KLF2 (KLF transcription factor 2) - Rat Genome Database

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Gene: KLF2 (KLF transcription factor 2) Chlorocebus sabaeus
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Symbol: KLF2
Name: KLF transcription factor 2
RGD ID: 18407882
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN cellular response to endothelin (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to interleukin-1 (ortholog); ASSOCIATED WITH Colorectal Neoplasms (ortholog); COVID-19 (ortholog); lung disease (ortholog); FOUND IN chromatin (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Krueppel-like factor 2; Kruppel like factor 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1614,832,013 - 14,834,744 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl614,832,029 - 14,837,462 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660744,637,274 - 4,640,383 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF2Green MonkeyCOVID-19  ISORGD:13517019068941mRNA:decreased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226|REF_RGD_ID:28912744
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF2Green Monkeyprimary immunodeficiency disease  ISORGD:13517018554872ClinVar Annotator: match by term: Inherited Immunodeficiency DiseasesClinVar 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF2Green MonkeyColorectal Neoplasms  ISORGD:13517019068941CTD Direct Evidence: marker/mechanismCTDPMID:30510241
KLF2Green Monkeylung disease  ISORGD:13517019068941CTD Direct Evidence: marker/mechanismCTDPMID:21053160


Biological Process
1 to 20 of 28 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF2Green Monkeycell morphogenesis acts_upstream_of_or_withinIEAUniProtKB:Q60843|ensembl:ENSMUSP00000064823150520179 EnsemblGO_REF:0000107
KLF2Green Monkeycellular response to endothelin  ISORGD:13592209068941 RGDPMID:18406357|REF_RGD_ID:2316543
KLF2Green Monkeycellular response to fluid shear stress involved_inIEAUniProtKB:Q9Y5W3|ensembl:ENSP00000248071150520179 EnsemblGO_REF:0000107
KLF2Green Monkeycellular response to hydrogen peroxide  ISORGD:13592209068941 RGDPMID:18406357|REF_RGD_ID:2316543
KLF2Green Monkeycellular response to interleukin-1  ISORGD:13592209068941 RGDPMID:18406357|REF_RGD_ID:2316543
KLF2Green Monkeycellular response to laminar fluid shear stress involved_inIEAUniProtKB:Q9Y5W3|ensembl:ENSP00000248071150520179 EnsemblGO_REF:0000107
KLF2Green Monkeycellular response to tumor necrosis factor  ISORGD:13592209068941 RGDPMID:18406357|REF_RGD_ID:2316543
KLF2Green Monkeycellular stress response to acid chemical involved_inIEAUniProtKB:Q9Y5W3|ensembl:ENSP00000248071150520179 EnsemblGO_REF:0000107
KLF2Green Monkeyepigenetic regulation of gene expression acts_upstream_of_or_withinIEAUniProtKB:Q60843|ensembl:ENSMUSP00000064823150520179 EnsemblGO_REF:0000107
KLF2Green Monkeyerythrocyte homeostasis acts_upstream_of_or_withinIEAUniProtKB:Q60843|ensembl:ENSMUSP00000064823150520179 EnsemblGO_REF:0000107
KLF2Green Monkeyerythrocyte maturation acts_upstream_of_or_withinIEAUniProtKB:Q60843|ensembl:ENSMUSP00000064823150520179 EnsemblGO_REF:0000107
KLF2Green Monkeyin utero embryonic development acts_upstream_of_or_withinIEAUniProtKB:Q60843|ensembl:ENSMUSP00000064823150520179 EnsemblGO_REF:0000107
KLF2Green Monkeymulticellular organism growth acts_upstream_of_or_withinIEAUniProtKB:Q60843|ensembl:ENSMUSP00000064823150520179 EnsemblGO_REF:0000107
KLF2Green Monkeynegative regulation of interleukin-6 production  ISORGD:13592209068941 RGDPMID:19192484|REF_RGD_ID:2316542
KLF2Green Monkeynegative regulation of sprouting angiogenesis involved_inIEAUniProtKB:Q9Y5W3|ensembl:ENSP00000248071150520179 EnsemblGO_REF:0000107
KLF2Green Monkeynegative regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:Q9Y5W3|ensembl:ENSP00000248071150520179 EnsemblGO_REF:0000107
KLF2Green Monkeypositive regulation of DNA-templated transcription  ISORGD:13592209068941 RGDPMID:15540987|REF_RGD_ID:2316547
KLF2Green Monkeypositive regulation of DNA-templated transcription involved_inIEAUniProtKB:Q9Y5W3|ensembl:ENSP00000248071150520179 EnsemblGO_REF:0000107
KLF2Green Monkeypositive regulation of DNA-templated transcription acts_upstream_of_or_withinIEAUniProtKB:Q60843|ensembl:ENSMUSP00000064823150520179 EnsemblGO_REF:0000107
KLF2Green Monkeypositive regulation of nitric oxide biosynthetic process acts_upstream_ofIEAUniProtKB:Q9Y5W3|ensembl:ENSP00000248071150520179 EnsemblGO_REF:0000107
1 to 20 of 28 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF2Green Monkeychromatin located_inIEAUniProtKB:Q9Y5W3|ensembl:ENSP00000248071150520179 EnsemblGO_REF:0000107
KLF2Green Monkeynucleus located_inIEAUniProtKB:Q60843|ensembl:ENSMUSP00000064823150520179 EnsemblGO_REF:0000107

