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Gene: LHX8 (LIM homeobox 8) Homo sapiens

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Symbol:

LHX8

Name:

LIM homeobox 8

RGD ID:

1606630

HGNC Page

HGNC:28838

Description:

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in forebrain neuron development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including female gonad development; forebrain neuron differentiation; and odontogenesis of dentin-containing tooth. Predicted to be located in chromatin. Predicted to be active in nucleus.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

Lhx7; LIM homeobox protein 8; LIM-homeodomain protein Lhx8; LIM/homeobox protein Lhx8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Lhx8 (LIM homeobox protein 8)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Rattus norvegicus (Norway rat):	Lhx8 (LIM homeobox 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Lhx8 (LIM homeobox 8)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	LHX8 (LIM homeobox 8)	NCBI	Ortholog
Canis lupus familiaris (dog):	LHX8 (LIM homeobox 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lhx8 (LIM homeobox 8)	NCBI	Ortholog
Sus scrofa (pig):	LHX8 (LIM homeobox 8)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	LHX8 (LIM homeobox 8)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Lhx8 (LIM homeobox 8)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Lhx8 (LIM homeobox 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lhx8 (LIM homeobox protein 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lhx8a (LIM homeobox 8a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	Awh	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lim-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lhx8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus laevis (African clawed frog):	lhx8.S	Alliance	DIOPT (Xenbase)
Xenopus laevis (African clawed frog):	lhx8.L	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	75,128,434 - 75,199,454 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	75,128,434 - 75,161,533 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	75,594,119 - 75,627,218 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	75,366,707 - 75,399,806 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	73,839,451 - 73,872,551 (+)	NCBI		Celera
Cytogenetic Map	1	p31.1	NCBI
HuRef	1	73,728,993 - 73,762,092 (+)	NCBI		HuRef
CHM1_1	1	75,709,516 - 75,742,604 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	74,970,280 - 75,041,301 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LHX8	Human	Binge Drinking		ISO	Lhx8 (Rattus norvegicus)	597538603	mRNA:decreased expression:basal forebrain cholinergic neurons	RGD

