Txnrd2 (thioredoxin reductase 2) - Rat Genome Database

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Gene: Txnrd2 (thioredoxin reductase 2) Chinchilla lanigera
Analyze
Symbol: Txnrd2
Name: thioredoxin reductase 2
RGD ID: 8723748
Description: ENCODES a protein that exhibits protein homodimerization activity (ortholog); protein-containing complex binding (ortholog); thioredoxin-disulfide reductase (NADPH) activity (ortholog); INVOLVED IN cell redox homeostasis (ortholog); heart development (ortholog); hemopoiesis (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); cardiomyopathy (ortholog); FOUND IN axon (ortholog); cytosol (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: thioredoxin reductase 2, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,152,152 - 18,204,327 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,150,060 - 18,205,775 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon  (ISO)
cytosol  (ISO)
dendrite  (ISO)
mitochondrion  (ISO)
neuronal cell body  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Txnrd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,152,152 - 18,204,327 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,150,060 - 18,205,775 (+)NCBIChiLan1.0ChiLan1.0
TXNRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,875,522 - 19,941,818 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,875,517 - 19,941,820 (-)EnsemblGRCh38hg38GRCh38
GRCh372219,863,045 - 19,929,341 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,243,040 - 18,309,359 (-)NCBINCBI36Build 36hg18NCBI36
Celera223,715,110 - 3,780,635 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,482,976 - 3,549,921 (-)NCBIHuRef
CHM1_12219,862,754 - 19,929,123 (-)NCBICHM1_1
T2T-CHM13v2.02220,252,392 - 20,319,509 (-)NCBIT2T-CHM13v2.0
Txnrd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,245,167 - 18,297,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,245,134 - 18,297,823 (+)EnsemblGRCm39 Ensembl
GRCm381618,426,417 - 18,479,073 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,426,384 - 18,479,073 (+)EnsemblGRCm38mm10GRCm38
MGSCv371618,426,510 - 18,479,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,339,980 - 18,392,633 (+)NCBIMGSCv36mm8
Celera1619,000,768 - 19,053,648 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.41NCBI
Txnrd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,024,321 - 96,072,475 (-)NCBIGRCr8
mRatBN7.21182,519,996 - 82,568,156 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,519,999 - 82,568,156 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,248,515 - 91,296,556 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,909,738 - 83,957,780 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,963,250 - 83,011,292 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,667,994 - 86,716,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,667,997 - 86,716,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,762,304 - 89,809,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,513,361 - 84,561,673 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,553,962 - 84,602,292 (-)NCBI
Celera1181,297,140 - 81,345,203 (-)NCBICelera
Cytogenetic Map11q23NCBI
TXNRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22329,502,482 - 29,570,007 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12232,050,064 - 32,117,323 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,636,703 - 2,704,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12218,310,134 - 18,375,681 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2218,311,714 - 18,375,497 (-)Ensemblpanpan1.1panPan2
TXNRD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,381,823 - 29,430,239 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,381,975 - 29,430,206 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,338,309 - 29,387,889 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,783,348 - 30,833,188 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,783,323 - 30,833,184 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,831,592 - 28,881,196 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,456,722 - 28,506,335 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,542,394 - 29,592,091 (+)NCBIUU_Cfam_GSD_1.0
Txnrd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118138,906,728 - 138,964,122 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366193,791,418 - 3,847,626 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366193,789,940 - 3,847,286 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNRD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,356,831 - 51,383,262 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,355,731 - 51,385,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,992,386 - 55,021,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TXNRD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,803,178 - 5,868,224 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl195,813,099 - 5,866,674 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660851,062,817 - 1,128,610 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txnrd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624747514,158 - 569,154 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624747485,012 - 569,175 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000021694   ⟹   ENSCLAP00000021491
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544218,152,152 - 18,204,327 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000021695   ⟹   ENSCLAP00000021492
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544218,152,152 - 18,204,327 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000021696   ⟹   ENSCLAP00000021493
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544218,152,152 - 18,204,327 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000021697   ⟹   ENSCLAP00000021494
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544218,152,155 - 18,204,321 (+)Ensembl
RefSeq Acc Id: XM_013517794   ⟹   XP_013373248
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544218,150,060 - 18,205,775 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013517795   ⟹   XP_013373249
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544218,150,060 - 18,205,775 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013517796   ⟹   XP_013373250
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544218,152,135 - 18,205,775 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013517797   ⟹   XP_013373251
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544218,152,135 - 18,205,775 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013517798   ⟹   XP_013373252
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544218,152,168 - 18,205,775 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013517799   ⟹   XP_013373253
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544218,154,420 - 18,205,775 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013517800   ⟹   XP_013373254
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544218,155,929 - 18,205,775 (+)NCBI
Sequence:
RefSeq Acc Id: XP_013373248   ⟸   XM_013517794
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VYT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373249   ⟸   XM_013517795
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VYT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373250   ⟸   XM_013517796
- Peptide Label: isoform X3
- UniProtKB: A0A8C2W339 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373251   ⟸   XM_013517797
- Peptide Label: isoform X4
- UniProtKB: A0A8C2W339 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373252   ⟸   XM_013517798
- Peptide Label: isoform X5
- UniProtKB: A0A8C2W339 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373253   ⟸   XM_013517799
- Peptide Label: isoform X6
- UniProtKB: A0A8C2W339 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373254   ⟸   XM_013517800
- Peptide Label: isoform X7
- UniProtKB: A0A8C2VYT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000021492   ⟸   ENSCLAT00000021695
RefSeq Acc Id: ENSCLAP00000021491   ⟸   ENSCLAT00000021694
RefSeq Acc Id: ENSCLAP00000021494   ⟸   ENSCLAT00000021697
RefSeq Acc Id: ENSCLAP00000021493   ⟸   ENSCLAT00000021696

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014718 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021694 ENTREZGENE
  ENSCLAT00000021694.1 UniProtKB/TrEMBL
  ENSCLAT00000021695.1 UniProtKB/TrEMBL
  ENSCLAT00000021696.1 UniProtKB/TrEMBL
  ENSCLAT00000021697.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.30 UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/TrEMBL
  FAD/NAD-linked_Rdtase_dimer_sf UniProtKB/TrEMBL
  GSHR/TRXR-like UniProtKB/TrEMBL
  Pyr_nuc-diS_OxRdtase UniProtKB/TrEMBL
  Pyr_nucl-diS_OxRdtase_dimer UniProtKB/TrEMBL
  Pyr_OxRdtase_I_AS UniProtKB/TrEMBL
NCBI Gene Txnrd2 ENTREZGENE
PANTHER GLUTATHIONE REDUCTASE UniProtKB/TrEMBL
  THIOREDOXIN REDUCTASE 2 UniProtKB/TrEMBL
Pfam Pyr_redox_2 UniProtKB/TrEMBL
  Pyr_redox_dim UniProtKB/TrEMBL
PIRSF Mercury_reductase_MerA UniProtKB/TrEMBL
PRINTS FADPNR UniProtKB/TrEMBL
  PNDRDTASEI UniProtKB/TrEMBL
PROSITE PYRIDINE_REDOX_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
  SSF55424 UniProtKB/TrEMBL
UniProt A0A8C2VW22_CHILA UniProtKB/TrEMBL
  A0A8C2VYT9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W159_CHILA UniProtKB/TrEMBL
  A0A8C2W339 ENTREZGENE, UniProtKB/TrEMBL