LHX8 (LIM homeobox 8) - Rat Genome Database

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Gene: LHX8 (LIM homeobox 8) Canis lupus familiaris
Analyze
Symbol: LHX8
Name: LIM homeobox 8
RGD ID: 12353597
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); INVOLVED IN female gonad development (ortholog); forebrain neuron development (ortholog); forebrain neuron differentiation (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN female germ cell nucleus (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LIM/homeobox protein Lhx8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1671,329,711 - 71,355,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl671,329,820 - 71,352,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha673,992,529 - 74,018,201 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0671,921,509 - 71,947,201 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl671,920,999 - 71,947,701 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1671,416,782 - 71,442,453 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0671,362,129 - 71,387,952 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0671,856,878 - 71,882,562 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LHX8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1671,329,711 - 71,355,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl671,329,820 - 71,352,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha673,992,529 - 74,018,201 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0671,921,509 - 71,947,201 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl671,920,999 - 71,947,701 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1671,416,782 - 71,442,453 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0671,362,129 - 71,387,952 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0671,856,878 - 71,882,562 (-)NCBIUU_Cfam_GSD_1.0
LHX8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,128,434 - 75,199,454 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,128,434 - 75,161,533 (+)EnsemblGRCh38hg38GRCh38
GRCh37175,594,119 - 75,627,218 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,366,707 - 75,399,806 (+)NCBINCBI36Build 36hg18NCBI36
Celera173,839,451 - 73,872,551 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef173,728,993 - 73,762,092 (+)NCBIHuRef
CHM1_1175,709,516 - 75,742,604 (+)NCBICHM1_1
T2T-CHM13v2.0174,970,280 - 75,041,301 (+)NCBIT2T-CHM13v2.0
Lhx8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393154,011,925 - 154,036,190 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3154,011,931 - 154,036,296 (-)EnsemblGRCm39 Ensembl
GRCm383154,306,288 - 154,330,560 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3154,306,294 - 154,330,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv373153,969,257 - 153,993,524 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363154,242,163 - 154,265,944 (-)NCBIMGSCv36mm8
Celera3160,766,458 - 160,790,689 (-)NCBICelera
Cytogenetic Map3H4NCBI
cM Map379.12NCBI
Lhx8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82245,904,712 - 245,929,376 (-)NCBIGRCr8
mRatBN7.22243,244,958 - 243,269,624 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2243,244,961 - 243,269,416 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2251,069,403 - 251,090,965 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02248,963,243 - 248,984,805 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02243,862,639 - 243,884,232 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02260,572,205 - 260,598,744 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2260,574,190 - 260,596,777 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02279,235,991 - 279,260,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42252,216,608 - 252,239,112 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12252,231,217 - 252,253,719 (-)NCBI
Celera2235,171,406 - 235,193,860 (-)NCBICelera
Cytogenetic Map2q45NCBI
Lhx8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542317,644,871 - 17,668,781 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542317,644,691 - 17,668,969 (-)NCBIChiLan1.0ChiLan1.0
LHX8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21151,724,416 - 151,752,072 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11150,884,884 - 150,912,497 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,356,372 - 74,383,984 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1176,324,804 - 76,357,879 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl176,324,804 - 76,357,879 (+)Ensemblpanpan1.1panPan2