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LHX8	Human	1-naphthyl isothiocyanate	decreases expression	ISO	Lhx8 (Rattus norvegicus)	6480464	1-Naphthylisothiocyanate results in decreased expression of LHX8 mRNA	CTD	PMID:30723492
LHX8	Human	17beta-estradiol	multiple interactions	ISO	Lhx8 (Rattus norvegicus)	6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LHX8 mRNA	CTD	PMID:32741896
LHX8	Human	17beta-estradiol 3-benzoate	multiple interactions	ISO	Lhx8 (Rattus norvegicus)	6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LHX8 mRNA	CTD	PMID:32741896
LHX8	Human	2,3',4,4',5-Pentachlorobiphenyl	increases expression	ISO	Lhx8 (Mus musculus)	6480464	2 more ...	CTD	PMID:31388691
LHX8	Human	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Lhx8 (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of LHX8 mRNA	CTD	PMID:21570461 and PMID:24058054
LHX8	Human	3-chloropropane-1,2-diol	increases expression	ISO	Lhx8 (Rattus norvegicus)	6480464	alpha-Chlorohydrin results in increased expression of LHX8 mRNA	CTD	PMID:28522335
LHX8	Human	4,4'-diaminodiphenylmethane	decreases expression	ISO	Lhx8 (Rattus norvegicus)	6480464	4 and 4'-diaminodiphenylmethane results in decreased expression of LHX8 mRNA	CTD	PMID:30723492
LHX8	Human	6-propyl-2-thiouracil	decreases expression	ISO	Lhx8 (Rattus norvegicus)	6480464	Propylthiouracil results in decreased expression of LHX8 mRNA	CTD	PMID:30047161
LHX8	Human	acetamide	decreases expression	ISO	Lhx8 (Rattus norvegicus)	6480464	acetamide results in decreased expression of LHX8 mRNA	CTD	PMID:31881176
LHX8	Human	aflatoxin B1	affects expression	EXP		6480464	Aflatoxin B1 affects the expression of LHX8 protein	CTD	PMID:20106945
LHX8	Human	all-trans-retinoic acid	increases expression	ISO	Lhx8 (Mus musculus)	6480464	Tretinoin results in increased expression of LHX8 mRNA	CTD	PMID:16000160
LHX8	Human	all-trans-retinoic acid	increases expression	EXP		6480464	Tretinoin results in increased expression of LHX8 mRNA	CTD	PMID:21934132
LHX8	Human	alpha-Zearalanol	increases expression	ISO	Lhx8 (Rattus norvegicus)	6480464	Zeranol results in increased expression of LHX8 mRNA	CTD	PMID:35163327
LHX8	Human	ammonium chloride	affects expression	ISO	Lhx8 (Rattus norvegicus)	6480464	Ammonium Chloride affects the expression of LHX8 mRNA	CTD	PMID:16483693
LHX8	Human	amosite asbestos	decreases methylation	EXP		6480464	Asbestos and Amosite results in decreased methylation of LHX8 promoter	CTD	PMID:29626692
LHX8	Human	arsane	increases methylation	EXP		6480464	Arsenic results in increased methylation of LHX8 gene	CTD	PMID:24525453
LHX8	Human	arsane	affects methylation	EXP		6480464	Arsenic affects the methylation of LHX8 gene	CTD	PMID:25304211
LHX8	Human	arsenic atom	increases methylation	EXP		6480464	Arsenic results in increased methylation of LHX8 gene	CTD	PMID:24525453
LHX8	Human	arsenic atom	affects methylation	EXP		6480464	Arsenic affects the methylation of LHX8 gene	CTD	PMID:25304211
LHX8	Human	arsenite(3-)	increases methylation	EXP		6480464	arsenite results in increased methylation of LHX8 promoter	CTD	PMID:23974009
LHX8	Human	belinostat	increases expression	EXP		6480464	belinostat results in increased expression of LHX8 mRNA	CTD	PMID:26272509
LHX8	Human	belinostat	multiple interactions	EXP		6480464	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LHX8 mRNA	CTD	PMID:27188386
LHX8	Human	benzo[a]pyrene	decreases expression	ISO	Lhx8 (Rattus norvegicus)	6480464	Benzo(a)pyrene results in decreased expression of LHX8 mRNA	CTD	PMID:21839799
LHX8	Human	benzo[a]pyrene	affects methylation	EXP		6480464	Benzo(a)pyrene affects the methylation of LHX8 5' UTR and Benzo(a)pyrene affects the methylation of LHX8 promoter	CTD	PMID:27901495
LHX8	Human	bis(2-chloroethyl) sulfide	increases expression	ISO	Lhx8 (Mus musculus)	6480464	Mustard Gas results in increased expression of LHX8 mRNA	CTD	PMID:15674843
LHX8	Human	bis(2-ethylhexyl) phthalate	affects methylation	ISO	Lhx8 (Mus musculus)	6480464	Diethylhexyl Phthalate affects the methylation of LHX8 gene	CTD	PMID:24458533
LHX8	Human	bis(2-ethylhexyl) phthalate	increases expression	ISO	Lhx8 (Mus musculus)	6480464	Diethylhexyl Phthalate results in increased expression of LHX8 mRNA	CTD	PMID:33754040
LHX8	Human	bis(2-ethylhexyl) phthalate	decreases expression	ISO	Lhx8 (Mus musculus)	6480464	Diethylhexyl Phthalate results in decreased expression of LHX8 mRNA and Diethylhexyl Phthalate results in decreased expression of LHX8 protein	CTD	PMID:24458533 and PMID:33754040
LHX8	Human	bisphenol A	affects methylation	ISO	Lhx8 (Mus musculus)	6480464	bisphenol A affects the methylation of LHX8 gene	CTD	PMID:24458533
LHX8	Human	bisphenol A	decreases expression	ISO	Lhx8 (Rattus norvegicus)	6480464	bisphenol A results in decreased expression of LHX8 mRNA	CTD	PMID:25181051
LHX8	Human	bisphenol A	decreases expression	ISO	Lhx8 (Mus musculus)	6480464	bisphenol A results in decreased expression of LHX8 mRNA	CTD	PMID:24458533
LHX8	Human	butanal	decreases expression	EXP		6480464	butyraldehyde results in decreased expression of LHX8 mRNA	CTD	PMID:26079696
LHX8	Human	CGP 52608	multiple interactions	EXP		6480464	CGP 52608 promotes the reaction [RORA protein binds to LHX8 gene]	CTD	PMID:28238834
LHX8	Human	chlorpyrifos	increases expression	ISO	Lhx8 (Mus musculus)	6480464	Chlorpyrifos results in increased expression of LHX8 mRNA	CTD	PMID:37019170
LHX8	Human	choline	multiple interactions	ISO	Lhx8 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LHX8 gene	CTD	PMID:20938992
LHX8	Human	cisplatin	multiple interactions	EXP		6480464	[Cisplatin co-treated with jinfukang] results in decreased expression of LHX8 mRNA	CTD	PMID:27392435
LHX8	Human	cisplatin	decreases expression	EXP		6480464	Cisplatin results in decreased expression of LHX8 mRNA	CTD	PMID:27392435
LHX8	Human	crocidolite asbestos	decreases methylation	EXP		6480464	Asbestos and Crocidolite results in decreased methylation of LHX8 promoter	CTD	PMID:29626692
LHX8	Human	cyclosporin A	increases expression	EXP		6480464	Cyclosporine results in increased expression of LHX8 mRNA	CTD	PMID:20106945
LHX8	Human	cyclosporin A	decreases methylation	EXP		6480464	Cyclosporine results in decreased methylation of LHX8 promoter	CTD	PMID:27989131
LHX8	Human	dorsomorphin	multiple interactions	EXP		6480464	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...	CTD	PMID:27188386
LHX8	Human	endosulfan	decreases expression	ISO	Lhx8 (Rattus norvegicus)	6480464	Endosulfan results in decreased expression of LHX8 mRNA	CTD	PMID:29391264
LHX8	Human	entinostat	increases expression	EXP		6480464	entinostat results in increased expression of LHX8 mRNA	CTD	PMID:26272509
LHX8	Human	entinostat	multiple interactions	EXP		6480464	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LHX8 mRNA	CTD	PMID:27188386
LHX8	Human	ethanol	affects expression	ISO	Lhx8 (Mus musculus)	6480464	Ethanol affects the expression of LHX8 mRNA	CTD	PMID:30319688
LHX8	Human	folic acid	multiple interactions	ISO	Lhx8 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LHX8 gene	CTD	PMID:20938992
LHX8	Human	furan	decreases expression	ISO	Lhx8 (Rattus norvegicus)	6480464	furan results in decreased expression of LHX8 mRNA	CTD	PMID:25539665
LHX8	Human	indole-3-methanol	multiple interactions	ISO	Lhx8 (Rattus norvegicus)	6480464	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LHX8 mRNA	CTD	PMID:22129741
LHX8	Human	L-methionine	multiple interactions	ISO	Lhx8 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LHX8 gene	CTD	PMID:20938992
LHX8	Human	leflunomide	increases expression	ISO	Lhx8 (Mus musculus)	6480464	leflunomide results in increased expression of LHX8 mRNA	CTD	PMID:19751817
LHX8	Human	mercury dibromide	multiple interactions	EXP		6480464	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LHX8 mRNA	CTD	PMID:27188386
LHX8	Human	methoxychlor	affects methylation	ISO	Lhx8 (Rattus norvegicus)	6480464	Methoxychlor affects the methylation of LHX8 gene	CTD	PMID:35440735
LHX8	Human	N-acetyl-L-cysteine	multiple interactions	ISO	Lhx8 (Rattus norvegicus)	6480464	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LHX8 mRNA	CTD	PMID:22129741
LHX8	Human	N-nitrosodiethylamine	multiple interactions	ISO	Lhx8 (Rattus norvegicus)	6480464	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LHX8 mRNA	CTD	PMID:22129741
LHX8	Human	orphenadrine	affects expression	ISO	Lhx8 (Rattus norvegicus)	6480464	Orphenadrine affects the expression of LHX8 mRNA	CTD	PMID:23665939
LHX8	Human	p-chloromercuribenzoic acid	increases expression	EXP		6480464	p-Chloromercuribenzoic Acid results in increased expression of LHX8 mRNA	CTD	PMID:26272509
LHX8	Human	p-chloromercuribenzoic acid	multiple interactions	EXP		6480464	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LHX8 mRNA	CTD	PMID:27188386
LHX8	Human	panobinostat	multiple interactions	EXP		6480464	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LHX8 mRNA	CTD	PMID:27188386
LHX8	Human	panobinostat	increases expression	EXP		6480464	panobinostat results in increased expression of LHX8 mRNA	CTD	PMID:26272509
LHX8	Human	pentanal	decreases expression	EXP		6480464	pentanal results in decreased expression of LHX8 mRNA	CTD	PMID:26079696
LHX8	Human	perfluorohexanesulfonic acid	decreases expression	ISO	Lhx8 (Mus musculus)	6480464	perfluorohexanesulfonic acid results in decreased expression of LHX8 mRNA	CTD	PMID:37995155
LHX8	Human	phenobarbital	decreases expression	ISO	Lhx8 (Rattus norvegicus)	6480464	Phenobarbital results in decreased expression of LHX8 mRNA	CTD	PMID:30047161
LHX8	Human	propanal	decreases expression	EXP		6480464	propionaldehyde results in decreased expression of LHX8 mRNA	CTD	PMID:26079696
LHX8	Human	SB 431542	multiple interactions	EXP		6480464	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...	CTD	PMID:27188386
LHX8	Human	serpentine asbestos	decreases methylation	EXP		6480464	Asbestos and Serpentine results in decreased methylation of LHX8 gene	CTD	PMID:29523930
LHX8	Human	sunitinib	increases expression	EXP		6480464	Sunitinib results in increased expression of LHX8 mRNA	CTD	PMID:31533062
LHX8	Human	testosterone	multiple interactions	ISO	Lhx8 (Rattus norvegicus)	6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LHX8 mRNA	CTD	PMID:32741896
LHX8	Human	thioacetamide	decreases expression	ISO	Lhx8 (Rattus norvegicus)	6480464	Thioacetamide results in decreased expression of LHX8 mRNA	CTD	PMID:23411599 and PMID:34492290
LHX8	Human	titanium dioxide	decreases methylation	ISO	Lhx8 (Mus musculus)	6480464	titanium dioxide results in decreased methylation of LHX8 gene	CTD	PMID:35295148
LHX8	Human	titanium dioxide	increases methylation	ISO	Lhx8 (Mus musculus)	6480464	titanium dioxide results in increased methylation of LHX8 gene	CTD	PMID:35295148
LHX8	Human	trichostatin A	increases expression	EXP		6480464	trichostatin A results in increased expression of LHX8 mRNA	CTD	PMID:24935251 and PMID:26272509
LHX8	Human	trichostatin A	multiple interactions	EXP		6480464	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LHX8 mRNA	CTD	PMID:27188386
LHX8	Human	triclosan	decreases expression	EXP		6480464	Triclosan results in decreased expression of LHX8 mRNA	CTD	PMID:30510588
LHX8	Human	trimellitic anhydride	decreases expression	ISO	Lhx8 (Mus musculus)	6480464	trimellitic anhydride results in decreased expression of LHX8 mRNA	CTD	PMID:19042947
LHX8	Human	valproic acid	affects expression	EXP		6480464	Valproic Acid affects the expression of LHX8 mRNA	CTD	PMID:25979313
LHX8	Human	valproic acid	increases expression	EXP		6480464	Valproic Acid results in increased expression of LHX8 mRNA	CTD	PMID:24383497 more ...
LHX8	Human	valproic acid	multiple interactions	EXP		6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LHX8 mRNA	CTD	PMID:27188386
LHX8	Human	zearalenone	decreases expression	ISO	Lhx8 (Mus musculus)	6480464	Zearalenone results in decreased expression of LHX8 mRNA and Zearalenone results in decreased expression of LHX8 protein	CTD	PMID:28089945

