LHX8 (LIM homeobox 8) - Rat Genome Database

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Gene: LHX8 (LIM homeobox 8) Homo sapiens
Analyze
Symbol: LHX8
Name: LIM homeobox 8
RGD ID: 1606630
HGNC Page HGNC:28838
Description: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in forebrain neuron development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including female gonad development; forebrain neuron differentiation; and odontogenesis of dentin-containing tooth. Predicted to be located in female germ cell nucleus. Predicted to be part of chromatin. Predicted to be active in nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Lhx7; LIM homeobox protein 8; LIM-homeodomain protein Lhx8; LIM/homeobox protein Lhx8
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,128,434 - 75,199,454 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,128,434 - 75,161,533 (+)EnsemblGRCh38hg38GRCh38
GRCh37175,594,119 - 75,627,218 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,366,707 - 75,399,806 (+)NCBINCBI36Build 36hg18NCBI36
Celera173,839,451 - 73,872,551 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef173,728,993 - 73,762,092 (+)NCBIHuRef
CHM1_1175,709,516 - 75,742,604 (+)NCBICHM1_1
T2T-CHM13v2.0174,970,280 - 75,041,301 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9598319   PMID:10611327   PMID:12477932   PMID:14702039   PMID:16327884   PMID:16690745   PMID:17207965   PMID:17305537   PMID:17624344   PMID:18574220   PMID:18978678   PMID:19274049  
PMID:20082688   PMID:20572854   PMID:20634891   PMID:20672350   PMID:21143530   PMID:21462296   PMID:21856374   PMID:21873635   PMID:22204396   PMID:22435649   PMID:23455924   PMID:24316404  
PMID:24981860   PMID:25416956   PMID:25814554   PMID:26186194   PMID:26871637   PMID:28473536   PMID:28514442   PMID:32296183   PMID:32814053   PMID:33961781   PMID:35140242   PMID:35152224  
PMID:36029299   PMID:36366827   PMID:36602025  


Genomics

Comparative Map Data
LHX8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,128,434 - 75,199,454 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,128,434 - 75,161,533 (+)EnsemblGRCh38hg38GRCh38
GRCh37175,594,119 - 75,627,218 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,366,707 - 75,399,806 (+)NCBINCBI36Build 36hg18NCBI36
Celera173,839,451 - 73,872,551 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef173,728,993 - 73,762,092 (+)NCBIHuRef
CHM1_1175,709,516 - 75,742,604 (+)NCBICHM1_1
T2T-CHM13v2.0174,970,280 - 75,041,301 (+)NCBIT2T-CHM13v2.0
Lhx8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393154,011,925 - 154,036,190 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3154,011,931 - 154,036,296 (-)EnsemblGRCm39 Ensembl
GRCm383154,306,288 - 154,330,560 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3154,306,294 - 154,330,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv373153,969,257 - 153,993,524 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363154,242,163 - 154,265,944 (-)NCBIMGSCv36mm8
Celera3160,766,458 - 160,790,689 (-)NCBICelera
Cytogenetic Map3H4NCBI
cM Map379.12NCBI
Lhx8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82245,904,712 - 245,929,376 (-)NCBIGRCr8
mRatBN7.22243,244,958 - 243,269,624 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2243,244,961 - 243,269,416 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2251,069,403 - 251,090,965 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02248,963,243 - 248,984,805 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02243,862,639 - 243,884,232 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02260,572,205 - 260,598,744 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2260,574,190 - 260,596,777 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02279,235,991 - 279,260,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42252,216,608 - 252,239,112 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12252,231,217 - 252,253,719 (-)NCBI
