RIOK2 (RIO kinase 2) - Rat Genome Database

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Gene: RIOK2 (RIO kinase 2) Chlorocebus sabaeus
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Symbol: RIOK2
Name: RIO kinase 2
RGD ID: 18391766
Description: ENCODES a protein that exhibits ATP binding (inferred); protein kinase activity (inferred); protein serine/threonine kinase activity (inferred); INVOLVED IN maturation of SSU-rRNA (inferred); positive regulation of ribosomal small subunit export from nucleus (inferred); positive regulation of rRNA processing (inferred); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC103247849; serine/threonine-protein kinase RIO2; serine/threonine-protein kinase RIO2-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1490,992,940 - 91,010,016 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl490,996,371 - 91,010,036 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604939,647,567 - 39,671,772 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RIOK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1490,992,940 - 91,010,016 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl490,996,371 - 91,010,036 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604939,647,567 - 39,671,772 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
RIOK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38597,160,867 - 97,183,247 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl597,160,867 - 97,183,247 (-)EnsemblGRCh38hg38GRCh38
GRCh37596,496,571 - 96,518,951 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36596,524,397 - 96,544,700 (-)NCBINCBI36Build 36hg18NCBI36
Build 34596,524,396 - 96,544,700NCBI
Celera592,380,971 - 92,403,748 (-)NCBICelera
Cytogenetic Map5q15NCBI
HuRef591,686,274 - 91,709,022 (-)NCBIHuRef
CHM1_1595,929,175 - 95,951,630 (-)NCBICHM1_1
T2T-CHM13v2.0597,661,631 - 97,684,062 (-)NCBIT2T-CHM13v2.0
Riok2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391717,594,594 - 17,615,161 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1717,594,571 - 17,615,161 (+)EnsemblGRCm39 Ensembl
GRCm381717,374,332 - 17,394,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1717,374,309 - 17,394,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv371717,511,296 - 17,531,863 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361717,074,154 - 17,098,589 (+)NCBIMGSCv36mm8
Celera1718,322,390 - 18,343,205 (+)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map179.77NCBI
Riok2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,776,215 - 66,792,480 (+)NCBIGRCr8
mRatBN7.2158,103,132 - 58,119,397 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl158,103,084 - 58,120,512 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx162,941,961 - 62,958,386 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0171,633,479 - 71,649,966 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0164,851,986 - 64,868,412 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0159,130,008 - 59,146,457 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl159,129,951 - 59,146,776 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0160,057,339 - 60,073,788 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4155,897,247 - 55,913,533 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1155,900,191 - 55,916,476 (+)NCBI
Celera154,297,817 - 54,314,118 (+)NCBICelera
Cytogenetic Map1q12NCBI
Riok2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541815,487,248 - 15,513,831 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541815,487,248 - 15,509,490 (+)NCBIChiLan1.0ChiLan1.0
RIOK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2492,412,899 - 92,433,579 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1590,566,534 - 90,587,226 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0592,473,239 - 92,494,763 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1598,026,237 - 98,048,360 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl598,028,426 - 98,048,256 (-)Ensemblpanpan1.1panPan2
RIOK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1312,548,830 - 12,571,312 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl312,548,847 - 12,571,298 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha313,888,964 - 13,911,359 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0312,432,261 - 12,454,732 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl312,432,300 - 12,456,110 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1312,386,660 - 12,409,131 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0312,387,940 - 12,410,400 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0312,587,610 - 12,610,085 (+)NCBIUU_Cfam_GSD_1.0
Riok2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213168,108,339 - 168,128,473 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365236,293,710 - 6,314,999 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365236,293,735 - 6,313,840 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIOK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12103,802,044 - 103,823,566 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22107,632,269 - 107,655,935 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Riok2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474315,808,445 - 15,828,415 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 7 55
Low 13 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000012328   ⟹   ENSCSAP00000010369
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl490,996,371 - 91,010,036 (-)Ensembl
RefSeq Acc Id: XM_037982235   ⟹   XP_037838163
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604939,647,567 - 39,671,772 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037838163 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010369.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000010369   ⟸   ENSCSAT00000012328
RefSeq Acc Id: XP_037838163   ⟸   XM_037982235


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014233 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012328.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Rio2 UniProtKB/TrEMBL
  RIO_kinase UniProtKB/TrEMBL
  RIO_kinase_CS UniProtKB/TrEMBL
NCBI Gene RIOK2 ENTREZGENE
PANTHER SER/THR-PROTEIN KINASE RIO2 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE RIO2 UniProtKB/TrEMBL
Pfam RIO1 UniProtKB/TrEMBL
PROSITE RIO1 UniProtKB/TrEMBL
SMART RIO UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9RP30_CHLSB UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-03 RIOK2  RIO kinase 2  LOC103247849  serine/threonine-protein kinase RIO2-like  Data merged from RGD:18489611 737654 PROVISIONAL