,891 - 45,367,426 (-)Ensembl
GRCm38745,709,463 - 45,718,002 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,709,467 - 45,718,002 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,964,833 - 52,973,372 (-)NCBIGRCm37mm9NCBIm37
MGSCv36745,578,303 - 45,585,957 (-)NCBImm8
Celera741,172,020 - 41,180,543 (-)NCBICelera
Cytogenetic Map7B3NCBI
SPHK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1948,619,291 - 48,630,717 (+)EnsemblGRCh38hg38GRCh38
GRCh381948,619,409 - 48,630,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,122,763 - 49,133,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,814,360 - 53,825,474 (+)NCBINCBI36hg18NCBI36
Build 341953,814,359 - 53,825,473NCBI
Celera1945,987,413 - 45,998,527 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,501,739 - 45,513,199 (+)NCBIHuRef
CHM1_11949,124,423 - 49,135,537 (+)NCBICHM1_1
Sphk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,180,872 - 96,188,592 (-)NCBI
Rnor_6.0 Ensembl1101,692,973 - 101,697,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01101,692,972 - 101,700,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,771,785 - 102,779,436 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,178,615 - 96,182,920 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,256,726 - 96,261,031 (-)NCBI
Celera190,434,071 - 90,438,377 (-)NCBICelera
Cytogenetic Map1q22NCBI
Sphk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,917,301 - 1,928,493 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,921,479 - 1,929,450 (-)NCBIChiLan1.0ChiLan1.0
SPHK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11954,213,166 - 54,224,033 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,213,166 - 54,224,767 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01945,620,980 - 45,631,786 (+)NCBIMhudiblu_PPA_v0panPan3
SPHK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,681,425 - 107,689,790 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,680,599 - 107,689,707 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,202,917 - 107,211,393 (-)NCBI
ROS_Cfam_1.01108,205,468 - 108,213,966 (-)NCBI
UMICH_Zoey_3.11107,872,017 - 107,880,502 (-)NCBI
UNSW_CanFamBas_1.01107,519,318 - 107,527,797 (-)NCBI
UU_Cfam_GSD_1.01108,355,012 - 108,363,506 (-)NCBI
Sphk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,050,633 - 21,058,418 (+)NCBI
SpeTri2.0NW_0049366642,668,708 - 2,676,608 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPHK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,979,012 - 53,986,770 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,982,911 - 53,986,779 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,726,086 - 49,734,104 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPHK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,865,921 - 41,881,889 (+)NCBI
ChlSab1.1 Ensembl641,867,139 - 41,881,268 (+)Ensembl
Sphk2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248325,246,328 - 5,254,247 (-)NCBI

Position Markers
RH129117  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38745,710,335 - 45,710,526UniSTSGRCm38
MGSCv37752,965,705 - 52,965,896UniSTSGRCm37
Celera741,172,892 - 41,173,083UniSTS
Cytogenetic Map7B4UniSTS
cM Map723.0UniSTS
Sphk2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37752,967,626 - 52,968,947UniSTSGRCm37
Celera741,174,813 - 41,176,134UniSTS
Cytogenetic Map7B4UniSTS
cM Map7 UniSTS
C76851  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38745,710,485 - 45,710,644UniSTSGRCm38
MGSCv37752,965,855 - 52,966,014UniSTSGRCm37
Celera741,173,042 - 41,173,201UniSTS
Cytogenetic Map7B4UniSTS
cM Map723.0UniSTS
Whitehead/MRC_RH7569.21UniSTS
RH141779  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38745,709,830 - 45,710,004UniSTSGRCm38
MGSCv37752,965,200 - 52,965,374UniSTSGRCm37
Celera741,172,387 - 41,172,561UniSTS
Cytogenetic Map7B4UniSTS
cM Map723.0UniSTS
Sphk2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38745,712,256 - 45,713,577UniSTSGRCm38
MGSCv37752,967,626 - 52,968,947UniSTSGRCm37
Celera741,174,813 - 41,176,134UniSTS
Cytogenetic Map7B4UniSTS
cM Map7 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7346321287493512Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360000072900000Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71278145246781452Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71278145246781452Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1333306047333196Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71343577947435779Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71360000047700000Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71690336849509583Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71958059053580679Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined72014282554142942Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72302446357024609Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72323914857239292Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72341710757417107Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72719819161202351Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72789112561891125Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3033306081485905Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73206509766065329Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73274478466744933Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3379830258499217Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3379830258499217Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3379830258499217Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3379830258499217Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73379830258499217Mouse
1357731Lvrq6_mliver weight QTL 6 (mouse)Not determined73379830258499217Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73379830258499217Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73379830258499217Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73379830258499217Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73440327768403475Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73450000051500000Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73466713968667295Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73479812168798270Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73658059092745138Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736580590116817642Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73760000072400000Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73760000087400000Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73824163872241834Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73877180072771936Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined740024463103860803Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74149907275499217Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74149907275499217Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745512542119094307Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74560000079600000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1783
