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Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons.

Authors: Waldmann, R  Bassilana, F  De Weille, J  Champigny, G  Heurteaux, C  Lazdunski, M 
Citation: Waldmann R, etal., J Biol Chem 1997 Aug 22;272(34):20975-8.
Pubmed: (View Article at PubMed) PMID:9261094

We have cloned and expressed a novel proton-gated Na+ channel subunit that is specific for sensory neurons. In COS cells, it forms a Na+ channel that responds to a drop of the extracellular pH with both a rapidly inactivating and a sustained Na+ current. This biphasic kinetic closely resembles that of the H+-gated current described in sensory neurons of dorsal root ganglia (1). Both the abundance of this novel H+-gated Na+ channel subunit in sensory neurons and the kinetics of the channel suggest that it is part of the channel complex responsible for the sustained H+-activated cation current in sensory neurons that is thought to be important for the prolonged perception of pain that accompanies tissue acidosis (1, 2).

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RGD ID: 1299543
Created: 2004-06-01
Species: All species
Last Modified: 2006-04-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.