Celera2235,171,406 - 235,193,860 (-)NCBICelera
Cytogenetic Map2q45NCBI
Lhx8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542317,644,871 - 17,668,781 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542317,644,691 - 17,668,969 (-)NCBIChiLan1.0ChiLan1.0
LHX8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21151,724,416 - 151,752,072 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11150,884,884 - 150,912,497 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,356,372 - 74,383,984 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1176,324,804 - 76,357,879 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl176,324,804 - 76,357,879 (+)Ensemblpanpan1.1panPan2
LHX8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1671,329,711 - 71,355,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl671,329,820 - 71,352,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha673,992,529 - 74,018,201 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0671,921,509 - 71,947,201 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl671,920,999 - 71,947,701 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1671,416,782 - 71,442,453 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0671,362,129 - 71,387,952 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0671,856,878 - 71,882,562 (-)NCBIUU_Cfam_GSD_1.0
Lhx8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505886,811,952 - 86,842,076 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365712,326,920 - 2,351,779 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365712,326,851 - 2,352,428 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LHX8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6138,074,855 - 138,099,810 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16138,074,673 - 138,102,025 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26128,034,492 - 128,061,739 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LHX8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12058,016,078 - 58,043,651 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2058,017,298 - 58,041,479 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603359,429,912 - 59,454,728 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lhx8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474221,638,856 - 21,662,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474221,638,213 - 21,662,979 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LHX8
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p32.3-31.1(chr1:52595352-76767765)x3 copy number gain See cases [RCV000051822] Chr1:52595352..76767765 [GRCh38]
Chr1:53061024..77233450 [GRCh37]
Chr1:52833612..77006038 [NCBI36]
Chr1:1p32.3-31.1		 pathogenic
GRCh38/hg38 1p31.1-13.3(chr1:72661709-107456880)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]|See cases [RCV000051825] Chr1:72661709..107456880 [GRCh38]
Chr1:73127392..107999502 [GRCh37]
Chr1:72899980..107801025 [NCBI36]
Chr1:1p31.1-13.3		 pathogenic
GRCh38/hg38 1p32.1-31.1(chr1:59632500-76730877)x1 copy number loss See cases [RCV000053842] Chr1:59632500..76730877 [GRCh38]
Chr1:60098172..77196562 [GRCh37]
Chr1:59870760..76969150 [NCBI36]
Chr1:1p32.1-31.1		 pathogenic
NM_001001933.1(LHX8):c.900C>T (p.Ser300=) single nucleotide variant Malignant melanoma [RCV000064896] Chr1:75156982 [GRCh38]
Chr1:75622667 [GRCh37]
Chr1:75395255 [NCBI36]
Chr1:1p31.1		 not provided
NM_001001933.1(LHX8):c.268-1346C>A single nucleotide variant Lung cancer [RCV000090967] Chr1:75139639 [GRCh38]
Chr1:75605324 [GRCh37]
Chr1:1p31.1		 uncertain significance
GRCh38/hg38 1p32.1-22.3(chr1:58819605-86098611)x1 copy number loss See cases [RCV000136913] Chr1:58819605..86098611 [GRCh38]
