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Gene: SLC38A3 (solute carrier family 38 member 3) Chlorocebus sabaeus

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Symbol:

SLC38A3

Name:

solute carrier family 38 member 3

RGD ID:

18771647

Description:

ENCODES a protein that exhibits neutral L-amino acid:sodium symporter activity (ortholog); INVOLVED IN cellular response to potassium ion starvation (ortholog); female pregnancy (ortholog); glutamine transport (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 1 (ortholog); developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 102 (ortholog); FOUND IN basolateral plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sodium-coupled neutral amino acid transporter 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	11,591,680 - 11,606,291 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	11,591,717 - 11,606,355 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	155,378,802 - 155,395,004 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 1 (ISO)

developmental and epileptic encephalopathy (ISO)

developmental and epileptic encephalopathy 102 (ISO)

Dwarfism (ISO)

early infantile epileptic encephalopathy (ISO)

Endotoxemia (ISO)

genetic disease (ISO)

metabolic acidosis (ISO)

primary ciliary dyskinesia (ISO)

visual epilepsy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid transmembrane transport (IEA)

asparagine transport (IEA)

cellular response to potassium ion starvation (IEA,ISO)

female pregnancy (ISO)

glutamine secretion (IEA)

glutamine transport (IEA,ISO)

histidine transport (IEA,ISO)

intracellular amino acid homeostasis (IEA)

L-alanine transport (IEA)

L-asparagine import across plasma membrane (ISO)

L-glutamine import across plasma membrane (IEA)

L-histidine import across plasma membrane (IEA)

L-histidine transport (ISO)

positive regulation of glutamine transport (ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

Cellular Component

apical plasma membrane (IEA)

basolateral plasma membrane (ISO)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

L-alanine transmembrane transporter activity (IEA)

L-asparagine transmembrane transporter activity (IEA)

L-asparagine, sodium:proton antiporter activity (IEA)

L-glutamine transmembrane transporter activity (IEA)

L-glutamine, sodium:proton antiporter activity (IEA)

L-histidine transmembrane transporter activity (IEA)

L-histidine, sodium:proton antiporter activity (IEA)

neutral L-amino acid:sodium symporter activity (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

SLC38A3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	11,591,680 - 11,606,291 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	11,591,717 - 11,606,355 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	155,378,802 - 155,395,004 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

SLC38A3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	50,205,271 - 50,221,486 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	50,205,246 - 50,221,486 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	50,242,704 - 50,258,918 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	50,217,696 - 50,233,410 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	50,217,708 - 50,233,406	NCBI
Celera	3	50,215,521 - 50,231,235 (+)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	50,298,378 - 50,314,094 (+)	NCBI		HuRef
CHM1_1	3	50,194,967 - 50,210,681 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	50,234,602 - 50,250,823 (+)	NCBI		T2T-CHM13v2.0

Slc38a3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	107,528,353 - 107,546,167 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	107,527,833 - 107,546,729 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	107,651,154 - 107,668,968 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	107,650,634 - 107,669,530 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	107,553,486 - 107,569,705 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	107,509,256 - 107,525,475 (-)	NCBI		MGSCv36	mm8
Celera	9	107,256,617 - 107,273,287 (-)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	58.69	NCBI

Slc38a3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,202,534 - 117,220,310 (-)	NCBI		GRCr8
mRatBN7.2	8	108,323,889 - 108,339,959 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	108,323,894 - 108,339,988 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	113,950,584 - 113,966,611 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,149,742 - 112,165,769 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	109,992,524 - 110,008,551 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,406,258 - 116,423,752 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,406,241 - 116,422,366 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	115,761,368 - 115,779,081 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	112,898,405 - 112,914,444 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	112,917,859 - 112,933,899 (-)	NCBI
Celera	8	107,630,163 - 107,646,202 (-)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Slc38a3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	2,023,694 - 2,050,708 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	2,023,694 - 2,046,556 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC38A3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	50,188,107 - 50,203,856 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	50,192,882 - 50,208,631 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	50,133,631 - 50,149,394 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	51,367,939 - 51,383,657 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	51,367,939 - 51,383,657 (+)	Ensembl	panpan1.1		panPan2

