DIO2 (iodothyronine deiodinase 2)

Gene: DIO2 (iodothyronine deiodinase 2) Chlorocebus sabaeus

Analyze

Symbol:

DIO2

Name:

iodothyronine deiodinase 2

RGD ID:

18384100

Description:

ENCODES a protein that exhibits thyroxine 5'-deiodinase activity (ortholog); thyroxine 5-deiodinase activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN brown fat cell differentiation (ortholog); cellular lipid metabolic process (ortholog); positive regulation of cold-induced thermogenesis (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); endometriosis (ortholog); genetic disease (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

deiodinase, iodothyronine type II; LOC103229433; type II iodothyronine deiodinase; uncharacterized LOC103229433

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	57,521,806 - 57,536,508 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666053	45,260,845 - 45,447,678 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

endometriosis (ISO)

genetic disease (ISO)

hypertension (ISO)

Insulin Resistance (ISO)

Mesothelioma (ISO)

Metabolic Syndrome (ISO)

obesity (ISO)

thyroid gland disease (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brown fat cell differentiation (ISO)

cellular lipid metabolic process (ISO)

positive regulation of cold-induced thermogenesis (ISO)

response to lipopolysaccharide (ISO)

thyroid hormone catabolic process (ISO)

thyroid hormone generation (ISO)

thyroid hormone metabolic process (ISO)

Molecular Function

thyroxine 5'-deiodinase activity (ISO)

thyroxine 5-deiodinase activity (ISO)

ubiquitin protein ligase binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DIO2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	57,521,806 - 57,536,508 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666053	45,260,845 - 45,447,678 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

DIO2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	80,197,526 - 80,231,057 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	80,197,526 - 80,387,757 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	80,663,869 - 80,697,400 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	79,733,622 - 79,748,278 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	79,733,622 - 79,748,276	NCBI
Celera	14	60,701,940 - 60,716,595 (-)	NCBI		Celera
Cytogenetic Map	14	q31.1	NCBI
HuRef	14	60,829,594 - 60,863,130 (-)	NCBI		HuRef
CHM1_1	14	80,604,355 - 80,637,840 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	74,407,785 - 74,441,322 (-)	NCBI		T2T-CHM13v2.0

Dio2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	90,691,326 - 90,705,812 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	90,691,326 - 90,705,812 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	90,724,552 - 90,739,038 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	90,724,552 - 90,738,438 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	91,962,992 - 91,976,878 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	91,129,943 - 91,143,828 (-)	NCBI		MGSCv36	mm8
Celera	12	92,060,514 - 92,074,181 (-)	NCBI		Celera
Cytogenetic Map	12	D3	NCBI
cM Map	12	44.05	NCBI

Dio2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	115,396,308 - 115,410,594 (-)	NCBI		GRCr8
mRatBN7.2	6	109,665,523 - 109,679,809 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	109,665,523 - 109,679,809 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	109,817,319 - 109,831,629 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	110,116,102 - 110,130,412 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	109,485,837 - 109,500,136 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	114,475,156 - 114,489,443 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	114,476,142 - 114,476,723 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	123,743,030 - 123,752,835 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	114,307,758 - 114,317,563 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	107,438,850 - 107,453,155 (-)	NCBI		Celera
RH 3.4 Map	6	755.1	RGD
Cytogenetic Map	6	q31	NCBI

Dio2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	3,950,983 - 3,960,355 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	3,946,830 - 3,961,049 (-)	NCBI	ChiLan1.0	ChiLan1.0

DIO2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	81,289,683 - 81,308,269 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	80,506,186 - 80,527,254 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	60,756,781 - 60,775,255 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	79,956,305 - 79,970,938 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

DIO2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	52,686,211 - 52,695,226 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	52,686,211 - 52,695,226 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	52,244,364 - 52,253,381 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	52,915,654 - 52,924,683 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	52,910,578 - 53,101,827 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	52,604,180 - 52,613,191 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	52,606,880 - 52,615,892 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	52,999,420 - 53,008,436 (-)	NCBI		UU_Cfam_GSD_1.0

Dio2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	23,285,838 - 23,299,412 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936488	8,769,555 - 8,783,157 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DIO2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	103,096,433 - 103,323,258 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	103,096,414 - 103,110,749 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	109,299,323 - 109,308,576 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Dio2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624734	21,787,705 - 21,802,096 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007987466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037984328	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037984329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037984330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037984331	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037984332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037984333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_007987466 ⟹ XP_007985657

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	24	57,521,806 - 57,536,508 (-)	NCBI
Vero_WHO_p1.0	NW_023666053	45,260,845 - 45,377,811 (-)	NCBI

