ASIC3 (acid sensing ion channel subunit 3) - Rat Genome Database

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Gene: ASIC3 (acid sensing ion channel subunit 3) Chlorocebus sabaeus
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Symbol: ASIC3
Name: acid sensing ion channel subunit 3
RGD ID: 18674952
Description: ENCODES a protein that exhibits ligand-gated sodium channel activity (ortholog); INVOLVED IN detection of chemical stimulus involved in sensory perception (ortholog); detection of chemical stimulus involved in sensory perception of pain (ortholog); detection of mechanical stimulus involved in sensory perception (ortholog); ASSOCIATED WITH Inflammation (ortholog); lethal congenital glycogen storage disease of heart (ortholog); long QT syndrome (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: acid-sensing ion channel 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,226,940 - 119,234,626 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,230,796 - 119,234,696 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607215,198,711 - 15,205,127 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ASIC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,226,940 - 119,234,626 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,230,796 - 119,234,696 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607215,198,711 - 15,205,127 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ASIC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387151,048,292 - 151,052,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7151,048,292 - 151,052,756 (+)EnsemblGRCh38hg38GRCh38
GRCh377150,745,379 - 150,749,843 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,376,885 - 150,380,774 (+)NCBINCBI36Build 36hg18NCBI36
Build 347150,183,609 - 150,187,488NCBI
Celera7145,302,914 - 145,307,152 (+)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,557,715 - 144,562,179 (+)NCBIHuRef
CHM1_17150,753,727 - 150,758,191 (+)NCBICHM1_1
T2T-CHM13v2.07152,221,380 - 152,225,844 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27150,074,918 - 150,079,382 (+)NCBI
Asic3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,618,449 - 24,622,836 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,618,390 - 24,622,833 (+)EnsemblGRCm39 Ensembl
GRCm38524,413,451 - 24,417,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,413,392 - 24,417,835 (+)EnsemblGRCm38mm10GRCm38
MGSCv37523,919,269 - 23,923,652 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36523,923,516 - 23,927,899 (+)NCBIMGSCv36mm8
Celera521,363,200 - 21,367,641 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.72NCBI
Asic3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,652,946 - 11,657,415 (-)NCBIGRCr8
mRatBN7.2410,760,509 - 10,764,987 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,760,597 - 10,764,643 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,906,873 - 15,910,919 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,727,066 - 11,731,112 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,078,850 - 10,082,896 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,287,868 - 7,293,295 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,288,855 - 7,292,901 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,300,219 - 7,304,265 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,125,614 - 6,129,660 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,125,613 - 6,129,660 (-)NCBI
Celera46,375,165 - 6,379,211 (-)NCBICelera
Cytogenetic Map4q11NCBI
Asic3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,488,249 - 5,491,447 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,487,788 - 5,491,562 (+)NCBIChiLan1.0ChiLan1.0
ASIC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,467,618 - 187,474,669 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,478,716 - 39,485,845 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,633,357 - 142,639,571 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,786,835 - 154,792,289 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,786,835 - 154,792,289 (+)Ensemblpanpan1.1panPan2
ASIC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,099,023 - 15,104,088 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,099,883 - 15,104,080 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,706,096 - 15,712,334 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,820,077 - 16,826,314 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,822,357 - 16,826,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,192,516 - 15,198,753 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,775,203 - 15,780,207 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,824,677 - 15,830,914 (+)NCBIUU_Cfam_GSD_1.0
Asic3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,424,673 - 6,428,461 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,474,995 - 6,478,711 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,473,305 - 6,478,756 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASIC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,172,471 - 6,180,440 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,172,410 - 6,180,440 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,542,445 - 6,547,297 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Asic3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,567,541 - 5,570,851 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248005,567,516 - 5,571,292 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000004754   ⟹   ENSCSAP00000002997
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl21119,230,796 - 119,234,696 (+)Ensembl
RefSeq Acc Id: XM_007983470   ⟹   XP_007981661
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.121119,226,940 - 119,234,626 (+)NCBI
Vero_WHO_p1.0NW_02366607215,199,513 - 15,205,123 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007983473   ⟹   XP_007981664
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.121119,226,940 - 119,234,626 (+)NCBI
Vero_WHO_p1.0NW_02366607215,198,711 - 15,205,127 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007983474   ⟹   XP_007981665
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.121119,226,940 - 119,234,624 (+)NCBI
Vero_WHO_p1.0NW_02366607215,198,711 - 15,205,127 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037990973   ⟹   XP_037846901
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607215,199,344 - 15,205,123 (+)NCBI
RefSeq Acc Id: XM_037990974   ⟹   XP_037846902
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607215,199,513 - 15,205,068 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007981661 (Get FASTA)   NCBI Sequence Viewer  
  XP_007981664 (Get FASTA)   NCBI Sequence Viewer  
  XP_007981665 (Get FASTA)   NCBI Sequence Viewer  
  XP_037846901 (Get FASTA)   NCBI Sequence Viewer  
  XP_037846902 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000002997.1
RefSeq Acc Id: XP_007981661   ⟸   XM_007983470
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R308 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007981664   ⟸   XM_007983473
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R308 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007981665   ⟸   XM_007983474
- Peptide Label: isoform X5
- UniProtKB: A0A0D9R308 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000002997   ⟸   ENSCSAT00000004754
RefSeq Acc Id: XP_037846901   ⟸   XM_037990973
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R308 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037846902   ⟸   XM_037990974
- Peptide Label: isoform X4
- UniProtKB: A0A0D9R308 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006723 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004754.1 UniProtKB/TrEMBL
Gene3D-CATH acid-sensing ion channel 1 domain UniProtKB/TrEMBL
  Acid-sensing ion channel domain UniProtKB/TrEMBL
  YojJ-like UniProtKB/TrEMBL
InterPro ENaC UniProtKB/TrEMBL
  ENaC_chordates UniProtKB/TrEMBL
  ENaC_CS UniProtKB/TrEMBL
NCBI Gene ASIC3 ENTREZGENE
PANTHER ACID-SENSING ION CHANNEL 3 UniProtKB/TrEMBL
  PTHR11690 UniProtKB/TrEMBL
Pfam ASC UniProtKB/TrEMBL
PRINTS AMINACHANNEL UniProtKB/TrEMBL
PROSITE ASC UniProtKB/TrEMBL
UniProt A0A0D9R308 ENTREZGENE, UniProtKB/TrEMBL