Molecular Function
1 to 10 of 10 rows

  
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
KLF2Green MonkeyDNA binding enablesIEAUniProtKB:Q9Y5W3|ensembl:ENSP00000248071150520179 EnsemblGO_REF:0000107
KLF2Green MonkeyDNA-binding transcription factor activity enablesIEAUniProtKB:Q60843|UniProtKB:Q9Y5W3|ensembl:ENSMUSP00000064823|ensembl:ENSP00000248071150520179 EnsemblGO_REF:0000107
KLF2Green MonkeyDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:Q9Y5W3|ensembl:ENSP00000248071150520179 EnsemblGO_REF:0000107
KLF2Green MonkeyDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAPANTHER:PTN007743409150520179 TreeGrafterGO_REF:0000118
KLF2Green Monkeyprotein binding enablesISOUniProtKB:Q928319068941 PMID:16617118IntActPMID:16617118
KLF2Green Monkeyprotein binding enablesISOUniProtKB:Q9HCE7|UniProtKB:Q9HCE7-29068941 PMID:21382345IntActPMID:21382345
KLF2Green Monkeyprotein binding enablesISOUniProtKB:Q8BZZ39068941 PMID:11375995UniProtPMID:11375995
KLF2Green MonkeyRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAPANTHER:PTN007743409150520179 TreeGrafterGO_REF:0000118
KLF2Green Monkeysequence-specific double-stranded DNA binding enablesIEAUniProtKB:Q9Y5W3|ensembl:ENSP00000248071150520179 EnsemblGO_REF:0000107
KLF2Green Monkeyzinc ion binding enablesIEAUniProtKB-KW:KW-0863150520179 UniProtGO_REF:0000043
1 to 10 of 10 rows

PMID:30032202  



KLF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1614,832,013 - 14,834,744 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl614,832,029 - 14,837,462 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660744,637,274 - 4,640,383 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
KLF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381916,324,826 - 16,328,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1916,324,826 - 16,328,685 (+)EnsemblGRCh38hg38GRCh38
GRCh371916,435,637 - 16,439,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,296,651 - 16,299,345 (+)NCBINCBI36Build 36hg18NCBI36
Build 341916,296,650 - 16,299,337NCBI
Celera1916,337,566 - 16,340,260 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1916,006,724 - 16,007,405 (+)NCBIHuRef
CHM1_11916,435,181 - 16,437,875 (+)NCBICHM1_1
T2T-CHM13v2.01916,459,702 - 16,463,562 (+)NCBIT2T-CHM13v2.0
Klf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,072,906 - 73,075,498 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl873,072,877 - 73,075,500 (+)EnsemblGRCm39 Ensembl
GRCm38872,319,062 - 72,321,654 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,319,033 - 72,321,656 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,842,961 - 74,845,553 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36875,248,022 - 75,250,338 (+)NCBIMGSCv36mm8
Celera876,656,424 - 76,659,017 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.99NCBI
Klf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,555,136 - 17,557,768 (-)NCBIGRCr8
mRatBN7.21617,521,107 - 17,523,739 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,514,552 - 17,523,944 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,587,223 - 17,589,173 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,720,530 - 18,722,483 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,640,143 - 17,642,093 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,223,087 - 19,225,037 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,223,087 - 19,225,037 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,084,196 - 19,086,146 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,941,780 - 17,943,730 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11617,941,777 - 17,943,728 (-)NCBI
Celera1617,739,313 - 17,741,263 (-)NCBICelera
Cytogenetic Map16p14NCBI
KLF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22021,194,451 - 21,197,283 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11920,200,667 - 20,203,238 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01915,812,506 - 15,815,244 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11916,792,497 - 16,794,143 (+)NCBIpanpan1.1PanPan1.1panPan2
KLF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12046,182,565 - 46,183,704 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,096,492 - 46,098,925 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02046,670,279 - 46,672,712 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2046,670,789 - 46,672,713 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12045,904,933 - 45,907,365 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02046,316,205 - 46,318,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02046,591,720 - 46,594,153 (-)NCBIUU_Cfam_GSD_1.0
KLF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl261,270,199 - 61,273,138 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1261,270,733 - 61,273,037 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2260,903,997 - 60,904,625 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Klf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,021,865 - 1,023,279 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in KLF2
38 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20


RefSeq Transcripts XM_007995639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JBLKOC010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000003798   ⟹   ENSCSAP00000002072
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl614,832,029 - 14,837,462 (+)Ensembl
RefSeq Acc Id: XM_007995639   ⟹   XP_007993830
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1614,832,013 - 14,834,744 (+)NCBI
Vero_WHO_p1.0NW_0236660744,637,274 - 4,640,383 (-)NCBI
Sequence:
Protein RefSeqs XP_007993830 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000002072
  ENSCSAP00000002072.1
RefSeq Acc Id: XP_007993830   ⟸   XM_007995639
- UniProtKB: A0A0D9R0D3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000002072   ⟸   ENSCSAT00000003798



1 to 15 of 15 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000005764 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003798.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report csab:103234105 UniProtKB/TrEMBL
NCBI Gene KLF2 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 2 UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A0D9R0D3 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-12 KLF2  KLF transcription factor 2  KLF2  Kruppel like factor 2  Symbol and/or name change 5135510 APPROVED