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LHX8	Human	female gonad development	acts_upstream_of_or_within	ISO	MGI:2182594	9068941	PMID:16690745	MGI	PMID:16690745
LHX8	Human	forebrain neuron development	involved_in	IBA	MGI:1096343 more ...	150520179		GO_Central	GO_REF:0000033
LHX8	Human	forebrain neuron development	acts_upstream_of_or_within	ISO	MGI:1306803	9068941	PMID:15217369	MGI	PMID:15217369
LHX8	Human	forebrain neuron differentiation	acts_upstream_of_or_within	ISO	MGI:3603531	9068941	PMID:15978004	MGI	PMID:15978004
LHX8	Human	learning or memory	acts_upstream_of_or_within	ISO	MGI:3603531	9068941	PMID:15978004	MGI	PMID:15978004
LHX8	Human	neuron differentiation	involved_in	IBA	FB:FBgn0002023 more ...	150520179		GO_Central	GO_REF:0000033
LHX8	Human	odontogenesis of dentin-containing tooth	acts_upstream_of_or_within	ISO	Lhx8 (Mus musculus)	9068941	PMID:12703558	MGI	PMID:12703558
LHX8	Human	regulation of DNA-templated transcription	involved_in	IEA	InterPro:IPR017970	150520179		InterPro	GO_REF:0000002
LHX8	Human	regulation of transcription by RNA polymerase II	involved_in	IEA	GO:0000981	150520179		GOC	GO_REF:0000108
LHX8	Human	regulation of transcription by RNA polymerase II	involved_in	IBA	FB:FBgn0267978 more ...	150520179		GO_Central	GO_REF:0000033
LHX8	Human	response to ethanol		ISO	Lhx8 (Rattus norvegicus)	9068941		RGD	PMID:37402853 and REF_RGD_ID:597538603

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LHX8	Human	chromatin	located_in	ISA	tfclass:3.1.5	150520179		NTNU_SB	GO_REF:0000113
LHX8	Human	female germ cell nucleus	located_in	ISO	Lhx8 (Mus musculus)	9068941	PMID:18753606	MGI	PMID:18753606
LHX8	Human	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	150520179		UniProt	GO_REF:0000043
LHX8	Human	nucleus	is_active_in	IBA	FB:FBgn0267978 more ...	150520179		GO_Central	GO_REF:0000033
LHX8	Human	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	150520179		UniProt	GO_REF:0000044
LHX8	Human	nucleus	located_in	IEA	UniRule:UR000401037	150520179		UniProt	GO_REF:0000104

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LHX8	Human	DNA binding	enables	IEA	UniProtKB-KW:KW-0238 and UniProtKB-KW:KW-0371	150520179		UniProt	GO_REF:0000043
LHX8	Human	DNA binding	enables	IEA	UniRule:UR000401037	150520179		UniProt	GO_REF:0000104
LHX8	Human	DNA binding	enables	IEA	InterPro:IPR001356	150520179		InterPro	GO_REF:0000002
LHX8	Human	DNA-binding transcription factor activity, RNA polymerase II-specific	enables	IEA	InterPro:IPR017970	150520179		InterPro	GO_REF:0000002
LHX8	Human	DNA-binding transcription factor activity, RNA polymerase II-specific	enables	IBA	MGI:1100513 more ...	150520179		GO_Central	GO_REF:0000033
LHX8	Human	DNA-binding transcription factor activity, RNA polymerase II-specific	enables	ISA	tfclass:3.1.5	150520179		NTNU_SB	GO_REF:0000113
LHX8	Human	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	150520179		UniProt	GO_REF:0000043
LHX8	Human	protein binding	enables	IPI	UniProtKB:Q6QHK4	150520179	PMID:33961781	IntAct	PMID:33961781
LHX8	Human	protein binding	enables	IPI	UniProtKB:O15353 more ...	150520179	PMID:32296183	IntAct	PMID:32296183
LHX8	Human	protein binding	enables	IPI	UniProtKB:G5E9A7 more ...	150520179	PMID:32814053	IntAct	PMID:32814053
LHX8	Human	protein binding	enables	IPI	UniProtKB:P57682 more ...	150520179	PMID:25416956	IntAct	PMID:25416956
LHX8	Human	protein binding	enables	IPI	UniProtKB:A0A0S2Z4M1	150520179	PMID:26871637	IntAct	PMID:26871637
LHX8	Human	protein binding	enables	IPI	UniProtKB:Q86U70	150520179	PMID:35140242	IntAct	PMID:35140242
LHX8	Human	RNA polymerase II transcription regulatory region sequence-specific DNA binding	enables	IBA	FB:FBgn0267978 more ...	150520179		GO_Central	GO_REF:0000033
LHX8	Human	sequence-specific DNA binding	enables	IEA	ARBA:ARBA00026779	150520179		UniProt	GO_REF:0000117
LHX8	Human	sequence-specific double-stranded DNA binding	enables	IDA		150520179	PMID:28473536	ARUK-UCL	PMID:28473536

