MCU (mitochondrial calcium uniporter) - Rat Genome Database

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Gene: MCU (mitochondrial calcium uniporter) Chlorocebus sabaeus
Analyze
Symbol: MCU
Name: mitochondrial calcium uniporter
RGD ID: 18563414
Description: ENCODES a protein that exhibits identical protein binding (ortholog); uniporter activity (ortholog); INVOLVED IN mitochondrial calcium ion homeostasis (ortholog); mitochondrial calcium ion transmembrane transport (ortholog); positive regulation of mitochondrial calcium ion concentration (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; FOUND IN mitochondrial inner membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcium uniporter protein, mitochondrial; LOC103216017; uncharacterized LOC103216017
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1958,383,650 - 58,594,542 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl958,383,235 - 58,571,480 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604818,983,576 - 19,197,698 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MCU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1958,383,650 - 58,594,542 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl958,383,235 - 58,571,480 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604818,983,576 - 19,197,698 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MCU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381072,692,143 - 72,887,694 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1072,692,143 - 72,887,694 (+)EnsemblGRCh38hg38GRCh38
GRCh371074,451,901 - 74,647,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,121,895 - 74,317,458 (+)NCBINCBI36Build 36hg18NCBI36
Build 341074,121,894 - 74,317,456NCBI
Celera1067,737,028 - 67,932,591 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1068,445,749 - 68,641,292 (+)NCBIHuRef
CHM1_11074,733,636 - 74,929,181 (+)NCBICHM1_1
T2T-CHM13v2.01073,563,507 - 73,759,075 (+)NCBIT2T-CHM13v2.0
Mcu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,282,806 - 59,453,231 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1059,282,806 - 59,452,514 (-)EnsemblGRCm39 Ensembl
GRCm381059,446,984 - 59,617,409 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,446,984 - 59,616,692 (-)EnsemblGRCm38mm10GRCm38
MGSCv371058,911,181 - 59,079,440 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361058,843,954 - 58,853,517 (-)NCBIMGSCv36mm8
Celera1060,548,700 - 60,716,418 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.55NCBI
Mcu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,960,520 - 28,123,103 (-)NCBIGRCr8
mRatBN7.22027,417,529 - 27,580,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,417,526 - 27,580,110 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2028,428,977 - 28,592,231 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02027,815,235 - 27,978,481 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02028,559,862 - 28,721,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02029,037,452 - 29,199,224 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,038,480 - 29,199,224 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02030,840,963 - 31,003,860 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2028,862,404 - 29,023,532 (-)NCBICelera
Cytogenetic Map20q11NCBI
Mcu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,752,584 - 18,936,507 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543718,750,779 - 18,800,149 (-)NCBIChiLan1.0ChiLan1.0
MCU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2884,870,738 - 85,063,141 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11084,876,077 - 85,068,463 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,243,282 - 69,435,193 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11071,707,819 - 71,898,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1071,845,335 - 71,898,545 (+)Ensemblpanpan1.1panPan2
MCU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,309,376 - 23,508,480 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,309,391 - 23,506,586 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha423,429,107 - 23,646,906 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0423,576,055 - 23,794,462 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl423,594,897 - 23,794,509 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1423,475,570 - 23,693,680 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0423,674,337 - 23,892,420 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,029,405 - 24,247,491 (+)NCBIUU_Cfam_GSD_1.0
Mcu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,636,667 - 57,698,310 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365216,131,216 - 6,313,830 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365216,129,392 - 6,191,035 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,678,393 - 75,721,500 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11475,518,533 - 75,721,502 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21481,585,088 - 81,788,094 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Mcu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247546,445,741 - 6,618,806 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000006653   ⟹   ENSCSAP00000004854
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl958,383,235 - 58,571,480 (-)Ensembl
RefSeq Acc Id: XM_007963100   ⟹   XP_007961291
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1958,383,650 - 58,594,542 (-)NCBI
Vero_WHO_p1.0NW_02366604818,983,576 - 19,197,698 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005244127
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604818,983,576 - 19,197,683 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007961291 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004854
  ENSCSAP00000004854.1
RefSeq Acc Id: XP_007961291   ⟸   XM_007963100
- UniProtKB: A0A0D9R8B5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000004854   ⟸   ENSCSAT00000006653


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008594 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006653.1 UniProtKB/TrEMBL
InterPro MCU_C UniProtKB/TrEMBL
  MCU_fam UniProtKB/TrEMBL
NCBI Gene MCU ENTREZGENE
PANTHER CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR13462 UniProtKB/TrEMBL
Pfam MCU UniProtKB/TrEMBL
UniProt A0A0D9R8B5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-03 MCU  mitochondrial calcium uniporter  LOC103216017  uncharacterized LOC103216017  Data merged from RGD:18489606 737654 PROVISIONAL