Count of miRNA genes:557
Interacting mature miRNAs:665
Transcripts:ENSMUST00000072836, ENSMUST00000107737, ENSMUST00000107738
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001172561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_203280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006541012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006541013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC167242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF245448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF415214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK016616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY256088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000072836   ⟹   ENSMUSP00000072615
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl745,710,285 - 45,715,207 (-)Ensembl
RefSeq Acc Id: ENSMUST00000107737   ⟹   ENSMUSP00000103366
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl745,709,467 - 45,718,002 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210060   ⟹   ENSMUSP00000147391
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl745,710,267 - 45,717,902 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211340   ⟹   ENSMUSP00000147787
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl745,712,058 - 45,713,443 (-)Ensembl
RefSeq Acc Id: NM_001172561   ⟹   NP_001166032
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,358,887 - 45,367,426 (-)NCBI
GRCm38745,709,463 - 45,718,002 (-)ENTREZGENE
MGSCv37752,964,833 - 52,973,372 (-)RGD
Celera741,172,020 - 41,180,543 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_020011   ⟹   NP_064395
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,358,887 - 45,364,631 (-)NCBI
GRCm38745,709,463 - 45,715,207 (-)NCBI
MGSCv37752,964,833 - 52,973,372 (-)RGD
Celera741,172,020 - 41,180,543 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_203280   ⟹   NP_975009
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,358,887 - 45,367,426 (-)NCBI
GRCm38745,709,463 - 45,718,002 (-)ENTREZGENE
MGSCv37752,964,833 - 52,973,372 (-)RGD
Celera741,172,020 - 41,180,543 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006541012   ⟹   XP_006541075
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,359,685 - 45,364,557 (-)NCBI
GRCm38745,710,261 - 45,715,135 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006541013   ⟹   XP_006541076
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,359,685 - 45,364,606 (-)NCBI
GRCm38745,710,261 - 45,715,182 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153276   ⟹   XP_036009169
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,359,690 - 45,367,367 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_975009   ⟸   NM_203280
- UniProtKB: Q9JIA7 (UniProtKB/Swiss-Prot),   Q3U912 (UniProtKB/TrEMBL),   Q58E38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_064395   ⟸   NM_020011
- UniProtKB: Q9JIA7 (UniProtKB/Swiss-Prot),   Q58E38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001166032   ⟸   NM_001172561
- UniProtKB: Q9JIA7 (UniProtKB/Swiss-Prot),   Q58E38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006541076   ⟸   XM_006541013
- Peptide Label: isoform X1
- UniProtKB: Q9JIA7 (UniProtKB/Swiss-Prot),   Q58E38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006541075   ⟸   XM_006541012
- Peptide Label: isoform X1
- UniProtKB: Q9JIA7 (UniProtKB/Swiss-Prot),   Q58E38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000103366   ⟸   ENSMUST00000107737
RefSeq Acc Id: ENSMUSP00000147787   ⟸   ENSMUST00000211340
RefSeq Acc Id: ENSMUSP00000072615   ⟸   ENSMUST00000072836
RefSeq Acc Id: ENSMUSP00000147391   ⟸   ENSMUST00000210060
RefSeq Acc Id: XP_036009169   ⟸   XM_036153276
- Peptide Label: isoform X1
Protein Domains
DAGKc

Promoters
RGD ID:8664073
Promoter ID:EPDNEW_M10068
Type:initiation region
Name:Sphk2_2
Description:Mus musculus sphingosine kinase 2 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10069  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38745,717,079 - 45,717,139EPDNEW
RGD ID:8664075
Promoter ID:EPDNEW_M10069
Type:initiation region
Name:Sphk2_1
Description:Mus musculus sphingosine kinase 2 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10068  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38745,717,927 - 45,717,987EPDNEW
RGD ID:6841948
Promoter ID:MM_KWN:50451
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000075178,   NM_020011,   OTTMUST00000056089,   UC009GWW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36752,969,036 - 52,973,562 (+)MPROMDB
RGD ID:6842090
Promoter ID:MM_KWN:50452
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   MEF_B6
Transcripts:NM_001172561,   NM_203280
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36752,973,146 - 52,974,337 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1861380 AgrOrtholog
Ensembl Genes ENSMUSG00000057342 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000072615 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000103366 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147391 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147787 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000072836 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000107737 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000210060 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000211340 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATP-NAD_kinase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD/diacylglycerol_kinase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56632 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1861380 ENTREZGENE
NCBI Gene 56632 ENTREZGENE
Pfam DAGK_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sphk2 PhenoGen
PROSITE DAGK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DAGKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GS43_MOUSE UniProtKB/TrEMBL
  Q3U912 ENTREZGENE, UniProtKB/TrEMBL
  Q58E38 ENTREZGENE, UniProtKB/TrEMBL
  Q9JIA7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q91VA9 UniProtKB/Swiss-Prot
  Q9DBH6 UniProtKB/Swiss-Prot