#	Reference Title	Reference Citation
1.	HMGB1 neuroimmune signaling and REST-G9a gene repression contribute to ethanol-induced reversible suppression of the cholinergic neuron phenotype.	Crews FT, etal., Mol Psychiatry. 2023 Dec;28(12):5159-5172. doi: 10.1038/s41380-023-02160-6. Epub 2023 Jul 4.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:9598319	PMID:10611327	PMID:12477932	PMID:14702039	PMID:16327884	PMID:16690745	PMID:17207965	PMID:17305537	PMID:17624344	PMID:18574220	PMID:18978678	PMID:19274049
PMID:20082688	PMID:20572854	PMID:20634891	PMID:20672350	PMID:21143530	PMID:21462296	PMID:21856374	PMID:21873635	PMID:22204396	PMID:22435649	PMID:23455924	PMID:24316404
PMID:24981860	PMID:25416956	PMID:25814554	PMID:26186194	PMID:26871637	PMID:28473536	PMID:28514442	PMID:32296183	PMID:32814053	PMID:33961781	PMID:35140242	PMID:35152224
PMID:36029299	PMID:36366827	PMID:36602025	PMID:38703583

LHX8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	75,128,434 - 75,199,454 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	75,128,434 - 75,161,533 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	75,594,119 - 75,627,218 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	75,366,707 - 75,399,806 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	73,839,451 - 73,872,551 (+)	NCBI		Celera
Cytogenetic Map	1	p31.1	NCBI
HuRef	1	73,728,993 - 73,762,092 (+)	NCBI		HuRef
CHM1_1	1	75,709,516 - 75,742,604 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	74,970,280 - 75,041,301 (+)	NCBI		T2T-CHM13v2.0

Lhx8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	154,011,925 - 154,036,190 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	154,011,931 - 154,036,296 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	154,306,288 - 154,330,560 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	154,306,294 - 154,330,659 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	153,969,257 - 153,993,524 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	154,242,163 - 154,265,944 (-)	NCBI		MGSCv36	mm8
Celera	3	160,766,458 - 160,790,689 (-)	NCBI		Celera
Cytogenetic Map	3	H4	NCBI
cM Map	3	79.12	NCBI

Lhx8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	245,904,712 - 245,929,376 (-)	NCBI		GRCr8
mRatBN7.2	2	243,244,958 - 243,269,624 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	243,244,961 - 243,269,416 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	251,069,403 - 251,090,965 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	248,963,243 - 248,984,805 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	243,862,639 - 243,884,232 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	260,572,205 - 260,598,744 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	260,574,190 - 260,596,777 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	279,235,991 - 279,260,188 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	252,216,608 - 252,239,112 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	252,231,217 - 252,253,719 (-)	NCBI
Celera	2	235,171,406 - 235,193,860 (-)	NCBI		Celera
Cytogenetic Map	2	q45	NCBI

Lhx8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	17,644,871 - 17,668,781 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	17,644,691 - 17,668,969 (-)	NCBI	ChiLan1.0	ChiLan1.0

LHX8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	151,724,416 - 151,752,072 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	150,884,884 - 150,912,497 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	74,356,372 - 74,383,984 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	76,324,804 - 76,357,879 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	76,324,804 - 76,357,879 (+)	Ensembl	panpan1.1		panPan2

LHX8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	71,329,711 - 71,355,851 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	71,329,820 - 71,352,945 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	73,992,529 - 74,018,201 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	71,921,509 - 71,947,201 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	71,920,999 - 71,947,701 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	71,416,782 - 71,442,453 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	71,362,129 - 71,387,952 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	71,856,878 - 71,882,562 (-)	NCBI		UU_Cfam_GSD_1.0

Lhx8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	86,811,952 - 86,842,076 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936571	2,326,920 - 2,351,779 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936571	2,326,851 - 2,352,428 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LHX8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	138,074,855 - 138,099,810 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	138,074,673 - 138,102,025 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	128,034,492 - 128,061,739 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LHX8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	58,016,078 - 58,043,651 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	58,017,298 - 58,041,479 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	59,429,912 - 59,454,728 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lhx8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	21,638,856 - 21,662,776 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	21,638,213 - 21,662,979 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in LHX8
33 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	675
Count of miRNA genes:	265
Interacting mature miRNAs:	308
Transcripts:	ENST00000294638, ENST00000356261, ENST00000559413, ENST00000607240
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578620	LDLPS20_H	Low density lipoprotein particle size QTL 21 (human)	2.04	0.00046	LDL particle size		1	52531105	78531105	Human
597329746	GWAS1425820_H	neuroticism measurement, cognitive function measurement QTL GWAS1425820 (human)		2e-14	cognitive behavior trait (VT:0010450)		1	75180787	75180788	Human
597188691	GWAS1284765_H	nonanoylcarnitine (C9) measurement QTL GWAS1284765 (human)		9e-12	nonanoylcarnitine (C9) measurement		1	75139308	75139309	Human
1578602	LDLPS21_H	Low density lipoprotein particle size QTL 21 (human)	2.05	0.00037	LDL particle size		1	52531105	78531105	Human
597225356	GWAS1321430_H	self reported educational attainment QTL GWAS1321430 (human)		2e-09	self reported educational attainment		1	75150877	75150878	Human
597225357	GWAS1321431_H	self reported educational attainment QTL GWAS1321431 (human)		2e-12	self reported educational attainment		1	75180787	75180788	Human
597205582	GWAS1301656_H	generalized anxiety disorder QTL GWAS1301656 (human)		4e-08	generalized anxiety disorder		1	75129466	75129467	Human
597183790	GWAS1279864_H	hexanoylcarnitine measurement QTL GWAS1279864 (human)		2e-16	hexanoylcarnitine measurement		1	75139308	75139309	Human
597526954	GWAS1623028_H	diverticulitis QTL GWAS1623028 (human)		0.0000002	diverticulitis		1	75159713	75159714	Human
2316890	GLUCO302_H	Glucose level QTL 302 (human)		0.005	Glucose level		1	68532992	94532992	Human
2289499	BW445_H	Body weight QTL 445 (human)	2.26		Body morphometry	waist to hip ratio	1	68532992	94532992	Human
1578594	LDLPS19_H	Low density lipoprotein particle size QTL 19 (human)	2.56	0.00009	LDL particle size		1	52531105	78531105	Human
597186114	GWAS1282188_H	octanoylcarnitine measurement QTL GWAS1282188 (human)		1e-14	octanoylcarnitine measurement		1	75139308	75139309	Human
1581539	BP75_H	Blood pressure QTL 75 (human)	2.4	0.001	Blood pressure	pulse pressure	1	68532992	94532992	Human
2292793	PRSTS24_H	Prostate tumor susceptibility QTL 24 (human)			Prostate tumor susceptibility	late onset	1	68532992	94532992	Human