Chr1:59285277..86564294 [GRCh37]
Chr1:59057865..86336882 [NCBI36]
Chr1:1p32.1-22.3		 pathogenic
GRCh38/hg38 1p31.3-31.1(chr1:64072618-75518432)x3 copy number gain See cases [RCV000142452] Chr1:64072618..75518432 [GRCh38]
Chr1:64538290..75984117 [GRCh37]
Chr1:64310878..75756705 [NCBI36]
Chr1:1p31.3-31.1		 pathogenic
GRCh38/hg38 1p31.3-31.1(chr1:66865125-77123381)x1 copy number loss See cases [RCV000143129] Chr1:66865125..77123381 [GRCh38]
Chr1:67330808..77589066 [GRCh37]
Chr1:67103396..77361654 [NCBI36]
Chr1:1p31.3-31.1		 pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p31.1(chr1:72578280-77429541)x3 copy number gain not provided [RCV000585144] Chr1:72578280..77429541 [GRCh37]
Chr1:1p31.1		 uncertain significance
GRCh37/hg19 1p31.3-31.1(chr1:63252828-77402595)x1 copy number loss See cases [RCV000446378] Chr1:63252828..77402595 [GRCh37]
Chr1:1p31.3-31.1		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p31.1-22.1(chr1:72044544-92505091)x1 copy number loss See cases [RCV000510161] Chr1:72044544..92505091 [GRCh37]
Chr1:1p31.1-22.1		 pathogenic
GRCh37/hg19 1p31.3-22.3(chr1:64321264-88153669)x1 copy number loss See cases [RCV000511392] Chr1:64321264..88153669 [GRCh37]
Chr1:1p31.3-22.3		 pathogenic|uncertain significance
GRCh37/hg19 1p31.1(chr1:74848936-80324850)x3 copy number gain See cases [RCV000510973] Chr1:74848936..80324850 [GRCh37]
Chr1:1p31.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p31.3-31.1(chr1:61351024-79583933)x1 copy number loss See cases [RCV000512152] Chr1:61351024..79583933 [GRCh37]
Chr1:1p31.3-31.1		 pathogenic
GRCh37/hg19 1p31.1(chr1:72103442-77186974)x3 copy number gain not provided [RCV000684586] Chr1:72103442..77186974 [GRCh37]
Chr1:1p31.1		 likely pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_001256114.2(LHX8):c.783G>T (p.Val261=) single nucleotide variant LHX8-related condition [RCV003926219]|not provided [RCV000963759] Chr1:75156895 [GRCh38]
Chr1:75622580 [GRCh37]
Chr1:1p31.1		 benign
NM_001256114.2(LHX8):c.92C>T (p.Ala31Val) single nucleotide variant LHX8-related condition [RCV003972894]|not provided [RCV000970048] Chr1:75137116 [GRCh38]
Chr1:75602801 [GRCh37]
Chr1:1p31.1		 benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
GRCh37/hg19 1p31.1(chr1:71410579-78131158) copy number gain not provided [RCV000767771] Chr1:71410579..78131158 [GRCh37]
Chr1:1p31.1		 pathogenic
NM_001256114.2(LHX8):c.411C>T (p.Asp137=) single nucleotide variant LHX8-related condition [RCV003962865]|not provided [RCV000970049] Chr1:75143169 [GRCh38]
Chr1:75608854 [GRCh37]
Chr1:1p31.1		 benign
GRCh37/hg19 1p31.3-22.3(chr1:67851233-86101340)x1 copy number loss not provided [RCV000846441] Chr1:67851233..86101340 [GRCh37]
Chr1:1p31.3-22.3		 pathogenic
Single allele deletion not provided [RCV000844927] Chr1:66085524..88429789 [GRCh37]
Chr1:1p31.3-22.2		 not provided
GRCh37/hg19 1p31.3-31.1(chr1:66868168-77106425)x1 copy number loss not provided [RCV000847457] Chr1:66868168..77106425 [GRCh37]
Chr1:1p31.3-31.1		 pathogenic
NM_001256114.2(LHX8):c.944C>T (p.Ala315Val) single nucleotide variant not provided [RCV001815675] Chr1:75157056 [GRCh38]
Chr1:75622741 [GRCh37]
Chr1:1p31.1		 uncertain significance
GRCh37/hg19 1p31.3-22.1(chr1:68180293-92731957) copy number loss not specified [RCV002053392] Chr1:68180293..92731957 [GRCh37]
Chr1:1p31.3-22.1		 pathogenic
Single allele duplication not specified [RCV002286371] Chr1:66885559..77949895 [GRCh38]
Chr1:1p31.3-31.1		 uncertain significance
NM_001256114.2(LHX8):c.886A>G (p.Met296Val) single nucleotide variant Inborn genetic diseases [RCV002980480] Chr1:75156998 [GRCh38]
Chr1:75622683 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001256114.2(LHX8):c.673G>C (p.Asp225His) single nucleotide variant Inborn genetic diseases [RCV002788555] Chr1:75143937 [GRCh38]
