AMBP (alpha-1-microglobulin/bikunin precursor) - Rat Genome Database

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Gene: AMBP (alpha-1-microglobulin/bikunin precursor) Chlorocebus sabaeus
Analyze
Symbol: AMBP
Name: alpha-1-microglobulin/bikunin precursor
RGD ID: 18759420
Description: ENCODES a protein that exhibits antioxidant activity (ortholog); carbohydrate binding (ortholog); chondroitin sulfate binding (ortholog); INVOLVED IN cellular oxidant detoxification (ortholog); cellular response to reactive oxygen species (ortholog); cytochrome c metabolic process (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); adult respiratory distress syndrome (ortholog); asthma (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); matrix side of mitochondrial inner membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC103218974; protein AMBP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11225,508,516 - 25,526,821 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1225,508,682 - 25,527,016 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603517,294,343 - 17,312,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 9 of 9 rows

  
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AMBPGreen Monkeyacute kidney failure  ISOAMBP (Homo sapiens)9068941CTD more ...CTDPMID:28885000 and PMID:8963945
AMBPGreen MonkeyChemical and Drug Induced Liver Injury  ISOAMBP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18779383
AMBPGreen MonkeyDrug-Related Side Effects and Adverse Reactions  ISOAMBP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:28885000
AMBPGreen Monkeymood disorder  ISOAMBP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:29987918
AMBPGreen MonkeyNeoplasm Invasiveness  ISOAMBP (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:14644129
AMBPGreen Monkeytransitional cell carcinoma  ISOAMBP (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:14644129


Biological Process

  

Cellular Component
1 to 19 of 19 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AMBPGreen Monkeycell surface  ISOAmbp (Rattus norvegicus)9068941 RGDPMID:15533056 and REF_RGD_ID:6904219
AMBPGreen Monkeycytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
AMBPGreen Monkeycytosol located_inIEAUniProtKB-SubCell:SL-0091150520179 UniProtGO_REF:0000044
AMBPGreen Monkeyendoplasmic reticulum located_inIEAUniProtKB-SubCell:SL-0095150520179 UniProtGO_REF:0000044
AMBPGreen Monkeyendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
AMBPGreen Monkeyextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
AMBPGreen Monkeyextracellular space  ISOAmbp (Rattus norvegicus)9068941 RGDPMID:11307954 and REF_RGD_ID:6904220
AMBPGreen Monkeyextracellular space  ISOAmbp (Chinchilla lanigera)9068941 RGDPMID:2579763 more ...
AMBPGreen Monkeyextracellular space located_inISOAMBP (Homo sapiens)9068941 PMID:15683711UniProtPMID:15683711
AMBPGreen Monkeymatrix side of mitochondrial inner membrane located_inISOAMBP (Homo sapiens)9068941 PMID:23157686UniProtPMID:23157686
AMBPGreen Monkeymembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
AMBPGreen Monkeymitochondrial inner membrane located_inIEAUniProtKB-SubCell:SL-0168150520179 UniProtGO_REF:0000044
AMBPGreen Monkeymitochondrial inner membrane located_inIEAUniProtKB-KW:KW-0999150520179 UniProtGO_REF:0000043
AMBPGreen Monkeymitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
AMBPGreen Monkeynuclear membrane located_inIEAUniProtKB-SubCell:SL-0182150520179 UniProtGO_REF:0000044
AMBPGreen Monkeynucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
AMBPGreen Monkeyplasma membrane located_inIEAUniProtKB-KW:KW-1003150520179 UniProtGO_REF:0000043
AMBPGreen Monkeyplasma membrane located_inIEAUniProtKB:P02760 and ensembl:ENSP00000265132150520179 EnsemblGO_REF:0000107
AMBPGreen Monkeyplasma membrane located_inIEAUniProtKB-SubCell:SL-0039150520179 UniProtGO_REF:0000044
1 to 19 of 19 rows

