COBL (cordon-bleu WH2 repeat protein) - Rat Genome Database

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Gene: COBL (cordon-bleu WH2 repeat protein) Chlorocebus sabaeus
Analyze
Symbol: COBL
Name: cordon-bleu WH2 repeat protein
RGD ID: 18368593
Description: ENCODES a protein that exhibits actin monomer binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); collateral sprouting in absence of injury (ortholog); digestive tract development (ortholog); ASSOCIATED WITH genetic disease (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN axon (ortholog); cell cortex (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein cordon-bleu
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1217,501,647 - 7,803,175 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl217,598,126 - 7,803,177 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606214,578,093 - 14,882,079 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
COBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1217,501,647 - 7,803,175 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl217,598,126 - 7,803,177 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606214,578,093 - 14,882,079 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
COBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38751,016,212 - 51,316,809 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl751,016,212 - 51,316,818 (-)EnsemblGRCh38hg38GRCh38
GRCh37751,083,909 - 51,384,506 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36751,051,404 - 51,351,990 (-)NCBINCBI36Build 36hg18NCBI36
Build 34750,858,118 - 51,158,705NCBI
Celera751,148,737 - 51,449,348 (-)NCBICelera
Cytogenetic Map7p12.1NCBI
HuRef750,933,696 - 51,137,285 (-)NCBIHuRef
CHM1_1751,086,207 - 51,386,564 (-)NCBICHM1_1
T2T-CHM13v2.0751,177,453 - 51,478,069 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2751,089,893 - 51,390,521 (-)NCBI
Cobl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391112,186,676 - 12,415,022 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1112,186,608 - 12,414,960 (-)EnsemblGRCm39 Ensembl
GRCm381112,236,676 - 12,465,022 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1112,236,608 - 12,464,960 (-)EnsemblGRCm38mm10GRCm38
MGSCv371112,136,679 - 12,364,963 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361112,136,681 - 12,364,803 (-)NCBIMGSCv36mm8
Celera1112,678,618 - 12,909,422 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map117.3NCBI
Cobl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81491,041,721 - 91,274,272 (-)NCBIGRCr8
mRatBN7.21486,828,137 - 87,060,682 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1486,828,139 - 87,060,800 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1491,237,296 - 91,483,692 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01492,481,631 - 92,728,031 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01488,949,260 - 89,195,657 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01492,341,949 - 92,497,169 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1492,342,957 - 92,577,936 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01492,142,186 - 92,321,314 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41493,154,637 - 93,309,406 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11492,994,412 - 93,340,571 (-)NCBI
Celera1485,826,388 - 85,975,943 (-)NCBICelera
Cytogenetic Map14q21NCBI
COBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2655,888,527 - 56,188,488 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17104,213,250 - 104,513,211 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0751,652,318 - 51,952,256 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1751,894,468 - 52,114,849 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl751,895,807 - 52,097,841 (-)Ensemblpanpan1.1panPan2
COBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1182,206,957 - 2,386,333 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl182,208,260 - 2,459,206 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha182,249,781 - 2,393,765 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0182,317,922 - 2,462,079 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl182,264,613 - 2,514,854 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1182,289,962 - 2,433,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0182,286,890 - 2,430,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0182,423,375 - 2,567,362 (-)NCBIUU_Cfam_GSD_1.0
Cobl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118105,650,726 - 105,902,001 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936686621,502 - 872,824 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.19136,850,521 - 137,055,249 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29150,659,325 - 150,667,343 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Cobl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247403,332,977 - 3,399,915 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 18 36
Low 17 12 24
Below cutoff 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000014124   ⟹   ENSCSAP00000012102
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl217,598,126 - 7,803,177 (+)Ensembl
RefSeq Acc Id: XM_007981295   ⟹   XP_007979486
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1217,501,664 - 7,803,175 (+)NCBI
Vero_WHO_p1.0NW_02366606214,578,093 - 14,882,078 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007981296   ⟹   XP_007979487
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1217,501,743 - 7,803,175 (+)NCBI
Vero_WHO_p1.0NW_02366606214,578,093 - 14,882,078 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007981297   ⟹   XP_007979488
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1217,501,647 - 7,803,175 (+)NCBI
Vero_WHO_p1.0NW_02366606214,578,093 - 14,882,079 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007981298   ⟹   XP_007979489
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1217,501,647 - 7,803,175 (+)NCBI
Vero_WHO_p1.0NW_02366606214,578,093 - 14,882,077 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007979486 (Get FASTA)   NCBI Sequence Viewer  
  XP_007979487 (Get FASTA)   NCBI Sequence Viewer  
  XP_007979488 (Get FASTA)   NCBI Sequence Viewer  
  XP_007979489 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000012102.1
Reference Protein Sequences
RefSeq Acc Id: XP_007979488   ⟸   XM_007981297
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RU13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007979489   ⟸   XM_007981298
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RU13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007979486   ⟸   XM_007981295
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RU13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007979487   ⟸   XM_007981296
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RU13 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000012102   ⟸   ENSCSAT00000014124


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016032 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014124.1 UniProtKB/TrEMBL
InterPro COBL-like UniProtKB/TrEMBL
  Cordon-bleu_ubiquitin_domain UniProtKB/TrEMBL
  WH2_dom UniProtKB/TrEMBL
NCBI Gene COBL ENTREZGENE
PANTHER PROTEIN CORDON-BLEU UniProtKB/TrEMBL
  PTHR47008 UniProtKB/TrEMBL
Pfam Cobl UniProtKB/TrEMBL
  WH2 UniProtKB/TrEMBL
PROSITE WH2 UniProtKB/TrEMBL
SMART WH2 UniProtKB/TrEMBL
UniProt A0A0D9RU13 ENTREZGENE, UniProtKB/TrEMBL