Sequence:

show sequence

ATGGCTATTTTTGACCATTTTCCTTTGTTTCTTTTGGTCTAGTGCATTGGGTCAAGGATTTAGG
AAGAAAGAAGAGATTGAGTCATAGTTTCAGAAAAGAAAGGAGGGTGAAGGGGAACCAGAGCGCA
CAAGGGAACTGACTCAGGAGGCAGAGAAGATGGGCATCCTCAGCGTAGACTTGCTGATCACACT
GCAAATTCTGCCAGTTTTTTTCTCCAACTGCCTCTTCCTGGCGCTCTATGACTCGGTCATTCTG
CTCAAGCACGTGGTGCTGCTGTTGAGCCGCTCCAAGTCCACTCGCGGAGAGTGGCGGCGCATGC
TGACCTCAGAGGGACTGCGCTGCGTCTGGAAGAGCTTCCTCCTCGATGCCTACAAACAGCTAAA
TTGTCCTCCATCAGGTTTTAGCAAAGATGGACACATTTTATGACTAGTATATGAAGCTTATAAA
AGCAGACTACTGGTCTACTCACATTTGGATTTATGGATGGTGAAATTGGGTGAGGATGCCCCCA
ATTCCAGTGTGGTGCATGTCTCCAGTGCAGAAGGAGGTGACAACAGTGGCCACGGTACCCAGGA
GAAGATAGCTGAGGGCGCCGCATGCCACCTCCTTGACTTTGCTAGCCCTGAGCGCCCACTAGTG
GTCAACTTTGGTTCAGCCACTTGACCTCCTTTCACGAGCCAGCTGCCAGCCTTCCGCAAACTGG
TGGAAGAGTTCTCCTCAGTGGCCGACTTCCTGCTGGTCTACATTGATGAGGCTCATCCATCAGA
TGGCTGGGCGATACCTGGGGACTCCTCTTTGTCTTTTGAGGTGAAGAAGCACCAGAACCAGGAA
GATCGATGTGCAGCAGCCCAGCAGCTTCTGGAGCGTTTCTCCTTGCCGCCCCAGTGCCGAGTTG
TGGCTGACCGCATGGACAATAATGCCAACATAGCTTACGGGGTAGCCTTTGAACGTGTGTGCAT
TGTGCAGAGACAGAAAATCGCTTATCTGGGAGGAAAGGGCCCCTTCTCCTACAACCTTCAAGAA
GTCCGGCATTGGCTGGAGAAGAATTTCAGCAAGAGATGAAAGAAAACTAGATTAGCTGGTTAAA
GGTATGATTATAAGAGAGCTCATTGTTTTATAAAGTTATATAAAGGCAAGGACATTAAGAACTG
AATCCCTATTTCAACAGAGCCCTATTGGCTTACTGAAAGACAGAAGTTTATCGGAAGAACATGA
ATCTCT

hide sequence

RefSeq Acc Id:

XM_037984328 ⟹ XP_037840256

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666053	45,260,845 - 45,447,678 (-)	NCBI

RefSeq Acc Id:

XM_037984329 ⟹ XP_037840257

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666053	45,260,845 - 45,275,042 (-)	NCBI

RefSeq Acc Id:

XM_037984330 ⟹ XP_037840258

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666053	45,260,845 - 45,279,537 (-)	NCBI

RefSeq Acc Id:

XM_037984331 ⟹ XP_037840259

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666053	45,260,845 - 45,377,804 (-)	NCBI

RefSeq Acc Id:

XM_037984332 ⟹ XP_037840260

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666053	45,266,017 - 45,377,809 (-)	NCBI

RefSeq Acc Id:

XM_037984333 ⟹ XP_037840261

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666053	45,260,845 - 45,279,377 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007985657	(Get FASTA)	NCBI Sequence Viewer
	XP_037840256	(Get FASTA)	NCBI Sequence Viewer
	XP_037840257	(Get FASTA)	NCBI Sequence Viewer
	XP_037840258	(Get FASTA)	NCBI Sequence Viewer
	XP_037840259	(Get FASTA)	NCBI Sequence Viewer
	XP_037840260	(Get FASTA)	NCBI Sequence Viewer
	XP_037840261	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_007985657 ⟸ XM_007987466
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_037840256 ⟸ XM_037984328
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_037840259 ⟸ XM_037984331
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_037840258 ⟸ XM_037984330
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_037840261 ⟸ XM_037984333
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_037840257 ⟸ XM_037984329
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_037840260 ⟸ XM_037984332
- Peptide Label:	isoform X3

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	DIO2	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-03	DIO2	iodothyronine deiodinase 2	LOC103229433	uncharacterized LOC103229433	Data merged from RGD:18539167	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD