Lhx8 (LIM homeobox 8) - Rat Genome Database

Name: Lhx8
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Lhx8 (LIM homeobox 8) Chinchilla lanigera

Analyze

Symbol:

Lhx8

Name:

LIM homeobox 8

RGD ID:

8832697

Description:

ENCODES a protein that exhibits sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN female gonad development (ortholog); forebrain neuron development (ortholog); forebrain neuron differentiation (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN female germ cell nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LIM/homeobox protein Lhx8

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LHX8 (LIM homeobox 8)	NCBI	Ortholog
Mus musculus (house mouse):	Lhx8 (LIM homeobox protein 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Lhx8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LHX8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LHX8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lhx8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LHX8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LHX8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lhx8 (LIM homeobox 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	17,644,871 - 17,668,781 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	17,644,691 - 17,668,969 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

female gonad development (ISO)

forebrain neuron development (ISO)

forebrain neuron differentiation (ISO)

learning or memory (ISO)

odontogenesis of dentin-containing tooth (ISO)

Cellular Component

female germ cell nucleus (ISO)

Molecular Function

protein binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Lhx8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	17,644,871 - 17,668,781 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	17,644,691 - 17,668,969 (-)	NCBI	ChiLan1.0	ChiLan1.0

LHX8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	75,128,434 - 75,199,454 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	75,128,434 - 75,161,533 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	75,594,119 - 75,627,218 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	75,366,707 - 75,399,806 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	73,839,451 - 73,872,551 (+)	NCBI		Celera
Cytogenetic Map	1	p31.1	NCBI
HuRef	1	73,728,993 - 73,762,092 (+)	NCBI		HuRef
CHM1_1	1	75,709,516 - 75,742,604 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	74,970,280 - 75,041,301 (+)	NCBI		T2T-CHM13v2.0

Lhx8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	154,011,925 - 154,036,190 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	154,011,931 - 154,036,296 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	154,306,288 - 154,330,560 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	154,306,294 - 154,330,659 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	153,969,257 - 153,993,524 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	154,242,163 - 154,265,944 (-)	NCBI		MGSCv36	mm8
Celera	3	160,766,458 - 160,790,689 (-)	NCBI		Celera
Cytogenetic Map	3	H4	NCBI
cM Map	3	79.12	NCBI

Lhx8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	245,904,712 - 245,929,376 (-)	NCBI		GRCr8
mRatBN7.2	2	243,244,958 - 243,269,624 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	243,244,961 - 243,269,416 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	251,069,403 - 251,090,965 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	248,963,243 - 248,984,805 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	243,862,639 - 243,884,232 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	260,572,205 - 260,598,744 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	260,574,190 - 260,596,777 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	279,235,991 - 279,260,188 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	252,216,608 - 252,239,112 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	252,231,217 - 252,253,719 (-)	NCBI
Celera	2	235,171,406 - 235,193,860 (-)	NCBI		Celera
Cytogenetic Map	2	q45	NCBI

LHX8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	151,724,416 - 151,752,072 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	150,884,884 - 150,912,497 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	74,356,372 - 74,383,984 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	76,324,804 - 76,357,879 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	76,324,804 - 76,357,879 (+)	Ensembl	panpan1.1		panPan2

LHX8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	71,329,711 - 71,355,851 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	71,329,820 - 71,352,945 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	73,992,529 - 74,018,201 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	71,921,509 - 71,947,201 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	71,920,999 - 71,947,701 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	71,416,782 - 71,442,453 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	71,362,129 - 71,387,952 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	71,856,878 - 71,882,562 (-)	NCBI		UU_Cfam_GSD_1.0

Lhx8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	86,811,952 - 86,842,076 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936571	2,326,920 - 2,351,779 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936571	2,326,851 - 2,352,428 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LHX8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	138,074,855 - 138,099,810 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	138,074,673 - 138,102,025 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	128,034,492 - 128,061,739 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LHX8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	58,016,078 - 58,043,651 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	58,017,298 - 58,041,479 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	59,429,912 - 59,454,728 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lhx8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	21,638,856 - 21,662,776 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	21,638,213 - 21,662,979 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013514370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01023858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01023859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01120861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000005892 ⟹ ENSCLAP00000005791

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955423	17,644,871 - 17,668,781 (-)	Ensembl

RefSeq Acc Id:

XM_013514370 ⟹ XP_013369824

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955423	17,644,691 - 17,668,969 (-)	NCBI