Molecular Function
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AMBPGreen Monkeyantioxidant activity enablesISOAMBP (Homo sapiens)9068941 PMID:22096585 and PMID:23642167UniProtPMID:22096585 and PMID:23642167
AMBPGreen Monkeycarbohydrate binding enablesISOAMBP (Homo sapiens)9068941 PMID:7513643DisProtPMID:7513643
AMBPGreen Monkeychondroitin sulfate binding enablesISOAMBP (Homo sapiens)9068941 PMID:16873769UniProtPMID:16873769
AMBPGreen Monkeycollagen fibril binding enablesISOAMBP (Homo sapiens)9068941 PMID:22096585UniProtPMID:22096585
AMBPGreen Monkeyheme binding enablesIEAUniProtKB:P02760 and ensembl:ENSP00000265132150520179 EnsemblGO_REF:0000107
AMBPGreen MonkeyIgA binding enablesIEAUniProtKB:P02760 and ensembl:ENSP00000265132150520179 EnsemblGO_REF:0000107
AMBPGreen Monkeyoxidoreductase activity, acting on NAD(P)H, heme protein as acceptor enablesISOAMBP (Homo sapiens)9068941 PMID:15683711UniProtPMID:15683711
AMBPGreen Monkeypeptidase inhibitor activity enablesIEAUniProtKB-KW:KW-0646150520179 UniProtGO_REF:0000043
AMBPGreen Monkeyprotein binding enablesISOUniProtKB:Q136439068941 PMID:25416956IntActPMID:25416956
AMBPGreen Monkeyprotein binding enablesISOUniProtKB:P19823 more ...9068941 PMID:16873769UniProtPMID:16873769
AMBPGreen Monkeyprotein binding enablesISOUniProtKB:P00734 and UniProtKB:P027689068941 PMID:9183005UniProtPMID:9183005
AMBPGreen Monkeyprotein binding enablesISOUniProtKB:P19823 and UniProtKB:P198279068941 PMID:20463016UniProtPMID:20463016
AMBPGreen Monkeyprotein binding enablesISOUniProtKB:O145619068941 PMID:23157686UniProtPMID:23157686
AMBPGreen Monkeyprotein binding enablesISOUniProtKB:P078589068941 PMID:16364318IntActPMID:16364318
AMBPGreen Monkeyprotein homodimerization activity enablesIEAUniProtKB:P02760 and ensembl:ENSP00000265132150520179 EnsemblGO_REF:0000107
AMBPGreen Monkeyserine-type endopeptidase inhibitor activity  ISOAmbp (Rattus norvegicus)9068941 RGDPMID:11307954 and REF_RGD_ID:6904220
AMBPGreen Monkeyserine-type endopeptidase inhibitor activity enablesIEAUniProtKB-KW:KW-0722150520179 UniProtGO_REF:0000043
AMBPGreen Monkeyserine-type endopeptidase inhibitor activity enablesIEAInterPro:IPR002223 and InterPro:IPR036880150520179 InterProGO_REF:0000002
1 to 18 of 18 rows