Chr1:75609622 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001256114.2(LHX8):c.331G>C (p.Asp111His) single nucleotide variant Inborn genetic diseases [RCV002803046] Chr1:75141078 [GRCh38]
Chr1:75606763 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001256114.2(LHX8):c.703G>A (p.Ala235Thr) single nucleotide variant Inborn genetic diseases [RCV002832621] Chr1:75148605 [GRCh38]
Chr1:75614290 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001256114.2(LHX8):c.19C>T (p.Arg7Trp) single nucleotide variant Inborn genetic diseases [RCV002961672] Chr1:75136633 [GRCh38]
Chr1:75602318 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001256114.2(LHX8):c.262C>T (p.Arg88Trp) single nucleotide variant Inborn genetic diseases [RCV002677634] Chr1:75141009 [GRCh38]
Chr1:75606694 [GRCh37]
Chr1:1p31.1		 uncertain significance
NM_001256114.2(LHX8):c.1A>C (p.Met1Leu) single nucleotide variant LHX8-related condition [RCV003906713]|not provided [RCV003406559] Chr1:75136615 [GRCh38]
Chr1:75602300 [GRCh37]
Chr1:1p31.1		 benign|likely benign
GRCh37/hg19 1p31.1-22.3(chr1:73616197-87012961)x1 copy number loss not provided [RCV003885448] Chr1:73616197..87012961 [GRCh37]
Chr1:1p31.1-22.3		 likely pathogenic
NM_001256114.2(LHX8):c.964+4G>C single nucleotide variant LHX8-related condition [RCV003981990] Chr1:75157080 [GRCh38]
Chr1:75622765 [GRCh37]
Chr1:1p31.1		 likely benign
NM_001256114.2(LHX8):c.213G>A (p.Glu71=) single nucleotide variant LHX8-related condition [RCV003957350] Chr1:75137237 [GRCh38]
Chr1:75602922 [GRCh37]
Chr1:1p31.1		 likely benign
NM_001256114.2(LHX8):c.75+9G>A single nucleotide variant LHX8-related condition [RCV003929749] Chr1:75136698 [GRCh38]
Chr1:75602383 [GRCh37]
Chr1:1p31.1		 likely benign
NM_001256114.2(LHX8):c.606C>T (p.Ala202=) single nucleotide variant LHX8-related condition [RCV003934176] Chr1:75143870 [GRCh38]
Chr1:75609555 [GRCh37]
Chr1:1p31.1		 likely benign
NM_001256114.2(LHX8):c.741A>G (p.Lys247=) single nucleotide variant LHX8-related condition [RCV003942085] Chr1:75148643 [GRCh38]
Chr1:75614328 [GRCh37]
Chr1:1p31.1		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:675
Count of miRNA genes:265
Interacting mature miRNAs:308
Transcripts:ENST00000294638, ENST00000356261, ENST00000559413, ENST00000607240
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-149363  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37175,601,032 - 75,601,337UniSTSGRCh37
Build 36175,373,620 - 75,373,925RGDNCBI36
Celera173,846,364 - 73,846,669RGD
Cytogenetic Map1p31.1UniSTS
HuRef173,735,910 - 73,736,215UniSTS
TNG Radiation Hybrid Map141017.0UniSTS
SHGC-6203  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37175,615,914 - 75,616,018UniSTSGRCh37
Build 36175,388,502 - 75,388,606RGDNCBI36
Celera173,861,247 - 73,861,351RGD
Cytogenetic Map1p31.1UniSTS
HuRef173,750,789 - 73,750,893UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 11 5 1 2 2 20 2 2 20 10
Low 31 5 332 156 30 5 130 41 560 42 414 386 152 2 6
Below cutoff 485 333 532 19 124 19 589 450 873 50 203 494 155 336 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001001933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047421040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054336668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054336669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB050476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC099786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC118550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000294638   ⟹   ENSP00000294638
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl175,128,434 - 75,161,533 (+)Ensembl
RefSeq Acc Id: ENST00000356261   ⟹   ENSP00000348597
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl175,134,388 - 75,161,533 (+)Ensembl
