Mcu (mitochondrial calcium uniporter) - Rat Genome Database

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Gene: Mcu (mitochondrial calcium uniporter) Heterocephalus glaber
Analyze
Symbol: Mcu
Name: mitochondrial calcium uniporter
RGD ID: 18909800
Description: ENCODES a protein that exhibits identical protein binding (ortholog); uniporter activity (ortholog); INVOLVED IN calcium import into the mitochondrion (ortholog); calcium-mediated signaling (ortholog); glucose homeostasis (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN calcium channel complex (ortholog); mitochondrial inner membrane (ortholog); uniplex complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcium uniporter protein, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247546,445,741 - 6,618,806 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Mcu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247546,445,741 - 6,618,806 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MCU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381072,692,143 - 72,887,694 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1072,692,143 - 72,887,694 (+)EnsemblGRCh38hg38GRCh38
GRCh371074,451,901 - 74,647,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,121,895 - 74,317,458 (+)NCBINCBI36Build 36hg18NCBI36
Build 341074,121,894 - 74,317,456NCBI
Celera1067,737,028 - 67,932,591 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1068,445,749 - 68,641,292 (+)NCBIHuRef
CHM1_11074,733,636 - 74,929,181 (+)NCBICHM1_1
T2T-CHM13v2.01073,563,507 - 73,759,075 (+)NCBIT2T-CHM13v2.0
Mcu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,282,806 - 59,453,231 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1059,282,806 - 59,452,514 (-)EnsemblGRCm39 Ensembl
GRCm381059,446,984 - 59,617,409 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,446,984 - 59,616,692 (-)EnsemblGRCm38mm10GRCm38
MGSCv371058,911,181 - 59,079,440 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361058,843,954 - 58,853,517 (-)NCBIMGSCv36mm8
Celera1060,548,700 - 60,716,418 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.55NCBI
Mcu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,960,520 - 28,123,103 (-)NCBIGRCr8
mRatBN7.22027,417,529 - 27,580,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,417,526 - 27,580,110 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2028,428,977 - 28,592,231 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02027,815,235 - 27,978,481 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02028,559,862 - 28,721,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02029,037,452 - 29,199,224 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,038,480 - 29,199,224 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02030,840,963 - 31,003,860 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2028,862,404 - 29,023,532 (-)NCBICelera
Cytogenetic Map20q11NCBI
Mcu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,752,584 - 18,936,507 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543718,750,779 - 18,800,149 (-)NCBIChiLan1.0ChiLan1.0
MCU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2884,870,738 - 85,063,141 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11084,876,077 - 85,068,463 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,243,282 - 69,435,193 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11071,707,819 - 71,898,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1071,845,335 - 71,898,545 (+)Ensemblpanpan1.1panPan2
MCU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,309,376 - 23,508,480 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,309,391 - 23,506,586 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha423,429,107 - 23,646,906 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0423,576,055 - 23,794,462 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl423,594,897 - 23,794,509 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1423,475,570 - 23,693,680 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0423,674,337 - 23,892,420 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,029,405 - 24,247,491 (+)NCBIUU_Cfam_GSD_1.0
Mcu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,636,667 - 57,698,310 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365216,131,216 - 6,313,830 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365216,129,392 - 6,191,035 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,678,393 - 75,721,500 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11475,518,533 - 75,721,502 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21481,585,088 - 81,788,094 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1958,383,650 - 58,594,542 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl958,383,235 - 58,571,480 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604818,983,576 - 19,197,698 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_004846251   ⟹   XP_004846308
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247546,445,741 - 6,618,806 (+)NCBI
RefSeq Acc Id: XM_004846252   ⟹   XP_004846309
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247546,573,261 - 6,618,806 (+)NCBI
RefSeq Acc Id: XM_021259606   ⟹   XP_021115265
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247546,535,640 - 6,618,806 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004846308 (Get FASTA)   NCBI Sequence Viewer  
  XP_004846309 (Get FASTA)   NCBI Sequence Viewer  
  XP_021115265 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000020275
Reference Protein Sequences
RefSeq Acc Id: XP_004846308   ⟸   XM_004846251
- Peptide Label: isoform X1
- UniProtKB: G5C2H8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021115265   ⟸   XM_021259606
- Peptide Label: isoform X2
- UniProtKB: G5C2H8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004846309   ⟸   XM_004846252
- Peptide Label: isoform X3
- UniProtKB: G5C2H8 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014506 ENTREZGENE
Ensembl Transcript ENSHGLT00000020477 ENTREZGENE
InterPro MCU_C UniProtKB/TrEMBL
  MCU_fam UniProtKB/TrEMBL
NCBI Gene Mcu ENTREZGENE
PANTHER CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL UniProtKB/TrEMBL
  CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam MCU UniProtKB/TrEMBL
UniProt G5C2H8 ENTREZGENE, UniProtKB/TrEMBL