SLC38A3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	39,108,387 - 39,122,526 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	39,109,211 - 39,114,849 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	39,029,425 - 39,043,601 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	39,464,652 - 39,478,831 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	39,462,412 - 39,478,967 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	38,832,227 - 38,846,403 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	39,236,334 - 39,250,516 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	39,515,831 - 39,530,233 (-)	NCBI		UU_Cfam_GSD_1.0

Slc38a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	64,989,382 - 65,005,427 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	1,749,853 - 1,768,476 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	1,749,919 - 1,765,885 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC38A3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	32,683,126 - 32,704,535 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	32,683,131 - 32,699,803 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	35,861,884 - 35,878,403 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Slc38a3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	4,078,014 - 4,096,080 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	4,078,084 - 4,092,330 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	17	33	33	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007984296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038003886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000012436 ⟹ ENSCSAP00000010472

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	22	11,591,717 - 11,606,355 (+)	Ensembl

RefSeq Acc Id:

XM_007984296 ⟹ XP_007982487

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	22	11,591,680 - 11,606,291 (+)	NCBI
Vero_WHO_p1.0	NW_023666041	155,378,802 - 155,395,004 (-)	NCBI

Sequence:

show sequence

CATCCCCACCGTCGCTGTTGTCGCTGTTGCAGCCCTGAGTTCAGCTGGGAGCAGAGTGGACCGC
ACCGGCCCGAGCGGAGCGCCGCGCGTGCCCAGCCGCGAGGCCAGACATCTGACTGTTGGTGTGA
GACTGGTGCTCCTGGTGTTGTGCCCTGAGCCATGGAGGTGCCTTTGCAGACAGAGATGGTGGAG
CTGGTGCCCAATGGCAAACACTCAGAGGGGCTGCTCCCAGTCATCACACCTATGGCAGGCAACC
AGAGGGTCGAGGACCCCACAGGGAGCTGTATTGAGGGCAAGAGCTTCCTACAGAAAAGTCCCAG
CAAGGAGCCACACTTCACCGACTTCGAGGGGAAGACATCATTTGGGATGTCAGTGTTCAACCTC
AGCAATGCCATCATGGGCAGCGGCATCCTCGGACTCGCCTATGCCATGGCCAATACGGGCATTA
TCCTTTTCCTGTTCCTGTTGACGGCTGTCGCCTTGCTCTCCAGCTACTCCATCCACCTGCTACT
CAAGTCCTCAGGGGTCGTCGGCATCCGTGCCTATGAGCAGCTGGGCTACCGTGCCTTTGGGACC
CCAGGAAAGCTGGCAGCAGCCCTGGCCATCACGCTCCAGAACATCGGAGCCATGTCCAGCTACT
TGTACATCATCAAGTCTGAGCTGCCACTTGTCATACAGACCTTCCTGAACCTGGAGGAGAAAAC
CTCGGACTGGTACATGAATGGGAACTACCTGGTGATCCTTGTTTCTGTCATCATCATTCTGCCC