RefSeq Acc Id: ENST00000607240
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl175,159,288 - 75,161,531 (+)Ensembl
RefSeq Acc Id: ENST00000696555   ⟹   ENSP00000512714
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl175,134,388 - 75,161,533 (+)Ensembl
RefSeq Acc Id: NM_001001933   ⟹   NP_001001933
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38175,128,434 - 75,161,533 (+)NCBI
GRCh37175,594,119 - 75,627,218 (+)RGD
Build 36175,366,707 - 75,399,806 (+)NCBI Archive
Celera173,839,451 - 73,872,551 (+)RGD
HuRef173,728,993 - 73,762,092 (+)ENTREZGENE
CHM1_1175,709,516 - 75,742,604 (+)NCBI
T2T-CHM13v2.0174,970,280 - 75,003,384 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001256114   ⟹   NP_001243043
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38175,134,388 - 75,161,533 (+)NCBI
GRCh37175,594,119 - 75,627,218 (+)NCBI
HuRef173,728,993 - 73,762,092 (+)NCBI
CHM1_1175,715,964 - 75,742,604 (+)NCBI
T2T-CHM13v2.0174,976,238 - 75,003,384 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017001316   ⟹   XP_016856805
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38175,134,388 - 75,199,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017001317   ⟹   XP_016856806
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38175,136,383 - 75,199,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047421040   ⟹   XP_047276996
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38175,136,383 - 75,161,533 (+)NCBI
RefSeq Acc Id: XM_054336668   ⟹   XP_054192643
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0174,976,238 - 75,041,301 (+)NCBI
RefSeq Acc Id: XM_054336669   ⟹   XP_054192644
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0174,978,184 - 75,003,384 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001001933   ⟸   NM_001001933
- Peptide Label: isoform 1
- UniProtKB: E9PGE3 (UniProtKB/Swiss-Prot),   Q68G74 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001243043   ⟸   NM_001256114
- Peptide Label: isoform 2
- UniProtKB: Q68G74 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016856805   ⟸   XM_017001316
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016856806   ⟸   XM_017001317
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000294638   ⟸   ENST00000294638
RefSeq Acc Id: ENSP00000348597   ⟸   ENST00000356261
RefSeq Acc Id: ENSP00000512714   ⟸   ENST00000696555
RefSeq Acc Id: XP_047276996   ⟸   XM_047421040
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054192643   ⟸   XM_054336668
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054192644   ⟸   XM_054336669
- Peptide Label: isoform X2
Protein Domains
Homeobox   LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68G74-F1-model_v2 AlphaFold Q68G74 1-356 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:28838 AgrOrtholog
COSMIC LHX8 COSMIC
Ensembl Genes ENSG00000162624 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000294638 ENTREZGENE
  ENST00000294638.9 UniProtKB/Swiss-Prot
  ENST00000356261 ENTREZGENE
  ENST00000356261.4 UniProtKB/Swiss-Prot
  ENST00000696555.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000162624 GTEx
HGNC ID HGNC:28838 ENTREZGENE
Human Proteome Map LHX8 Human Proteome Map
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:431707 UniProtKB/Swiss-Prot
NCBI Gene 431707 ENTREZGENE
OMIM 604425 OMIM
PANTHER LIM/HOMEOBOX PROTEIN LHX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM/HOMEOBOX PROTEIN LHX8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142671553 PharmGKB
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0A8Q3WLD2_HUMAN UniProtKB/TrEMBL
  E9PGE3 ENTREZGENE
  LHX8_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6SV70_HUMAN UniProtKB/TrEMBL
  Q6SV71_HUMAN UniProtKB/TrEMBL
  Q9BYB7_HUMAN UniProtKB/TrEMBL
UniProt Secondary E9PGE3 UniProtKB/Swiss-Prot