AMBP (alpha-1-microglobulin/bikunin precursor) - Rat Genome Database

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Gene: AMBP (alpha-1-microglobulin/bikunin precursor) Sus scrofa
Analyze
Symbol: AMBP
Name: alpha-1-microglobulin/bikunin precursor (Ensembl:alpha-1-microglobulin/bikunin)
RGD ID: 13845036
Description: ENCODES a protein that exhibits antioxidant activity (ortholog); carbohydrate binding (ortholog); chondroitin sulfate binding (ortholog); INVOLVED IN cellular oxidant detoxification (ortholog); cellular response to reactive oxygen species (ortholog); cytochrome c metabolic process (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); adult respiratory distress syndrome (ortholog); asthma (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); matrix side of mitochondrial inner membrane (ortholog); INTERACTS WITH (S)-colchicine; 2,4-dinitrophenol; antimycin A
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-1 microglobulin; bikunin; ITIL; protein AMBP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1254,683,891 - 254,703,225 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11254,683,885 - 254,703,220 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21285,710,963 - 285,725,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1qNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:1696914   PMID:1703444   PMID:2408637   PMID:11683720   PMID:14681463   PMID:21947951   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AMBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1254,683,891 - 254,703,225 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11254,683,885 - 254,703,220 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21285,710,963 - 285,725,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1qNCBI
AMBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389114,060,127 - 114,078,300 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9114,060,127 - 114,078,328 (-)EnsemblGRCh38hg38GRCh38
GRCh379116,822,407 - 116,840,580 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369115,862,228 - 115,880,536 (-)NCBINCBI36Build 36hg18NCBI36
Build 349113,901,963 - 113,920,269NCBI
Celera987,469,703 - 87,488,044 (-)NCBICelera
Cytogenetic Map9q32NCBI
HuRef986,428,731 - 86,447,071 (-)NCBIHuRef
CHM1_19116,968,857 - 116,987,201 (-)NCBICHM1_1
T2T-CHM13v2.09126,258,798 - 126,276,960 (-)NCBIT2T-CHM13v2.0
Ambp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39463,061,512 - 63,072,409 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl463,061,512 - 63,073,036 (-)EnsemblGRCm39 Ensembl
GRCm38463,143,275 - 63,154,172 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl463,143,275 - 63,154,799 (-)EnsemblGRCm38mm10GRCm38
MGSCv37462,804,313 - 62,815,176 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36462,629,640 - 62,640,503 (-)NCBIMGSCv36mm8
Celera461,799,977 - 61,810,839 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.96NCBI
Ambp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8581,583,621 - 81,593,938 (-)NCBIGRCr8
mRatBN7.2576,568,094 - 76,578,416 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl576,568,094 - 76,578,331 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx578,967,475 - 78,977,717 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,784,609 - 80,794,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,760,118 - 80,770,360 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0578,975,690 - 78,986,021 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,975,678 - 78,985,990 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0583,093,799 - 83,104,019 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4580,119,742 - 80,129,962 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1580,124,854 - 80,135,075 (-)NCBI
Celera575,505,542 - 75,515,762 (-)NCBICelera
Cytogenetic Map5q24NCBI
Ambp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541913,478,552 - 13,492,327 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541913,478,904 - 13,492,329 (+)NCBIChiLan1.0ChiLan1.0
AMBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21125,296,801 - 25,317,823 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1925,299,162 - 25,320,209 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0985,157,680 - 85,176,253 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19113,525,136 - 113,543,680 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9113,525,835 - 113,543,422 (-)Ensemblpanpan1.1panPan2
AMBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11168,338,644 - 68,353,366 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1168,338,389 - 68,351,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1166,741,500 - 66,756,216 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01169,461,851 - 69,476,622 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1169,461,782 - 69,475,427 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11167,978,768 - 67,993,416 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01168,009,752 - 68,024,455 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01168,747,753 - 68,762,492 (-)NCBIUU_Cfam_GSD_1.0
Ambp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947183,631,164 - 183,643,649 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364873,399,792 - 3,412,088 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11225,508,516 - 25,526,821 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1225,508,682 - 25,527,016 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603517,294,343 - 17,312,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ambp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476021,047,303 - 21,068,076 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476021,047,576 - 21,064,698 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.
Variants