Lhx8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505886,811,952 - 86,842,076 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365712,326,920 - 2,351,779 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365712,326,851 - 2,352,428 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LHX8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6138,074,855 - 138,099,810 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16138,074,673 - 138,102,025 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26128,034,492 - 128,061,739 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LHX8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12058,016,078 - 58,043,651 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2058,017,298 - 58,041,479 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603359,429,912 - 59,454,728 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lhx8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474221,638,856 - 21,662,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474221,638,213 - 21,662,979 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LHX8
343 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 1 4
Below cutoff 1 1 10 4 4 6 5 10 4 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000043981   ⟹   ENSCAFP00000043085
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl671,329,820 - 71,352,945 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845008114   ⟹   ENSCAFP00845006373
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl671,920,999 - 71,947,701 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845008124   ⟹   ENSCAFP00845006379
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl671,921,625 - 71,947,701 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845008133   ⟹   ENSCAFP00845006386
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl671,921,625 - 71,947,701 (-)Ensembl
RefSeq Acc Id: XM_038480455   ⟹   XP_038336383
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1671,416,782 - 71,442,453 (-)NCBI
RefSeq Acc Id: XM_038534894   ⟹   XP_038390822
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha673,992,529 - 74,018,201 (-)NCBI
RefSeq Acc Id: XM_038538924   ⟹   XP_038394852
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0671,856,878 - 71,882,562 (-)NCBI
RefSeq Acc Id: XM_038603052   ⟹   XP_038458980
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0671,362,129 - 71,387,952 (-)NCBI
RefSeq Acc Id: XM_038670394   ⟹   XP_038526322
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0671,921,509 - 71,947,201 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000043085   ⟸   ENSCAFT00000043981
RefSeq Acc Id: XP_038336383   ⟸   XM_038480455
RefSeq Acc Id: XP_038458980   ⟸   XM_038603052
RefSeq Acc Id: XP_038526322   ⟸   XM_038670394
- UniProtKB: A0A8C0Q3Z7 (UniProtKB/TrEMBL),   A0A8I3MQE6 (UniProtKB/TrEMBL),   A0A8I3RTK6 (UniProtKB/TrEMBL),   A0A8P0NTI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390822   ⟸   XM_038534894
- UniProtKB: A0A8C0Q3Z7 (UniProtKB/TrEMBL),   A0A8I3MQE6 (UniProtKB/TrEMBL),   A0A8I3RTK6 (UniProtKB/TrEMBL),   A0A8P0NTI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038394852   ⟸   XM_038538924
- UniProtKB: A0A8C0Q3Z7 (UniProtKB/TrEMBL),   A0A8I3MQE6 (UniProtKB/TrEMBL),   A0A8I3RTK6 (UniProtKB/TrEMBL),   A0A8P0NTI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845006386   ⟸   ENSCAFT00845008133
RefSeq Acc Id: ENSCAFP00845006379   ⟸   ENSCAFT00845008124
RefSeq Acc Id: ENSCAFP00845006373   ⟸   ENSCAFT00845008114
Protein Domains
Homeobox   LIM zinc-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020401 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018221 UniProtKB/TrEMBL
  ENSCAFG00040000998 UniProtKB/TrEMBL
  ENSCAFG00845004534 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000043981.4 UniProtKB/TrEMBL
  ENSCAFT00000100379.1 UniProtKB/TrEMBL
  ENSCAFT00000101533.1 UniProtKB/TrEMBL
  ENSCAFT00030033561.1 UniProtKB/TrEMBL
  ENSCAFT00030033647.1 UniProtKB/TrEMBL
  ENSCAFT00040001839.1 UniProtKB/TrEMBL
  ENSCAFT00040001858.1 UniProtKB/TrEMBL
  ENSCAFT00845008114.1 UniProtKB/TrEMBL
  ENSCAFT00845008124 ENTREZGENE
  ENSCAFT00845008124.1 UniProtKB/TrEMBL
  ENSCAFT00845008133.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Znf_LIM UniProtKB/TrEMBL
NCBI Gene LHX8 ENTREZGENE
PANTHER LIM/HOMEOBOX PROTEIN LHX UniProtKB/TrEMBL
  LIM/HOMEOBOX PROTEIN LHX8 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
  LIM UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  LIM_DOMAIN_1 UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
  LIM UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF46689 UniProtKB/TrEMBL
UniProt A0A8C0Q3Z7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RN17_CANLF UniProtKB/TrEMBL
  A0A8I3MQE6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MWU7_CANLF UniProtKB/TrEMBL
  A0A8I3RTK6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NTI7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TJI5_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:42668 ENTREZGENE