Sequence:

show sequence

TAAGAACAGAAGGTCAGAGGGTGGTGACGGCTACCGTGGCCTCCCTGGACCGAGTCTCGCTTGT
GGCTCTGCTGTCCTTCGCCTTAGCTTTTATCAGGCTCTTTGGGGCGGAGAGGGAGGCGATCCGC
AGACCTCGACAGCCTGTGCCCCGCCGGAGCTGGAATGTGACAAGCAGCCCCAGCAGTGCCATGT
ATTGGAAGAGCGACCCGATGTTTGTGTGTAAACTAGAGGAAAAGGACGTGCCGGGGCTGGCCGT
TCCCCCCGAGAAGAGCCGGCGGCTCATGTCGGAGGAGTGCGGGCGCCCCGCAGCCCTGGCGGCC
GGCAGGACTCGGAAAGGCGCCGGGGACGAAGGACTGCAGGTGAGCCCCGAGGGAGCGGGGGACG
AGGACTCGAGCTCCTCCTCGGCCCCGCTGTCCCCGTCGTCCTCGCCGCAGTCCATGGCCTCGGG
CTCCGGCTGTCCGCCCGGCAAGTGCGTGTGCAGCAGCTGCGGCCTGGAGATCGTGGACAAGTAC
CTGCTCAAGGTGAACGACCTGTGCTGGCATGTCCGGTGCCTCTCCTGCAGTGTCTGCAGAACCT
CCCTCGGAAGGCACACCAGCTGTTACATTAAGGACAAAGACATTTTCTGCAAACTCGATTATTT
CAGAAGATACGGAACTCGCTGCTCTCGATGCGGCAGGCACATCCACTCTACTGACTGGGTCCGC
AGGGCCAAAGGAAATGTCTATCACTTGGCGTGTTTCGCCTGCTTCTCTTGCAAAAGGCAACTTT
CCACGGGAGAGGAGTTTGCGTTGGTGGAAGAGAAAGTCCTCTGCAGAGTGCATTATGACTGCAT
GCTTGATAATTTAAAAAGAGAAGTGGAAAATGGTAACGGAATTAGTGTGGAAGGTGCCCTCCTC
ACAGAACAAGATGTTAATCATCCAAAACCAGCAAAAAGAGCTCGGACCAGCTTTACCGCAGATC
AGCTCCAGGTTATGCAAGCACAATTTGCTCAGGACAACAACCCAGATGCACAGACCCTCCAGAA
ACTGGCAGAAAGGACAGGCTTGAGCAGACGTGTGATACAGGTGTGGTTTCAGAATTGTAGAGCA
CGCCACAAGAAACACGTCAGTCCCAATCACTCCTCCTCTGCCCCTGTCACGGCGGTCCCGCCCT
CCAGGCTGTCTCCACCCATGCTGGAGGAAATGGCGTACTCTGCCTACGTGCCCCAGGACGGGAT
GCTCACTGCTCTGCACAGCTACATGGATGCTCATTCACCAACAACTCTTGGACTCCAGCCCTTG
TTACCCCATTCAATGACACAGCTGCCAATAAGTCATACCTAAGTCCTTTTTTCAGGGATAGAAA
TGATTGAGGTTATAAACTTGTCATTCATTATGTATAAAACACCATTGAACAGATAGTAATGTTA
ATTTTTTATTTAACACCCAAAGCATTTGCAACATCACTTTGCTACCCAGGTATGTATCTCTAGT
TGGC

hide sequence

Protein Sequences


Protein RefSeqs	XP_013369824	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000005791
	ENSCLAP00000005791.1

RefSeq Acc Id:

XP_013369824 ⟸ XM_013514370

- UniProtKB:

A0A8C2UU15 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MYWKSDPMFVCKLEEKDVPGLAVPPEKSRRLMSEECGRPAALAAGRTRKGAGDEGLQVSPEGAG
DEDSSSSSAPLSPSSSPQSMASGSGCPPGKCVCSSCGLEIVDKYLLKVNDLCWHVRCLSCSVCR
TSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQ
LSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTA
DQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSAPVTAVP
PSRLSPPMLEEMAYSAYVPQDGMLTALHSYMDAHSPTTLGLQPLLPHSMTQLPISHT

hide sequence

RefSeq Acc Id:

ENSCLAP00000005791 ⟸ ENSCLAT00000005892

Protein Domains

Homeobox LIM zinc-binding

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000004105	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000005892	ENTREZGENE
	ENSCLAT00000005892.1	UniProtKB/TrEMBL
Gene3D-CATH	Cysteine Rich Protein	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	Znf_LIM	UniProtKB/TrEMBL
NCBI Gene	Lhx8	ENTREZGENE
PANTHER	LIM/HOMEOBOX PROTEIN LHX	UniProtKB/TrEMBL
	LIM/HOMEOBOX PROTEIN LHX8	UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/TrEMBL
	LIM	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
	LIM_DOMAIN_1	UniProtKB/TrEMBL
	LIM_DOMAIN_2	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
	LIM	UniProtKB/TrEMBL
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/TrEMBL
	SSF46689	UniProtKB/TrEMBL
UniProt	A0A8C2UU15	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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