SHGC-149363

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	1	75,601,032 - 75,601,337	UniSTS	GRCh37
Build 36	1	75,373,620 - 75,373,925	RGD	NCBI36
Celera	1	73,846,364 - 73,846,669	RGD
Cytogenetic Map	1	p31.1	UniSTS
HuRef	1	73,735,910 - 73,736,215	UniSTS
TNG Radiation Hybrid Map	1	41017.0	UniSTS

SHGC-6203

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	1	75,615,914 - 75,616,018	UniSTS	GRCh37
Build 36	1	75,388,502 - 75,388,606	RGD	NCBI36
Celera	1	73,861,247 - 73,861,351	RGD
Cytogenetic Map	1	p31.1	UniSTS
HuRef	1	73,750,789 - 73,750,893	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system
157	517	342	316	1694	865	979	2	186	159	25	427	774	915	18	1453	165	784	900	162


RefSeq Transcripts	NM_001001933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001256114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017001316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017001317	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047421040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054336668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054336669	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB050476	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC099786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC118550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH013373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK094667	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC036423	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC040321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000294638 ⟹ ENSP00000294638

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	75,128,434 - 75,161,533 (+)	Ensembl

Ensembl Acc Id:

ENST00000356261 ⟹ ENSP00000348597

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	75,134,388 - 75,161,533 (+)	Ensembl

Ensembl Acc Id:

ENST00000607240

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	75,159,288 - 75,161,531 (+)	Ensembl

Ensembl Acc Id:

ENST00000696555 ⟹ ENSP00000512714

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	75,134,388 - 75,161,533 (+)	Ensembl

RefSeq Acc Id:

NM_001001933 ⟹ NP_001001933

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	75,128,434 - 75,161,533 (+)	NCBI
GRCh37	1	75,594,119 - 75,627,218 (+)	RGD
Build 36	1	75,366,707 - 75,399,806 (+)	NCBI Archive
Celera	1	73,839,451 - 73,872,551 (+)	RGD
HuRef	1	73,728,993 - 73,762,092 (+)	ENTREZGENE
CHM1_1	1	75,709,516 - 75,742,604 (+)	NCBI
T2T-CHM13v2.0	1	74,970,280 - 75,003,384 (+)	NCBI

Sequence:

show sequence

AGAGGCAAGAGGCTAGCGGCTGGACCACTTGTGCTGGAGTGGTAAAGAACTATCATGAATCCATTTACTGAAAGTGTCCATTTCTGAACTCACCCTAAAGAGGACAAACACCGCAAAGTAGTTAAAAG
TCAGGCATTCGCGTCGGACGTCTGGGTTTGAATTCTGCCCTGGCTTGACTGGAAACGCTTCCCCTATTTCTTCCGTAGCGGACCGGGAGAGCTTACTGGCGCTCTGCGAACCGGCTGGAAAGAAACAC
CGAGTCACTCGTACAGACTCTTGGTCGCAGAACTTGGCTTTCCGCTATTGGTCCTCCAGAACCGCTTGAAACAACTGGCCCCAGCTGGCGCATCAGACCGCAGTGAGGAATGCCGCGGGGCGGGTGGC
GAAGGCAGGGTCTGCCCGCCAGTGGATTCCCGGGTGTCCCGCGTGGAGCAGGCTTGCCCAGCTGGGAAGCCCATCAAACCTCAGTCTTGGCCCACAGTGGGAGAGAGACCAGTGGGTCCCAGACGGAG
GCCCTCGCCCGCTTTTGGCGACCTCCACTGGCGTGAATAAAAGCACCCCTCTCTTACCCTCAGAAACTGTGGGTAGCAAGGTATAAAACGGAGTCTGGGACCGGTAAGTCCCAAGGTGAGCCCGTATA
CAGCTCTGCCATCTCTGAGGGGTTATGCAGATTCTGAGCAGGTGTCAGGGGCTCATGTCAGAGGAGTGCGGGCGGACTACAGCCCTGGCGGCCGGGAGGACTCGCAAAGGCGCCGGGGAAGAGGGACT
GGTGAGCCCCGAGGGAGCGGGGGACGAGGACTCGTGCTCCTCCTCGGCCCCGCTGTCCCCGTCGTCCTCGCCCCGGTCCATGGCCTCGGGCTCCGGCTGCCCTCCTGGCAAGTGTGTGTGCAACAGTT
GCGGCCTGGAGATCGTGGACAAATACCTTCTCAAGGTGAATGACCTATGCTGGCATGTCCGGTGTCTCTCCTGCAGTGTTTGCAGAACCTCCCTAGGAAGGCACACCAGCTGTTATATTAAAGACAAA
GACATTTTCTGCAAACTTGATTATTTCAGAAGGTATGGAACTCGCTGCTCTCGATGTGGGAGACACATCCATTCTACTGACTGGGTCCGGAGAGCCAAGGGGAATGTCTATCACTTGGCATGCTTTGC
CTGCTTTTCCTGCAAAAGGCAACTTTCCACAGGAGAGGAGTTTGCTTTGGTGGAAGAGAAAGTCCTCTGCAGAGTACATTATGACTGCATGCTGGATAATTTAAAAAGAGAAGTAGAAAATGGGAATG
GGATTAGTGTGGAAGGTGCCCTCCTCACAGAGCAAGATGTTAACCATCCAAAACCAGCAAAAAGAGCTCGGACCAGCTTTACAGCAGATCAGCTTCAGGTTATGCAAGCACAATTTGCTCAGGACAAC
AACCCAGATGCACAGACACTCCAGAAATTGGCAGAAAGGACAGGCTTGAGCAGACGTGTGATACAGGTGTGGTTTCAGAATTGTAGAGCACGCCACAAGAAACACGTCAGTCCTAATCACTCATCCTC
CACCCCAGTCACAGCAGTCCCACCCTCCAGGCTGTCTCCACCCATGTTAGAAGAAATGGCTTATTCTGCCTACGTGCCCCAAGATGGAACGATGTTAACTGCGCTGCATAGTTATATGGATGCTCATT
CACCAACAACTCTTGGACTCCAGCCCTTGTTACCCCATTCAATGACACAACTGCCAATAAGTCATACCTAATTCTTTTTTCAGGGATAGACTTGATTAAGGATATAAATTTGTCATTTATTATGTATA
AAATACCATTGAAAAGATATTACTGTTAATTTTTTATTTAACACCTAAAGCATTTCCAACATCACTTTGCTGCCCAGGTATGTATCTATAGTTGGCCTGCAAGACACTTTTATTAATTCTTCATTTTT
TGTAAAACTTATGTTTACAAGAAGAAAACAAATCAAAACATTTTTTGTATTGTCTGGAAATAGTTCACTCTAGTGTGTATCTGTTAATTTATTTGTCATCAAAAGAGCACTTTGCCTAAAAGAAAGGA
CTGACAAGTGTGCAAAATGTTTACAATCTTTTGTGAAATTGTAGTTTATCATTAGTTTGTATCTGTAAGTTATTGTAATAAATATTACCTGTATTTTTTGTTATATACAACTTTATACTTTGAAGCTT
GTATCTGTGAATTTGCAACTGAAATTTATTTTGCCAATGTTTTCTGAATGAACTGAATAAAGCTTCTGTTGTAGCATGCCATGCAAACACATTATTGTGTTTGTGGTTGATGAATTATGGCTGTAAAT
AACACTATAGTTTAATAAGCCCACCATTCTGAGTTTATTAAACATTTTCCATTCTTGTGAAAATTTCAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001256114 ⟹ NP_001243043

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	75,134,388 - 75,161,533 (+)	NCBI
GRCh37	1	75,594,119 - 75,627,218 (+)	NCBI
HuRef	1	73,728,993 - 73,762,092 (+)	NCBI
CHM1_1	1	75,715,964 - 75,742,604 (+)	NCBI
T2T-CHM13v2.0	1	74,976,238 - 75,003,384 (+)	NCBI

Sequence:

show sequence

AGTGCTCACTTCACTCAGAGCTCAGTGAAGCTGGGAAAGGAATTTTAAGAACGGTTCATCAGAAAGTGGTCAGGCCACAGCGGCCTCTTTGGACGAAGACACACTTGTAGCATTATCCTTCTCGGCAT
CAGCTTTTATTAGTGGATCGGGGCGGGGGAGGGGGGAGATCGGCAGACACGGACAGCCTCTGACCCTCTGGAGTTGGTATGTGATAAGCAGCCCTAGCAGTGCCATGTATTGGAAGAACGATCAGATG
TTTGTGTGTAAACTAGTAGCAAAGGACGTGCCGGAGCTGGCAGTTCCCCCTGAGAAGGTGAGCGAGCCGACGCCTGGCCAGACCAGCTGAATCGCAGTGTCCTTGAAACTCGAGTTGTTTGGGCTCCT
AAACAAGGTTCAGAAACTACCTGTAACGGCCTCATCTTCAGACCTGGCAATTTTTTTTTTTTATTACGTAGTAGCGTTAGTCAGTAATCATTGCACTCCCTCCCCAAAAGCTCACTTAACCTGAGACA
TGGAGACTGTAATTTGGGAGATGAAGCCTCGAGCCTAAGGCGCTCTCAGGTCCATTGTCAGGGGCTCATGTCAGAGGAGTGCGGGCGGACTACAGCCCTGGCGGCCGGGAGGACTCGCAAAGGCGCCG
GGGAAGAGGGACTGGTGAGCCCCGAGGGAGCGGGGGACGAGGACTCGTGCTCCTCCTCGGCCCCGCTGTCCCCGTCGTCCTCGCCCCGGTCCATGGCCTCGGGCTCCGGCTGCCCTCCTGGCAAGTGT
GTGTGCAACAGTTGCGGCCTGGAGATCGTGGACAAATACCTTCTCAAGGTGAATGACCTATGCTGGCATGTCCGGTGTCTCTCCTGCAGTGTTTGCAGAACCTCCCTAGGAAGGCACACCAGCTGTTA
TATTAAAGACAAAGACATTTTCTGCAAACTTGATTATTTCAGAAGGTATGGAACTCGCTGCTCTCGATGTGGGAGACACATCCATTCTACTGACTGGGTCCGGAGAGCCAAGGGGAATGTCTATCACT
TGGCATGCTTTGCCTGCTTTTCCTGCAAAAGGCAACTTTCCACAGGAGAGGAGTTTGCTTTGGTGGAAGAGAAAGTCCTCTGCAGAGTACATTATGACTGCATGCTGGATAATTTAAAAAGAGAAGTA
GAAAATGGGAATGGGATTAGTGTGGAAGGTGCCCTCCTCACAGAGCAAGATGTTAACCATCCAAAACCAGCAAAAAGAGCTCGGACCAGCTTTACAGCAGATCAGCTTCAGGTTATGCAAGCACAATT
TGCTCAGGACAACAACCCAGATGCACAGACACTCCAGAAATTGGCAGAAAGGACAGGCTTGAGCAGACGTGTGATACAGGTGTGGTTTCAGAATTGTAGAGCACGCCACAAGAAACACGTCAGTCCTA
ATCACTCATCCTCCACCCCAGTCACAGCAGTCCCACCCTCCAGGCTGTCTCCACCCATGTTAGAAGAAATGGCTTATTCTGCCTACGTGCCCCAAGATGGAACGATGTTAACTGCGCTGCATAGTTAT
ATGGATGCTCATTCACCAACAACTCTTGGACTCCAGCCCTTGTTACCCCATTCAATGACACAACTGCCAATAAGTCATACCTAATTCTTTTTTCAGGGATAGACTTGATTAAGGATATAAATTTGTCA
TTTATTATGTATAAAATACCATTGAAAAGATATTACTGTTAATTTTTTATTTAACACCTAAAGCATTTCCAACATCACTTTGCTGCCCAGGTATGTATCTATAGTTGGCCTGCAAGACACTTTTATTA
ATTCTTCATTTTTTGTAAAACTTATGTTTACAAGAAGAAAACAAATCAAAACATTTTTTGTATTGTCTGGAAATAGTTCACTCTAGTGTGTATCTGTTAATTTATTTGTCATCAAAAGAGCACTTTGC
CTAAAAGAAAGGACTGACAAGTGTGCAAAATGTTTACAATCTTTTGTGAAATTGTAGTTTATCATTAGTTTGTATCTGTAAGTTATTGTAATAAATATTACCTGTATTTTTTGTTATATACAACTTTA
TACTTTGAAGCTTGTATCTGTGAATTTGCAACTGAAATTTATTTTGCCAATGTTTTCTGAATGAACTGAATAAAGCTTCTGTTGTAGCATGCCATGCAAACACATTATTGTGTTTGTGGTTGATGAAT
TATGGCTGTAAATAACACTATAGTTTAATAAGCCCACCATTCTGAGTTTATTAAACATTTTCCATTCTTGTGAAAATTTCAA

hide sequence

RefSeq Acc Id:

XM_017001316 ⟹ XP_016856805

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	75,134,388 - 75,199,454 (+)	NCBI

Sequence:

show sequence

TCACTTCACTCAGAGCTCAGTGAAGCTGGGAAAGGAATTTTAAGAACGGTTCATCAGAAAGTGGTCAGGCCACAGCGGCCTCTTTGGACGAAGACACACTTGTAGCATTATCCTTCTCGGCATCAGCT
TTTATTAGTGGATCGGGGCGGGGGAGGGGGGAGATCGGCAGACACGGACAGCCTCTGACCCTCTGGAGTTGGTATGTGATAAGCAGCCCTAGCAGTGCCATGTATTGGAAGAACGATCAGATGTTTGT
GTGTAAACTAGTAGCAAAGGACGTGCCGGAGCTGGCAGTTCCCCCTGAGAAGGTGAGCGAGCCGACGCCTGGCCAGACCAGCTGAATCGCAGTGTCCTTGAAACTCGAGTTGTTTGGGCTCCTAAACA
AGGTTCAGAAACTACCTGTAACGGCCTCATCTTCAGACCTGGCAATTTTTTTTTTTTATTACGTAGTAGCGTTAGTCAGTAATCATTGCACTCCCTCCCCAAAAGCTCACTTAACCTGAGACATGGAG
ACTGTAATTTGGGAGATGAAGCCTCGAGCCTAAGGCGCTCTCAGGTCCATTGTCAGGGGCTCATGTCAGAGGAGTGCGGGCGGACTACAGCCCTGGCGGCCGGGAGGACTCGCAAAGGCGCCGGGGAA
GAGGGACTGGTGAGCCCCGAGGGAGCGGGGGACGAGGACTCGTGCTCCTCCTCGGCCCCGCTGTCCCCGTCGTCCTCGCCCCGGTCCATGGCCTCGGGCTCCGGCTGCCCTCCTGGCAAGTGTGTGTG
CAACAGTTGCGGCCTGGAGATCGTGGACAAATACCTTCTCAAGGTGAATGACCTATGCTGGCATGTCCGGTGTCTCTCCTGCAGTGTTTGCAGAACCTCCCTAGGAAGGCACACCAGCTGTTATATTA
AAGACAAAGACATTTTCTGCAAACTTGATTATTTCAGAAGGTATGGAACTCGCTGCTCTCGATGTGGGAGACACATCCATTCTACTGACTGGGTCCGGAGAGCCAAGGGGAATGTCTATCACTTGGCA
TGCTTTGCCTGCTTTTCCTGCAAAAGGCAACTTTCCACAGGAGAGGAGTTTGCTTTGGTGGAAGAGAAAGTCCTCTGCAGAGTACATTATGACTGCATGCTGGATAATTTAAAAAGAGAAGTAGAAAA
TGGGAATGGGATTAGTGTGGAAGGTGCCCTCCTCACAGAGCAAGATGTTAACCATCCAAAACCAGCAAAAAGAGCTCGGACCAGCTTTACAGCAGATCAGCTTCAGGTTATGCAAGCACAATTTGCTC
AGGACAACAACCCAGATGCACAGACACTCCAGAAATTGGCAGAAAGGACAGGCTTGAGCAGACGTGTGATACAGGTGTGGTTTCAGAATTGTAGAGCACGCCACAAGAAACACGTCAGTCCTAATCAC
TCATCCTCCACCCCAGTCACAGCAGTCCCACCCTCCAGGCTGTCTCCACCCATGTTAGAAGAAATGGCTTATTCTGCCTACGTGCCCCAAGATGGAACGATGTTAACTGCGCTGCATAGTTATATGGA
TGACACACATGCAGCCGTGCACATTCATCTGCCTGGAAGAATGTGGAGATTCCAAGGTTATTCTAACAATGGATCAAGTTCAGGCTCCACGTTAATTTGTAAGTACAATGAAAACATCTTTCTCTTTT
GATAAACTTTT

hide sequence

RefSeq Acc Id:

XM_017001317 ⟹ XP_016856806

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	75,136,383 - 75,199,454 (+)	NCBI

Sequence:

show sequence

CCCCGCGCCGAGGCTGGGGCGGGCAGCACGCTCGGAACTTCTGATCTGTTTCTCCATACTTTCT
CCCCCTCCTACTCCGCAGTGTCAGGGGCTCATGTCAGAGGAGTGCGGGCGGACTACAGCCCTGGCGGCCGGGAGGACTCGCAAAGGCGCCGGGGAAGAGGGACTGGTGAGCCCCGAGGGAGCGGGGGA
CGAGGACTCGTGCTCCTCCTCGGCCCCGCTGTCCCCGTCGTCCTCGCCCCGGTCCATGGCCTCGGGCTCCGGCTGCCCTCCTGGCAAGTGTGTGTGCAACAGTTGCGGCCTGGAGATCGTGGACAAAT
ACCTTCTCAAGGTGAATGACCTATGCTGGCATGTCCGGTGTCTCTCCTGCAGTGTTTGCAGAACCTCCCTAGGAAGGCACACCAGCTGTTATATTAAAGACAAAGACATTTTCTGCAAACTTGATTAT
TTCAGAAGGTATGGAACTCGCTGCTCTCGATGTGGGAGACACATCCATTCTACTGACTGGGTCCGGAGAGCCAAGGGGAATGTCTATCACTTGGCATGCTTTGCCTGCTTTTCCTGCAAAAGGCAACT
TTCCACAGGAGAGGAGTTTGCTTTGGTGGAAGAGAAAGTCCTCTGCAGAGTACATTATGACTGCATGCTGGATAATTTAAAAAGAGAAGTAGAAAATGGGAATGGGATTAGTGTGGAAGGTGCCCTCC
TCACAGAGCAAGATGTTAACCATCCAAAACCAGCAAAAAGAGCTCGGACCAGCTTTACAGCAGATCAGCTTCAGGTTATGCAAGCACAATTTGCTCAGGACAACAACCCAGATGCACAGACACTCCAG
AAATTGGCAGAAAGGACAGGCTTGAGCAGACGTGTGATACAGGTGTGGTTTCAGAATTGTAGAGCACGCCACAAGAAACACGTCAGTCCTAATCACTCATCCTCCACCCCAGTCACAGCAGTCCCACC
CTCCAGGCTGTCTCCACCCATGTTAGAAGAAATGGCTTATTCTGCCTACGTGCCCCAAGATGGAACGATGTTAACTGCGCTGCATAGTTATATGGATGACACACATGCAGCCGTGCACATTCATCTGC
CTGGAAGAATGTGGAGATTCCAAGGTTATTCTAACAATGGATCAAGTTCAGGCTCCACGTTAATTTGTAAGTACAATGAAAACATCTTTCTCTTTTGATAAACTTTT

hide sequence

RefSeq Acc Id:

XM_047421040 ⟹ XP_047276996

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	75,136,383 - 75,161,533 (+)	NCBI

RefSeq Acc Id:

XM_054336668 ⟹ XP_054192643

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	1	74,976,238 - 75,041,301 (+)	NCBI

RefSeq Acc Id:

XM_054336669 ⟹ XP_054192644

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	1	74,978,184 - 75,003,384 (+)	NCBI


Protein RefSeqs	NP_001001933	(Get FASTA)	NCBI Sequence Viewer
	NP_001243043	(Get FASTA)	NCBI Sequence Viewer
	XP_016856805	(Get FASTA)	NCBI Sequence Viewer
	XP_016856806	(Get FASTA)	NCBI Sequence Viewer
	XP_047276996	(Get FASTA)	NCBI Sequence Viewer
	XP_054192643	(Get FASTA)	NCBI Sequence Viewer
	XP_054192644	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH40321	(Get FASTA)	NCBI Sequence Viewer
	AAR18074	(Get FASTA)	NCBI Sequence Viewer
	BAB40306	(Get FASTA)	NCBI Sequence Viewer
	EAX06405	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000294638
	ENSP00000294638.5
	ENSP00000348597
	ENSP00000348597.3
GenBank Protein	Q68G74	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001001933 ⟸ NM_001001933
- Peptide Label:	isoform 1
- UniProtKB:	E9PGE3 (UniProtKB/Swiss-Prot), Q68G74 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MQILSRCQGLMSEECGRTTALAAGRTRKGAGEEGLVSPEGAGDEDSCSSSAPLSPSSSPRSMASGSGCPPGKCVCNSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDY FRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQ KLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSTPVTAVPPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHSPTTLGLQPLLPHSMTQLPISHT hide sequence

RefSeq Acc Id:	NP_001243043 ⟸ NM_001256114
- Peptide Label:	isoform 2
- UniProtKB:	Q68G74 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MSEECGRTTALAAGRTRKGAGEEGLVSPEGAGDEDSCSSSAPLSPSSSPRSMASGSGCPPGKCVCNSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSR CGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSR RVIQVWFQNCRARHKKHVSPNHSSSTPVTAVPPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHSPTTLGLQPLLPHSMTQLPISHT hide sequence

RefSeq Acc Id:

XP_016856805 ⟸ XM_017001316

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSEECGRTTALAAGRTRKGAGEEGLVSPEGAGDEDSCSSSAPLSPSSSPRSMASGSGCPPGKCVCNSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSR
CGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSR
RVIQVWFQNCRARHKKHVSPNHSSSTPVTAVPPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDDTHAAVHIHLPGRMWRFQGYSNNGSSSGSTLICKYNENIFLF

hide sequence

RefSeq Acc Id:

XP_016856806 ⟸ XM_017001317

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSEECGRTTALAAGRTRKGAGEEGLVSPEGAGDEDSCSSSAPLSPSSSPRSMASGSGCPPGKCVCNSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSR
CGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSR
RVIQVWFQNCRARHKKHVSPNHSSSTPVTAVPPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDDTHAAVHIHLPGRMWRFQGYSNNGSSSGSTLICKYNENIFLF

hide sequence

Ensembl Acc Id:

ENSP00000294638 ⟸ ENST00000294638

Protein Domains

Homeobox LIM zinc-binding

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68G74-F1-model_v2	AlphaFold	Q68G74	1-356	view protein structure

Database	Acc Id	Source(s)
COSMIC	LHX8	COSMIC
Ensembl Genes	ENSG00000162624	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000294638	ENTREZGENE
	ENST00000294638.9	UniProtKB/Swiss-Prot
	ENST00000356261	ENTREZGENE
	ENST00000356261.4	UniProtKB/Swiss-Prot
Gene3D-CATH	Cysteine Rich Protein	UniProtKB/Swiss-Prot
	Homeodomain-like	UniProtKB/Swiss-Prot
GTEx	ENSG00000162624	GTEx
HGNC ID	HGNC:28838	ENTREZGENE
Human Proteome Map	LHX8	Human Proteome Map
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot
	Homeobox_CS	UniProtKB/Swiss-Prot
	Homeobox_dom	UniProtKB/Swiss-Prot
	LIM_Homeobox_TF	UniProtKB/Swiss-Prot
	Znf_LIM	UniProtKB/Swiss-Prot
KEGG Report	hsa:431707	UniProtKB/Swiss-Prot
NCBI Gene	431707	ENTREZGENE
OMIM	604425	OMIM
PANTHER	LIM/HOMEOBOX PROTEIN LHX	UniProtKB/Swiss-Prot
	LIM/HOMEOBOX PROTEIN LHX8	UniProtKB/Swiss-Prot
Pfam	Homeodomain	UniProtKB/Swiss-Prot
	LIM	UniProtKB/Swiss-Prot
PharmGKB	PA142671553	PharmGKB
PROSITE	HOMEOBOX_1	UniProtKB/Swiss-Prot
	HOMEOBOX_2	UniProtKB/Swiss-Prot
	LIM_DOMAIN_1	UniProtKB/Swiss-Prot
	LIM_DOMAIN_2	UniProtKB/Swiss-Prot
SMART	HOX	UniProtKB/Swiss-Prot
	LIM	UniProtKB/Swiss-Prot
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/Swiss-Prot
	SSF46689	UniProtKB/Swiss-Prot
UniProt	A0A8Q3WLD2_HUMAN	UniProtKB/TrEMBL
	E9PGE3	ENTREZGENE
	LHX8_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6SV70_HUMAN	UniProtKB/TrEMBL
	Q6SV71_HUMAN	UniProtKB/TrEMBL
	Q9BYB7_HUMAN	UniProtKB/TrEMBL
UniProt Secondary	E9PGE3	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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