Sphk2 (sphingosine kinase 2) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Sphk2 (sphingosine kinase 2) Ictidomys tridecemlineatus
Analyze
Symbol: Sphk2
Name: sphingosine kinase 2
RGD ID: 12559270
Description: ENCODES a protein that exhibits D-erythro-sphingosine kinase activity (ortholog); nucleosomal histone binding (ortholog); sphinganine kinase activity (ortholog); INVOLVED IN blood vessel development (ortholog); brain development (ortholog); cellular response to phorbol 13-acetate 12-myristate (ortholog); PARTICIPATES IN ceramide signaling pathway; Fabry disease pathway; Gaucher's disease pathway; ASSOCIATED WITH Memory Disorders (ortholog); middle cerebral artery infarction (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366642,668,708 - 2,676,608 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
Sphk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366642,668,708 - 2,676,608 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPHK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1948,619,291 - 48,630,717 (+)EnsemblGRCh38hg38GRCh38
GRCh381948,619,409 - 48,630,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,122,763 - 49,133,662 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371949,122,548 - 49,133,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,814,360 - 53,825,474 (+)NCBINCBI36hg18NCBI36
Build 341953,814,359 - 53,825,473NCBI
Celera1945,987,413 - 45,998,527 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,501,739 - 45,513,199 (+)NCBIHuRef
CHM1_11949,124,423 - 49,135,537 (+)NCBICHM1_1
Sphk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,358,887 - 45,367,426 (-)NCBIGRCm39mm39
GRCm38745,709,463 - 45,718,002 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,709,467 - 45,718,002 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,964,833 - 52,973,372 (-)NCBIGRCm37mm9NCBIm37
MGSCv36745,578,303 - 45,585,957 (-)NCBImm8
Celera741,172,020 - 41,180,543 (-)NCBICelera
Cytogenetic Map7B3NCBI
Sphk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,180,872 - 96,188,592 (-)NCBI
Rnor_6.0 Ensembl1101,692,973 - 101,697,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01101,692,972 - 101,700,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,771,785 - 102,779,436 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,178,615 - 96,182,920 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,256,726 - 96,261,031 (-)NCBI
Celera190,434,071 - 90,438,377 (-)NCBICelera
Cytogenetic Map1q22NCBI
Sphk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,917,301 - 1,928,493 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,921,479 - 1,929,450 (-)NCBIChiLan1.0ChiLan1.0
SPHK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11954,213,166 - 54,224,033 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,213,166 - 54,224,767 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01945,620,980 - 45,631,786 (+)NCBIMhudiblu_PPA_v0panPan3
SPHK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1107,680,599 - 107,689,707 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11107,681,425 - 107,689,790 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
SPHK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,979,012 - 53,986,770 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,982,911 - 53,986,779 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,726,086 - 49,734,104 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPHK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,865,921 - 41,881,889 (+)NCBI
ChlSab1.1 Ensembl641,867,139 - 41,881,268 (+)Ensembl
Sphk2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248325,246,328 - 5,254,247 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005336633   ⟹   XP_005336690
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049366642,668,708 - 2,676,608 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013363497   ⟹   XP_013218951
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049366642,669,025 - 2,676,608 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021734148   ⟹   XP_021589823
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049366642,673,271 - 2,676,608 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021734149   ⟹   XP_021589824
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049366642,671,975 - 2,676,608 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005336690 (Get FASTA)   NCBI Sequence Viewer  
  XP_013218951 (Get FASTA)   NCBI Sequence Viewer  
  XP_021589823 (Get FASTA)   NCBI Sequence Viewer  
  XP_021589824 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005336690   ⟸   XM_005336633
- Peptide Label: isoform X1
- UniProtKB: I3MIU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013218951   ⟸   XM_013363497
- Peptide Label: isoform X1
- UniProtKB: I3MIU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021589824   ⟸   XM_021734149
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_021589823   ⟸   XM_021734148
- Peptide Label: isoform X2
- Sequence:
Protein Domains
DAGKc


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012266 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000010995 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000030173 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000012267 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOT00000041119 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10330 UniProtKB/TrEMBL
InterPro ATP-NAD_kinase_N UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/TrEMBL
  NAD/diacylglycerol_kinase_sf UniProtKB/TrEMBL
NCBI Gene Sphk2 ENTREZGENE
Pfam DAGK_cat UniProtKB/TrEMBL
PROSITE DAGK UniProtKB/TrEMBL
SMART DAGKc UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/TrEMBL
UniProt A0A287D9F2_ICTTR UniProtKB/TrEMBL
  I3MIU8 ENTREZGENE, UniProtKB/TrEMBL