TXNRD2 (thioredoxin reductase 2) - Rat Genome Database

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Gene: TXNRD2 (thioredoxin reductase 2) Chlorocebus sabaeus
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Symbol: TXNRD2
Name: thioredoxin reductase 2
RGD ID: 18653965
Description: ENCODES a protein that exhibits protein homodimerization activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN heart development (ortholog); hemopoiesis (ortholog); response to hyperoxia (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); cardiomyopathy (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: thioredoxin reductase 2, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,803,178 - 5,868,224 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl195,813,099 - 5,866,674 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660851,062,817 - 1,128,610 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TXNRD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,803,178 - 5,868,224 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl195,813,099 - 5,866,674 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660851,062,817 - 1,128,610 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TXNRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,875,522 - 19,941,818 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,875,517 - 19,941,820 (-)EnsemblGRCh38hg38GRCh38
GRCh372219,863,045 - 19,929,341 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,243,040 - 18,309,359 (-)NCBINCBI36Build 36hg18NCBI36
Celera223,715,110 - 3,780,635 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,482,976 - 3,549,921 (-)NCBIHuRef
CHM1_12219,862,754 - 19,929,123 (-)NCBICHM1_1
T2T-CHM13v2.02220,252,392 - 20,319,509 (-)NCBIT2T-CHM13v2.0
Txnrd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,245,167 - 18,297,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,245,134 - 18,297,823 (+)EnsemblGRCm39 Ensembl
GRCm381618,426,417 - 18,479,073 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,426,384 - 18,479,073 (+)EnsemblGRCm38mm10GRCm38
MGSCv371618,426,510 - 18,479,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,339,980 - 18,392,633 (+)NCBIMGSCv36mm8
Celera1619,000,768 - 19,053,648 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.41NCBI
Txnrd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,024,321 - 96,072,475 (-)NCBIGRCr8
mRatBN7.21182,519,996 - 82,568,156 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,519,999 - 82,568,156 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,248,515 - 91,296,556 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,909,738 - 83,957,780 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,963,250 - 83,011,292 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,667,994 - 86,716,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,667,997 - 86,716,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,762,304 - 89,809,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,513,361 - 84,561,673 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,553,962 - 84,602,292 (-)NCBI
Celera1181,297,140 - 81,345,203 (-)NCBICelera
Cytogenetic Map11q23NCBI
Txnrd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,152,152 - 18,204,327 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,150,060 - 18,205,775 (+)NCBIChiLan1.0ChiLan1.0
TXNRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22329,502,482 - 29,570,007 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12232,050,064 - 32,117,323 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,636,703 - 2,704,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12218,310,134 - 18,375,681 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2218,311,714 - 18,375,497 (-)Ensemblpanpan1.1panPan2
TXNRD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,381,823 - 29,430,239 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,381,975 - 29,430,206 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,338,309 - 29,387,889 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,783,348 - 30,833,188 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,783,323 - 30,833,184 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,831,592 - 28,881,196 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,456,722 - 28,506,335 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,542,394 - 29,592,091 (+)NCBIUU_Cfam_GSD_1.0
Txnrd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118138,906,728 - 138,964,122 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366193,791,418 - 3,847,626 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366193,789,940 - 3,847,286 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNRD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,356,831 - 51,383,262 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,355,731 - 51,385,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,992,386 - 55,021,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Txnrd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624747514,158 - 569,154 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624747485,012 - 569,175 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000010021   ⟹   ENSCSAP00000008124
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl195,813,099 - 5,866,674 (+)Ensembl
RefSeq Acc Id: XM_007975005   ⟹   XP_007973196
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1195,803,178 - 5,868,224 (+)NCBI
Vero_WHO_p1.0NW_0236660851,062,817 - 1,128,610 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007975006   ⟹   XP_007973197
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1195,803,178 - 5,868,224 (+)NCBI
Vero_WHO_p1.0NW_0236660851,062,817 - 1,128,610 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007975008   ⟹   XP_007973199
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1195,803,178 - 5,848,196 (+)NCBI
Vero_WHO_p1.0NW_0236660851,083,499 - 1,128,610 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007973196 (Get FASTA)   NCBI Sequence Viewer  
  XP_007973197 (Get FASTA)   NCBI Sequence Viewer  
  XP_007973199 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000008124
  ENSCSAP00000008124.1
RefSeq Acc Id: XP_007973196   ⟸   XM_007975005
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RHN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007973197   ⟸   XM_007975006
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RHN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007973199   ⟸   XM_007975008
- Peptide Label: isoform X3
Ensembl Acc Id: ENSCSAP00000008124   ⟸   ENSCSAT00000010021


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011933 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010021.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.30 UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/TrEMBL
  FAD/NAD-linked_Rdtase_dimer_sf UniProtKB/TrEMBL
  GSHR/TRXR-like UniProtKB/TrEMBL
  Pyr_nuc-diS_OxRdtase UniProtKB/TrEMBL
  Pyr_nucl-diS_OxRdtase_dimer UniProtKB/TrEMBL
  Pyr_OxRdtase_I_AS UniProtKB/TrEMBL
  Thioredoxin/glutathione_Rdtase UniProtKB/TrEMBL
NCBI Gene TXNRD2 ENTREZGENE
PANTHER GLUTATHIONE REDUCTASE UniProtKB/TrEMBL
  THIOREDOXIN REDUCTASE 2 UniProtKB/TrEMBL
Pfam Pyr_redox_2 UniProtKB/TrEMBL
  Pyr_redox_dim UniProtKB/TrEMBL
PIRSF Mercury_reductase_MerA UniProtKB/TrEMBL
PRINTS FADPNR UniProtKB/TrEMBL
  PNDRDTASEI UniProtKB/TrEMBL
PROSITE PYRIDINE_REDOX_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
  SSF55424 UniProtKB/TrEMBL
UniProt A0A0D9RHN5 ENTREZGENE, UniProtKB/TrEMBL