RGD Reference Report - Urinary excretion of low molecular weight proteins in patients with pure monoclonal light chain proteinuria. - Rat Genome Database

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Urinary excretion of low molecular weight proteins in patients with pure monoclonal light chain proteinuria.

Authors: Madalena, L  Facio, ML  Angerosa, M  Pandolfo, M  Bresciani, P  Alejandre, M  Pizzolato, M  Toblli, JE 
Citation: Madalena L, etal., J Nephrol. 2007 Nov-Dec;20(6):683-8.
RGD ID: 6904142
Pubmed: PMID:18046670   (View Abstract at PubMed)

BACKGROUND: Because urinary low molecular weight protein (LMWP) measurement shows changes in renal integrity at an early stage, beta2-microglobulin (B2m), retinol-binding protein (RBP) and alpha1-microglobulin (A1m) were evaluated in 24-hour urine collection of 65 patients with pure monoclonal light chain (MLC) proteinuria and in 47 patients with different kidney diseases (DKDs) for comparison. METHODS AND RESULTS: Albumin, kappa, lambda, A1m and B2m were measured by immunonephelometry. RBP was determined by ELISA. The mean values of LMWP quantitation were significant for origin of the disease (MLC and DKD) (p<0.05) and renal failure (RF) (p<0.001) (MANOVA). Tukey HSD test only showed significant differences for LMWP between MLC patients with RF and DKD patients without RF. The mean value of A1m was different between patients with and without RF in each group (p<0.05 for MLC, and p<0.01 for DKD). In the group without RF, the frequency of A1m excretion above 12 mg/L differed between MLC patients and DKD patients (p<0.01). CONCLUSION: A tubular dysfunction occurred in a great number of patients excreting pure MLC even in those with well-preserved renal function, as it did in patients with DKDs. In patients with MLC without RF, A1m might be measured for the early recognition of tubular involvement.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
kidney failure  IEP 6904142 RGD 
kidney failure  ISOAMBP (Homo sapiens)6904142; 6904142 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ambp  (alpha-1-microglobulin/bikunin precursor)

Genes (Mus musculus)
Ambp  (alpha 1 microglobulin/bikunin precursor)

Genes (Homo sapiens)
AMBP  (alpha-1-microglobulin/bikunin precursor)

Objects referenced in this article
Gene ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Homo sapiens

Additional Information