Mrgpra6 (MAS-related GPR, member A6) - Rat Genome Database

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Gene: Mrgpra6 (MAS-related GPR, member A6) Mus musculus
Analyze
No known orthologs.
Symbol: Mrgpra6
Name: MAS-related GPR, member A6
RGD ID: 1616392
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human MRGPRX4 (MAS related GPR family member X4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mas-related G-protein coupled receptor member A6; Mrg; MrgA6; MrgA6 G protein-coupled receptor
RGD Orthologs
Alliance Genes
More Info homologs ...
Related Pseudogenes: Mrgprx3-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
NCBI Annotation Information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,835,465 - 46,839,164 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,835,455 - 46,854,668 (-)EnsemblGRCm39 Ensembl
GRCm38747,185,717 - 47,189,416 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl747,185,707 - 47,204,920 (-)EnsemblGRCm38mm10GRCm38
MGSCv37754,441,136 - 54,444,725 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36747,053,788 - 47,057,377 (-)NCBIMGSCv36mm8
Celera742,668,973 - 42,670,398 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11551509   PMID:12397184   PMID:12477932   PMID:12909716   PMID:21873635  


Genomics

Variants

.
Variants in Mrgpra6
127 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:198
Count of miRNA genes:190
Interacting mature miRNAs:195
Transcripts:ENSMUST00000073793
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3349772758148965Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3349772758148965Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3349772758148965Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3349772758148965Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73349772758148965Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73349772758148965Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse

Markers in Region
UniSTS:490631  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera742,668,973 - 42,670,398UniSTS
Cytogenetic Map7B4UniSTS
UniSTS:494113  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera742,668,924 - 42,670,459UniSTS
Cytogenetic Map7B4UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000073793   ⟹   ENSMUSP00000073463
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl746,835,465 - 46,839,164 (-)Ensembl
GRCm38.p6 Ensembl747,185,717 - 47,189,416 (-)Ensembl
RefSeq Acc Id: ENSMUST00000186456   ⟹   ENSMUSP00000140353
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl746,835,455 - 46,854,668 (-)Ensembl
GRCm38.p6 Ensembl747,185,707 - 47,204,920 (-)Ensembl
RefSeq Acc Id: NR_131899
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39746,835,465 - 46,839,164 (-)NCBI
GRCm38747,185,717 - 47,189,416 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001295466 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI32199 (Get FASTA)   NCBI Sequence Viewer  
  AAI32205 (Get FASTA)   NCBI Sequence Viewer  
  AAK91792 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000073463.5
  ENSMUSP00000140353.2
GenBank Protein Q91ZC6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: ENSMUSP00000140353   ⟸   ENSMUST00000186456
RefSeq Acc Id: ENSMUSP00000073463   ⟸   ENSMUST00000073793
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91ZC6-F1-model_v2 AlphaFold Q91ZC6 1-301 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3033107 AgrOrtholog
Ensembl Genes ENSMUSG00000052303 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000073793.5 UniProtKB/Swiss-Prot
  ENSMUST00000186456.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRA UniProtKB/Swiss-Prot
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:381886 UniProtKB/Swiss-Prot
MGD MGI:3033107 ENTREZGENE
NCBI Gene 381886 ENTREZGENE
PANTHER PTHR11334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11334:SF33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mrgpra6 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRA UniProtKB/Swiss-Prot
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WQV0_MOUSE UniProtKB/TrEMBL
  A3KMK5 ENTREZGENE
  E9QN26 ENTREZGENE
  MRGA6_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A3KMK5 UniProtKB/Swiss-Prot
  E9QN26 UniProtKB/Swiss-Prot