CTGGCACTGATGCGGCAGCTTGGCTACCTGGGCTACTCCAGCGGCTTCTCTCTTAGCTGCATGG
TGTTCTTCCTAATTGCAGTCATCTACAAAAAGTTCCACGTGCCCTGCCCACTGCCCCCCAACTT
CAACAACACCACAGGCAACTTCAGCCACATGGAGGTCATGAAGGAGAAGGTGCAGCTGCAGATC
GAGCCTGAGGCTGCAGCCTTTTGCACTCCCAGTTACTTCACGCTCAACTCACAGACAGCATACA
CCATCCCCATCATGGCCTTCGCCTTCGTCTGCCACCCCGAGGTGCTGCCCATCTATACCGAGCT
CAAGGACCCCTCCAAGAAGAAGATGCAGCATATCTCCAACCTGTCCATCGCCGTCATGTACATC
ATGTACTTCCTGGCTGCCCTCTTTGGCTACCTCACCTTCTATGATGGGGTGGAGTCAGAGCTGC
TGCATACCTACAGCAAGGTGGACCCATTTGACGTGCTGATCCTGTGTGTGCGTGTAGCCGTGCT
GACAGCAGTCACGCTCACAGTGCCCATCGTTCTGTTCCCGGTGCGCCGCGCCATCCAGCAGATG
CTGTTTCCGAACCAGGAGTTCAGCTGGCTGCGGCATGTGCTTATTGCTATTGGCCTGCTCACTT
GTATCAACCTGCTGGTCATCTTTGCCCCAAACATCCTGGGCATCTTTGGGGTCATCGGTGCCAC
ATCTGCCCCATGCCTCATCTTCATCTTCCCTGCCATCTTCTACTTCCGAATCATGCCCACGGAG
AAGGAGCCTGCGAGATCCACCCCCAAAATCCTGGCCCTATGTTTTGCTGTGCTTGGCTTCTTGC
TGATGACCATGAGCTTGAGCTTCATCATCATTGACTGGGCCTCAGGGACCAGCCGGCACGGAGG
AAACCACTAGGGTGACCCTCATGCTGTTCTGTCTACTCACCCTAGCAGCCCTGCCCAGACTCTT
CAGCCCCTGCTCCCATCCAGTGGCCAGTCGGGGGAGGAGAAAGACGCGATTAACACTGTGGCAT
TCAGCCAGGCCCCATGTCCTCTCTGTGGAAGGTTTTTGTTCAAGAGCCAGGACCAAGGCCCTTG
GGCCACTACCCTGCCACGCTCCAGAGCAGCAGGGGCTTCTTGAACTGGGAGCAGGGTGGGGCTG
TCGCCTTAGATCCCACCCAAGCCCCTCATTCCCTCCTTGCACAGATGCGTACACTAGGGCCCAG
CAGCTGCCTCCTGAGGAGATACAGCCTGTAGAAACATACAGAGCTGGAATCAGCCTAGAGCCAT
TCCCCTACCCTGCTGCTAGGCCACGGTCTGTGCCCTGGGGCCTCATCTTCCCAGCCCACTTGTT
TTTCCCCCTTTTATTCCCTAGGCCCTTTTCAGACACTTGGGCCCTTGGATACTCTTCTCCCACC
CCCCTTCACAGGATGGCACCCTCCCATACCCCATAGCTGGGACCAGCAGGTTCTGCTGAGGGTG
GGGCTGGTGTAGCTATCCCCAAGAGACCCCTGCCCTGTCCCTTCACCAGTCCTGGGGAGGCTGG
GACTCCCCCTGCCACAAGCCTGGGCCACAGCTCACATTCCACTGCTGGGAGAAGAGATAGGCCG
AGGCCCAGAGTGGCCTGCCCCCGGGAGCCAAAGACCCCAGTGGCCACACTGGGACAGGGTGGGG
AGGCTGGCAGCCCTCTTTTATAAATATTATACATAAGACCAGC

hide sequence

RefSeq Acc Id:

XM_038003886 ⟹ XP_037859814

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666041	155,379,311 - 155,388,695 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007982487	(Get FASTA)	NCBI Sequence Viewer
	XP_037859814	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000010472
	ENSCSAP00000010472.1

RefSeq Acc Id:	XP_007982487 ⟸ XM_007984296
- UniProtKB:	A0A0D9RPD3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000010472 ⟸ ENSCSAT00000012436

RefSeq Acc Id:	XP_037859814 ⟸ XM_038003886
- UniProtKB:	A0A0D9RPD3 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000014343	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000012436.1	UniProtKB/TrEMBL
InterPro	AA_transpt_TM	UniProtKB/TrEMBL
KEGG Report	csab:103227662	UniProtKB/TrEMBL
NCBI Gene	SLC38A3	ENTREZGENE
PANTHER	AMINO ACID TRANSPORTER	UniProtKB/TrEMBL
	SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 3	UniProtKB/TrEMBL
Pfam	Aa_trans	UniProtKB/TrEMBL
UniProt	A0A0D9RPD3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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