.
Variants in AMBP
933 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
mesenchyme
mesoderm
nervous system
renal system
reproductive system
2 6 5 3 6 3 1

Sequence


Ensembl Acc Id: ENSSSCT00000033497   ⟹   ENSSSCP00000029018
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1254,683,891 - 254,698,406 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000088896   ⟹   ENSSSCP00000071727
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1254,684,088 - 254,703,225 (-)Ensembl
RefSeq Acc Id: NM_001164006   ⟹   NP_001157478
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11254,683,885 - 254,698,406 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083336   ⟹   XP_020938995
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11254,683,885 - 254,703,220 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001157478 (Get FASTA)   NCBI Sequence Viewer  
  XP_020938995 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK57993 (Get FASTA)   NCBI Sequence Viewer  
  CAA36306 (Get FASTA)   NCBI Sequence Viewer  
  CAA37725 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000029018
  ENSSSCP00000071727
GenBank Protein P04366 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_020938995   ⟸   XM_021083336
- Peptide Label: isoform X1
- UniProtKB: A0A5G2RC04 (UniProtKB/TrEMBL),   F1SN71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157478   ⟸   NM_001164006
- Peptide Label: precursor
- UniProtKB: A0A480P2R0 (UniProtKB/TrEMBL),   A0A4X1V0L0 (UniProtKB/TrEMBL),   F1SN71 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000071727   ⟸   ENSSSCT00000088896
Ensembl Acc Id: ENSSSCP00000029018   ⟸   ENSSSCT00000033497
Protein Domains
BPTI/Kunitz inhibitor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005485 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000033497 ENTREZGENE
  ENSSSCT00000088896 ENTREZGENE
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
  4.10.410.10 UniProtKB/Swiss-Prot
InterPro A1-microglobln UniProtKB/Swiss-Prot
  AMBP UniProtKB/Swiss-Prot
  Calycin UniProtKB/Swiss-Prot
  Kunitz_BPTI UniProtKB/Swiss-Prot
  Kunitz_BPTI_sf UniProtKB/Swiss-Prot
  Lipocalin_CS UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
  Prtase_inh_Kunz-CS UniProtKB/Swiss-Prot
NCBI Gene AMBP ENTREZGENE
PANTHER PROTEIN AMBP UniProtKB/Swiss-Prot
  PTHR46676 UniProtKB/Swiss-Prot
Pfam Kunitz_BPTI UniProtKB/Swiss-Prot
  Lipocalin UniProtKB/Swiss-Prot
PRINTS A1MCGLOBULIN UniProtKB/Swiss-Prot
  BASICPTASE UniProtKB/Swiss-Prot
  LIPOCALIN UniProtKB/Swiss-Prot
PROSITE BPTI_KUNITZ_1 UniProtKB/Swiss-Prot
  BPTI_KUNITZ_2 UniProtKB/Swiss-Prot
  LIPOCALIN UniProtKB/Swiss-Prot
SMART SM00131 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot
  SSF57362 UniProtKB/Swiss-Prot
UniProt A0A480P2R0 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1V0L0 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1V273_PIG UniProtKB/TrEMBL
  A0A5G2RC04 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0TWT1_PIG UniProtKB/TrEMBL
  A0A8D0VD35_PIG UniProtKB/TrEMBL
  A0A8D1DAY1_PIG UniProtKB/TrEMBL
  AMBP_PIG UniProtKB/Swiss-Prot
  F1SN71 ENTREZGENE, UniProtKB/TrEMBL
  P04366 ENTREZGENE
UniProt Secondary P34954 UniProtKB/Swiss-Prot
VGNC ID VGNC:109523 ENTREZGENE