PMID:22301074   PMID:30032202  



AMBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11225,508,516 - 25,526,821 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1225,508,682 - 25,527,016 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603517,294,343 - 17,312,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
AMBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389114,060,127 - 114,078,300 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9114,060,127 - 114,078,328 (-)EnsemblGRCh38hg38GRCh38
GRCh379116,822,407 - 116,840,580 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369115,862,228 - 115,880,536 (-)NCBINCBI36Build 36hg18NCBI36
Build 349113,901,963 - 113,920,269NCBI
Celera987,469,703 - 87,488,044 (-)NCBICelera
Cytogenetic Map9q32NCBI
HuRef986,428,731 - 86,447,071 (-)NCBIHuRef
CHM1_19116,968,857 - 116,987,201 (-)NCBICHM1_1
T2T-CHM13v2.09126,258,798 - 126,276,960 (-)NCBIT2T-CHM13v2.0
Ambp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39463,061,512 - 63,072,409 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl463,061,512 - 63,073,036 (-)EnsemblGRCm39 Ensembl
GRCm38463,143,275 - 63,154,172 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl463,143,275 - 63,154,799 (-)EnsemblGRCm38mm10GRCm38
MGSCv37462,804,313 - 62,815,176 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36462,629,640 - 62,640,503 (-)NCBIMGSCv36mm8
Celera461,799,977 - 61,810,839 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.96NCBI
Ambp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8581,583,621 - 81,593,938 (-)NCBIGRCr8
mRatBN7.2576,568,094 - 76,578,416 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl576,568,094 - 76,578,331 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx578,967,475 - 78,977,717 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,784,609 - 80,794,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,760,118 - 80,770,360 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0578,975,690 - 78,986,021 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,975,678 - 78,985,990 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0583,093,799 - 83,104,019 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4580,119,742 - 80,129,962 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1580,124,854 - 80,135,075 (-)NCBI
Celera575,505,542 - 75,515,762 (-)NCBICelera
Cytogenetic Map5q24NCBI
Ambp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541913,478,552 - 13,492,327 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541913,478,904 - 13,492,329 (+)NCBIChiLan1.0ChiLan1.0
AMBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21125,296,801 - 25,317,823 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1925,299,162 - 25,320,209 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0985,157,680 - 85,176,253 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19113,525,136 - 113,543,680 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9113,525,835 - 113,543,422 (-)Ensemblpanpan1.1panPan2
AMBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11168,338,644 - 68,353,366 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1168,338,389 - 68,351,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1166,741,500 - 66,756,216 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01169,461,851 - 69,476,622 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1169,461,782 - 69,475,427 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11167,978,768 - 67,993,416 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01168,009,752 - 68,024,455 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01168,747,753 - 68,762,492 (-)NCBIUU_Cfam_GSD_1.0
Ambp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947183,631,164 - 183,643,649 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364873,399,792 - 3,412,088 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1254,683,891 - 254,703,225 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11254,683,885 - 254,703,220 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21285,710,963 - 285,725,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1qNCBI
Ambp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476021,047,303 - 21,068,076 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476021,047,576 - 21,064,698 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in AMBP
626 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
68 30 18 30 30 56 18


RefSeq Transcripts XM_007968323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000010668   ⟹   ENSCSAP00000008757
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1225,508,682 - 25,527,016 (+)Ensembl
RefSeq Acc Id: XM_007968323   ⟹   XP_007966514
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11225,508,516 - 25,526,821 (+)NCBI
Vero_WHO_p1.0NW_02366603517,294,343 - 17,312,444 (-)NCBI
Sequence:
Protein RefSeqs XP_007966514 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000008757.1
RefSeq Acc Id: XP_007966514   ⟸   XM_007968323
- UniProtKB: A0A0D9RJG8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000008757   ⟸   ENSCSAT00000010668



1 to 28 of 28 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000012575 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010668.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/TrEMBL
  4.10.410.10 UniProtKB/TrEMBL
InterPro A1-microglobln UniProtKB/TrEMBL
  AMBP UniProtKB/TrEMBL
  Calycin UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
KEGG Report csab:103218974 UniProtKB/TrEMBL
NCBI Gene AMBP ENTREZGENE
PANTHER PROTEIN AMBP UniProtKB/TrEMBL
  PTHR46676 UniProtKB/TrEMBL
Pfam Kunitz_BPTI UniProtKB/TrEMBL
  Lipocalin UniProtKB/TrEMBL
PRINTS A1MCGLOBULIN UniProtKB/TrEMBL
  BASICPTASE UniProtKB/TrEMBL
  LIPOCALIN UniProtKB/TrEMBL
PROSITE BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
  LIPOCALIN UniProtKB/TrEMBL
SMART SM00131 UniProtKB/TrEMBL
Superfamily-SCOP SSF50814 UniProtKB/TrEMBL
  SSF57362 UniProtKB/TrEMBL
UniProt A0A0D9RJG8 ENTREZGENE, UniProtKB/TrEMBL
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-09 AMBP  alpha-1-microglobulin/bikunin precursor  LOC103218974  alpha-1-microglobulin/bikunin precursor  Symbol and/or name change 5135510 APPROVED
2020-12-08 LOC103218974  alpha-1-microglobulin/bikunin precursor  AMBP  alpha-1-microglobulin/bikunin precursor  Symbol and/or name change 5135510 APPROVED